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Calcium imaging and dynamic causal modelling reveal brain-wide changes in effective connectivity and synaptic dynamics during epileptic seizures

Richard E. Rosch, Paul R. Hunter, Torsten Baldeweg, Karl J. Friston, Martin P. Meyer, Saad Jbabdi
2018 PLoS Computational Biology  
If citing, it is advised that you check and use the publisher's definitive version for pagination, volume/issue, and date of publication details.  ...  And where the final published version is provided on the Research Portal, if citing you are again advised to check the publisher's website for any subsequent corrections.  ...  Acknowledgments We thank the King's College London fish facility staff at Guy's Hospital campus for their excellent fish husbandry and care.  ... 
doi:10.1371/journal.pcbi.1006375 pmid:30138336 fatcat:6dd7oelwjfayfjw5j5phawfcnu

Imaging and dynamic causal modelling reveal brain-wide changes in effective connectivity and synaptic dynamics during epileptic seizures [article]

Richard E Rosch, Paul Hunter, Torsten Baldeweg, Karl Friston, Martin Meyer
2017 bioRxiv   pre-print
This dynamic causal modelling of seizures in the zebrafish brain reveals concurrent changes in synaptic coupling at macro- and mesoscale.  ...  Empirically measured spectral changes of spontaneous neuronal activity during the seizure are then modelled using neural mass models, allowing Bayesian inference on changes in effective network connectivity  ...  Discussion In this report we combine light-sheet imaging of the intact larval zebrafish brain during PTZ-induced seizures with dynamic causal modelling in order to identify network-wide connectivity changes  ... 
doi:10.1101/160259 fatcat:nwypbd4sajhgtkytbld3u4igp4

The Enlightened Brain: Novel Imaging Methods Focus on Epileptic Networks at Multiple Scales

L. Federico Rossi, Dimitri M. Kullmann, Robert C. Wykes
2018 Frontiers in Cellular Neuroscience  
State of the art two-photon microscopy and wide-field fluorescence imaging can record the activity in epileptic networks at multiple scales, from neuronal microcircuits to brain-wide networks.  ...  depends on the topology of brain-wide functional connectivity.  ...  Lastly, wide field imaging can also reveal the causal interaction between seizures and other circuit dysfunctions such as cortical and subcortical spreading depression (Farkas et al., 2008) , which have  ... 
doi:10.3389/fncel.2018.00082 pmid:29632475 pmcid:PMC5879108 fatcat:tc7zyljeg5donix7fbrx3fu6ee

Higher-order hub cells involved in feedforward motifs as critical factors in epileptic network instability [article]

Darian Hadjiabadi, Matthew Lovett-Barron, Ivan Raikov, Fraser Sparks, Zhenrui Liao, Scott C. Baraban, Jure Leskovec, Attila Losonczy, Karl Deisseroth, Ivan Soltesz
2020 bioRxiv   pre-print
We performed whole-brain single-cell calcium imaging of the larval zebrafish brain in an acute seizure model.  ...  calcium imaging in zebrafish combined with effective connectivity modeling was used to study epileptic network instabilityPreseizure whole brain networks were more sensitive to simulated targeted perturbation  ...  Acknowledgements The authors would like to thank Michael Kunst for access to zebrafish structural connectivity data, members of the Soltesz Lab and Maxwell Collard for helpful discussions.  ... 
doi:10.1101/2020.10.20.340364 fatcat:hpikxt4sdvdm7lucpvnmdijdbu

Concepts of Connectivity and Human Epileptic Activity

Louis Lemieux, Jean Daunizeau, Matthew C. Walker
2011 Frontiers in Systems Neuroscience  
We then show how essentially similar methodologies, and more recently models addressing causality, have been used to characterize whole-brain and regional networks using functional MRI data.  ...  We are motivated by the following two perceived needs: firstly, to relate the various measures of connectivity found in the field of epilepsy research to the more general language of functional and effective  ...  epilepsy [David et al., 2008a ; see Section "Signal Generation and Effective Connectivity Modeling in Epilepsy" on dynamic causal modeling (DCM)].  ... 
doi:10.3389/fnsys.2011.00012 pmid:21472027 pmcid:PMC3065658 fatcat:74bxbrc3xjgexmsx3ivw6k2jv4

Functional Genomics of Epilepsy and Associated Neurodevelopmental Disorders Using Simple Animal Models: From Genes, Molecules to Brain Networks

Richard Rosch, Dominic R. W. Burrows, Laura B. Jones, Colin H. Peters, Peter Ruben, Éric Samarut
2019 Frontiers in Cellular Neuroscience  
In this review, we will summarize how the use of simple animal models can fill the gap between genetic diagnosis and functional and phenotypic correlates of gene function in vivo.  ...  In particular, we will discuss how these simple animals offer the possibility to study gene function at multiple scales, from molecular function (i.e., ion channel activity), to cellular circuit and brain  ...  Furthermore, the development of various transgenic reporters of cellular activity, such as GCaMP and RGECO enable the imaging of calcium dynamics in single cells and whole brain networks during behavior  ... 
doi:10.3389/fncel.2019.00556 pmid:31920556 pmcid:PMC6923670 fatcat:sqy2ur45xzbltovcpssb6qvlau

Role of inhibitory control in modulating spread of focal ictal activity [article]

Jyun-you Liou, Hongtao Ma, Michael Wenzel, Mingrui Zhao, Eliza Baird-Daniel, Elliot Smith, Andrew Daniel, Ronald G. Emerson, Rafael Yuste, Theodore H. Schwartz, Catherine Schevon
2017 bioRxiv   pre-print
Here, we used a multielectrode array, wide field calcium imaging, and two-photon calcium imaging to study focal seizure propagation pathways in an acute rodent neocortical 4-aminopyridine model.  ...  Our study suggests both classical and epileptic network propagation could arise from inhibition defects without pre-existing pathological connectivity changes, and that preferred propagation pathways may  ...  Figure 7 Wide-field calcium imaging of the two-focus epileptic network All rights reserved.  ... 
doi:10.1101/146407 fatcat:ul3mhwxwergexgjix225cj3rxa

Potassium Dynamics in the Epileptic Cortex: New Insights on an Old Topic

Flavio Fröhlich, Maxim Bazhenov, Vicente Iragui-Madoz, Terrence J. Sejnowski
2007 The Neuroscientist  
The authors thank Jay Coggan, Justin Elstrott, and Luke Wylie for helpful comments and discussions. F. F. acknowledges Anita Fröhlich for excellent assistance and support.  ...  Historically, it was hypothesized that [K + ] o is the causal factor for epileptic seizures.  ...  We review some of the main modeling results to illustrate the power of computational models in studying the role of [K + ] o dynamics in epileptic seizures.  ... 
doi:10.1177/1073858408317955 pmid:18997121 pmcid:PMC2854295 fatcat:rhshjqufzfbzfl7jpivgudckrq

Modeling Epilepsy Using Human Induced Pluripotent Stem Cells-Derived Neuronal Cultures Carrying Mutations in Ion Channels and the Mechanistic Target of Rapamycin Pathway

Octavia Yifang Weng, Yun Li, Lu-Yang Wang
2022 Frontiers in Molecular Neuroscience  
It is characterized by periods of seizure activity of the brain as a result of excitation and inhibition (E/I) imbalance, which is regarded as the core underpinning of epileptic activity.  ...  excitability, synaptic transmission and circuits, ultimately E/I imbalance and behavioral phenotypes in epilepsy.  ...  AUTHOR CONTRIBUTIONS OW, YL, and L-YW contributed to conception and design of the study. OW wrote the first draft of the manuscript.  ... 
doi:10.3389/fnmol.2022.810081 pmid:35359577 pmcid:PMC8960276 fatcat:hsbxdkdnybagroesxwzui5eykm

Modeling Neurotransmission: Computational Tools to Investigate Neurological Disorders

Daniela Gandolfi, Giulia Maria Boiani, Albertino Bigiani, Jonathan Mapelli
2021 International Journal of Molecular Sciences  
A wide range of computational models in fact have been developed to explore the alterations of the mechanisms involved in neurotransmission following the emergence of neurological pathologies.  ...  The investigation of synaptic functions remains one of the most fascinating challenges in the field of neuroscience and a large number of experimental methods have been tuned to dissect the mechanisms  ...  The funders had no role in the design of the design of the study; in the collection, analyses, or interpretation of data; or in the writing of the manuscript.  ... 
doi:10.3390/ijms22094565 pmid:33925434 fatcat:6iflkeumhbb65e7uftrzsldl6q

High-frequency oscillations: The state of clinical research

Birgit Frauscher, Fabrice Bartolomei, Katsuhiro Kobayashi, Jan Cimbalnik, Maryse A. van 't Klooster, Stefan Rampp, Hiroshi Otsubo, Yvonne Höller, Joyce Y. Wu, Eishi Asano, Jerome Engel, Philippe Kahane (+2 others)
2017 Epilepsia  
of HFOs in seizures and epileptogenesis.  ...  Future studies on HFOs combining novel high-resolution in vivo imaging techniques and precise control of neuronal behavior using optogenetics or chemogenetics will provide evidence about the causal role  ...  We confirm that we have read the Journal's position on issues involved in ethical publication and affirm that this report is consistent with those guidelines.  ... 
doi:10.1111/epi.13829 pmid:28666056 pmcid:PMC5806699 fatcat:i7adxcircvbg5fy26jdkfeazli

GABAergic Interneurons in Seizures: Investigating Causality With Optogenetics

Vincent Magloire, Marion S Mercier, Dimitri M Kullmann, Ivan Pavlov
2018 The Neuroscientist  
in network dynamics.  ...  Recent developments in optogenetics, combined with genetic tools and advanced electrophysiological and imaging techniques, allow us for the first time to assess the causal roles of identified cell-types  ...  Here, we focus on studies that have employed optogenetic and imaging techniques to target and manipulate GABAergic interneurons and review what these techniques have revealed about the causal role of these  ... 
doi:10.1177/1073858418805002 pmid:30317911 pmcid:PMC6745605 fatcat:tli3w2g5trfo7m7lalllt5ct74

Nicotinic receptor channelopathies and epilepsy

Ortrud K. Steinlein, Daniel Bertrand
2009 Pflügers Archiv: European Journal of Physiology  
In this work, we review, in the light of the latest discoveries, the effects caused by the mutations on the physiological properties of the receptors and the impact of such mutations on neuronal network  ...  It also marked the first step towards the today widely acknowledged concept of epilepsies as channelopathies.  ...  Acknowledgments This work was supported by the Swiss National Science Foundation to DB (3100A0-101787/2) and by the DFG (STE16511-2, BE 3834/1-2) to OKS and to DB.  ... 
doi:10.1007/s00424-009-0766-8 pmid:20016990 fatcat:ofkyznld2neohd3qy2m7hrvpge

Neural circuit mechanisms of post–traumatic epilepsy

Robert F. Hunt, Jeffery A. Boychuk, Bret N. Smith
2013 Frontiers in Cellular Neuroscience  
Several models ofTBI have been developed to investigate the relationship between trauma, seizures, and epilepsy-related changes in neural circuit function.  ...  These include alterations to inhibitory interneurons and formation of new, excessive recurrent excitatory synaptic connectivity.  ...  INHIBITORY CIRCUIT CHANGES GABAergic interneurons form robust local synaptic connections with principal cells and play an important role in controlling cortical activity.  ... 
doi:10.3389/fncel.2013.00089 pmid:23785313 pmcid:PMC3684786 fatcat:nguf3gem4fhj3nxy34ff4psp74

Functional holography analysis: Simplifying the complexity of dynamical networks

Itay Baruchi, Danny Grossman, Vladislav Volman, Mark Shein, John Hunter, Vernon L. Towle, Eshel Ben-Jacob
2006 Chaos  
Then we demonstrate that by applying the FH analysis to modeled and real neural networks as well as recorded brain activity, hidden causal manifolds with simple yet characteristic geometrical and topological  ...  By this analysis, the existence of hidden causal manifolds with simple yet characteristic geometrical and topological features in the complex biological activity can be deciphered.  ...  The internal dynamics of neurons during the SBE are also well captured by such a model neuronal network with uniform synaptic connectivity.  ... 
doi:10.1063/1.2183408 pmid:16599778 fatcat:re45mdbkenbhvczkm3exf5zhia
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