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Set-based multi-scale modeling and analysis signal transduction pathways
[article]
2020
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Finally, biological processes can span different time scales ranging from seconds to days. ...
Mathematical modeling of biological systems together with quantitative biochemical and cell biological analyses allow deep insights into the often complex molecular interconnections within a biological ...
We further combine the set-based framework with classification methods, which allows to stratify a patient cohort into risk categroies for developing inflammatory diseases based on data from the short-term ...
doi:10.25673/32467
fatcat:5ir6ks7cjrf2no3dk5xbsfum5a
New methods for cluster analysis and their applications to the biology of B cells and diffuse large B-cell lymphoma
2021
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Computed by a method called ASTRICS, it is based on local dimensionality reduction and triangulation of alpha shapes. ...
Cluster analysis of CyTOF data is important for understanding heterogeneity in biological cell populations, which has clinical implications in cancer biology. ...
Classification of the molecular subtype of a cancer patient by gene expression profiling often determines their course of therapy, therefore definition of subtypes is clinically important. ...
doi:10.14288/1.0401098
fatcat:fov7ukxqdvfrhh56dsutb2sdn4
Reinforcement Learning (Dagstuhl Seminar 13321) The Critical Internet Infrastructure (Dagstuhl Seminar 13322) Coding Theory (Dagstuhl Seminar 13351) Interaction with Information for Visual Reasoning (Dagstuhl Seminar 13352)
unpublished
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They use the same technology as IBM's ink-jet printer from 50 years ago, high dimensional and high throughput, measuring the intensity of the fluorescence (proportional to the number of certain proteins ...
Nowé, "Hypervolume-based Multi-Objective Reinforcement Learning," in Proc. of the 7th Int'l Conf. on Evolutionary Multi-Criterion Optimization (EMO'13), LNCS, Vol. 7811, pp. 352-366, Springer, 2013. ...
Almeida
Andreas Dress
Titus Kühne
Laxmi Parida
License
Creative Commons BY 3.0 Unported license
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The Stratification of Disease into Discrete Subtypes and its Implications for Science, 'Medical ...
fatcat:iz3co5xisfejfbnx2t6ptrorfm
Characterizing the fitness landscapes of gut symbionts in defined community and diet contexts
2014
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Funding: Supported by a grant from the NIH (DK064540). Data generated for Fig. ...
This work was supported in part by grants from the NIH (DK70977 and DK30292) and the Crohn's and Colitis Foundation of America. ...
perturbation may be strongly impacted by the functional classification of the genes involved. ...
doi:10.7936/k7j964hz
fatcat:pgyeskypxfdc5kf3bcli2zkyly