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Cannabis users exhibit increased cortical activation during resting state compared to non-users

Shikha Prashad, Elizabeth S. Dedrick, Francesca M. Filbey
2018 NeuroImage  
Cannabis users exhibited decreased delta and increased theta, beta, and gamma power compared to controls, suggesting increased cortical activation in resting state and a disinhibition of inhibitory functions  ...  These results suggest that there are differences in cortical activity and connectivity between cannabis users and non-using controls in the resting state that may be related to putative cognitive impairments  ...  Cannabis users exhibited increased cortical activation compared to controls Resting state activity in cannabis users was characterized as the inverse of typical frequency dynamics in that they exhibited  ... 
doi:10.1016/j.neuroimage.2018.06.031 pmid:29894828 pmcid:PMC6693493 fatcat:pjqctju6l5hhhoqz6lr6idqyae

Mechanisms contributing to cognitive deficits in cannabis users

Romina Mizrahi, Jeremy J. Watts, Kuei Y. Tseng
2017 Neuropharmacology  
Studies from preclinical animal models indicate that sustained activation of CB1 receptor signaling is a major contributing factor for the onset of cognitive deficits associated to chronic cannabis use  ...  Yet, very few studies have been designed to directly assess the role of CB1 receptors in mediating the effects of cannabis on human brain function.  ...  Acknowledgments Supported by Rosalind Franklin University and NIH Grant R01-MH105488 to KYT  ... 
doi:10.1016/j.neuropharm.2017.04.018 pmid:28414051 pmcid:PMC5540783 fatcat:asex6bj76fcnvkrjl6g36bvnwy

Neuroimaging in cannabis use: a systematic review of the literature

R. Martín-Santos, A. B. Fagundo, J. A. Crippa, Z. Atakan, S. Bhattacharyya, P. Allen, P. Fusar-Poli, S. Borgwardt, M. Seal, G. F. Busatto, P. McGuire
2009 Psychological Medicine  
Studies of acute administration of THC or marijuana report increased resting activity and activation of the frontal and anterior cingulate cortex during cognitive tasks.  ...  The functional studies suggest that resting global and prefrontal blood flow are lower in cannabis users than in controls.  ...  Non-acute effects on resting state activity We included seven case-control studies that compared resting rCBF in cannabis users and healthy subjects.  ... 
doi:10.1017/s0033291709990729 pmid:19627647 fatcat:7fhqs2qd2ne5vonf3mdxibd45y

The neuropsychopharmacology of cannabis: A review of human imaging studies

Michael A.P. Bloomfield, Chandni Hindocha, Sebastian F. Green, Matthew B. Wall, Rachel Lees, Katherine Petrilli, Harry Costello, M. Olabisi Ogunbiyi, Matthijs G. Bossong, Tom P. Freeman
2019 Pharmacology and Therapeutics  
Heavy repeated cannabis use, particularly during adolescence, has been associated with adverse effects on these systems, which increase the risk of mental illnesses including addiction and psychosis.  ...  Cannabidiol, a non-intoxicating cannabinoid found in some forms of cannabis, may offset some of these acute effects.  ...  However, depressed cannabis users exhibited increased activation to preferred music in the putamen, anterior cingulate and right frontal regions compared to non-users and nondepressed users.  ... 
doi:10.1016/j.pharmthera.2018.10.006 pmid:30347211 pmcid:PMC6416743 fatcat:g3ynqubp2nfinhciupju7dvvwa

Structural and Functional Imaging Studies in Chronic Cannabis Users: A Systematic Review of Adolescent and Adult Findings

Albert Batalla, Sagnik Bhattacharyya, Murat Yücel, Paolo Fusar-Poli, Jose Alexandre Crippa, Santiago Nogué, Marta Torrens, Jesús Pujol, Magí Farré, Rocio Martin-Santos, Lin Lu
2013 PLoS ONE  
Functional neuroimaging studies suggest different patterns of resting global and brain activity during the performance of several cognitive tasks both in adolescents and adults, which may indicate compensatory  ...  The growing concern about cannabis use, the most commonly used illicit drug worldwide, has led to a significant increase in the number of human studies using neuroimaging techniques to determine the effect  ...  During the non-inhibitory trials, differences were located in right prefrontal, insular and parietal cortices, with cannabis users showing greater activation in these areas compared to the controls.  ... 
doi:10.1371/journal.pone.0055821 pmid:23390554 pmcid:PMC3563634 fatcat:pffvgfex3navzibcbmsgltjcfu

1301 – Structural and functional imaging studies in chronic cannabis users: a systematic review of adolescent and adult findings

A. Batalla, S. Bhattachayyria, M. Yucel, P. Fusar-Poli, J.A. Crippa, S. Nogué, M. Torrens, J. Pujol, M. Farré, R. Martín-Santos
2013 European psychiatry  
Functional neuroimaging studies suggest different patterns of resting global and brain activity during the performance of several cognitive tasks both in adolescents and adults, which may indicate compensatory  ...  The growing concern about cannabis use, the most commonly used illicit drug worldwide, has led to a significant increase in the number of human studies using neuroimaging techniques to determine the effect  ...  During the non-inhibitory trials, differences were located in right prefrontal, insular and parietal cortices, with cannabis users showing greater activation in these areas compared to the controls.  ... 
doi:10.1016/s0924-9338(13)76359-4 fatcat:q63hx57xf5hnvkgllvla5iyafe

Examining Inhibitory Affective Processing Within the Rostral Anterior Cingulate Cortex Among Abstinent Cannabis-Using Adolescents and Young Adults

Ryan M. Sullivan, Kristin E. Maple, Alexander L. Wallace, Alicia M. Thomas, Krista M. Lisdahl
2022 Frontiers in Psychiatry  
The present study aimed to examine whether abstinent cannabis users demonstrated abnormal functional activation and connectivity of the bilateral rACC during an emotional inhibitory processing task, and  ...  Results showed decreased bilateral rACC activation in cannabis users during fearful response inhibition, although groups did not show any context-dependent connectivity differences between the left or  ...  In the current study, cannabis users exhibited decreased right and left rACC recruitment during successful response inhibition to fearful faces compared to calm faces.  ... 
doi:10.3389/fpsyt.2022.851118 pmid:35418882 pmcid:PMC8995473 fatcat:5rlc6bq4ofesvkaujuz76lbkky

The Influence of Recreational Substance Use in TMS Research

Claudia V. Turco, Sarah O. Arsalan, Aimee J. Nelson
2020 Brain Sciences  
(1) Background: Transcranial magnetic stimulation (TMS) approaches are widely used to study cortical and corticospinal function.  ...  The increasing prevalence of recreational substance use poses a significant challenge for executing TMS studies, but there is a lack of clarity regarding the influence of these substances on sensorimotor  ...  [109] reported that schizophrenia patients dependent on cannabis show increased SICI compared to non-users.  ... 
doi:10.3390/brainsci10100751 pmid:33080965 fatcat:5unhyed2kjgxlhh5axbax4magq

Impact of Cannabis Use on Brain Structure and Function in Suppressed HIV Infection

Kalpana J Kallianpur, Rasmus Birn, Lishomwa C Ndhlovu, Scott A Souza, Brooks Mitchell, Robert Paul, Dominic C Chow, Lindsay Kohorn, Cecilia M Shikuma
2020 Journal of Behavioral and Brain Science  
Relationships of cannabis use to resting-state functional connectivity (RSFC) and to 9 regional brain volumes were assessed with corrections for multiple comparisons.  ...  Peripheral blood cytokines and monocyte subsets were measured in the HIV+ group and examined in relation to cannabis exposure.  ...  HIV+ individuals exhibit visual processing/attention deficits [76] [77] and diminished activation in primary visual cortices during visual task [78] [79] [80] and resting [81] conditions.  ... 
pmid:32968547 pmcid:PMC7508465 fatcat:5sg7f5aokrg6lbroycx6onzbmy

Effects of Cannabis on the Adolescent Brain

Joanna Jacobus, Susan Tapert
2014 Current pharmaceutical design  
substances (e.g., alcohol) to better understand the role of regular cannabis use on neurodevelopmental trajectories.  ...  It remains unclear whether such disadvantages reflect pre-existing differences that lead to increased substances use and further changes in brain architecture and behavioral outcomes.  ...  Resting state activity was also altered, as THC increased baseline activity [72] .  ... 
doi:10.2174/13816128113199990426 pmid:23829363 pmcid:PMC3930618 fatcat:5q5fovmhrrauvccrysmrygaqgy

A Transcranial Magnetic Stimulation Study of the Effects of Cannabis Use on Motor Cortical Inhibition and Excitability

Paul B Fitzgerald, Suzanne Williams, Zafiris J Daskalakis
2009 Neuropsychopharmacology  
Chronic cannabis use is associated with a reduction in cortical inhibition potentially related to activity at the GABA A receptors.  ...  Both cannabis using groups (heavy and light use) demonstrated a reduction in short interval cortical inhibition compared with healthy controls, but there was no difference in other measures of cortical  ...  A study of information processing speed in cannabis users also found normal performance in an acute use state with impaired performance in a non-acute state although this could be confounded by withdrawal  ... 
doi:10.1038/npp.2009.71 pmid:19571796 fatcat:lkxnie45undkzlog5t27qhjorm

Testing the role of the posterior cingulate cortex in processing salient stimuli in cannabis users: an rTMS study

Shikha Prashad, Elizabeth S. Dedrick, Wing Ting To, Sven Vanneste, Francesca M. Filbey
2018 European Journal of Neuroscience  
Cannabis users exhibited increased amplitude in P3 and faster latencies in the P3, N2, and P2 components in response to self-relevant stimuli compared to controls during baseline that normalized after  ...  These results suggest that cannabis users exhibited heightened salience to external self-relevant stimuli that were modulated after rTMS.  ...  Data accessibility The data are available upon request to Francesca Filbey.  ... 
doi:10.1111/ejn.14194 pmid:30290037 pmcid:PMC6767056 fatcat:xrlhzbsjh5fxjps3z57zlcjndq

Adolescent Substance Use and the Brain: Behavioral, Cognitive and Neuroimaging Correlates

Shahnaza Hamidullah, Hayley H. A. Thorpe, Jude A. Frie, Richard D. Mccurdy, Jibran Y. Khokhar
2020 Frontiers in Human Neuroscience  
Adolescence is an important ontogenetic period that is characterized by behaviors such as enhanced novelty-seeking, impulsivity, and reward preference, which can give rise to an increased risk for substance  ...  adolescence may relate to behavioral and neuroimaging-based outcomes.  ...  2004) , have been observed in adolescent cannabis users compared to non-users during working memory tasks.  ... 
doi:10.3389/fnhum.2020.00298 pmid:32848673 pmcid:PMC7418456 fatcat:2oo24fdtrbcengdiqu2vid4mxu

Cognitive consequences of cannabis use: Comparison with abuse of stimulants and heroin with regard to attention, memory and executive functions

T LUNDQVIST
2005 Pharmacology, Biochemistry and Behavior  
Heavy cannabis use is associated with reduced function of the attentional/executive system, as exhibited by decreased mental flexibility, increased perserveration, and reduced learning, to shift and/or  ...  This review aims to compare cognitive consequence between cannabis, and stimulants and heroin with regards to attention, memory and executive functions.  ...  Thus, cannabis produces various metabolic changes in the brain. Long-term cannabis users appear to have lower resting levels of CBF compared with non-smokers.  ... 
doi:10.1016/j.pbb.2005.02.017 pmid:15925403 fatcat:f6rrr73gcbh6xo2tzut3nbshvu

The Role of Gamma Oscillations in the Pathophysiology of Substance Use Disorders

Jessica U. Ramlakhan, Ming Ma, Reza Zomorrodi, Daniel M. Blumberger, Yoshihiro Noda, Mera S. Barr
2020 Journal of Personalized Medicine  
Thus, the purpose of this review was to investigate the impact of alcohol, tobacco, cannabis, cocaine, and amphetamine on gamma activity, among pre-clinical and clinical populations during acute and chronic  ...  exposure and withdrawal states.  ...  Increased frontal gamma power in alcoholics compared to controls during non-target processing.  ... 
doi:10.3390/jpm11010017 pmid:33379187 fatcat:jhanlylz5jatto5u2ig6b4yc34
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