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Iron deposition in Parkinson's disease by quantitative susceptibility mapping

Qiqi Chen, Yiting Chen, Yue Zhang, Furu Wang, Hongchang Yu, Caiyuan Zhang, Zhen Jiang, Weifeng Luo
2019 BMC Neuroscience  
Patients with Parkinson's disease (PD) have elevated levels of brain iron, especially in the nigrostriatal dopaminergic system. The purpose of this study was to evaluate the iron deposition in the substantia nigra (SN) and other deep gray matter nuclei of PD patients using quantitative susceptibility mapping (QSM) and its clinical relationship, and to explore whether there is a gradient of iron deposition pattern in globus pallidus (GP)-fascicula nigrale (FN)-SN pathway.
doi:10.1186/s12868-019-0505-9 pmid:31117957 pmcid:PMC6532252 fatcat:zle6bqk26vax5napmnlj2hvn2u

Suzuki Cross-Coupling Reactions in Dicationic Room Temperature Ionic Liquid

Chuanyue Zhang, Ruobing Shi, Caiyuan Chen, Chuanming Jin
2013 Youji huaxue  
研究论文 双阳离子型室温离子液体中 Suzuki 偶联反应研究 张传越 石若冰 陈才元 金传明 * (湖北师范学院污染物分析与资源化技术湖北省重点实验室 黄石 435002) 摘要 合成了具有钳子型的双咪唑阳离子核的室温离子液体 2, 它的相转变温度为-51 ℃, 热力学分解温度为 412 ℃, 利用该离子液体作反应溶剂研究了不同钯催化剂 PdCl 2 , Pd(OAc) 2 , Pd-NHC 配合物 3 存在下的 Suzuki 偶联反应. 结 果表明: 在 NaOAc 作碱, 0.5 mol%的 Pd-NHC 配合物 3 存在下溴代苯衍生物与苯硼酸反应具有较高的活性, 产率可以达 到 85%以上, Pd-NHC 配合物 3 催化剂能更好地负载在钳子型双阳离子核室温离子液体 2 中, 该反应体系能重复循环使 用多次, 且分离简单、重现性强、环境友好. 关键词 室温离子液体; Suzuki 偶联反应; N-杂卡宾配合物; 钯 Abstract Room temperature ionic liquid (RTIL) 2 with pincer bisimidazole cationic
more » ... nuclei was prepared. Its phase transition and thermal decomposition temperature are -51 and 412 ℃, respectively. Suzuki reactions have been studied when different catalyst PdCl 2 , Pd(OAc) 2 , Pd-N-heterocyclic carbene complex 3 were used in RTIL 2. The results indicate that aryl bromide can react with phenylboronic acid in the yield of over 85% in the presence of NaOAc and 0.5 mol% Pd-NHC 3, and the loading capability of Pd-NHC 3 in RTIL 2 is best. This high efficient catalytic system is environmentally benign, recoverable and easily separated with products.
doi:10.6023/cjoc201211002 fatcat:hxbhrvpo2vftfgsbmlkvahuhpe

Research on Auto Parts Industry Upgrading Based on Internet of Things

Chen Caiyuan, Wang Long
2015 Open Electrical & Electronic Engineering Journal  
Based on the importance of development and upgrading of auto parts industry, the article analyzes the location of auto parts industry. In order to achieve further development and upgrade, five factors influencing China auto parts industry upgrading are put forward afterwards in this paper. They are market demands, resource supply, technology level, system and policy and international trade. An empirical analysis is made by multivariate statistical regression methods and testifies the result of
more » ... ualitative analysis above and then gets the quantitative conclusion.
doi:10.2174/1874129001509010474 fatcat:2mubg2v43bdqdoysy26u6lbc74

HELLP syndrome complicated by pulmonary edema: a case report

Caiyuan Mai, Bin Wang, Rong Chen, Dongmei Duan, Lijuan Lv, Qiong Lei, Xiaohong Lin, Jiying Wen, Jianmin Niu
2018 Open Medicine  
HELLP syndrome is a combination of symptoms described as hemolysis, elevated liver enzymes and low platelets. HELLP is a common life-threatening complication of pregnancy thought to be a variant or complication of preeclampsia. In this case report, we aimed to present a woman with acute postpartum HELLP syndrome complicated by pulmonary edema after caesarean section following severe preeclampsia. Our experience suggests that early detection of HELLP syndrome and timely management will bring good outcomes.
doi:10.1515/med-2018-0075 pmid:30426089 pmcid:PMC6227785 fatcat:wm3r7vgbnbbnbd3e7unqjkf4ym

The Association Between Dry Eye Disease With Depression, Anxiety and Sleep Disturbance During COVID-19

Qing He, Zhuo Chen, Caiyuan Xie, Lin Liu, Ruihua Wei
2022 Frontiers in Psychiatry  
Objective: This study aimed to investigate the relationship between dry eye disease (DED) with anxiety and depression. Additionally, the mediating effect of sleep quality on this relationship was explored.Methods: 321 patients with DED were recruited from Tianjin Medical University Eye Hospital clinic and surveyed using demographic questionnaires, the Ocular Surface Disease Index (OSDI), Hospital Anxiety and Depression Scale (HADS), and Pittsburgh Sleep Quality Index (PSQI). Regression analysis
more » ... and the bootstrap method were used to investigate the influence of sleep on the relationship between DED, anxiety and depression.Results: Among the patients with DED, 86 (26.79%), 85 (26.48%), and 54 (16.82%) patients presented with anxiety, depression, and both anxiety and depression respectively. The OSDI and PSQI score were positively correlated with depression and anxiety (all p < 0.01). The direct effects of OSDI on depression and anxiety were significant (P < 0.01). Additionally, the bootstrap test showed significant mediating effects of subjective sleep quality [95% CI [0.003–0.016] (depression); [0.001–0.011] (anxiety)] and sleep latency [95% CI [0.001–0.010] (depression); [0.001–0.008] (anxiety)]. These results indicated that the severity of DED symptoms, as measured by the OSDI score, affected anxiety and depression through a direct and an indirect pathway mediated by subjective sleep quality and sleep latency.Conclusions: The results indicated that there was a significant correlation between DED and anxiety and depression. Moreover, subjective sleep quality and sleep latency were a mediator of the relationship between DED symptoms and anxiety and depression.
doi:10.3389/fpsyt.2021.802302 pmid:35069294 pmcid:PMC8766963 fatcat:lal2hsvxqvcufdo7xdmclzcuru

Rapid deterioration of Mooren's ulcers after conjunctival flap: a review of 2 cases

Saiqun Li, Yuqing Deng, Caiyuan Du, Haixiang Huang, Jing Zhong, Ling Chen, Bowen Wang, Jin Yuan
2017 BMC Ophthalmology  
Our report lends further supportive to the findings of Chen [22] .  ...  Chen and associates previously observed a Mooren's ulcer that relapsed in one patient after amniotic membrane grafting was combined with conjunctival flap (excised from the opposite healthy eye).  ... 
doi:10.1186/s12886-017-0488-1 pmid:28619029 pmcid:PMC5472947 fatcat:x7nzmtbqz5gvpajai4salvvcu4

Intravoxel incoherent motion diffusion-weighted MR imaging of the liver using respiratory-cardiac double triggering

Jinning Li, Caiyuan Zhang, Yanfen Cui, Huanhuan Liu, Weibo Chen, Guilong Wang, Dengbin Wang
2017 OncoTarget  
To investigate the influence of respiratory-cardiac double triggering (RCT) on intravoxel incoherent motion (IVIM) diffusion-weighted imaging (DWI) for the liver, twelve healthy volunteers underwent liver DWI twice respectively with respiratory triggering (RT) and RCT schemes. Signal-to-noise ratios (SNRs) of the images, values, repeatability (evaluating with within-subject coefficient of variation), and variability of quantitative parameters, including apparent diffusion coefficient (ADC),
more » ... diffusion coefficient (D), perfusion fraction (f), and perfusion-related diffusion coefficient (D*), were evaluated for each DWI sequence. Results showed that the use of RCT scheme significantly enhanced SNRs (P < 0.001), improved the measurement precision (P ≤ 0.023) and repeatability (P ≤ 0.009) of ADC, D, and f values, decreased the variability of ADC and D values (P ≤ 0.015). Furthermore, this improvement was not completely confined to the left liver lobe, but also observed for the right liver lobe. Moreover, the precision of D* values in the right lobe (P < 0.001) and its repeatability in the left lobe (P = 0.002) were also significantly improved. Thus, our findings suggest that RCT is a more effective physiological scheme for improving SNRs, the precision, repeatability, and variability of quantitative parameters than RT for IVIM-DWI in the liver.
doi:10.18632/oncotarget.21824 pmid:29212282 pmcid:PMC5706928 fatcat:izzdwqouy5g3rp57asibkkajsm

Diffusion kurtosis imaging evaluating epithelial–mesenchymal transition in colorectal carcinoma xenografts model: a preliminary study

Huanhuan Liu, Wenbin Shen, Caiyuan Zhang, Yanfen Cui, Jinning Li, Tingting Zhang, Weibo Chen, Dengbin Wang
2017 Scientific Reports  
Epithelial-mesenchymal transition (EMT) plays an important role in aggravating invasiveness and metastatic behavior of colorectal cancer (CRC). Identification of EMT is important for structuring treatment strategy, but has not yet been studied by using noninvasive imaging modality. Diffusion kurtosis imaging (DKI) is an advanced diffusion weighted model that could reflect tissue microstructural changes in vivo. In this study, EMT was induced in CRC cells (HCT116) by overexpressing Snail1 gene.
more » ... e aimed to investigate the value of DKI in identifying EMT in CRC and decipher the correlations between DKI-derived parameters and EMT biomarker E-cadherin and cell proliferative index Ki-67 expression. Our results revealed that HCT116/Snail1 cells presented changes consistent with EMT resulting in significant increase in migration and invasion capacities. DKI could identify CRC with EMT, in which the DKI-derived parameter diffusivity was significantly lower, and kurtosis was significantly higher than those in the CRC/Control. Diffusivity was negatively and kurtosis was positively correlated with Ki-67 expression, whereas diffusivity was positively and kurtosis was negatively correlated with E-cadherin expression. Therefore, our study concluded that DKI can identify EMT in CRC xenograft tumors. EMTcontained CRC tumors with high Ki-67 and low E-cadherin expression were vulnerable to have lower diffusivity and higher kurtosis coefficients. Colorectal cancer (CRC) is one of the most common malignant tumors in the world. With the improvement of surgical techniques and chemoradiotherapy, the 5-year survival rate of patients with rectal cancer has increased during the past decade 1 . However, tumor recurrence and metastasis are still major causes of death in patients with rectal cancer 2 . Epithelial-mesenchymal transition (EMT) is a series of molecular changes endowing epithelial cells with mesenchymal properties 3 , which is a critical process enables tumor cells to migrate and metastasize to distant sites 4 . According to the previous research, EMT is characterized by repression of membranous E-cadherin expression, and overexpression of Snail1, N-cadherin, and nuclear β-catenin proteins 3 . EMT has been documented as a potential biomarker for metastatic presence in several malignant tumors; meanwhile, it has been associated with chemoresistance in other tumors, including CRC 3, 5-11 . Therefore, identification of CRC with EMT is important for structuring treatment strategy and predicting the prognosis, since EMT may provide a predictive biomarker to tailor the neoadjuvant therapies and a novel therapeutic target to allow for improved response to neoadjuvant therapies 11 . Currently, magnetic resonance imaging (MRI) has been widely implemented in diagnosing and staging CRC for its excellence in depiction of soft tissue by means of various anatomical and functional imaging sequences. Recently, an advanced diffusion-weighted imaging (DWI) model, diffusion kurtosis imaging (DKI) has been Published: xx xx xxxx OPEN www.nature.com/scientificreports/ 2 Scientific REPORts | 7: 11424 |
doi:10.1038/s41598-017-11808-7 pmid:28900220 pmcid:PMC5595886 fatcat:wzafzvasdnalfjh5h4oyqcljve

18F-labeled magnetic nanoparticles for monitoring anti-angiogenic therapeutic effects in breast cancer xenografts

Yanshu Wang, Huanhuan Liu, Defan Yao, Jinning Li, Shuyan Yang, Caiyuan Zhang, Weibo Chen, Dengbin Wang
2019 Journal of Nanobiotechnology  
All the MR imaging was performed by using a 3.0 T MR system (Ingenia, Philips, Medical System, Best, Netherlands) with an eight-channel receiver coil of 5.0cm inner diameter (Chen guang Medical Technologies  ... 
doi:10.1186/s12951-019-0534-7 fatcat:lbyrlcgq7nbkniywkqq4lqht34

Reservoir Characteristics of Tight Sandstone and Sweet Spot Prediction of Dibei Gas Field in Eastern Kuqa Depression, Northwest China

Guangjie Zhao, Xianqing Li, Mancang Liu, Caiyuan Dong, Daye Chen, Jizhen Zhang
2022 Energies  
Great progress has been made in the exploration of tight sandstone gas resources in Kuqa depression. Great progress has been made in Dibei structural belt, which proves the previously unproven favorable area for tight sandstone gas. The physical properties, controlling factors, and characteristics of tight sandstone from the Ahe (J1a) Formation in the Dibei gas reservoir are analyzed. The results show that the tight sandstone of the J1a Formation is mainly feldspar lithic sandstone, with low
more » ... osity (average 9.1%) and low permeability (average 0.09 mD). Compaction (average compaction rate 61.9%) reduces porosity more than cementation (average cementation rate 14.3%). Secondary dissolution pores (average thin section porosity is 3.4%) dominate. The homogenization temperature has two peaks; the first peak is 85–110 °C, and the other peak is 115–140 °C, indicating that oil and gas experienced two filling stages at 12 Ma and 4.5 Ma, respectively. Eodiagenesis, A substage of mesogenetic diagenesis, and B substage of mesogenetic diagenesis happened in the area. Tight sandstone is developed in the B substage of mesogenetic diagenesis. The main controlling factors of diagenesis are: strong dissolution and structural pore increase; oil and gas charging and overpressure. The reservoir forming mode of the Dibei gas reservoir is: crude oil filling in the Late Neogene (12 Ma); reservoir densification in the late deposition of Kangcun Formation (7 Ma), mature natural gas filling in the early deposition of Kuqa Formation (4.5 Ma), and gas reservoir formed after transformation and adjustment in the deposition period of Quaternary (2 Ma). According to this model, it is predicted that the favorable area of the Dibei gas reservoir is in the southeast of the Yinan 2 well. This study provides guidance for the study of tight sandstone gas in other areas of the Kuqa Depression.
doi:10.3390/en15093135 fatcat:hlkzyo67qvejzgt3xu2mr32rfy

Anemia and Low Albumin Levels Are Associated with Severe Community-Acquired Pneumonia in Pregnancy: A Case-Control Study

Yanjun He, Miaogen Li, Caiyuan Mai, Lujing Chen, Xiaoman Zhang, Jianyong Zhou, Zhiguo Yang, Jia Ni, Yongxing Chen, Mian Cai, Qinglian Qi, Zaidong Yang
2019 Tohoku journal of experimental medicine  
A study in East Asia reported an incidence of CAP in pregnancy of 0.7% over a one-year period (Chen et al. 2012) .  ...  In a retrospective analysis of 1,462 patients with pneumonia in pregnancy, Chen et al. (2012) found that 93% of patients suffered from bacterial infections.  ... 
doi:10.1620/tjem.248.297 pmid:31462598 fatcat:eotikbdy45azjbsathpcmbfd2a

Simultaneous determination of pyraclostrobin and thiophanate-methyl and its metabolite carbendazim residues in soil and citrus by QuEChERS-liquid chromatography- tandem mass spectrometry

Fuqin LI, Lihong SHI, Fei WANG, Caiyuan SUN, Di KANG, Yuping ZHANG, Lingzhu CHEN, Deyu HU
2017 Chinese Journal of Chromatography  
色谱, 2016, 34(10) : 1005 [27] Zheng X P, Ding L P, Chen Z T, et al. Chinese Journal of Chromatography, 2015, 33(6) : 652 郑香平, 丁立平, 陈志涛, 等. 色谱, 2015, 33(6) : 652 [28] Chen X X, Xu J, Liu X G, et al.  ...  determination of pyraclostrobin and thiophanate• methyl and its metabolite carbendazim residues in soil and citrus by QuEChERS•liquid chromatography• tandem mass spectrometry LI Fuqin, SHI Lihong, WANG Fei, SUN Caiyuan  ... 
doi:10.3724/sp.j.1123.2017.01031 pmid:29048789 fatcat:li7ohjmcknhfvoe7jtz35bz65e

MicroRNA-16 is putatively involved in the NF-κB pathway regulation in ulcerative colitis through adenosine A2a receptor (A2aAR) mRNA targeting

Ting Tian, Yu Zhou, Xiao Feng, Shicai Ye, Hao Wang, Weiyun Wu, Wenkai Tan, Caiyuan Yu, Juxiang Hu, Rong Zheng, Zonghao Chen, Xinyu Pei (+1 others)
2016 Scientific Reports  
MicroRNAs (miRNAs) act as important post-transcriptional regulators of gene expression by targeting the 3′-untranslated region of their target genes. Altered expression of miR-16 is reported in human ulcerative colitis (UC), but its role in the development of the disease remains unclear. Adenosine through adenosine A2a receptor (A2aAR) could inhibit nuclear factor-kappaB (NF-κB) signaling pathway in inflammation. Here we identified overexpression of miR-16 and down-regulation of A2aAR in the
more » ... onic mucosa of active UC patients. We demonstrated that miR-16 negatively regulated the expression of the A2aAR at the post-transcriptional level. Furthermore, transfection of miR-16 mimics promoted nuclear translocation of NF-κB p65 protein and expression of pro-inflammatory cytokines, IFN-γ and IL-8 in colonic epithelial cells. Treatment with miR-16 inhibitor could reverse these effects in cells. The A2aAR-mediated effects of miR-16 on the activation of the NF-κB signaling pathway were confirmed by the A2aAR knockdown assay. Our results suggest that miR-16 regulated the immune and inflammatory responses, at least in part, by suppressing the expression of the A2aAR to control the activation of the NF-κB signaling pathway. Inflammatory bowel disease (IBD) is a chronic and relapsing inflammatory disorder of the gastrointestinal tract that affects millions of people worldwide. IBD includes ulcerative colitis (UC) and Crohn's disease (CD). The pathophysiology of UC remains unknown and is thought to involve disease risk genes, dysregulated gene expression and abnormal immune response to environmental triggers 1,2 . Mature miRNAs are a class of small, non-coding RNA molecules that are 20-25 nucleotides in length. They bind to the 3′ -untranslated region (3′ -UTR) of their target messenger RNAs (mRNAs) and mediate translational repression and mRNA degradation 3 . miRNAs regulate several biological processes including cell proliferation, apoptosis, metabolism, differentiation 4 , inflammation, and immune responses by suppressing the expression of their target genes. Recent research has implicated the involvement of miRNAs in human diseases including IBD. There is increasing evidence indicating altered miRNAs expression in UC associated with the development of the disease 5-12 . The expression of miR-126, miR-150, and miR-155 was significantly up regulated in UC patients and in murine colitis models. These miRNAs contribute to the inflammatory reaction via regulating the NF-κ B signaling pathway 8-10 . Activation of NF-κ B signaling pathway is markedly induced in tissues affected with UC and it promotes the transcription of various pro-inflammatory cytokine genes such as interferon-gamma (IFN-γ ), interleukin-1beta (IL-1β ), and interleukin-8 (IL-8) [13] [14] [15] . Alternatively, down-regulation of certain miRNAs were reported in UC patients and in murine colitis models, such as miR-19a (targeting tumour necrosis factor-alpha (TNF-α )) and miR-192 (targeting macrophage inflammatory protein 2-alpha (MIP-2α )) in intestinal epithelial cells 11,12 . Further, a study using genome-wide microarray screening has identified enhanced levels of miR-16
doi:10.1038/srep30824 pmid:27476546 pmcid:PMC4967855 fatcat:aujnqibg5zdnvlow2mjsln45h4

Downregulation of microRNA‑126 is inversely correlated with insulin receptor substrate‑1 protein expression in colorectal cancer and is associated with advanced stages of disease

Shicai Ye, Caiyuan Yu, Guixia Zhang, Feixiong Shi, Yongze� Chen, Jianyun Yang, Weiyun Wu, Yu Zhou
2020 Oncology Letters  
Colorectal cancer (CRC) is a common human malignant tumor, and the fourth most common cause of cancer-associated mortality in China. However, the pathogenesis of CRC is not yet fully understood. The present study aimed to investigate the expression and clinical significance of microRNA (miR)-126 and insulin receptor substrate-1 (IRS-1), as well as the role of miR-126 in the prognosis of patients with CRC. A total of 86 colorectal tissue specimens, including 40 CRC and adjacent normal tissue, 26
more » ... colorectal adenoma tissue and 20 normal colorectal tissue samples, were collected for the present study. Reverse transcription-quantitative PCR analysis was performed to determine miR-126 and IRS-1 mRNA expression levels, while western blotting and immunohistochemistry (IHC) analyses were performed to determine IRS-1 protein expression levels. The correlation between miR-126 and IRS-1 expression, as well as the association between altered miR-126 and IRS-1 expression levels and clinicopathological characteristics, and the overall survival time of patients with CRC were assessed. The results demonstrated that miR-126 expression was significantly downregulated, while IRS-1 protein expression was upregulated in CRC tissues compared with that in adjacent normal tissues, colorectal adenoma tissues and normal colorectal tissues, respectively. IHC analysis exhibited strong positive staining of IRS-1 protein in CRC tissues, while absent or weak staining of IRS-1 protein was detected in adjacent normal tissues, colorectal adenoma tissues and normal colorectal tissues. miR-126 expression was inversely correlated with IRS-1 protein expression in CRC tissues (r=-0.420; P<0.05). Furthermore, downregulated miR-126 expression was associated with advanced clinicopathological characteristics of the disease and a shorter overall survival time in patients with CRC. Taken together, the results of the present study suggest that miR-126 downregulation may be a candidate molecular marker predictive of poor prognosis of patients with CRC.
doi:10.3892/ol.2020.11796 pmid:32782558 pmcid:PMC7400408 fatcat:nopc7o42erhbhb62qbzjbfyhym

Kam Guilzhouh nyim Guangxxih di Benxtux Wenchual nyim Zihyuanc dih Gonxliix: Kam Local Indigenous Knowledge and Sustainable Resource Management in Guizhou and Guangxi Provinces, China

Amy Eisenberg, Paul John Amato, Deng Tao
2009 Ethnobotany Research and Applications  
It grows in forests, thickets and moist, shaded areas of valleys (Chen & Tamanian 2000:210) .  ...  Callicarpa kwangtungensis grows in mixed forests of China (Chen & Gilbert 1994:15) . Centella asiatica (L.)  ... 
doi:10.17348/era.7.0.67-113 fatcat:wrx5ox2vpndajafmajxdmzstke
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