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Genetic alterations in cervical cancer

Khalida Wani, C K K Nair
2003 Indian journal of experimental biology  
Recurrent amplifications have been mapped to the short arm of chromosome 3 in invasive cancer. Microsatellite instability and mutator phenotype do not play a major role in cervical carcinogenesis.  ...  Identification of these alterations could help to provide a better understanding of the disease and thus improve treatment.  ...  Cervical cancer represents the fifth most common neoplasm worldwide and is second on ly to breast cancer as a cause of ca ncer mortality in women I.  ... 
pmid:15248474 fatcat:yl3tu3diavhvti4cjt4doed34q

Risk of Cancer Mortality in Spanish Towns Lying in the Vicinity of Pollutant Industries

Rebeca Ramis, Pablo Fernandez-Navarro, Javier Garcia-Perez, Elena Boldo, Diana Gomez-Barroso, Gonzalo Lopez-Abente
2012 ISRN Oncology  
Our objective is to study cancer mortality risk associated with residence in the vicinity of pollutant factories. We used data on industries for year 2007 (3458 facilities).  ...  Almost all tumours related to the digestive system and the respiratory system showed increased risks.  ...  The socio-demographic indicators (Socs) included were chosen for their availability at municipal level and potential explanatory ability vis-à-vis certain geographic mortality patterns: population size  ... 
doi:10.5402/2012/614198 pmid:23193486 pmcid:PMC3463942 fatcat:z3acck2fm5htvmarjk4vzdbshm

Progression and trajectory network of age-related functional impairments and their associations with mortality: a two-decade prospective study [article]

Hui Chen, Binghan Wang, Rongxia Lv, Tianjing Zhou, Jie Shen, Huan Song, Xiaolin Xu, Yuan Ma, Changzheng Yuan
2022 medRxiv   pre-print
Conclusions: ARFIs were highly interconnected as a network and were associated with mortality, which highlighted the importance of integrated strategies to monitor and manage the ARFIs to achieve healthy  ...  Setting: The Health and Retirement Study (HRS, 2000-2020). Participants: A total of 17 914 HRS participants aged from 51 to 90 years in 2000.  ...  Acknowledgments The author would like to express genuine gratitude to the participants and staffs of the Health and Retirement Study, who contributed greatly to the academic community and made this study  ... 
doi:10.1101/2022.08.25.22279239 fatcat:res35wux3bff5fu7kk4ghhhg3i

Next Generation Cancer Protection: The Bivalent HPV Vaccine for Females

Diane M. Harper, Stephen L. Vierthaler
2011 ISRN Obstetrics and Gynecology  
Nearly a half a million women throughout the world develop cervical cancer every year Parkin and Bray ("Chapter 2. The burden of HPVrelated cancers," Vaccine, vol. 24, no. 3, pp.  ...  It is in this setting that Cervarix could reduce the incidence of cervical cancer to about 9.5/100,000 women.  ...  Less data detail longitudinal studies of incident high-risk HPV infection in women older than 40 years and its meaning visà vis CIN 3 and cervical cancer progression.  ... 
doi:10.5402/2011/457204 pmid:22111017 pmcid:PMC3216348 fatcat:zr4t76qwpzcujb72ne4anuz64q

Systematic Review Protocol for the Hexavalent Chromium IRIS Assessment (Preliminary Assessment Materials) [article]

Catherine Gibbons, Alan Sasso, Xabier Arzuaga, Johanna Congleton, Barbara Glenn, Rebecca Nachman, Larissa Pardo, Elizabeth Radke, Paul Reinhardt, Amina Wilkins, Erin Yost, David Lehmann
2019 Zenodo  
The Integrated Risk Information System (IRIS) Program is undertaking a reassessment of the health effects of hexavalent chromium (Cr[VI]).  ...  studies (Proctor et al., 2016; Gibb et al., 2015) and a National Toxicology Program (NTP) bioassay that reported increased incidences of tumors in rats and mice exposed to Cr(VI) in drinking water (NTP  ...  of Cr(VI) and increased incidence of lung cancer in humans.  ... 
doi:10.5281/zenodo.2654896 fatcat:mngjwvsfsvdwdfc4jow47hfgpq

Soil, geography and human disease: a critical review of the importance of medical cartography

Peter W. Abrahams
2006 Progress in physical geography  
Soils have a profound impact on the causation and geographical distribution of human disease and well-being.  ...  the development of aetiological hypotheses, help in the planning and management of public health problems, and assess the impact of any beneficial strategies.  ...  The soil zinc/copper ratio has been suggested as a co-factor responsible for the high incidence of stomach cancer in north Wales. such as, for example, small bar graphs showing the distribution and relative  ... 
doi:10.1191/0309133306pp493ra fatcat:l5d5nzixxfe37mi624uff5vt3e

Molybdenum Salts Possess Potent Angiogenic Modulatory Properties: Validation on Chorioallantoic Membrane (CAM) of Chicken

Ashok Munjal, Rekha Khandia, Pratibha Vishwakarm, Abhinav Dwivedi, Anshumala Kujur, Kuldeep Dhama
2016 Asian Journal of Animal and Veterinary Advances  
The resealed eggs were incubated for 72 h in a humid incubator chamber at 37±1EC. Then the eggs were opened to observe the gross and histopathological alterations for angiogenesis modulation.  ...  Objective: Angiogenesis plays critical and essential role in various physiological processes of animals and humans.  ...  Authors of the manuscript thank and acknowledge their respective Universities/ Institutes.  ... 
doi:10.3923/ajava.2017.44.49 fatcat:zno6eemiavdffbfl5oanovjb3i

2018 Eastern Regional Meeting

2018 Journal of Investigative Medicine  
Purpose of study Identifying inherited gene mutations can reduce cancer incidence and mortality.  ...  Conclusions This study summarises the estimate of breast cancer incidence and mortality in Caribbean women and known prevalence of BRCA1/2 and PALB2 breast cancer gene mutations in this cohort.  ... 
doi:10.1136/jim-2018-000730 fatcat:md7icxjkcjcbbkmvg2zkjfjac4

Causal inference in cancer epidemiology: what is the role of Mendelian randomization? [article]

James Yarmolinsky, Kaitlin H Wade, Rebecca C Richmond, Ryan J Langdon, Caroline J Bull, Kate M Tilling, Caroline L Relton, Sarah J Lewis, George Davey Smith, Richard M Martin
2017 bioRxiv   pre-print
However, some methodological and conceptual challenges in the implementation of MR are particularly pertinent when applying this method to cancer aetiology and prognosis, including reverse causation arising  ...  We summarize recent studies in the cancer literature that have adopted a MR framework to highlight strengths of this approach compared to conventional epidemiological studies.  ...  Alcohol and incidence of oesophageal cancer .  ... 
doi:10.1101/223966 fatcat:ypefn4ngtjc45h334h6uxlfgwi

A five-year survey of the literature in cancer of the cervix

1955 American Journal of the Medical Sciences  
: These findings were Col roborated by Stephenson and Grace in a survey of 100 patients with cervical cancer, correlated with 100 patients with cancer in other sites®®, The cet vical cancer patients showed  ...  ., F.A.C.S ASSOCIATI BAYLOR UNIVERSITY SCHOOI Durinc the past 5 vears there has been an increase in the reported inci- dence of cervical cancer and a concom- itant decrease in mortality from cancer of  ... 
pmid:13268447 fatcat:mcjcc36ecngqtmmldscq7kjub4

Nutrition and Diet in the Prevention and Treatment of Cancer

1999 Journal of clinical biochemistry and nutrition  
Similarly, breast cancer [1] although relatively rare fifty years ago compared with present incidence, was frequently associated with obesity and a diet low in fruit and vegetables but high in animal fats  ...  For more than half a century there has been widespread belief that many forms of cancer are somehow associated with diet and that good nutrition might help to prevent cancer.  ...  Similar linear relationships with fat intake are seen for colon cancer (Fig. 3) and prostate cancer deaths, showing a fundamental role of dietary fat in the causation of human cancer.  ... 
doi:10.3164/jcbn.26.135 fatcat:z5xmmhpztvfb5nqh2pcxkgqcve


John A. Wall
1955 American Journal of the Medical Sciences  
: These findings were Col roborated by Stephenson and Grace in a survey of 100 patients with cervical cancer, correlated with 100 patients with cancer in other sites®®, The cet vical cancer patients showed  ...  ., F.A.C.S ASSOCIATI BAYLOR UNIVERSITY SCHOOI Durinc the past 5 vears there has been an increase in the reported inci- dence of cervical cancer and a concom- itant decrease in mortality from cancer of  ... 
doi:10.1097/00000441-195523060-00011 fatcat:dkdgg7hqbrehdk2vrqa6qq2fue

Breast Cancer Screening Amongst Arabic Women Living in the State of Qatar: Preliminary Results of the Cross-Sectional Community Based Survey

Tam Truong Donnelly
2011 Qatar Foundation Annual Research Forum Proceedings  
Population-based cancer registry is a co-coordinating facility of co-operating hospital records in a selected geographic area to collect, combine, compare and evaluate uniformly defined information on  ...  Hinkley, California is a desert community known for the "erin Brockovich" film that alleged a cancer excess from chromium 6 [Cr(vi)] contaminated groundwater. inhaled Cr(vi) is accepted as a cause  ...  The cohort was traced for cancer incidence through population, mortality and cancer registries. each person was followed up from his return to estonia until death, emigration or December 31, 2007.  ... 
doi:10.5339/qfarf.2011.bmp67 fatcat:mcvzric2xjcvjej7jkhi4uviae

Mechanisms of Carcinogenesis

F. J. C. Roe
1968 BMJ (Clinical Research Edition)  
Rowson, Institute of Laryngology and Otology, London, for his expert advice, and to Mrs A. Englefield and Miss L. Barlow for their assistance in the preparation of the manuscript.  ...  The study of correlations between genetic factors, environmental factors, and the incidence and progress of particular types of lesion would constitute the first logical step in the elucidation of the  ...  Multi-factorial Causation of Cancer If exposure to a particular agent is regularly associated with the subsequent development of cancer under a wide variety of circumstances and in a wide variety of species  ... 
doi:10.1136/bmj.3.5618.605-c fatcat:lzzjosalf5f5lhxirqkmkfw6pm

Review of 464 Cases of Carcinoma of Lung Treated by Resection

J. H. Gifford, J. K. B. Waddington
1957 BMJ (Clinical Research Edition)  
We thank all members of the Liverpool Thoracic Surgical Unit for the use of their case notes; the medical practitioners for their co-operation; Drs  ...  How can all the differences in incidence be related to the causation of peptic ulcer ?  ...  Integration It does not seem possible to integrate the many aetiological considerations into one neat explanation, and it is probable that peptic ulcer is the end-product of a variety of mechanisms.  ... 
doi:10.1136/bmj.1.5021.723 pmid:13404284 pmcid:PMC1974756 fatcat:dmqemkdpdrahtk5xhxwrttql3a
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