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The Energetic Cost of a Night on the Town

Caroline D. Rae
2014 Sleep  
Rae has indicated no financial conflicts of interest. Downloaded from by guest on 27 July 2018  ...  Nevertheless, there is plenty of food for thought in the report by Plante and colleagues. 1 CITATION Rae CD. The energetic cost of a night on the town. SLEEP 2014;37(12):1881-1882.  ... 
doi:10.5665/sleep.4230 pmid:25406115 pmcid:PMC4548504 fatcat:faharf5a6jgvnjk3xcbbwmp5ky

Emerging Concepts in Vector Development for Glial Gene Therapy: Implications for Leukodystrophies

Georg von Jonquieres, Caroline D. Rae, Gary D. Housley
2021 Frontiers in Cellular Neuroscience  
J., Marmion, D. J., Kirik, D., Chu, Y., Heindel, C., McCown, T., et al. (2017).  ...  .72.12.9873-9880.1998 PubMed Abstract | CrossRef Full Text | Google Scholar Keywords: leukodystrophies, gene therapy, glia, adeno-associated virus, hematopoietic stem cells Citation: von Jonquieres G, Rae  ... 
doi:10.3389/fncel.2021.661857 fatcat:z5wu3rdvfvamvla6oogwtcn4oa

Indoor air quality in Virginia waterpipe cafés

Caroline Oates Cobb, Andrea Rae Vansickel, Melissa D Blank, Kade Jentink, Mark J Travers, Thomas Eissenberg
2012 Tobacco Control  
Introduction-A revised indoor air quality law has been implemented in Virginia to protect the public from the harmful effects of secondhand smoke exposure. This legislation contains exemptions that include allowances for smoking in a room that is structurally separated and separately ventilated. The objective of the current study was to examine the impact of this law on air quality in waterpipe cafés, as well as to compare the air quality in these cafés to restaurants that allow cigarette
more » ... g and those where no smoking is permitted. Methods-Indoor air quality in 28 venues (17 waterpipe cafés, five cigarette smoking-permitted restaurants and six smoke-free restaurants (five with valid data)) in Virginia was assessed during 4 March to 27 May 2011. Real-time measurements of particulate matter (PM) with 2.5 µm aerodynamic diameter or smaller (PM 2.5 ) were obtained and occupant behaviour/venue characteristics were assessed. Results-The highest mean PM 2.5 concentration was observed for waterpipe café smoking rooms (374 µg/m 3 , n=17) followed by waterpipe café non-smoking rooms (123 µg/m 3 , n=11), cigarette smoking-permitted restaurant smoking rooms (119 µg/m 3 , n=5), cigarette smokingpermitted restaurant non-smoking rooms (26 µg/m 3 , n=5) and smoke-free restaurants (9 µg/m 3 , n=5). Smoking density was positively correlated with PM 2.5 across smoking rooms and the smoke-free restaurants. In addition, PM 2.5 was positively correlated between smoking and nonsmoking rooms of venues. Conclusions-The PM 2.5 concentrations observed among the waterpipe cafés sampled here indicated air quality in the waterpipe café smoking rooms was worse than restaurant rooms in which cigarette smoking was permitted, and state-required non-smoking rooms in waterpipe cafés may expose patrons and employees to PM 2.5 concentrations above national and international air quality standards. Reducing the health risks of secondhand smoke may require smoke-free establishments in which tobacco smoking sources such as water pipes are, like cigarettes, prohibited.
doi:10.1136/tobaccocontrol-2011-050350 pmid:22447194 pmcid:PMC3889072 fatcat:4nwqcumzmfah5anxls7jqappbm

CRPS is not associated with altered sensorimotor cortex GABA or glutamate

Barbara Lee, Luke A Henderson, Caroline D. Rae, Flavia Di Pietro
2020 eNeuro  
D, Plots demonstrating the age distribution of the two groups. The left plot shows subjects used for GABA, the middle plot for Glx, and the right plot for TPD.  ...  that the GABA concentration measured by MRS is largely extrasynaptic GABA, which better reflects the amount of GABA that can be released for tonic inhibition (Nasrallah et al., 2011; Ziemann, 2013; Rae  ... 
doi:10.1523/eneuro.0389-19.2020 pmid:31980452 pmcid:PMC7029188 fatcat:kbj7aamg7fesdgiyeknzq64geq

Impact of Inhibition of Glutamine and Alanine Transport on Cerebellar Glial and Neuronal Metabolism

Abhijit Das, Gregory Gauthier-Coles, Stefan Bröer, Caroline D. Rae
2022 Biomolecules  
role of cerebellar amino acid transporters in the cycling of glutamine and alanine in guinea pig cerebellar slices by inhibiting amino acid transporters and examining the resultant metabolism of [1-13C]D-glucose  ...  (Figures 1C,D ).  ...  (A), Total metabolite pools; (B), Total net fluxes of 13 C; (C), Net fluxes derived from [1-13 C]D-glucose; (D), Net fluxes derived from [1,2-13 C]acetate.  ... 
doi:10.3390/biom12091189 pmid:36139028 fatcat:mvrlxvijt5anvimsdo7ozvn4d4

Brain amyloid in virally suppressed HIV-associated neurocognitive disorder

Gemma C Howdle, Yann Quidé, Mustafa S Kassem, Kate Johnson, Caroline D Rae, Bruce J Brew, Lucette A Cysique
2020 Neurology: Neuroimmunology & Neuroinflammation  
0.11 d, e, f Medial frontal 0.87 (0.09) 1.02 (0.29) 1.03 (0.31) 2.25 (0.79) 2.49 (0.35) <0.0001 <0.05 d, e, f Orbitofrontal 1.13 (0.27) 1.14 (0.21) 1.13 (0.20) 2.71 (0.53) 2.92 (0.53)  ...  2.33 (0.40) 2.56 (0.46) <0.0001 0.42 d, e, f Pallidum 1.31 (0.49) 1.15 (0.33) 1.13 (0.28) 2.02 (0.25) 2.07 (0.73) <0.0001 0.25 b, d, e, f Table 3 3 Case 2 with a probable AD and MND  ... 
doi:10.1212/nxi.0000000000000739 pmid:32393651 pmcid:PMC7238897 fatcat:qw7fusdrdfeernajdfpyhtoh4a

Preserved cortical maps of the body in Complex Regional Pain Syndrome [article]

Flavia Mancini, Audrey P Wang, Mark M Shira, Zoey J Isherwood, James H McAuley, Giandomenico Iannetti, Martin I. Sereno, Lorimer Moseley, Caroline D Rae
2018 bioRxiv   pre-print
O l d f i e l d R C ( 1 9 7 1 ) T h e a s s e s s m e n t a n d a n a l y s i s o f h a n d e d n e s s : t h e E d i n b u r g h i n  ...  i t y g o h a n d i n h a n d .  ... 
doi:10.1101/409094 fatcat:owjosxre4nf5zlngbmjl4xc7xa

Brain amyloid in virally suppressed HIV-associated neurocognitive disorder

Gemma C. Howdle, Yann Quidé, Mustafa S. Kassem, Kate Johnson, Caroline D. Rae, Bruce J. Brew, Lucette A. Cysique
2020 Neurology: Neuroimmunology & Neuroinflammation  
0.11 d, e, f Medial frontal 0.87 (0.09) 1.02 (0.29) 1.03 (0.31) 2.25 (0.79) 2.49 (0.35) <0.0001 <0.05 d, e, f Orbitofrontal 1.13 (0.27) 1.14 (0.21) 1.13 (0.20) 2.71 (0.53) 2.92 (0.53)  ...  2.33 (0.40) 2.56 (0.46) <0.0001 0.42 d, e, f Pallidum 1.31 (0.49) 1.15 (0.33) 1.13 (0.28) 2.02 (0.25) 2.07 (0.73) <0.0001 0.25 b, d, e, f Table 3 3 Case 2 with a probable AD and MND  ... 
doi:10.1212/nxi.0000000000000739 fatcat:3edhrwdjkje4nakwmpgfftiyiy

Fine-grained mapping of cortical somatotopies in chronic Complex Regional Pain Syndrome

Flavia Mancini, Audrey P Wang, Mark M. Schira, Zoey J. Isherwood, James H. McAuley, Giandomenico D. Iannetti, Martin I. Sereno, G. Lorimer Moseley, Caroline D. Rae
2019 Journal of Neuroscience  
Patients were also asked to rate the average pain intensity experienced both over the 48 h and the 7 d preceding the MRI session.  ...  Indeed, a previous fMRI study reported a great similarity between the S1 map of the hand elicited by unimanual versus bimanual finger movements (Kikkert et al., 2016, their Fig. 2 D, E) .  ... 
doi:10.1523/jneurosci.2005-18.2019 pmid:31570533 pmcid:PMC6855684 fatcat:eocucyxl75g43izwpljtwoy4tm

A new role for α-ketoglutarate dehydrogenase complex: regulating metabolism through post-translational modification of other enzymes

Mary C. McKenna, Caroline D. Rae
2015 Journal of Neurochemistry  
This Editorial highlights a study by Gibson et al. (2015) published in this issue of JNeurochem, in which the authors reveal a novel role for the alpha-ketoglutarate dehydrogenase complex (KGDHC) in post-translational modification of proteins. KGDHC may catalyze post-translational modification of itself as well as several other proteins by succinylation of lysine residues. The authors' report of an enzyme responsible for succinylation of key mitochondrial enzymes represents a big step towards
more » ... r understanding of the complex functional metabolome.
doi:10.1111/jnc.13150 pmid:26052752 pmcid:PMC4945114 fatcat:dryvg4vnavea3ns5lhuvfk5eza

Anodal transcranial direct current stimulation increases brain intracellular pH and modulates bioenergetics

Caroline D. Rae, Vincent H.-C. Lee, Roger J. Ordidge, Angelo Alonzo, Colleen Loo
2013 International Journal of Neuropsychopharmacology  
Subjects were studied twice at similar times of day, with at least 2 d (or 1 wk if active tDCS preceded sham tDCS) between visits.  ...  There are no reports of loss of the choline signal in 1 H spectroscopy studies (Rango et al., 2008; Rae et al., 2009; Clark et al., 2011) .  ... 
doi:10.1017/s1461145713000084 pmid:23473040 fatcat:uzp3slgglzcq5ba2wewcp3yb4i

Health-related quality of life among children with acute lymphoblastic leukemia

William Furlong, Charlene Rae, David Feeny, Richard D. Gelber, Caroline Laverdiere, Bruno Michon, Lewis Silverman, Stephen Sallan, Ronald Barr
2012 Pediatric Blood & Cancer  
BACKGROUND-The objective was to quantify the health-related quality of life (HRQL) of children treated for acute lymphoblastic leukemia (ALL) and identify specific disabilities for remediation. PROCEDURE-Two types of subjects were included: ALL patients 5 plus years old in a multicenter clinical trial; and general population control groups. Patients were assessed during all 4 major phases of active treatment and approximately 2 years after treatment. Health status and HRQL were measured using
more » ... ALTH UTILITIES INDEX® (HUI®) Mark 2 (HUI2) and Mark 3 (HUI3). HRQL scores were used to calculate quality-adjusted life years (QALYs). Excess disability rates identified attributes for remediation. (n=749) were collected during the 5 phases. Mean HRQL increased from induction through the post-treatment phase (p<0.001). There were no significant demographic or treatment effects on HRQL, except for type of asparaginase during continuation therapy (p=0.005 for HUI2 and p=0.007 for HUI3). Differences in mean HRQL scores between patients and controls were important (p<0.001) during the active treatment phases but not during the post-treatment phase. Relative to controls, patients lost approximately 0.2 QALYs during Correspondence to: William Furlong, MSc, CRL 217, McMaster University, active treatment. Disability was evident in mobility/ambulation, emotion, self-care and pain, and declined over time. RESULTS-HUI assessments CONCLUSIONS-Patients with ALL experienced important but declining deficits in HRQL during active treatment phases: equivalent to losing approximately 2 months of life in perfect health. HRQL within the 2-years post-treatment phase was similar to controls. The policy challenge is to develop new treatment protocols producing fewer disabilities in mobility/ ambulation, emotion, self-care, and pain without compromising survival.
doi:10.1002/pbc.24096 pmid:22294502 pmcid:PMC4123756 fatcat:rqwbbzeb65fm3mxgop3bv4vd24

Atrophic brain signatures of mild forms of neurocognitive impairment in virally suppressed HIV infection

Madeleine J Nichols, Thomas M Gates, James R Soares, Kirsten J Moffat, Caroline D Rae, Bruce J Brew, Lucette A Cysique
2019 AIDS (London)  
Relative to the HIV-negative group, the HIV-positive group demonstrated subcortical grey (d = 0.50-0.60) and white matter (d = 0.43-0.69) atrophy, with relative cortical sparing (d = 0.23).  ... 
doi:10.1097/qad.0000000000002042 pmid:30325766 fatcat:ylwmzhkx3fbrzllobj4liqow74

Toluene inhalation in adolescent rats reduces flexible behaviour in adulthood and alters glutamatergic and GABAergic signalling

Teri M. Furlong, Jhodie R. Duncan, Laura H. Corbit, Caroline D. Rae, Benjamin D. Rowlands, Anthony D. Maher, Fatima A. Nasrallah, Carol J. Milligan, Steven Petrou, Andrew J. Lawrence, Bernard W. Balleine
2016 Journal of Neurochemistry  
al. 2009; Rae et al. 2014; Nasrallah et al. 2010a) .  ...  The second model contained data from a range of experiments using ligands active in the GABAergic system (Nasrallah et al. 2011; Nasrallah et al. 2007; Nasrallah et al. 2010b; Rae et al. 2015; Rae et  ... 
doi:10.1111/jnc.13858 pmid:27696399 fatcat:7qfett5ncvdbtoqrwnj26aohou

Reduced Glutamate in the Medial Prefrontal Cortex Is Associated With Emotional and Cognitive Dysregulation in People With Chronic Pain

Brooke Naylor, Negin Hesam-Shariati, James H. McAuley, Simon Boag, Toby Newton-John, Caroline D. Rae, Sylvia M. Gustin
2019 Frontiers in Neurology  
(D) A plot of Glu/ H 2 O ratios in people with chronic pain against NAA/ H 2 O ratios in the medial prefrontal cortex.  ... 
doi:10.3389/fneur.2019.01110 pmid:31849800 pmcid:PMC6903775 fatcat:uou3utcq5zdknkb5kzo4x5ui2e
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