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From Syntax to Semantics in Systems Biology Towards Automated Reasoning Tools [chapter]

François Fages
2006 Lecture Notes in Computer Science  
Computer aided inference of interaction networks, or computer aided drug target discovery, need nontrivial automated reasoning tools to assist the biologist.  ...  Following this approach, we are currently developing a mixed model of the cell cycle and the circadian cycle with applications to cancer therapies.  ...  Computer aided inference of interaction networks, or computer aided drug target discovery, need nontrivial automated reasoning tools to assist the biologist.  ... 
doi:10.1007/11732488_6 fatcat:og573cyqbvhbtfpezmop6lifmi

The Unconventionality of Nature: Biology, from Noise to Functional Randomness [chapter]

Barbara Bravi, Giuseppe Longo
2015 Lecture Notes in Computer Science  
Both forms of randomness constructively contribute to biological robustness, as resilience, far away from conventional computable dynamics, where elaboration and transmission of information are robust  ...  In biology, phenotypes' variability stems from stochastic gene expression as well as from extrinsic fluctuations that are largely based on the contingency of developmental paths and on ecosystemic changes  ...  In these computational frames, which are our fantastic, linguistic invention far away from nature and its material contingency, randomness has no place and all is done to avoid it, as "noise".  ... 
doi:10.1007/978-3-319-21819-9_1 fatcat:hsqpwn3avrguli3x5wbecogsk4

A Leader Genes Approach-based Tool for Molecular Genomics: From Gene-ranking to Gene-network Systems Biology and Biotargets Predictions

Nicola Luigi Bragazzi
2013 Journal of computer science and systems biology  
The Leader Genes approach, integrating the different available databases and genomics tools, enables the user to search for genes linked to a disease or a cellular process, and to visualize the class of  ...  the most important genes, that is to say those having the highest number of interconnections.  ...  Acknowledgments This project was supported by grants to FEN (Fondazione Elba Nicolini) by the FIRB Italnanonet (RBPR05JH2P) from MIUR (Ministero dell'Istruzione, Università e Ricerca; Italian Ministry  ... 
doi:10.4172/jcsb.1000113 fatcat:kupsw2iikzabrihv42kp3kdwee

Defragged Binary I Ching Genetic Code Chromosomes Compared to Nirenberg's and Transformed into Rotating 2D Circles and Squares and into a 3D 100% Symmetrical Tetrahedron Coupled to a Functional One to Discern Start From Non-Start Methionines through a Stella Octangula

Fernando Castro-Chavez
2012 journal of Proteome Science and Computational Biology  
in order to differentiate the start methionine from the methionine that is acting as a codifying non-start codon.  ...  BACKGROUND: Three binary representations of the genetic code according to the ancient I Ching of Fu-Xi will be presented, depending on their defragging capabilities by pairing based on three biochemical  ...  representations, but also now in 3D, coupling it to geometry, to arithmetic [42] , to bioinformatics, to mathematics in general, and now to art, as it has already been done with other aspects of science  ... 
doi:10.7243/2050-2273-1-3 pmid:23431415 pmcid:PMC3575644 fatcat:ecwzmyu4pjhtvh3pcezenv3omq

Cancer systems biology: signal processing for cancer research

Olli Yli-Harja, Antti Ylipaa, Matti Nykter, Wei Zhang
2011 Chinese Journal of Cancer  
Based on this approach, a new field has emerged, called cancer systems biology.  ...  Signal processing is a field of science traditionally focused on modeling electronic and communications systems, but recently it has turned to biological applications with astounding results.  ...  Systems Biology for Cancer Research Emerges from Efficient Use of Data Using mathematical models to extract knowledge out of massive amounts of biological data is the essence of a field of science called  ... 
doi:10.5732/cjc.011.10095 fatcat:xjvhtogk4vfdloifk4qckge3ey

Cancer computational biology

Zohar Yakhini, Igor Jurisica
2011 BMC Bioinformatics  
in establishing computer and information science as an important and fundamental component of modern biology.  ...  Samples are complex and heterogeneous, and cancer related mechanisms involve many layers of the process that leads from the genome to cellular function.  ...  Integrative computational biology in cancer research benefits from close collaboration among diverse disciplines -computational biology, cancer research, genomics, proteomics to name a few.  ... 
doi:10.1186/1471-2105-12-120 pmid:21521513 pmcid:PMC3111371 fatcat:p3vszjpn4nav7kxq2yklsizn5u

Cancer Bioinformatics in Cancer Therapy

2018 Advances in Proteomics and Bioinformatics  
This article will overview bioinformatics in cancer study and clinical applications-advantages and limitations associated with cancer therapeutics and drug developments.  ...  Despite technical advances, cancer bioinformatics has its own limitations at this stage.  ...  Acknowledge This work was funded by Shanghai Science and Technology Foundation of High Educations 97A49  ... 
doi:10.29011/2690-0092.100011 fatcat:55anlmmsyjfk7pdzrtwjuk5g6y

Spotlight on Cancer Research

2015 Nature  
a PhD in computational biology, mathematics, computer science or related discipline along with experience in applying machine learning techniques to large data sets and a familiarity with genomics and  ...  Team at London's Institute of Cancer Research, himself a computer scientist with a physics background (see From neutrinos to tumours).  ... 
doi:10.1038/nj0444 fatcat:zcf6uqvmgveivccar2zuswu4za

Cancer Nanotechnology

Mohammed Chyad Al-Noaemi
2018 Current Trends in Biomedical Engineering & Biosciences  
Nanotechnology has direct beneficial applications for medicine, environment, engineering, biology, chemistry, computing, materials science, and communications.  ...  The approaches to nanomedicine range from the medical use of nanomaterials, to nanoelectronics biosensors, and even possible future applications of molecular nanotechnology.  ...  Nanotechnology has direct beneficial applications for medicine, environment, engineering, biology, chemistry, computing, materials science, and communications.  ... 
doi:10.19080/ctbeb.2018.14.555832 fatcat:mh4sh3m435chhjwmet44i3n4ly

Bioinformatics: an overview for cancer research

Mamta Chowdhary, Asha Rani, Jyoti Parkash, Mohd Shahnaz, Dhruv Dev
2016 Journal of Drug Delivery and Therapeutics  
It is a multidisciplinary science that is made out of different kinds of other scientific fields like biology, computer science, chemistry, statistics, mathematics and others.  ...  apply bioinformatics to discover and diagnose diseases like cancer.  ...  Acknowledgement: The author wishes to acknowledge  ... 
doi:10.22270/jddt.v6i4.1290 fatcat:thqskzgzx5gznhfa5n5rwbvwkm

Technologies for Cancer Research

Tania Limongi
2020 Biomedical Journal of Scientific & Technical Research  
In order to assess data about the topic 'cancer technology', in the January of 2020, I conducted a literature search, using the Thomson Reuters Web of Science research portal.  ...  Progresses in many different technological contests are bit by bit contributing to make cancer a handier disease by adding new alternative materials and methods able to efficient treatment to be included  ...  substitute, contributes to assisting other subjects such as biochemistry, cellular and molecular biology, pharmacology and pathology in the fight against cancer (Table 1) January of 2020, I conducted  ... 
doi:10.26717/bjstr.2020.25.004141 fatcat:cc2net4nx5dk5p2xmgivpyi5wy

Introducing cancer convergence

Krastan B. Blagoev, David T. Ting, Herbert Levine, Yvonne Saenger, Thea D. Tlsty, Bo Sun
2017 Cancer Convergence  
Uncovering the principles of physics and biology that underlie the origin and progression of cancer and govern its response to treatment will be accomplished through a convergence of physical sciences  ...  , physicists, chemists, engineers, as well as data and computer scientists to publish boundary-pushing papers on a diversity of formal methodologies, conceptual insights and results from their laboratories  ...  Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.  ... 
doi:10.1186/s41236-017-0003-x pmid:29623955 pmcid:PMC5876691 fatcat:zjmbkb36tfazznkioldnhyeamq

Spotlight on Cancer Research

2010 Nature Cell Biology  
Sage was recently awarded a four year grant from the NCI Integrative Cancer Biology Program to establish a new Center for Cancer Systems Biology.  ...  Qualifications: A Ph.D. in physics, mathematics, statistics, computer science, electrical engineering, bioinformatics, or other relevant area is required.  ... 
doi:10.1038/nj0295 fatcat:pz5zs2763ndvbol3bdpgnhzyku

Jobs Wanted: Cancer Research

2011 Cancer Discovery  
Craig Thompson, MD, president and CEO of Memorial Sloan-Kettering Cancer Center in New York, suggests delving into the strong computational approach of systems biology to understand networks within and  ...  or from proteomics to microfabrication.  ... 
doi:10.1158/ pmid:22585150 fatcat:hg5ncv7inra7vdxubqjvfat4jy

Cancer target selection pressure

Joanne Kotz
2013 Science-Business eXchange  
Al-Lazikani leads the computational biology and chemogenomics team in both the unit and the Division of Cancer Therapeutics at ICR.  ...  Now, a team from The Institute of Cancer Research has created a computational algorithm that hones in on targets with strong biological validation that also are predicted to be druggable. 1 The approach  ... 
doi:10.1038/scibx.2013.128 fatcat:l25p3yzn4bgutaycjbomuegbpm
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