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AN ALTERNATIVE MODEL OF THE RELATIONSHIP BETWEEN THE CARCINOGENIC ACTIVITY OF POLYCYCLIC AROMATIC HYDROCARBONS AND THEIR MOLECULAR STRUCTURE

Vladimir Mukhomorov
2018 Journal of Biological and Scientific Opinion  
A new model is proposed that connects the carcinogenic activity of polycyclic aromatic hydrocarbons with their molecular structure.  ...  The model makes it possible to perform an express assessment of the carcinogenic activity of polycyclic aromatic hydrocarbons.  ...  The principles of this model may be easily understood, and model will necessary in understanding the mechanism of carcinogenic action of polycyclic aromatic hydrocarbons.  ... 
doi:10.7897/2321-6328.06383 fatcat:ix4heczasrds5h5pctqkfvmucm

Reducing the carcinogenic impact of pitch processing

O. F. Sidorov
2013 Coke and Chemistry  
The carcinogenic potential of polycyclic aromatic hydrocarbons is used to determine the quantitative risks for humans. The following principles are adopted in determining the carcinogenic potential.  ...  To that end, zones with high electron density that are associated with carcinogenic activity (segments 4C, 5C, and 6C in Fig. 3 , III) have been identified in the structure of polycyclic aromatic hydrocarbons  ... 
doi:10.3103/s1068364x13020063 fatcat:jl7lpfl2d5gzfibo6seweshgau

The New Model of Carcinogenic Activity of Polycyclic Hydrocarbons

Vladimir K. Mukhomorov
2021 WSEAS Transactions on Biology and Biomedicine  
The factors limiting the carcinogenic activity of polycyclic compounds are analyzed. The model fully interprets all observable data that were used to support previous early models  ...  A model is proposed that allows one to interpret the carcinogenic properties of polycyclic chemical compounds.  ...  For polycyclic aromatic hydrocarbons, carcinogenic activity increases with an increase in molecular descriptors γ and Z.  ... 
doi:10.37394/23208.2021.18.19 fatcat:wkhj2y5isjfa7gg5n5kc2dfu7y

The Role of Interindividual Variation in Human Carcinogenesis

Cong Lai, Peter G. Shields
1999 Journal of Nutrition  
Carcinogens enter the body from a variety of sources, but most require metabolic activation before they can damage DNA.  ...  The process of chemical carcinogenesis is a complex multistage process initiated by DNA damage in growth control genes.  ...  The first group of chemicals is comprised of direct-acting agents, which can react with DNA without metabolic activation to form carcinogen-DNA adducts.  ... 
doi:10.1093/jn/129.2.552s pmid:10064330 fatcat:zisu47dnnzboti6hxx5stjprje

Aromatic hydrocarbons. IV. Their fate following emission into the atmosphere and experimental exposure to washed air and synthetic smog

H L FALK, I MARKUL, P KOTIN
1956 A.M.A. archives of industrial health  
The presence of soot containing aromatic polycyclic hydrocarbons, including the po- tent carcinogen, 3,4,-benzpyrene, has been demonstrated in urban atmospheres by Waller,* Wedgewood and Cooper,’ and Goulden  ...  M. bons present in soot at the site of emission from vehicular exhausts were no longer in the These observations resulted in a search for, first, additional sources of aromatic hydrocarbon air pollu- tants  ... 
pmid:13275133 fatcat:37jhvapxnjbhtakzqil7m5z4uy

Carcinogenicity of benzo[a]pyrene derivatives: the bay region theory

D. M. Jerina, D. R. Thakker, Haruhiko Yagi, Wayne Levin, A. W. Wood, A. H. Conney
1978 Pure and Applied Chemistry  
The data support the "bay region" theory of hydrocarbon induced carcinogenicity which asserts that diol epoxides an angular benze rings of polycyclic hydrocarbons, in which the epoxide ring forms part  ...  A substantial body of carcinogenicity data is available for benzo[a)pyrene (BP), benzo[a)anthracene (BA), and numerous known and potential metabolites of these polycyclic hydrocarbons.  ...  INTRODUCTION The polycyclic aromatic hydrocarbon benzo[a)pyrene (BI') is one of the most prevalent environmental carcinogens to which man is exposed.  ... 
doi:10.1351/pac197850091033 fatcat:6oc66fqhtrd4bffrkftinierim

Urban air pollution by carcinogenic and genotoxic polyaromatic hydrocarbons in the former USSR

Khesina AYa
1994 Environmental Health Perspectives  
The content of major carcinogenic and genotoxic polyaromatic hydrocarbons (PAH) in urban air, vehicle, and industrial emissions is assessed.  ...  The feasibility of using benzo[alpyrene to assess PAH content in industrial and vehicle emissions was explored. PAH profiles in the ambient air and local emissions are compared.  ...  polycyclic aromatic hydrocarbons studied.  ... 
doi:10.1289/ehp.102-1566932 pmid:7821295 pmcid:PMC1566932 fatcat:ieshc5vv5ngdzewpt6oz5ubx2e

Bioremediation of Diesel Contaminated Marine Water by Bacteria: A Review and Bibliometric Analysis

Farah Eryssa Khalid, Zheng Syuen Lim, Suriana Sabri, Claudio Gomez-Fuentes, Azham Zulkharnain, Siti Aqlima Ahmad
2021 Journal of Marine Science and Engineering  
Hydrocarbon-degrading bacteria are ubiquitous in the nature and often exploited for their specialty to bioremediate the oil-polluted area.  ...  This paper provides an updated overview of diesel hydrocarbon degradation, the effects of oil spills on the environment and living organisms, and the potential role of high salinity bacteria to decontaminate  ...  This paper also contributes to the international SCAR research programme 'State of the Antarctic Ecosystem'. Conflicts of Interest: The authors declare no conflict of interest.  ... 
doi:10.3390/jmse9020155 fatcat:4intkzghp5h3djsiblvoaxptmm

Bioavailability and biotransformation of the mutagenic component of particulate emissions present in motor exhaust samples

J J Vostal
1983 Environmental Health Perspectives  
Similarly, long-term animal inhalation exposures to high concentrations of diesel particles did not induce the activity of hydrocarbon metabolizing enzymes or specific adverse immune response unless organic  ...  Mutagenic activity of diesel particulates was minimal or negative when tested in extracts obtained with biological fluids, was substantially dependent on the presence of nitroreductase in the microbial  ...  hydroxylase, either is expected to activate or detoxify the effects of carcinogenic polycyclic hydrocarbons.  ... 
doi:10.1289/ehp.8347269 pmid:6186478 pmcid:PMC1569410 fatcat:cr55lqrzcbe5zoivc4dqh7s7n4

ASSESSMENT OF PESTICIDES AND POLYCYCLIC AROMATIC HYDROCARBONS IN BEEF JERKY MEAT FROM NIGERIA AND THEIR DIETARY CONCENTRATION TO HUMAN

Emmanuel Ilesanmi Adeyeye, Olayinka Abidemi Ibigbami, Abiodun Folasade Akinsola, Olubunmi Adenike Akinwumi, Rauf Abioye Olatoye, Adeolu Jonathan Adesina, Abdul Ademola Olaleye
2021 Journal of Agricultural, Food and Environmental Sciences  
The study reports the concentrations, daily intake levels and possible potential health risks of 33 pesticides and 16 polycyclic aromatic hydrocarbons (PAHs) in beef jerky meat samples collected from sellers  ...  in Ado-Ekiti, Nigeria.  ...  .(2006).Polycyclic aromatic hydrocarbons (PAH) in Danish smoked fish and meat products.Polycyclic AromaticCompounds, 26, 163-184.Duke, O., &Albert, I.O.(2007).Polynuclear aromatic hydrocarbons concentrations  ... 
doi:10.55302/jafes21751009ia fatcat:sfkhulbtmnh5ncsvuod4kqa6im

On the problem of the connection between the electronic structure of polynuclear aromatic hydrocarbons and their carcinogenic effect

J KOUTECKY, R ZAHRADNIK
1961 Cancer Research  
ACKNOWLEDGMENTS The calculations of the ortho-localization energies were carried out on an automatic computer, type URAL, in the Institute of Theory of Information and Automation, Czechoslovak Academy  ...  of Sciences, under the direction of J.  ...  (20) for a number of important polycyclic aromatic hydrocarbons (Chart 1).  ... 
pmid:13753558 fatcat:7nqfzmnhpnforkgewmf2pp53n4

The Carcinogenic Hydrocarbons: Chemical Constitution and Carcinogenic Activity

G M Badger
1948 British Journal of Cancer  
THE METABOLISM OF POLYCYCLIC AROMATIC HYDROCARBONS So far as is known the carcinogenic and related non-carcinogenic polycyclic aromatic hydrocarbons all undergo hydroxylation or perhydroxylation in  ...  active principle.  ... 
doi:10.1038/bjc.1948.37 pmid:21772421 pmcid:PMC2007610 fatcat:p7jb5hclarh77j24nxaazd527q

Laboratory Contributions to the Tobacco-cancer Problem

E. L. Wynder
1959 BMJ (Clinical Research Edition)  
The first suspicion obviously falls upon the higher aromatic polycyclics, since it is, a well-established principle that the burning of any organic matter will give rise to these substances.2 19 A large  ...  to be carcinogenic to mouse skin. 23 38 Additional higher aromatic polycyclics identified but not yet tested for carcinogenic activity include benz(mno)fluoranthene, 10: 1 1-benzfluoranthene, and 11:  ... 
doi:10.1136/bmj.1.5118.317 pmid:13618630 pmcid:PMC1992493 fatcat:zsz77rsjcrctxf3aa2cmarri2m

An Instance of the Occurrence of Carcinogenic Substances in Certain Barnacles

M. B. Shimkin, B. K. Koe, L. Zechmeister
1951 Science  
Some of the fractions were crystallized and gave in hexane solution extinction curves that were typical for polycyclic aromatic hydrocarbons.  ...  The presence of an active carcinogen was unquestionably demonstrated.  ... 
doi:10.1126/science.113.2945.650 pmid:14845698 fatcat:afujdcsuzvfzll4vsmlh5quh2a

Structural Alerts of Mutagens and Carcinogens

Romualdo Benigni, Cecilia Bossa
2006 Current Computer - Aided Drug Design  
of studies aimed at highlighting the mechanisms of action of the mutagenic and carcinogenic chemicals.  ...  The identification of the Structural Alerts has had a great value both in terms of understanding mechanisms, and of assessing the risk posed by chemicals.  ...  K-region in polycyclic aromatic hydrocarbons 19. polycyclic aromatic system 20. sulfonate-bonded carbon (alkyl alkane sulfonate or dialkyl sulfate) 21. aliphatic N-nitro 22. α,β-unsaturated aldehyde (including  ... 
doi:10.2174/157340906777441663 fatcat:m2ilfv4bcnedzo4uim3oudiboy
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