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Catechol-O-methyltransferase (COMT) influences the connectivity of the prefrontal cortex at rest

Elizabeth M. Tunbridge, Sarah M. Farrell, Paul J. Harrison, Clare E. Mackay
2013 NeuroImage  
Catechol-O-methyltransferase (COMT) modulates dopamine in the prefrontal cortex (PFC) and influences PFC dopamine-dependent cognitive task performance.  ...  Our data show that COMT Val 158 Met affects the functional connectivity of the PFC at rest, complementing its prominent role in the activation and functional connectivity of this region during cognitive  ...  CEM was partly supported by the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre based at Oxford University Hospitals Trust Oxford University.  ... 
doi:10.1016/j.neuroimage.2012.11.059 pmid:23228511 pmcid:PMC3566589 fatcat:gvadr4ssavfsvfnvxvn56nji7u

Age-Dependent Effects of Catechol-O-Methyltransferase (COMT) Gene Val158Met Polymorphism on Language Function in Developing Children

Lisa Sugiura, Tomoko Toyota, Hiroko Matsuba-Kurita, Yoshimi Iwayama, Reiko Mazuka, Takeo Yoshikawa, Hiroko Hagiwara
2016 Cerebral Cortex  
Previous studies of the catechol-O-methyltransferase (COMT) Val 158 Met genotype and cognition have focused on prefrontally guided executive functions involving dopamine.  ...  Our findings indicate that the effects of the COMT genotype on language ability and cortical language processing may change in a narrow age window of 6-10 years.  ...  We also appreciate the Bennese Cooperation for compiling and scoring the Japanese language test data. Conflict of Interest: None declared.  ... 
doi:10.1093/cercor/bhw371 pmid:27909011 pmcid:PMC6044402 fatcat:aax3rh3mqjd75fe24f7hlkcnvu

Catechol-O-methyltransferase, dopamine, and sleep-wake regulation

Yves Dauvilliers, Mehdi Tafti, Hans Peter Landolt
2015 Sleep Medicine Reviews  
The catechol-O-methyltransferase (COMT) gene is an interesting candidate, being one of the major mammalian enzymes involved in the catabolism of catecholamines.  ...  Individuals homozygous for the Val allele show higher COMT activity, and lower dopaminergic signaling in prefrontal cortex (PFC) than subjects homozygous for the Met allele.  ...  Health » of the University of Zürich.  ... 
doi:10.1016/j.smrv.2014.10.006 pmid:25466290 fatcat:ksrpy4tae5f5hazywulyuhwqoy

Impact of Catechol-O-Methyltransferase on Prefrontal Brain Functioning in Schizophrenia Spectrum Disorders

Ann-Christine Ehlis, Andreas Reif, Martin J Herrmann, Klaus-Peter Lesch, Andreas J Fallgatter
2006 Neuropsychopharmacology  
The enzyme catechol-O-methyltransferase (COMT) has attracted increasing interest regarding a genetic disposition towards schizophrenias and as a modulator of prefrontal brain function.  ...  An impact of COMT genotype on cognition has been well established; however, the exact nature of this influence has yet to be elucidated.  ...  This study was supported by the Deutsche Forschungsgemeinschaft (Grant RE1632/1-1 to AR, KFO 125/1-1 to AR, AJF, and KPL, SFB 581 to KPL, and FA 361/8-1 + 2 to  ... 
doi:10.1038/sj.npp.1301151 pmid:16823382 fatcat:2rgz43vrjbel5mq5bvifqgfudu

Catechol-O-Methyltransferase Val158Met Polymorphism Modulates Gray Matter Volume and Functional Connectivity of the Default Mode Network

Tian Tian, Wen Qin, Bing Liu, Dawei Wang, Junping Wang, Tianzi Jiang, Chunshui Yu, Hengyi Rao
2013 PLoS ONE  
The effect of catechol-O-methyltransferase (COMT) Val158Met polymorphism on brain structure and function has been previously investigated separately and regionally; this prevents us from obtaining a full  ...  We then extracted these brain regions with GMV differences as seeds to compute resting-state functional connectivity (rsFC) with the rest of the brain; we also tested the genotypic differences and gender  ...  Introduction Catechol-O-methyltransferase (COMT) catalyzes the degradation of synaptic dopamine (DA) in the brain, especially in the prefrontal cortex (PFC), where COMT may account for more than half of  ... 
doi:10.1371/journal.pone.0078697 pmid:24147141 pmcid:PMC3797700 fatcat:nxaox2yxrrb5lmdovzh4xn34me

Catechol-O-methyltransferase genotype modifies executive functioning and prefrontal functional connectivity in women with anorexia nervosa

Angela Favaro, Maurizio Clementi, Renzo Manara, Romina Bosello, Monica Forzan, Alice Bruson, Elena Tenconi, Daniela Degortes, Francesca Titton, Francesco Di Salle, Paolo Santonastaso
2013 Journal of Psychiatry & Neuroscience  
The present study explores the effect of a functional polymorphism (Val158Met) in the catechol-O-methyltransferase (COMT) gene on the set-shifting abilities and prefrontal functional connectivity of patients  ...  Dopamine (DA) signalling seems to play a key role in modulating the prefrontal cortex, since both DA deficiency and excess nega tively influence the efficiency of cognitive functions.  ...  Conflict of interest: None declared. Contributors  ... 
doi:10.1503/jpn.120068 pmid:23046831 pmcid:PMC3692721 fatcat:wbfuaeyc2fcg5d2ck5f2mhgdt4

Catechol O-Methyltransferase val158met Genotype Influences Frontoparietal Activity during Planning in Patients with Parkinson's Disease

C. H. Williams-Gray, A. Hampshire, T. W. Robbins, A. M. Owen, R. A. Barker
2007 Journal of Neuroscience  
Our previous work suggests that a common functional polymorphism (val(158)met) within the catechol O-methyltransferase (COMT) gene underlies some of this executive heterogeneity.  ...  We scanned 31 patients with early PD who were homozygous for either valine (val) (n = 16) or methionine (met) (n = 15) at the COMT val(158)met polymorphism during performance of an executive task comprising  ...  One highly plausible hypothesis is that this heterogeneity has a genetic basis, and indeed our own previous work has demonstrated that a common polymorphism in the catechol O-methyltransferase gene (COMT  ... 
doi:10.1523/jneurosci.0774-07.2007 pmid:17475791 pmcid:PMC6672096 fatcat:5mmpkl3p4vecbe4uqmfxjbyrzq

The catechol-o-methyltransferase Val158Met polymorphism modulates the intrinsic functional network centrality of the parahippocampal cortex in healthy subjects

Xiaolong Zhang, Jin Li, Wen Qin, Chunshui Yu, Bing Liu, Tianzi Jiang
2015 Scientific Reports  
The influence of catechol-o-methyltransferase (COMT) Val 158 Met on brain activation and functional connectivity has been widely reported.  ...  The catechol-O-methyltransferase (COMT) gene, which contains a well-studied functional polymorphism (Val 158 Met), plays a critical role in central dopamine function through the degradation of the COMT  ...  Several studies have reported that the COMT Val variant is associated with inefficient prefrontal-related functional connectivities at rest and poor cognitive performance 8, 11, 12 .  ... 
doi:10.1038/srep10105 pmid:26054510 pmcid:PMC4460568 fatcat:vnt5e37dbjadhlrfvht7j5japu

The catechol-o-methyltransferase Val158Met polymorphism modulates organization of regional cerebral blood flow response to working memory in adults

Alicia F. Heim, Melissa J. Coyne, M. Ilyas Kamboh, Christopher Ryan, J. Richard Jennings
2013 International Journal of Psychophysiology  
This study examined the effect of Catechol-O-Methyltransferase (COMT) Val 158 Met genotypes on the co-activation of brain areas involved in cognition during a working memory (WM) task.  ...  However, relatively better performance was associated with less concomitance of dorsolateral prefrontal cortex (DLPFC) and cingulate cortex for Val/Val, but more concomitance of DLPFC with AH for Met/Met  ...  Acknowledgments We acknowledge the grant support of NHLBI HL57529, NHLBI HL101959 and NIA AG03653. This report is based on a larger project with additional primary contributions by Dr.  ... 
doi:10.1016/j.ijpsycho.2013.06.023 pmid:23810996 pmcid:PMC3818354 fatcat:t77glzfmcfeqvlmmfxztrxbloa

Catechol-O-Methyltransferase Val158Met Modulation of Prefrontal Parietal Striatal Brain Systems during Arithmetic and Temporal Transformations in Working Memory

H.-Y. Tan, Q. Chen, T. E. Goldberg, V. S. Mattay, A. Meyer-Lindenberg, D. R. Weinberger, J. H. Callicott
2007 Journal of Neuroscience  
Here, we used the genotype of the Val158Met polymorphism in catechol-O-methyltransferase (COMT) as an index of relative cortical dopamine bioavailability and tuning efficiency, to examine the spatial and  ...  load (COMT Val>Met), while performing arithmetic transformations further engaged this genotype effect in dorsolateral prefrontal cortex (DLPFC), as well as in parietal and striatal regions.  ...  We evaluated these predictions using candidate genetic variation in catechol-O-methyltransferase (COMT) known to influence cortical DA bioavailability (Chen et al., 2004) .  ... 
doi:10.1523/jneurosci.4041-07.2007 pmid:18057197 pmcid:PMC6673107 fatcat:ktlm376xxbc7vky34vohavtkqe

Effect of Catechol-O-Methyltransferase Genotype Polymorphism on Neurological and Psychiatric Disorders: Progressing Towards Personalized Medicine

Kosha Srivastava, Olive Ochuba, Jasmine K Sandhu, Tasnim Alkayyali, Sheila W Ruo, Ahsan Waqar, Ashish Jain, Christine Joseph, Sujan Poudel
2021 Cureus  
Different polymorphisms of the catechol-O-methyltransferase (COMT) gene affect the COMT enzyme activity.  ...  This article highlights how genetics influences the susceptibility of an individual to neurological and psychiatric diseases and the variations in the specific symptoms of those diseases.  ...  FIGURE 1: Role of catechol-O-methyltransferase in catecholamine metabolism Original diagram showing the metabolism of catecholamine by the catechol-o-methyltransferase enzyme.  ... 
doi:10.7759/cureus.18311 pmid:34725583 pmcid:PMC8553290 fatcat:yst6pskt7bd4lci2ajjelj2f5q

Synergistic associations of catechol-O-methyltransferase and brain-derived neurotrophic factor with executive function in aging are selective and modified by apolipoprotein E

Shraddha Sapkota, David Vergote, David Westaway, Jack Jhamandas, Roger A. Dixon
2015 Neurobiology of Aging  
Genetic polymorphisms of Catechol-O-methyltransferase (COMT) and Brain-derived neurotrophic factor (BDNF) have shown promising but inconsistent linkages with executive function (EF) in normal aging.  ...  Of two tested models of synergistic effects, the additive approach selectively supported a magnification hypothesis, which was qualified by the presence or absence of APOE ε4.  ...  More information about the VLS may be found at:  ... 
doi:10.1016/j.neurobiolaging.2014.06.020 pmid:25107496 pmcid:PMC4268316 fatcat:5hfm5vla7vagdc4kbmlfnnxjhy

Oppositional COMT Val158Met effects on resting state functional connectivity in adolescents and adults

Bernhard M. Meyer, Julia Huemer, Ulrich Rabl, Roland N. Boubela, Klaudius Kalcher, Andreas Berger, Tobias Banaschewski, Gareth Barker, Arun Bokde, Christian Büchel, Patricia Conrod, Sylvane Desrivières (+26 others)
2014 Brain Structure and Function  
the connec- Smith JF, Pillai A, Chen K, Horwitz B (2010) Identification and tivity of the prefrontal cortex at rest.  ...  Genetic adolescents and adults in prefrontal brain networks at rest. variation of COMT (COMT Val158Met) results in lower Resting state functional connectivity data were  ... 
doi:10.1007/s00429-014-0895-5 pmid:25319752 pmcid:PMC4667398 fatcat:fkaj637eynhmnmgk4lrsle4n6q

COMT Val158Met genotypes differentially influence subgenual cingulate functional connectivity in healthy females

Chris Baeken, Daniele Marinazzo, Stephan Claes, Guo-Rong Wu, Peter Van Schuerbeek, Johan De Mey, Robert Luypaert, Rudi De Raedt
2014 Frontiers in Human Neuroscience  
No studies have yet investigated the influence of the COMT Val 158 Met polymorphism (rs4680) on sgACC resting-state functional connectivity (rsFC) in healthy individuals.  ...  Brain imaging studies have consistently shown subgenual Anterior Cingulate Cortical (sgACC) involvement in emotion processing. catechol-O-methyltransferase (COMT) Val 158 and Met 158 polymorphisms may  ...  Gepts UZBrussel and supported by the Ghent University Multidisciplinary Research Partnership "The integrative neuroscience of behavioral control".  ... 
doi:10.3389/fnhum.2014.00481 pmid:25071511 pmcid:PMC4074702 fatcat:o54f2wd4qjcyrkz4yidxvpm3fa

COMT genotype, gambling activity, and cognition

Jon E. Grant, Eric W. Leppink, Sarah A. Redden, Brian L. Odlaug, Samuel R. Chamberlain
2015 Journal of Psychiatric Research  
Catechol-O-methyltransferase (COMT) plays a unique role in the regulation of dopamine in the prefrontal cortex and has been proposed to play a role in the cognitive dysfunction of problem gambling.  ...  This study adds to the growing literature on the role of COMT in impulsive behaviors by showing that the Val/Val genotype was associated with specific clinical and cognitive elements among young adults  ...  The catechol-O-methyltransferase (COMT) enzyme plays a unique role in the regulation of dopamine in the prefrontal cortex (Tunbridge et al., 2004) and has been proposed to be a potential target for the  ... 
doi:10.1016/j.jpsychires.2015.04.029 pmid:26028545 fatcat:r52h3wprdraplp5siwvdyqrhny
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