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Invited Commentary

Carolee J. Winstein
2011 Physical Therapy  
Address all correspondence to Dr Winstein at: winstein@usc.edu. DOI: 10.2522/ptj.20100248.ic f Physical Therapy Volume 91 Number 2 February 2011 ScienceDaily Staff.  ...  Winstein, PT, PhD, FAPTA, is Professor and Director of Research, Division Biokinesiology and Physical Therapy at the Herman Ostrow School of Dentistry, Department of Neurology, Keck School of Medicine,  ...  Winstein comments on the lack of a bold vision of research for the profession and the fact that there is no statement about the purpose for having a research agenda for the profession.  ... 
doi:10.2522/ptj.20100248.ic pmid:21285038 fatcat:yr57zrbjona4vf3qvyfmtchmze

Predictors of arm non-use in chronic stroke: a preliminary investigation [article]

Laurel J Buxbaum, Rini Varghese, Harrison Stoll, Carolee Winstein
2019 bioRxiv   pre-print
Woytowicz EJ, Westlake KP, Whitall J, Sainburg RL.  ...  J Clin Exp Neuropsychol. 1988. doi:10.1080/01688638808408245 24. Buxbaum LJ, Kyle KM, Menon R.  ... 
doi:10.1101/702159 fatcat:k7vhfs6vbzd35lbgtzilyfmimi

The Past, Present, and Future of Neurorehabilitation

Susan R. Harris, Carolee J. Winstein
2017 Pediatric Physical Therapy  
Winstein CJ, Stein J, Arena R, et al.  ...  J Neuroeng Rehabil. 2013;10:15. Bryanton C, Bosse J, Brien M, McLean J, McCormick A, Sveistrup H.  ...  Appendix Speakers and the Charge From the Planning Committee Speaker(s) Charge Carolee Winstein, Susan Harris Summarize the history of the STEP conferences, your thoughts/reflections on current PT  ... 
doi:10.1097/pep.0000000000000376 pmid:28654472 fatcat:psnfb33cezblxfseba2irbf4fm

Retrospective Exploratory Analysis of Task-Specific Effects on Brain Activity after Stroke [article]

Marika Demers, Rini Varghese, Carolee J Winstein
2021 medRxiv   pre-print
et al., 2003; Kaplon et al., 2007; Taub et al., 2013; Winstein and Wolf, 2014) .  ...  This provoked us to reanalyze an unpublished dataset from a companion study of the EXCITE trial (Winstein et al., 2003) in pursuit of evidence for cortical reorganization induced through task-specific  ...  Carolee Winstein: conceptualization, supervision, writing-reviewing and editing.  ... 
doi:10.1101/2021.08.20.21260371 fatcat:mx4khcky2rglrhl3r3xwvby3ky

The Efficiency, Efficacy, and Retention of Motor Training in Chronic Stroke [article]

Chunji Wang, Carolee J Winstein, David Z D'Argenio, Nicolas Schweighofer
2020 bioRxiv   pre-print
Winstein C, Lewthwaite R, Blanton SR, Wolf LB, Wishart L.  ...  J Neurol Phys Ther. . https://doi.org/10.1101/2020.01.27.922096 doi: bioRxiv preprint 34. 35. Hayward KS, Eng JJ, Boyd LA, Lakhani B, Bernhardt J, Lang CE.  ... 
doi:10.1101/2020.01.27.922096 fatcat:7ddtiurqfzd6pk6vvo3sgyx76a

Socially assistive robotics for post-stroke rehabilitation

Maja J Matarić, Jon Eriksson, David J Feil-Seifer, Carolee J Winstein
2007 Journal of NeuroEngineering and Rehabilitation  
Although there is a great deal of success in rehabilitative robotics applied to patient recovery post stroke, most of the research to date has dealt with providing physical assistance. However, new rehabilitation studies support the theory that not all therapy need be hands-on. We describe a new area, called socially assistive robotics, that focuses on non-contact patient/user assistance. We demonstrate the approach with an implemented and tested post-stroke recovery robot and discuss its
more » ... ial for effectiveness. Results: We describe a pilot study involving an autonomous assistive mobile robot that aids stroke patient rehabilitation by providing monitoring, encouragement, and reminders. The robot navigates autonomously, monitors the patient's arm activity, and helps the patient remember to follow a rehabilitation program. We also show preliminary results from a follow-up study that focused on the role of robot physical embodiment in a rehabilitation context. Conclusion: We outline and discuss future experimental designs and factors toward the development of effective socially assistive post-stroke rehabilitation robots.
doi:10.1186/1743-0003-4-5 pmid:17309795 pmcid:PMC1821334 fatcat:eo6d5pvkwrgixl7dmijwuw56mu

Corpus callosal microstructure predicts bimanual motor performance in chronic stroke survivors [article]

Rini Varghese, Brianna Chang, Bokkyu Kim, Sook-Lei Liew, Nicolas Schweighofer, Carolee J Winstein
2021 bioRxiv   pre-print
There is growing evidence for the utility of DTI-derived metrics in humans as prognostic biomarkers of recovery after stroke (Kim & Winstein, 2017; Puig et al., 2017) .  ...  Diffusion tensor imaging data for 41 chronic stroke survivors were available from a Phase 2B randomized controlled trial (Dose Optimization for Stroke Evaluation, ClinicalTrials.gov ID: NCT01749358) (Winstein  ... 
doi:10.1101/2021.05.14.443663 fatcat:2pgdrmo2lngb3edfck4c7lwure

Spectral Analyses of Wrist Motion in Individuals Poststroke

Eric Wade, Christina Chen, Carolee J. Winstein
2013 Neurorehabilitation and Neural Repair  
Background-Upper extremity use in daily life is a critical ingredient of continued functional recovery after cerebral stroke. However, time-evolutions of use-dependent motion quality are poorly understood due to limitations of existing measurement tools. Objective-Proof-of-concept study to determine if spectral analyses explain the variability of known temporal kinematic movement quality (ie, movement duration, number of peaks, jerk) for uncontrolled reach-to-grasp tasks. Methods-Ten
more » ... with chronic stroke performed unimanual goal-directed movements using both hands, with and without task object present, wearing accelerometers on each wrist. Temporal and spectral measures were extracted for each gesture. The effects of performance condition on outcome measures were determined using 2-way, within subject, hand (nonparetic vs paretic) × object (present vs absent) analysis of variance. Regression analyses determined if spectral measures explained the variability of the temporal measures. Results-There were main effects of hand on all 3 temporal measures and main effects of object on movement duration and peaks. For the paretic limb, spectral measures explain 41.2% and 51.1% of the variability in movement duration and peaks, respectively. For the nonparetic limb, spectral measures explain 40.1%, 42.5%, and 27.8% of the variability of movement duration, peaks, and jerk, respectively. Conclusions-Spectral measures explain the variability of motion efficiency and control in individuals with stroke. Signal power from 1.0 to 2.0 Hz is sensitive to changes in hand and object. Analyzing the evolution of this measure in ambient environments may provide as yet uncharted information useful for evaluating long-term recovery.
doi:10.1177/1545968313505911 pmid:24213957 pmcid:PMC3900236 fatcat:6dgodper5zc5tihek6s7n7oidu

Editorial: Combined Therapeutic Approaches to Neurological Rehabilitation

Elizabeth Rochon, Gail A. Eskes, Elizabeth R. Skidmore, Carolee J. Winstein
2022 Frontiers in Rehabilitation Sciences  
doi:10.3389/fresc.2022.918005 fatcat:qcxcogkkoraalbox34dalepv4u

Relationship Between Motor Capacity of the Contralesional and Ipsilesional Hand Depends on the Side of Stroke [article]

Rini Varghese, Carolee J Winstein
2019 bioRxiv   pre-print
There is considerable evidence that after a stroke, ipsilesional deficits increase as contralesional impairment increases. However, it is unclear whether this relationship differs based on the side of stroke. Here, we tested the hypothesis that the ipsilesional hand motor capacity co-varies with contralesional hand impairment only in individuals with left hemisphere damage. Forty-two pre-morbidly right-handed chronic stroke survivors (left hemisphere damage, LHD = 21) with mild-to-moderate
more » ... is (Upper Extremity Fugl-Meyer-UEFM range: 19-59) performed distal items of the Wolf Motor Function Test (dWMFT). We used univariate co-efficient of determination (R2) and multiple linear regression to assess the relationship between motor capacity of ipsilesional and contralesional hands. Contralesional UEFM, and dWMFT were found to be significant predictors of ipsilesional hand motor capacity (p < 0.0001 for both). Importantly, the relationship between contralesional and ipsilesional hands was significantly modified by side of stroke (model adjusted R2 = 0.26 and 0.42, respectively, p < 0.01). For individuals with LHD, contralesional impairment explained 42% and contralesional hand motor capacity explained 65% of the variance in ipsilesional hand motor capacity. However, this relationship was not statistically significant for individuals with right hemisphere damage (RHD, unadjusted R2 < 1% for UEFM and 9% for dWMFT, p > 0.05). In chronic stroke survivors with mild-to-moderate impairment, our findings demonstrate that the relationship between contralesional and ipsilesional motor deficits depends on the side of stroke. Specifically, deficits co-vary between the limbs of stroke survivors with left hemisphere damage but not right hemisphere damage.
doi:10.1101/635136 fatcat:qqtuchfdw5btrk27o34z4vslgm

Bimanual Training After Stroke: Are Two Hands Better Than One?

Dorian K. Rose, Carolee J. Winstein
2004 Topics in Stroke Rehabilitation  
(Adapted from Rose D, Winstein C. The coordination of bimanual rapid aiming movements following stroke. Clin Rehabil. In press.  ... 
doi:10.1310/xaum-lpbm-0rxd-rldk pmid:15592987 fatcat:fgvglsyrpbazzetfqto2fhvnse

Dual-task practice enhances motor learning: a preliminary investigation

Hui-Ting Goh, Katherine J. Sullivan, James Gordon, Gabriele Wulf, Carolee J. Winstein
2012 Experimental Brain Research  
beneficial to motor learning when the secondary task is difficult (Roche et al. in Percept Psychophys 69(4):513-522, 2007) or when it engages similar processes as the primary motor task (Hemond et al. in J  ...  Our findings are consistent with a well-known motor learning phenomenon, the learning-performance distinction (Kantak and Winstein 2012) .  ... 
doi:10.1007/s00221-012-3206-5 pmid:22886044 fatcat:4p3rxvivxvauzilftpech2avvi

In Memoriam: Richard Allen Schmidt (1941 – 2015)

Timothy D. Lee, Gabriele Wulf, Carolee J. Winstein, Howard N. Zelaznik
2015 Journal of Motor Behavior  
Several studies from Dick's lab demonstrated for the first time that learning was enhanced by reducing the feedback frequency (Winstein & Schmidt, 1990) , providing summary or average feedback (Schmidt  ... 
doi:10.1080/00222895.2016.1124687 pmid:26701105 fatcat:gfj25ywutbbnrdzqn4ozvwcrry

Anticipatory Planning of Functional Reach-to-Grasp

Caroline Tan, Jarugool Tretriluxana, Erica Pitsch, Nuttakarn Runnarong, Carolee J. Winstein
2012 Neurorehabilitation and Neural Repair  
Background-Intensive task-oriented training such as constraint-induced movement therapy (CIMT) is thought to engage motor learning and decision-making processes, including anticipatory action planning. Objective-To identify the effects of CIMT on anticipatory hand posture selection and movement time for task-specific reach-to-grasp performance. Methods-Subacute and chronic poststroke participants were recruited into CIMT (n = 10) or non-CIMT (n = 10) groups. Arm and hand functions were assessed
more » ... before and after 2 weeks with the Wolf Motor Function Test (WMFT), Motor Activity Log (MAL), and a unique skilled reachto-grasp task designed to test anticipatory hand posture selection. The reach-to-grasp tasks included power and precision grasping in 2 conditions achieved optimally with either a pronated (low difficulty) or supinated (high difficulty) hand posture. Outcome measures included success rate, frequency of optimal strategy selection, and movement time. Results-Between-group comparisons revealed a significant treatment effect for WMFT and MAL scores. The CIMT group showed larger gains in success rate, optimal posture selection (precision grasp only), and faster movement times for the supinated conditions. Conclusion-Together, a faster movement time and greater frequency of optimal hand posture selection in the more difficult task condition highlights a set of novel findings. These results provide evidence for training-induced improvements in upper-extremity function that support neurobehavioral recovery more than compensation. Although these findings are preliminary in view of the small sample size, the authors suggest that they may be useful to design and power larger-scale studies to further the understanding of the fundamental mechanisms induced by taskoriented training interventions in neurorehabilitation. Reprints and
doi:10.1177/1545968312437938 pmid:22434022 pmcid:PMC6015502 fatcat:enmijmueobb6hfrpusrkmmvwny

Bimanual Training After Stroke: Are Two Hands Better Than One?

Dorian K. Rose, Carolee J. Winstein
2004 Topics in Stroke Rehabilitation  
(Adapted from Rose D, Winstein C. The coordination of bimanual rapid aiming movements following stroke. Clin Rehabil. In press.  ... 
doi:10.1310/ncb1-jwaa-09qe-7txb pmid:15592987 fatcat:lt7anwplbbg3tcgxk5h7eajdse
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