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Exercise Improves Vascular Function, but does this Translate to the Brain?

Jill N. Barnes, Adam T. Corkery
<span title="2018-09-03">2018</span> <i title="IOS Press"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/dlwuw6bd4fdbzcmibycq2n7noy" style="color: black;">Brain Plasticity</a> </i> &nbsp;
Exercise and cardiorespiratory fitness may be most important during midlife, as physical activity and cardiorespiratory fitness during the middle-aged years are associated with future cognitive function  ...  The age-associated increase in blood pressure and impairment in vascular function may be attenuated or even reversed through lifestyle behaviors.  ...  between fitness, 242 brain structure, cerebral blood flow and cognition 243 [45]. 245 There is significant evidence that elevated car- and aging on the brain health [49, 53] . 268 The association  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3233/bpl-180075">doi:10.3233/bpl-180075</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/30564547">pmid:30564547</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC6296268/">pmcid:PMC6296268</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/ylqzqeyq4vdzhjhop3luujxane">fatcat:ylqzqeyq4vdzhjhop3luujxane</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190224122521/http://pdfs.semanticscholar.org/5837/120cb293e0960993edb12ff710cb7f2ea03e.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/58/37/5837120cb293e0960993edb12ff710cb7f2ea03e.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3233/bpl-180075"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296268" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Magnetic Resonance Imaging of Cardiovascular Function and the Brain

Albert de Roos, Jeroen van der Grond, Gary Mitchell, Jos Westenberg
<span title="2017-05-30">2017</span> <i title="Ovid Technologies (Wolters Kluwer Health)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/yp7myvwge5ef7jsub32vmdbdhy" style="color: black;">Circulation</a> </i> &nbsp;
of microglia cells in the brain. 7 These multiple risk factors may enhance aortic stiffening as an independent and key determinant of brain structure and cognitive function. 8 Age and hypertension strongly  ...  The proximal aorta acts as a coupling device between heart and brain perfusion, modulating the amount of pressure and flow pulsatility transmitted into the cerebral microcirculation.  ...  Acknowledgments The authors like to thank Soraya Arthur-Kovacs for excellent support in manuscript preparation. Funding: Dr.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1161/circulationaha.116.021978">doi:10.1161/circulationaha.116.021978</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/28559496">pmid:28559496</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC5475278/">pmcid:PMC5475278</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/bqgpbzsgzjaqtmmve2k3zectku">fatcat:bqgpbzsgzjaqtmmve2k3zectku</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200209095920/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC5475278&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/48/4c/484c33cd89d8dc52961ca5bbc56a6fdf7a43cbd6.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1161/circulationaha.116.021978"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5475278" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Cerebral hemodynamics of the aging brain: risk of Alzheimer disease and benefit of aerobic exercise

Takashi Tarumi, Rong Zhang
<span title="">2014</span> <i title="Frontiers Media SA"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/evju7ot335gbrctgmomg4gg6je" style="color: black;">Frontiers in Physiology</a> </i> &nbsp;
In this regard, habitual aerobic exercise is increasingly recognized for its benefits on brain structure and cognitive function.  ...  In this review, we will present the current evidence for the physiological mechanisms by which vascular health alters the structural and functional integrity of the aging brain and how improvements in  ...  ACKNOWLEDGMENTS This study was supported in part by the NIH grant R01AG033106-01and R01HL102457.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3389/fphys.2014.00006">doi:10.3389/fphys.2014.00006</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/24478719">pmid:24478719</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC3896879/">pmcid:PMC3896879</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/gvpahdlhejfotkfwqpnkrbvlt4">fatcat:gvpahdlhejfotkfwqpnkrbvlt4</a> </span>
<a target="_blank" rel="noopener" href="https://archive.org/download/pubmed-PMC3896879/PMC3896879-fphys.2014.00006.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> File Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/c6/4c/c64ce4cd05a2cc06e03119669a9c68c7ff968e29.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3389/fphys.2014.00006"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> frontiersin.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3896879" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Assessing cerebrovascular autoregulation from critical closing pressure and resistance area product during upright posture in aging and hypertension

Andrew D. Robertson, Heather Edgell, Richard L. Hughson
<span title="2014-07-15">2014</span> <i title="American Physiological Society"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/yji4wqi55zhhlmsszkszvwwnnu" style="color: black;">American Journal of Physiology. Heart and Circulatory Physiology</a> </i> &nbsp;
Examination of pulsatile measures in young, elderly, and hypertensive adults identified unique differences in how cerebral blood flow is regulated in upright posture. middle cerebral artery; carotid arteries  ...  The posturerelated swings in CrCP and RAP were related to changes in both the pulsatile and mean components of arterial pressure, independent of age, cardiac output, and carbon dioxide.  ...  ACKNOWLEDGMENTS We thank Danielle Greaves, Jackie Thibert, and Kathryn Zuj for technical assistance in data collection on this project.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1152/ajpheart.00086.2014">doi:10.1152/ajpheart.00086.2014</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/24858843">pmid:24858843</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/gd2pvbd6rrfwvkrdyd3hwycu3u">fatcat:gd2pvbd6rrfwvkrdyd3hwycu3u</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190225113854/http://pdfs.semanticscholar.org/6d7f/8524b2069a1b1b0e445d9d61f7657325781c.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/6d/7f/6d7f8524b2069a1b1b0e445d9d61f7657325781c.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1152/ajpheart.00086.2014"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a>

Review of 'the potential role of arterial stiffness in the pathogenesis of Alzheimer's disease'

Timothy M Hughes, Suzanne Craft, Oscar L Lopez
<span title="">2015</span> <i title="Future Medicine Ltd"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/bgkpdlxpr5hvdcoqsk6lw45afm" style="color: black;">Neurodegenerative Disease Management</a> </i> &nbsp;
In this review, we discuss the evidence linking arterial stiffness, hypertension and brain structural abnormalities in older adults.  ...  Arterial stiffness is emerging as an important risk marker for poor brain aging and dementia through its associations with cerebral small vessel disease, stroke, β-amyloid deposition, brain atrophy and  ...  Older adults have less elastin expression and function than arteries compared with middle-aged patients, in addition to a loss of distensibility in response to changes in pressure [46] .  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.2217/nmt.14.53">doi:10.2217/nmt.14.53</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/25894876">pmid:25894876</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC4423756/">pmcid:PMC4423756</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/pbf65wtsa5ftlkbvl7rwk4lzjy">fatcat:pbf65wtsa5ftlkbvl7rwk4lzjy</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20191202122201/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC4423756&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/b0/ef/b0ef25875c8ace596668833ee5d7e11b118d71e9.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.2217/nmt.14.53"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4423756" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Simultaneous Exercise and Cognitive Training in Virtual Reality Phase 2 Pilot Study: Impact on Brain Health and Cognition in Older Adults

Ashwin Sakhare, Joy Stradford, Roshan Ravichandran, Rong Deng, Julissa Ruiz, Keshav Subramanian, Jaymee Suh, Judy Pa
<span title="2021-08-11">2021</span> <i title="IOS Press"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/dlwuw6bd4fdbzcmibycq2n7noy" style="color: black;">Brain Plasticity</a> </i> &nbsp;
Brain and cognitive changes were assessed using MRI imaging and a cognitive battery. Results: Medium effect size (ES) improvements in cerebral flow and brain structure were observed.  ...  in older adults.  ...  cognitive training in VR on brain health 639 and cognition in a cohort of healthy, cognitively nor-640 mal older adults.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3233/bpl-210126">doi:10.3233/bpl-210126</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/34868877">pmid:34868877</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC8609488/">pmcid:PMC8609488</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/kmze3cgiwnhspf2lvookuv6lxe">fatcat:kmze3cgiwnhspf2lvookuv6lxe</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20210817113803/https://content.iospress.com/download/brain-plasticity/bpl210126?id=brain-plasticity%2Fbpl210126" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/93/60/9360d0275d450ff9fb8ce849be3ba78e541a56bf.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3233/bpl-210126"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8609488" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Cardiovascular Risk Factors Promote Brain Hypoperfusion Leading to Cognitive Decline and Dementia

Jack C. de la Torre
<span title="">2012</span> <i title="Hindawi Limited"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/ltwqvc6udzf7hbattxhy67rtkq" style="color: black;">Cardiovascular Psychiatry and Neurology</a> </i> &nbsp;
In elderly people whose cerebral perfusion is already diminished by their advanced age, additional reduction of cerebral blood flow stemming from abnormalities in the heart-brain vascular loop ostensibly  ...  This paper examines the evidence linking chronic brain hypoperfusion induced by a variety of cardiovascular deficits in the development of cognitive impairment preceding AD.  ...  in cerebral blood flow in nondemented older adults [115] .  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1155/2012/367516">doi:10.1155/2012/367516</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/23243502">pmid:23243502</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC3518077/">pmcid:PMC3518077</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/silkxycbcrcb7lofk4nz576zgi">fatcat:silkxycbcrcb7lofk4nz576zgi</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190223225633/http://pdfs.semanticscholar.org/4eba/84391055faa6d8ac1c2b9a3cd3117007ec9b.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/4e/ba/4eba84391055faa6d8ac1c2b9a3cd3117007ec9b.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1155/2012/367516"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> hindawi.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518077" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Pathological Continuum From the Rise in Pulse Pressure to Impaired Neurovascular Coupling and Cognitive Decline

<span title="2020-03-23">2020</span> <i title="Oxford University Press (OUP)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/tal6qjezergknnd4myghd2srqi" style="color: black;">American Journal of Hypertension</a> </i> &nbsp;
In other words, vascular dysfunction affects brain structure and function, and leads to cognitive failure. This is gathered under the term Vascular Cognitive Impairment and Dementia (VCID).  ...  diseases and even of psychiatric disorders, and the potential chronic deleterious effects of the pulsatile blood pressure on the cerebral microcirculation.  ...  CADASIL affects middle age adults with small subcortical infarcts and incomplete ischemic lesions of the WM and subcortical gray matter.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1093/ajh/hpaa001">doi:10.1093/ajh/hpaa001</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/32202623">pmid:32202623</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC7188799/">pmcid:PMC7188799</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/b55ejlhdhvfb5kuebjbcfepzui">fatcat:b55ejlhdhvfb5kuebjbcfepzui</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20210811045908/https://watermark.silverchair.com/hpaa001.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAr8wggK7BgkqhkiG9w0BBwagggKsMIICqAIBADCCAqEGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMwUq7nlELj1f4EYzlAgEQgIICcvq_V17mwIHx5J3LFHkgBUPT3qv6AhWscwgsX-iSOMlyS3NPneHS1pZnwAnGH2Eo8IwVM3cuq5ExHotMZ9jkHFscBKSAG1XWhiIBYV8EhjeqFo13OdB9A6w06Z_Nhs9O33jPCN-h2ak7qlYRX_n_C5pTqVLS8ezWZIM938giujwet_6uRffzWaGaxrEsct_E9ZluyDcEv0T58ie4lLrv0LqiP2ychx9uykgyqth5cfCNP6mysB8zg62c10vQBGmQpLOrypCkewa1m0kDQXhWOEOI8OUJSEYILXeVwlauojfn_9Wqo95jpQzkxkLHnAzi3geAXV2lzIwsgET_tuxG4gVPNymqa70ULe6nf1Uy_34qOVYEOMGOhdk_6ENr2mO4E_CuLhX1hadQV2EEoaaRAKUdnltJ68lVLak6O-obikaKd58orVc8kHeSqaMemihPDH82LYKYiOvHbklmWZ6Xf77W6mJIMdZnKlsAQJlHyqGpyjstY_Hv_WO2Gd9SzPURj2htH2bdLD-bgNSTd-DJ02ZFXEc2ZJGhBcP-LcZVztrNbqKERiulm9vxIO719oJqS4Fe95Ke3zXPEzOiHWTVJBgk1J7Jxb4PkqasPjMxiF6oacpsSy_U-qxAc4nQyVlnjTemujXKwyBAor82ppwCMhzncfJn2674aV8lsZXfaxOOeVzvr45UY9bQFs3Tc8k78xUWcLNy1A0GMljbYVnPaXbw8EoL4FuZPvugY9W2-k_tiFctDGFUuRq_gs-hQIdwG7fQC7wyB3qhYMcw8TzD5PigIcaP7IlVOittaBFMi-NC7M-BdukFO5sFHZQfPeu5rRr-" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/9c/fa/9cfae2af3ec6076d809cdefcb02c734bfa57631f.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1093/ajh/hpaa001"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> oup.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7188799" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Extracranial versus intracranial hydro-hemodynamics during aging: a PC-MRI pilot cross-sectional study

Armelle Lokossou, Serge Metanbou, Catherine Gondry-Jouet, Olivier Balédent
<span title="2020-01-14">2020</span> <i title="Springer Science and Business Media LLC"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/o7tyfoms2jcrbialut4jkepwoy" style="color: black;">Fluids and Barriers of the CNS</a> </i> &nbsp;
Both aging and changes in blood flow velocity between the extracranial (intraspinal) and intracranial regions of cerebral vessels have an impact on brain hydro-hemodynamics.  ...  There was a significant decrease in arterial cerebral blood flow and intracranial venous cerebral blood flow with aging.  ...  Furthermore, Lim et al. studied the pulsatility of anterior, middle and posterior cerebral arteries and cognitive functions in patients with middle to moderate Alzheimer's disease.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1186/s12987-019-0163-4">doi:10.1186/s12987-019-0163-4</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/31931818">pmid:31931818</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC6958565/">pmcid:PMC6958565</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/u62ggoo6arhthfvj3au6pbwupq">fatcat:u62ggoo6arhthfvj3au6pbwupq</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200210013234/https://fluidsbarrierscns.biomedcentral.com/track/pdf/10.1186/s12987-019-0163-4" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/05/8f/058f9b26da6b486d70d4bd2a7fd30cfabd4b4c4d.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1186/s12987-019-0163-4"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> springer.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6958565" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Measuring the Interaction Between the Macro- and Micro-Vasculature

Rachel E. Climie, Antonio Gallo, Dean S. Picone, Nicole Di Lascio, Thomas T. van Sloten, Andrea Guala, Christopher C. Mayer, Bernhard Hametner, Rosa Maria Bruno
<span title="2019-11-22">2019</span> <i title="Frontiers Media SA"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/dyhiozglrzgszfrxloytlygd7u" style="color: black;">Frontiers in Cardiovascular Medicine</a> </i> &nbsp;
Structural and functional dysfunction in both the macro- and microvasculature are a feature of essential hypertension.  ...  However, in response to aging, hypertension, and other disease states, arterial stiffening limits the buffering capacity of the elastic arteries, thus exposing the microvasculature to increased pulsatile  ...  In middle-aged and older adults, aortic stiffness and pressure pulsatility were associated with progression of neurovascular disease and cognitive decline (43) .  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3389/fcvm.2019.00169">doi:10.3389/fcvm.2019.00169</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/31824963">pmid:31824963</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC6882776/">pmcid:PMC6882776</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/f6u4vm33qvaydbsl54afb6edjy">fatcat:f6u4vm33qvaydbsl54afb6edjy</a> </span>
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Vascular Dementia

Alberto R. Ramos, Salim I. Dib, Clinton B. Wright
<span title="2013-07-12">2013</span> <i title="Springer Nature"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/sybkxsnecvelbgtn6yawrbrgru" style="color: black;">Current Translational Geriatrics and Experimental Gerontology Reports</a> </i> &nbsp;
In the elderly, in whom cerebral perfusion is diminished by the aging process, additional reduction in cerebral blood flow stemming from exposure to potentially modifiable vascular risk factors increases  ...  We further examine the evidence linking chronic brain hypoperfusion induced by a variety of cardiovascular diseases to the development of vascular dementia.  ...  The Framingham offspring studies reported that increases in systolic blood pressure among young adults was associated with early structural changes of subcortical structures in the anterior corpus callosum  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/s13670-013-0054-5">doi:10.1007/s13670-013-0054-5</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/26213642">pmid:26213642</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC4513364/">pmcid:PMC4513364</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/y6mdxd6zkrcwtigyh4pqgjobh4">fatcat:y6mdxd6zkrcwtigyh4pqgjobh4</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20180729171529/https://link.springer.com/content/pdf/10.1007%2Fs13670-013-0054-5.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/10/7c/107cb3b83a9619410205c03dfbbd5d9f32a09633.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/s13670-013-0054-5"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> springer.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4513364" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Early detection of microstructural white matter changes associated with arterial pulsatility

Todd A. D. Jolly, Grant A. Bateman, Christopher R. Levi, Mark W. Parsons, Patricia T. Michie, Frini Karayanidis
<span title="2013-11-18">2013</span> <i title="Frontiers Media SA"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/adcuz6lgabeidhngmk32v7egkq" style="color: black;">Frontiers in Human Neuroscience</a> </i> &nbsp;
In this study, we examine whether cerebral blood flow pulsatility is associated with macrostructural and microstructural changes in cerebral white matter in older adults with no or mild LA and no evidence  ...  Increased cerebral blood flow pulsatility is common in vascular dementia and is associated with macrostructural damage to cerebral white matter or leukoaraiosis (LA).  ...  We also thank Patrick Cooper for assistance with data collection and Jaime Rennie for assistance with image processing.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3389/fnhum.2013.00782">doi:10.3389/fnhum.2013.00782</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/24302906">pmid:24302906</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC3831342/">pmcid:PMC3831342</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/wewswfdxunelllh2p4sc2zyuva">fatcat:wewswfdxunelllh2p4sc2zyuva</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20210429012915/https://minerva-access.unimelb.edu.au/bitstream/handle/11343/256604/PMC3831342.pdf;jsessionid=6CD85088BF906F7B4D5850A30C72BDC8?sequence=1" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/c3/4b/c34beb8a319890b795fbcfe5c7dd18a8aa5cb61d.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3389/fnhum.2013.00782"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> frontiersin.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3831342" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Cerebral blood flow regulation and cognitive function: a role of arterial baroreflex function

Shigehiko Ogoh, Takashi Tarumi
<span title="2019-08-23">2019</span> <i title="Springer Science and Business Media LLC"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/fa3hsv3nebaifgtk2k2u2w7zqi" style="color: black;">Journal of Physiological Sciences</a> </i> &nbsp;
On the other hand, there is convincing evidence for arterial baroreflex function playing an important role in maintaining brain homeostasis, e.g., cerebral metabolism, cerebral hemodynamics, and cognitive  ...  For example, mild cognitive impairment attenuates the sensitivity of baroreflex, and Alzheimer's disease further decreases it.  ...  with lower fractional anisotropy (FA) and higher radial diffusivity (RD) in older adults, regardless of their cognitive status.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/s12576-019-00704-6">doi:10.1007/s12576-019-00704-6</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/31444691">pmid:31444691</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/sbodqmboxbghxl3lyuruhdjtjy">fatcat:sbodqmboxbghxl3lyuruhdjtjy</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200321112322/https://jps.biomedcentral.com/track/pdf/10.1007/s12576-019-00704-6" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/1b/24/1b24c3caa69673b85301951d6614f65166068fda.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/s12576-019-00704-6"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> springer.com </button> </a>

The influence of central arterial compliance on cerebrovascular hemodynamics: insights from endurance training intervention

Tsubasa Tomoto, Jun Sugawara, Yoshie Nogami, Kazutaka Aonuma, Seiji Maeda
<span title="">2015</span> <i title="American Physiological Society"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/4jikry225ve7jhl4hqwmsjjdue" style="color: black;">Journal of applied physiology</a> </i> &nbsp;
With advancing age, arterial stiffening deteriorates this function and produces the greater cerebral hemodynamic pulsatility that impacts vulnerable brain tissue.  ...  These results suggest that the training-induced improvement of carotid artery Windkessel function might offset the expected increase in the pulsatile component of cerebral perfusion induced by the enhanced  ...  GRANTS This study was supported, in part, by a Grant-in-Aid for Scientific Research from the Japanese Ministry of Education, Science, and Culture (grant no. 26670116).  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1152/japplphysiol.00129.2015">doi:10.1152/japplphysiol.00129.2015</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/26139214">pmid:26139214</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/z57yxbfoczhmzfezntkcim3inu">fatcat:z57yxbfoczhmzfezntkcim3inu</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190218015407/http://pdfs.semanticscholar.org/0883/a4a5b4191126b881cb3410d707b27c30adbd.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/08/83/0883a4a5b4191126b881cb3410d707b27c30adbd.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1152/japplphysiol.00129.2015"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a>

Physical Exercise for Individuals with Hypertension: It Is Time to Emphasize its Benefits on the Brain and Cognition

Maria LM Rêgo, Daniel AR Cabral, Eduardo C Costa, Eduardo B Fontes
<span title="2019-03-31">2019</span> <i title="SAGE Publications"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/4d4bshebkvcqtoahyqhrax76nm" style="color: black;">Clinical Medicine Insights: Cardiology</a> </i> &nbsp;
It has also been shown to cause severe functional and structural damage to the brain, leading to cognitive impairment and dementia.  ...  This narrative review discusses the pathophysiological mechanisms that hypertension promotes in the brain, and suggests PE as an important tool to prevent and reduce cognitive damage caused by hypertension  ...  However, 1 study with 1094 hypertensive middle-aged adults showed that the treatment of BP in midlife may prevent cognitive decline in later life.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1177/1179546819839411">doi:10.1177/1179546819839411</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/30967748">pmid:30967748</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC6444761/">pmcid:PMC6444761</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/levttrx7jbbrjbopfnyydhosxi">fatcat:levttrx7jbbrjbopfnyydhosxi</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20210526235436/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC6444761&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/a2/d0/a2d05ca937cfd915da332915624a260bae856476.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1177/1179546819839411"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> sagepub.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444761" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>
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