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Cardiac image modelling: Breadth and depth in heart disease

Avan Suinesiaputra, Andrew D. McCulloch, Martyn P. Nash, Beau Pontre, Alistair A. Young
2016 Medical Image Analysis  
The combination of population and patient-specific modelling will give new insights into the mechanisms of cardiac disease, in particular the development of heart failure, congenital heart disease, myocardial  ...  Also, for the individual patient, it is now possible to determine biophysical properties of myocardial tissue in health and disease by interpreting detailed imaging data using computational modelling.  ...  Acknowledgements The authors acknowledge the support of NHLBI R01HL121754 and The Health Research Council of New Zealand.  ... 
doi:10.1016/ pmid:27349830 pmcid:PMC5123588 fatcat:gzu2yc6nmvbxlkgiup45d7pdky

The Future of Cardiac Imaging

Pamela S. Douglas, Manuel D. Cerqueira, Daniel S. Berman, Kavitha Chinnaiyan, Meryl S. Cohen, Justin B. Lundbye, Rajan A.G. Patel, Partho P. Sengupta, Prem Soman, Neil J. Weissman, Timothy C. Wong, Federico Asch (+32 others)
2016 JACC Cardiovascular Imaging  
2) Who is the cardiac imager of the future and what is the role of the multimodality imager? 3) How can we nurture innovation and research in imaging?  ...  a discussion regarding the future of cardiac imaging among thought leaders in the field during a 2 day Think Tank.  ...  disease, heart failure), whereas another model might focus on a service line dedicated to cardiac imaging, integrating the traditional silos of cardiology and radiology specialties.  ... 
doi:10.1016/j.jcmg.2016.02.027 pmid:27712724 fatcat:jsuuegqyhrax5btzbfv7hrwgli

Myocardial Extracellular Volume Fraction Measured by Cardiac Magnetic Resonance Imaging Negatively Correlates With Cardiomyocyte Breadth in a Healthy Porcine Model

Shi-Jun Zhang, Di Chang, Ji-Yang Jin, Ya-Ling Wang, Lin Wang, Yuan-Cheng Wang, Zhen Wang, Shenghong Ju
2022 Frontiers in Cardiovascular Medicine  
The cardiomyocyte breadth (CmyB) in cross section was measured by hematoxylin and eosin staining to reflect the cardiomyocyte size.ResultsData were successfully acquired from 14 pigs.  ...  BackgroundThe extracellular volume fraction (ECV) derived from cardiac magnetic resonance imaging (MRI) is extensively used to evaluate myocardial fibrosis.  ...  ACKNOWLEDGMENTS We are grateful to Min Chen for her technical support in this study.  ... 
doi:10.3389/fcvm.2022.791963 pmid:35369328 pmcid:PMC8968101 fatcat:yafhacivnzb6pgvbt7vo5bklru

Optical Imaging of Voltage and Calcium in Cardiac Cells & Tissues

T. J. Herron, P. Lee, J. Jalife
2012 Circulation Research  
Because of its relevance in cardiac research, this imaging technology advances at a rapid pace.  ...  We then look at recent optical mapping studies in single cells, cardiomyocyte monolayers, atria, and whole hearts.  ...  Acknowledgments The authors thank Cellular Dynamics International for the generous donation of the iPSC-CM used in the experiment shown in Figure 8 , and Dr Tim Kamp for his mentorship in iPSC technology  ... 
doi:10.1161/circresaha.111.247494 pmid:22343556 pmcid:PMC3291718 fatcat:xeyatdaayzdmrcchgo2bnaslmq

The Cardiac Atlas Project—an imaging database for computational modeling and statistical atlases of the heart

Carissa G. Fonseca, Michael Backhaus, David A. Bluemke, Randall D. Britten, Jae Do Chung, Brett R. Cowan, Ivo D. Dinov, J. Paul Finn, Peter J. Hunter, Alan H. Kadish, Daniel C. Lee, Joao A. C. Lima (+5 others)
2011 Computer applications in the biosciences : CABIOS  
However, the accuracy and predictive power of such models is dependent upon the breadth and depth of noninvasive imaging datasets.  ...  Motivation: Integrative mathematical and statistical models of cardiac anatomy and physiology can play a vital role in understanding cardiac disease phenotype and planning therapeutic strategies.  ...  for the analysis of cardiac morphology including (i) visualization of images in 3D over time, and (ii) interactive construction of mathematical cardiac models from the images. (3) Develop standardized  ... 
doi:10.1093/bioinformatics/btr360 pmid:21737439 pmcid:PMC3150036 fatcat:wj43plouxnbjjamoot6qhl3f3e

Illuminating cardiac development: Advances in imaging add new dimensions to the utility of zebrafish genetics

Jeffrey J. Schoenebeck, Deborah Yelon
2007 Seminars in Cell and Developmental Biology  
The use of the zebrafish as a model organism for the analysis of cardiac development is no longer proof-of-principle science.  ...  and function.  ...  Research in the Yelon lab is supported by grants from the National Institutes of Health, the American Heart Association, and the March of Dimes.  ... 
doi:10.1016/j.semcdb.2006.12.010 pmid:17241801 pmcid:PMC1876688 fatcat:wbludbjtkvf4piularud6fbqjy

Two-Photon Imaging within the Murine Thorax without Respiratory and Cardiac Motion Artifact

Robert G. Presson, Mary Beth Brown, Amanda J. Fisher, Ruben M. Sandoval, Kenneth W. Dunn, Kevin S. Lorenz, Edward J. Delp, Paul Salama, Bruce A. Molitoris, Irina Petrache
2011 American Journal of Pathology  
We obtained extended intravital TPM imaging of the intact lung, arguably the organ most susceptible to both respiratory and cardiac motion.  ...  However, due to a relatively slow acquisition rate, TPM is especially sensitive to motion artifact, which presents a challenge when imaging tissues subject to respiratory and cardiac movement.  ...  ., for technical assistance with the microscope, and Jason Byars, who provided assistance with programming for gated imaging.  ... 
doi:10.1016/j.ajpath.2011.03.048 pmid:21703395 pmcid:PMC3123791 fatcat:3dgee5r3tfgb7efnymgcm543di

Unraveling the complexities of cardiac remodeling and hypertrophy — High-content screening and computational modeling

John W. Elrod, Jop H. van Berlo
2014 Journal of Molecular and Cellular Cardiology  
Physiological provocations, such as pregnancy and exercise, result in an increase in heart size accompanied by enhanced cardiac output that is completely reversible and not related to adverse events later  ...  Heart weight directly correlates with body weight in most mammals under homeostatic conditions [1] .  ...  Smith Charitable Trust (H1301) to JWE and NIH/NHLBI (HL112852) to JHvB.  ... 
doi:10.1016/j.yjmcc.2014.03.014 pmid:24742541 pmcid:PMC4413011 fatcat:thpwtvry5zd2pdbapbk3cbvfbu

Cardiovascular Modeling of Congenital Heart Disease Based on Neonatal Echocardiographic Images

M. Nakao, K. Maeda, R. Haraguchi, K. Kurosaki, K. Kagisaki, I. Shiraishi, K. Nakazawa, K. Minato
2012 IEEE Transactions on Information Technology in Biomedicine  
For the construction of cardiovascular models with a variety of congenital heart diseases, we propose a set of algorithms and interface that enable editing of the topology and shape of the three-dimensional  ...  It is successful in representing the important structures of the patient-specific heart vessels for better understanding in preoperative planning and electric medical recording of the congenital heart  ...  ACKNOWLEDGEMENTS This research has been supported by the Grant-in-Aid for Scientific Research for Young Scientists (A) (21680044) from The Ministry of Education, Culture, Sports, Science and Technology  ... 
doi:10.1109/titb.2011.2169418 pmid:21954219 fatcat:rwrja5xdkfgc5fhp5xcbvl4jry

Human Pluripotent Stem Cell-Derived Cardiac Cells: Application in Disease Modeling, Cell Therapy, and Drug Discovery

Juan Huang, Qi Feng, Li Wang, Bingying Zhou
2021 Frontiers in Cell and Developmental Biology  
In this review, we discuss the application of hPSCs in heart disease modeling, cell therapy, and next-generation drug discovery.  ...  Animal models have been the most extensively studied methods to recapitulate a wide variety of cardiac diseases, but these models exhibit species-specific differences in physiology, metabolism and genetics  ...  AUTHOR CONTRIBUTIONS All authors listed have made a substantial, direct and intellectual contribution to the work, and approved it for publication.  ... 
doi:10.3389/fcell.2021.655161 pmid:33869218 pmcid:PMC8049435 fatcat:rxod2sq4irdfnfzeqj76k4s7p4

Computational Models Reduce Complexity and Accelerate Insight Into Cardiac Signaling Networks

J. H. Yang, J. J. Saucerman
2011 Circulation Research  
This motivates new methods for investigating the mechanisms regulating cardiac signaling networks and the consequences these networks have on cardiac physiology and disease.  ...  Computational models have a long history in contributing to the understanding of cardiac physiology and are useful for identifying biological mechanisms, inferring multiscale consequences to cell signaling  ...  Computational models have enjoyed a long history in studies of cardiovascular physiology, with more depth than any other organ system (see accompanying articles in this series by Greenstein and Winslow  ... 
doi:10.1161/circresaha.110.223602 pmid:21212391 pmcid:PMC3076046 fatcat:fksyc75zwjemxdwnmxk5k4skxq

AATS 2012: "To model excellence"

Craig R. Smith
2012 Journal of Thoracic and Cardiovascular Surgery  
of the arrested heart with real-time visualization using computed tomography and magnetic resonance imaging.  ...  scope than that of all other heart disease combined.'' 10 Talk about a new race called Man!  ... 
doi:10.1016/j.jtcvs.2012.05.075 pmid:22980627 fatcat:fm3tj3ge5rcjjd5pkqmao4fqg4

Quasi-3D kinematic modeling and parametric image processing of a multiframe ECG-gated planar 99m Tc-sestaMIBI myocardial perfusion scintigraphic study

Dhan R. Jangid
1997 Journal of digital imaging  
flow (myocardial perfusional status) in ischemic heart disease/coronary artery disease, yet there is still no logical and consensus approach for extraction of kinematic information from Gp-MPS.  ...  This model could be used for assessing LV-function in [-+x, _+y, 2z, t]-domain by parametric image processing to achieve quasi-3D functional maps/ images (Stroke-image, Phase-image, Amplitude-image and  ...  flow (myocardial perfusional status) in ischemic heart disease/coronary artery disease, yet there is still no logical and consensus approach for extraction of kinematic information from Gp-MPS.  ... 
doi:10.1007/bf03168700 pmid:9268882 pmcid:PMC3452861 fatcat:ezlmasyhvne5xfsegdoeygwaru

Imaging technologies for monitoring the safety, efficacy and mechanisms of action of cell-based regenerative medicine therapies in models of kidney disease

Jack Sharkey, Lauren Scarfe, Ilaria Santeramo, Marta Garcia-Finana, Brian K. Park, Harish Poptani, Bettina Wilm, Arthur Taylor, Patricia Murray
2016 European Journal of Pharmacology  
optoacoustic tomography, can be used in combination with various imaging probes to track the fate and biodistribution of cell-based RMTs in rodent models of kidney disease, and evaluate their effect on  ...  Cell-based Regenerative Medicine Therapies (RMTs) have shown great promise in rodent models of kidney disease, but clinical translation is hampered due to the lack of adequate safety and efficacy data.  ...  In vivo imaging data in this article were obtained in the Centre for Preclinical Imaging (CPI) of the University of Liverpool.  ... 
doi:10.1016/j.ejphar.2016.06.056 pmid:27375077 pmcid:PMC5063540 fatcat:hbz2lq6mgvakxpbugj6w6kmwdq

My Heart, My Art: A novel Nepali medical student art project and the link to learning

Carol Ann Courneya, Bibana Cujec, Mili Joshi, Rolina Dhital
2017 Research and Humanities in Medical Education  
Aim: to examine art created by medical students for the breadth and depth of conceptual understanding that formed the foundation for its creation.  ...  Material and methods: First year medical students at the Patan Academy of Health Sciences in Nepal, in 2011, 2012, 2014 and 2016, were asked to volunteer and submit artistic interpretations of "cardiac  ...  The result was a multiyear repository of cardiac art that afforded the authors the opportunity to examine the artistic and conceptual breadth and depth of understanding required by the students in order  ... 
doaj:43e688d248c04c189df081db7e92416c fatcat:3vsg7r4cyvd4ralyzqmjmciyry
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