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COVID-19 biomarkers and their overlap with comorbidities in a disease biomarker data model

Nikhita Gogate, Daniel Lyman, Amanda Bell, Edmund Cauley, Keith A Crandall, Ashia Joseph, Robel Kahsay, Darren A Natale, Lynn M Schriml, Sabyasach Sen, Raja Mazumder
<span title="2021-05-20">2021</span> <i title="Oxford University Press"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/op7ztx4fhvairowgqifu7dnvsi" style="color: black;">Briefings in Bioinformatics</a> </i> &nbsp;
We have curated 145 COVID-19 biomarkers by developing a novel cross-cutting disease biomarker data model that allows integration and evaluation of biomarkers in patients with comorbidities.  ...  factors-compounding the complexity of COVID-19 pathobiology and potential biomarkers associated with the disease, as they become available.  ...  curator); Nuerye Ainiwan (bioinformatics curator); Pranav Mishra (bioinformatics curator); Renee Long (bioinformatics curator); Rishab Desai (bioinformatics curator); Rita Mazumder (Asst. coordinator and  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1093/bib/bbab191">doi:10.1093/bib/bbab191</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/34015823">pmid:34015823</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC8195003/">pmcid:PMC8195003</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/bv7cbd7unfcldhtykjofmmqe3q">fatcat:bv7cbd7unfcldhtykjofmmqe3q</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20210526100350/https://watermark.silverchair.com/bbab191.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAq8wggKrBgkqhkiG9w0BBwagggKcMIICmAIBADCCApEGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMOAikIKtOwba_BCffAgEQgIICYreUmb9lPyfun_CpnExUjBD17T4NJXe6Ymlvdp6sc5aEzJax1dwMZHUwa2Bh2DWgLDOWA55WDLtMvq56mEu9umNGnEuRm0YvJoWOKOnkTgfegEnqGxLBGPlwcHKx3QjRD6cF1AjI2r575LVqfnK_3sWBfdKDjgfMWrlHowkCry1X4ouYU6xT6x_AmVx0Iw0OFKZCodL38xFsI9MKwSYYMrEvNcefePkjPzTunAtn_K5Hhv9eTgS2gmR15g-K8up39nfcn0ZQPc6kBbfjiUsivgb6_Ew6Ya52wKcaHtCM9TwdBS6jwHR7SVBXg8IBGlCAooZSge3T9lLjNCvfJKxxMrRULTDvXI_uLotTF4YuIP2-oTGzy324lS4svrVkDe_AjGFR0l4tB4KRFKznaN6nVH_JAoS60VbtXnIHmdIPuwksuJGuehXoLC1Dc32xk0VZhDKSdt0ezIVYUvT3OI9FU2jHbiEsBbTlUOg3CdzmjuO88RgbHE_ZO7sA_T5AnNLRwwYL1PXLX_ciCq5-HYj_CbTqe4Qgv78RWJlxKWS3dsCc1UpEH0sGzUbCrW4oyf7aD2X_vfEHWEmRwjPgPPZbZwlKhYcn1FIuSTWGa66NfhoTqyw2qsZeB1yaWm7EjPuA2HGpp_W2ftwsWoPGnMsM8wFWseX_MYaIJ69gR9-xClRM4_cePdAVnpNGRr0W1wvYbMGN9EsbKoVuaNFVEwxksDH_-l1u5ASwq8kGyN3EjWxF4vukwUR5PQ9qG8IJJCcnz-UCF6pdw1MGuMAmodMOrOyUy5wOzPgWj_lN-pOXRP3AatM" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/ca/76/ca7655911d2ca6eb4951a3d3d064310f13ab773e.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1093/bib/bbab191"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> oup.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8195003" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Managing COVID-19 with a Clinical Decision Support Tool in a Community Health Network: Algorithm Development and Validation (Preprint)

Michael P. McRae, Isaac P. Dapkins, Iman Sharif, Judd Anderson, David Fenyo, Odai Sinokrot, Stella K. Kang, Nicolaos J. Christodoulides, Deniz Vurmaz, Glennon W. Simmons, Timothy M. Alcorn, Marco J. Daoura (+3 others)
<span title="2020-07-01">2020</span> <i title="JMIR Publications Inc."> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/f42mlbuaivhxrblrv2cbukmx4i" style="color: black;">Journal of Medical Internet Research</a> </i> &nbsp;
Model training data from 701 patients with COVID-19 were collected across practices within the Family Health Centers network at New York University Langone Health. A two-tiered model was developed.  ...  There is an urgent need for a COVID-19 disease severity assessment that can assist in patient triage and resource allocation for patients at risk for severe disease.  ...  The authors thank Zhibing Lu and colleagues of Zhongnan Hospital of Wuhan University for providing the data used for external validation in this study.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.2196/22033">doi:10.2196/22033</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/32750010">pmid:32750010</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/5scqmeahajhqro3dujs34r7ewa">fatcat:5scqmeahajhqro3dujs34r7ewa</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20210716044923/https://www.jmir.org/2020/8/e22033/PDF" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/ed/69/ed69b1066510f1c2be40570a79f5fd38fcbccf0a.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.2196/22033"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> Publisher / doi.org </button> </a>

A Dynamic Bayesian Model for Identifying High-Mortality Risk in Hospitalized COVID-19 Patients

Amir Momeni-Boroujeni, Rachelle Mendoza, Isaac J. Stopard, Ben Lambert, Alejandro Zuretti
<span title="2021-03-18">2021</span> <i title="MDPI AG"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/ih3pk7dryfhezlwfzumbigb6ry" style="color: black;">Infectious Disease Reports</a> </i> &nbsp;
Our prognostic model highlights the nuance of determining risk for COVID-19 patients and indicates that, rather than a single variable, a range of factors (at different points in hospitalization) are needed  ...  The data collected for the patients included demographics, comorbidities and laboratory values taken at admission and throughout the course of hospitalization.  ...  To quantify dynamic changes in biomarkers on in-hospital COVID-19 mortality risk, studies have either incorporated the difference in biomarker values between presentation and outcome within a Cox model  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3390/idr13010027">doi:10.3390/idr13010027</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/33803753">pmid:33803753</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/xkgnfqc6anf3zclcen4m3hveli">fatcat:xkgnfqc6anf3zclcen4m3hveli</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20210321024410/https://res.mdpi.com/d_attachment/idr/idr-13-00027/article_deploy/idr-13-00027.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/b8/b6/b8b675aa24d5f3e6b9618e8646c0e63a4cc0b42d.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3390/idr13010027"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> mdpi.com </button> </a>

Myocardial Injury Biomarkers and Cardiac Complications Associated with Mortality in Patients with COVID-19
Biomarcadores de Lesão Miocárdica e Complicações Cardíacas Associadas à Mortalidade em Pacientes com COVID-19

Paulo Ricardo Martins-Filho, José Augusto Soares Barreto-Filho, Victor Santana Santos
<span title="2020-08-28">2020</span> <i title="GN1 Genesis Network"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/qqwggfeqcrh2dhgu6f7lx3vjme" style="color: black;">Arquivos Brasileiros de Cardiologia</a> </i> &nbsp;
We performed a quantitative evidence synthesis of clinical data, myocardial injury biomarkers, and cardiac complications associated with in-hospital death in patients with COVID-19.  ...  SARS-CoV-2 is an emerging RNA virus associated with a severe acute respiratory disease known as COVID-19.  ...  In this study, we performed a quantitative evidence synthesis of clinical data, myocardial injury biomarkers, and cardiac complications associated with in-hospital death in patients with COVID-19.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.36660/abc.20200372">doi:10.36660/abc.20200372</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/32876196">pmid:32876196</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC8384270/">pmcid:PMC8384270</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/c3d54cjcibamraqfhwjq5hctmy">fatcat:c3d54cjcibamraqfhwjq5hctmy</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20201209104207/https://www.scielo.br/pdf/abc/v115n2/en_0066-782X-abc-115-02-0273.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/16/7c/167c1efa5fb4f0ee6ddf2904b7a889a89245bbe3.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.36660/abc.20200372"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8384270" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

An immune-based biomarker signature is associated with mortality in COVID-19 patients

Michael S. Abers, Ottavia M. Delmonte, Emily E. Ricotta, Jonathan Fintzi, Danielle Fink, Adriana A. de Jesus, Kol A. Zarember, Sara Alehashemi, Vasileios Oikonomou, Jigar V. Desai, Scott W. Canna, Bita Shakoory (+34 others)
<span title="2020-11-24">2020</span> <i title="American Society for Clinical Investigation"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/a46erlvuh5hclcoo4j2gig3pyq" style="color: black;">JCI Insight</a> </i> &nbsp;
Here, we analyzed levels of 66 soluble biomarkers in 175 Italian patients with COVID-19 ranging from mild/moderate to critical severity, and assessed type-I IFN-, type-II IFN-, and NF-κB-dependent whole  ...  Discordance between IFN-α2a protein and IFNA2 transcript levels in blood suggests that type-I IFNs during COVID-19 may be primarily produced by tissue-resident cells.  ...  Wang Kimberly Batty, and Laura Mendez for assisting with the analysis of soluble biomarkers; Joie Davis from the NIAID for her assistance with obtaining informed consent from COVID-19 patients who underwent  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1172/jci.insight.144455">doi:10.1172/jci.insight.144455</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/33232303">pmid:33232303</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC7821609/">pmcid:PMC7821609</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/atcn3c2h45asflmjxjn6zizpue">fatcat:atcn3c2h45asflmjxjn6zizpue</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20210428044051/https://df6sxcketz7bb.cloudfront.net/manuscripts/144000/144455/jci.insight.144455.v2.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/1e/24/1e241652f0dd1dd5d27ce5fcfaaaa36b18ff9e85.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1172/jci.insight.144455"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7821609" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Thrombo-inflammatory Biomarkers in COVID-19: Systematic Review and Meta-analysis of 17,052 patients

Rahul Chaudhary, Jalaj Garg, Damon E. Houghton, M. Hassan Murad, Ashok Kondur, Rohit Chaudhary, Waldemar E. Wysokinski, Robert D. McBane
<span title="2021-02-08">2021</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/diq75ggxwnekbirx3ezvdmbory" style="color: black;">Mayo Clinic Proceedings: Innovations, Quality &amp; Outcomes</a> </i> &nbsp;
To evaluate differences in thrombo-inflammatory biomarkers between patients with severe COVID-19 infection/death and mild infection.  ...  Patients with severe COVID-19/non-survivors were older, a greater proportion were men, had a higher prevalence of hypertension, diabetes, cardiac or cerebrovascular disease, chronic kidney disease, malignancy  ...  Comorbidities conferring higher risk coupled with thromboinflammatory biomarkers might assist in the development of risk prediction models for the severity and prognosis of COVID-19.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.mayocpiqo.2021.01.009">doi:10.1016/j.mayocpiqo.2021.01.009</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/33585800">pmid:33585800</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC7869679/">pmcid:PMC7869679</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/krtd2hol35c7ngjdexvf7rehem">fatcat:krtd2hol35c7ngjdexvf7rehem</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20210531173500/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC7869679&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/4c/1d/4c1ded7429420a724e73b5e6aaf0dda3758fe08a.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.mayocpiqo.2021.01.009"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> elsevier.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7869679" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Myocardium injury biomarkers predict prognosis of critically ill coronavirus disease 2019 (COVID-19) patients

Liang Cao, Sha Zhang, Xi Luo, Enxin Wang, Yang Bai, Zhe Li, Feng Li, Jing Ma, Haitao Liu
<span title="">2020</span> <i title="AME Publishing Company"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/e4xwuty42vartnbllfcshcgkhq" style="color: black;">Annals of Palliative Medicine</a> </i> &nbsp;
The coronavirus disease 2019 (COVID-19) pandemic is a once-in-century crisis to public health.  ...  These myocardium injury biomarkers appeared to correlate with the time of survival, and two multivariate models have suggested hs-cTnI was a novel prognostic factor with a sensitivity of 75.0% and a specificity  ...  Acknowledgments We greatly appreciate all front-line health care colleagues in Wuhan. We express gratitude to all the participants and their families.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.21037/apm-20-2112">doi:10.21037/apm-20-2112</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/33302676">pmid:33302676</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/eq7siqdqzjfsxhivs3rtsc2egm">fatcat:eq7siqdqzjfsxhivs3rtsc2egm</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20201207101431/http://apm.amegroups.com/article/download/56812/pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/ff/e3/ffe337cb341ede3784358f4540400768135fd8c3.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.21037/apm-20-2112"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a>

Comparing biomarkers for COVID-19 disease with commonly associated preexisting conditions and complications [article]

Jesse Huang
<span title="2020-10-05">2020</span> <i title="Cold Spring Harbor Laboratory"> medRxiv </i> &nbsp; <span class="release-stage" >pre-print</span>
This study aims to examine the plasma protein profile of COVID-19 patients and evaluate overlapping protein modules with biomarkers of common comorbidities.  ...  In conclusion, this study provides an overview of the systemic effects of COVID-19 and candidate biomarkers for clinical assessment of disease progression and the risk of systemic complications.  ...  In summary, this study provides an initial assessment of the overlapping biological processes associated with COVID-19 and related comorbidities.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1101/2020.10.02.20205609">doi:10.1101/2020.10.02.20205609</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/vqn7koiu6ra3nfawgueq3jdo5a">fatcat:vqn7koiu6ra3nfawgueq3jdo5a</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20201210105906/https://www.medrxiv.org/content/medrxiv/early/2020/10/05/2020.10.02.20205609.full.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/a1/02/a1026d5acda92459e4c110fe6c7526fce3ecac3e.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1101/2020.10.02.20205609"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> medrxiv.org </button> </a>

Cardiovascular rna markers and artificial intelligence may improve covid-19 outcome: position paper from the eu-cardiorna cost action ca17129

Lina Badimon, Emma L Robinson, Amela Jusic, Irina Carpusca, Leon J de Windt, Costanza Emanueli, Péter Ferdinandy, Wei Gu, Mariann Gyöngyösi, Matthias Hackl, Kanita Karaduzovic-Hadziabdic, Mitja Lustrek (+8 others)
<span title="2021-04-11">2021</span> <i title="Oxford University Press (OUP)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/kooh65zsfnakjdu6fxco3sqz6y" style="color: black;">Cardiovascular Research</a> </i> &nbsp;
The biomarker potential of circulating RNAs has been recognized in several disease conditions, including cardiovascular disease. RNA biomarkers may be useful in the current COVID-19 situation.  ...  Hence a significant proportion of infected patients develop cardiac events such as arrhythmias and heart failure. Patients with cardiovascular comorbidities are at highest risk of cardiac death.  ...  Frequent involvement of cardiovascular comorbidities is detected in patients with SARS-CoV-2 infection and up to 33% of hospitalized patients with a COVID-19 positive test have cardiac injury 4 evidenced  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1093/cvr/cvab094">doi:10.1093/cvr/cvab094</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/33839767">pmid:33839767</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC8083253/">pmcid:PMC8083253</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/zhoyffz76rc6dbzud6whagolka">fatcat:zhoyffz76rc6dbzud6whagolka</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20210421032637/https://watermark.silverchair.com/cvab094.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAsUwggLBBgkqhkiG9w0BBwagggKyMIICrgIBADCCAqcGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMFaZtcjO-J3q6zjO3AgEQgIICeGG3OKpon4GKB8KQ6t0K2dV9ah2ZZ95dey6MKfioBzVblkCqhqou8B38w-Fyi-Rc-Q7d6A575OTBtzoFnXleZE8raENmPl2ZpJQnBAzBCOXV1w-gvLYYPUf_aebBNqr8YYxnVz6I9oLIxXnSWTk2SMweeTHbYcdfoAXGiJMYa7HdAXbKY8qs8RMUnEzJMk2wZvxtCAvQy8Iy_KJNgT1-K-eCvlsCgOuyc7cIFItNfg37Tgp8q6StQjGhZ2VosgmCIKE8bX6gXrE-bDkEuBFdlHyIchAM-kOcF4UZHqRzEX_mpLQXaksbZL3jegMEZCnTqSWWGMPt1ly_VvbVd4ZijIkO8AbOjoF3TKDCdH_K3brw_zBVtICGMVgw2aTsxzSpDuLoTQ82h9mz5wMXubeY5bMtSPJeW5oQynyVA05JxDaWsG9nyJG51udfu3u2mN7v22axN73CC3zZexoYHw3el6v0OK-DsIaA4swZzNMOQ1V3C-lZiZOdNdRLIW4kFRZAQ6L7GEesijb12bYvepF-MnV0PMulLjA6gAUCXcRxHXxndi-h_rT2SsqqlzyeLO-MKZ2CsIxMsi5COfAscQfsXmwzOL4FIthy1Vta6fgtsvllQ8j5BxaVWlOOorcWE4fjcCpUysWAmRONi6HABjUlJcwQuqb0EaM-I3390aTpnb54bWK9QkRHWw8vo7xRbaQKYNUS7j3grge3Clat5TzJLI2kBtPbbOZtAq1qmKjB65neC0eCqfnLwY8mT0Yp-s8rkFPxGZcSXqMQZ_2JRubGTbcQiCRTSC5--LEApXrmerVn0kxmTSzFrHTYLRL-mfFvglDM3vcGYqeY" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/8d/6d/8d6d0e967aaf986cea652949fba9744d59314eff.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1093/cvr/cvab094"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> oup.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8083253" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Inflammatory biomarkers as independent prognosticators of 28-day mortality for COVID-19 patients admitted to general medicine or ICU wards: a retrospective cohort study

Tyler Pitre, on behalf of the COREG Investigators, Aaron Jones, Johnny Su, Wryan Helmeczi, Grace Xu, Catherine Lee, Adib Shamsuddin, Adhora Mir, Sarah MacGregor, MyLinh Duong, Terence Ho (+3 others)
<span title="2021-01-26">2021</span> <i title="Springer Science and Business Media LLC"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/cerg7qhfj5dr3eaqpqviap34au" style="color: black;">Internal and Emergency Medicine</a> </i> &nbsp;
Inflammatory biomarkers may be associated with disease severity and increased mortality in COVID-19 patients but have not been studied in North American populations.  ...  Of 336 COVID-19-positive patients, 267 required hospital admission, and 69 were seen in the emergency room and discharged.  ...  A recent meta-analysis which included 16 Chinese studies found an association between several important blood biomarkers and their association with disease severity in COVID-19 hospitalized patients.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/s11739-021-02637-8">doi:10.1007/s11739-021-02637-8</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/33496923">pmid:33496923</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC7836340/">pmcid:PMC7836340</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/ppq464hlyngxlg677ewf5m6pva">fatcat:ppq464hlyngxlg677ewf5m6pva</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20210428100046/https://link.springer.com/content/pdf/10.1007/s11739-021-02637-8.pdf?error=cookies_not_supported&amp;code=a22c2153-5cfc-496f-9dc3-fd77a40a99f9" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/49/78/4978a2ae9f86cf44f048ce59264c64b2d5a3386b.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/s11739-021-02637-8"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> springer.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7836340" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Adaptive metabolic and inflammatory responses identified using accelerated aging metrics are linked to adverse outcomes in severe SARS-CoV-2 infection

Alejandro Márquez-Salinas, Carlos A Fermín-Martínez, Neftalí Eduardo Antonio-Villa, Arsenio Vargas-Vázquez, Enrique C. Guerra, Alejandro Campos-Muñoz, Lilian Zavala-Romero, Roopa Mehta, Jessica Paola Bahena-López, Edgar Ortiz-Brizuela, María Fernanda González-Lara, Carla M Roman-Montes (+6 others)
<span title="2021-03-15">2021</span> <i title="Oxford University Press (OUP)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/rnjjhbhxbvavnhsd4ttolow52i" style="color: black;">The journals of gerontology. Series A, Biological sciences and medical sciences</a> </i> &nbsp;
Methods In this retrospective cohort study, we assessed cases admitted to a COVID-19 reference center in Mexico City. PhenoAge and PhenoAgeAccel were estimated using laboratory values at admission.  ...  Cox proportional hazards models were fitted to estimate risk for COVID-19 lethality and adverse outcomes (ICU admission, intubation, or death).  ...  used in their estimation may overlap with those which are altered within pathophysiological processes in COVID-19, particularly inflammatory markers, fasting glucose and serum albumin [8] .  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1093/gerona/glab078">doi:10.1093/gerona/glab078</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/33721886">pmid:33721886</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/w3ufcngsifevlbgwh75qh6lmdi">fatcat:w3ufcngsifevlbgwh75qh6lmdi</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20210319102950/https://watermark.silverchair.com/glab078.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAtMwggLPBgkqhkiG9w0BBwagggLAMIICvAIBADCCArUGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMufIQl6jm7KrXhLszAgEQgIIChvBO4Cuk2ZjsoRS1BiR6lVt3c3-5OZLAMNN0KDNDHyhVumCw7AdhINakPQsCVMWyDdAdYVMUqtfQGi5lqjKFX8kDxq-3nhV6k8vyhMZa_DhSCh5s59YdSwiO_AkG5BLY3ICMp1E7NFjuRuABkL-NMb7kYGwfYYV7-KwlOfugepBtnxFcGXHj8jaQR35BCiS41DExJMOzxSVBdVPFqmOoRbfTq37-vli1i9bSmkFtVGyyfMxy9EvrFRG1PA-AbbLrMaGfEGyWQFzsc0u1ibndQW_ELcWVe-oL4lSrQiYntMMZhNs4V6oIlws9aNQ931s5jpnvgMkVnnktPAzWs1KQp_irvXl_PAurNz0GMEXr8e4ugXoehbpG47D03I8_OW_BW1ZuFHVGgP1sOV7VlTvg37M9qXH8Ci9o64u6S7ebhJfr3Xl0OLYZRbxpFgGzNVzLrzfLX0SupklujH2BUxZJaWAYxMAbVwp2fxJTA0YwhtSv29EdylrrBCBy_FILQrp3aiMDgIiOFwmYu0nbeIEWC8ueIWxOA-tJjdkbktszzXjM1jii9wxLuTDXC6FtuOlcMWQPyaulvSPszUkf7j_rdotChhhzCkjoTESn5QttO0YS1mx1wqaCXuMFfOX5xmR5PLY4ac58l1b3N92i-rpvEBrpSVrRgR1FzONDg0l11-hDBQyiocDENU7WbYmT-TuRW5LfEWdDI751XpEfttxdAAiibjnsPKJDQVgWa-rxPuL4XPvnrGWZSGCaVeb-0DYnJ14GNC1QNc4F34VwnHWKjkB60WyMcIzN3pOnfJPTsxN4gWd9UOPM3Edw3crelYwxscnWiH4qQrcB0dn7r7ABQ4VGST0GbgY" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/5f/15/5f1573f135eac67dbf13f080f5143a3bab172a66.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1093/gerona/glab078"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> oup.com </button> </a>

Differential Peripheral Blood Glycoprotein Profiles in Symptomatic and Asymptomatic COVID-19 [article]

Chad Pickering, Bo Zhou, Gege Xu, Rachel Rice, Hector Huang, Tho Pham, Jeffrey Shapiro, Xin Cong, Saborni Chakraborty, Karlie Edwards, Srinavasa Reddy, Faheem Giurgis (+3 others)
<span title="2022-01-08">2022</span> <i title="Cold Spring Harbor Laboratory"> medRxiv </i> &nbsp; <span class="release-stage" >pre-print</span>
differential protein glyco-isoform distributions of 597 abundant serum glycopeptides and non-glycosylated peptides in 50 individuals who had been seriously ill with COVID-19 and in 22 individuals who  ...  These may be representative of either COVID-19-specific consequences or of susceptibility to or predisposition for a severe course of the disease.  ...  [23] also reported increased protein levels of C5a in a small cohort of patients with severe COVID-19 disease.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1101/2022.01.07.21267956">doi:10.1101/2022.01.07.21267956</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/235jluylkraj3blb4gisikv6kq">fatcat:235jluylkraj3blb4gisikv6kq</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20220112053423/https://www.medrxiv.org/content/medrxiv/early/2022/01/08/2022.01.07.21267956.full.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/ca/f3/caf3d7dce4b29111df7b9d30057ba1bf99f84501.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1101/2022.01.07.21267956"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> medrxiv.org </button> </a>

Difference in Biomarkers Between COVID-19 Patients and Other Pulmonary Infection Patients

Jingyi Dai, Yingrong Du, Jianpeng Gao, Jun Zhao, Lin Wang, Ying Huang, Jiawei Xia, Yu Luo, Shenghao Li, Edward B McNeil
<span title="2020-07-28">2020</span> <i title="Informa UK Limited"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/byn6f6xo55ewllntvzauylzwsu" style="color: black;">Infection and Drug Resistance</a> </i> &nbsp;
The first two dimensions of the PLS-DA model could classify COVID-19 and other pulmonary infection patients with an accuracy of 96.6% (95.1% in the cross-validation model).  ...  The pandemic due to the novel coronavirus disease 2019 (COVID-19) has resulted in an increasing number of patients need to be tested.  ...  Jinyu Duan for his help in data collection. This work was supported by "The Project of Health Science and Technology Talents Ten Hundred Thousand' in Kunming".  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.2147/idr.s257936">doi:10.2147/idr.s257936</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/32801798">pmid:32801798</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC7397211/">pmcid:PMC7397211</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/kjjako75urgefdnyd63guihef4">fatcat:kjjako75urgefdnyd63guihef4</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200728052201/https://www.dovepress.com/front_end/cr_data/cache/pdf/download_1595913721_5f1fb5f9347e0/idr-257936-difference-in-biomarkers-between-covid-19-patients-and-other.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/72/24/72247b0da5fa7a7b8b5977e903e86fd7832d3b33.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.2147/idr.s257936"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7397211" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

COVID-19 Risk Stratification and Mortality Prediction in Hospitalized Indian Patients [article]

Shanmukh Alle, Samreen Siddiqui, Akshay Kanakan, Akshit Garg, Akshaya Karthikeyan, Neha Mishra, Swati Waghdhare, Akansha Tyagi, Bansidhar Tarai, Pranjal Pratim Hazarika, Poonam Das, Sandeep Budhiraja (+15 others)
<span title="2020-12-22">2020</span> <i title="Cold Spring Harbor Laboratory"> medRxiv </i> &nbsp; <span class="release-stage" >pre-print</span>
The clinical course of coronavirus disease 2019 (COVID-19) infection is highly variable with the vast majority recovering uneventfully but a small fraction progressing to severe disease and death.  ...  This study presents risk stratification and mortality prediction models based on usual clinical data from 544 COVID-19 patients from New Delhi, India using machine learning methods.  ...  Recent 31 studies have used various machine learning algorithms for analysing COVID-19 32 patients' clinical data and providing disease prognosis [9, 10] . Hao et al.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1101/2020.12.19.20248524">doi:10.1101/2020.12.19.20248524</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/baqmqz4ztzcmloirpkpofvruqa">fatcat:baqmqz4ztzcmloirpkpofvruqa</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20210427221941/https://www.medrxiv.org/content/medrxiv/early/2020/12/22/2020.12.19.20248524.full.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/c5/55/c555febbb5e14d9bb61a0a19ddc1f443ef6718f9.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1101/2020.12.19.20248524"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> medrxiv.org </button> </a>

Predictors of COVID ‐19 severity: A literature review

Benjamin Gallo Marin, Ghazal Aghagoli, Katya Lavine, Lanbo Yang, Emily J. Siff, Silvia S. Chiang, Thais P. Salazar‐Mather, Luba Dumenco, Michael C Savaria, Su N. Aung, Timothy Flanigan, Ian C. Michelow
<span title="2020-07-30">2020</span> <i title="Wiley"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/srfwllxfnfbbfedk7c2a534euq" style="color: black;">Reviews in Medical Virology</a> </i> &nbsp;
The coronavirus disease 2019 (COVID-19) pandemic is a rapidly evolving global emergency that continues to strain healthcare systems.  ...  COVID-19 severity and mortality.  ...  22 Data also suggest that male sex is a variable that is independently associated with COVID-19 severity. 24, 25 | Comorbidities Pre-existing conditions, such as cardiovascular disease, chronic  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1002/rmv.2146">doi:10.1002/rmv.2146</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/32845042">pmid:32845042</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/ot72rx3d6zcyzjc2qdnvfrjd5q">fatcat:ot72rx3d6zcyzjc2qdnvfrjd5q</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20210323223626/https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/rmv.2146" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/64/23/64238455028d54ece6af90d0f4ad767d4083dd6a.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1002/rmv.2146"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> wiley.com </button> </a>
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