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COPS--a novel workbench for explorations in fold space

S. J. Suhrer, M. Wiederstein, M. Gruber, M. J. Sippl
2009 Nucleic Acids Research  
Exploiting this relationship we implemented the Fold Space Navigator, a tool that makes navigation in fold space as convenient as browsing through a file system.  ...  through the Fold Space Navigator.  ...  ACKNOWLEDGEMENTS The structure superposition program TopMatch used to construct COPS is provided by Proceryon Science for Life GmbH ( under an academic license agreement which  ... 
doi:10.1093/nar/gkp411 pmid:19465386 pmcid:PMC2703906 fatcat:xkjszmfnajc3phrd5mdiqx3344

Cartilage Stiffness Effect on Foot Biomechanics of Chinese Bound Foot: A Finite Element Analysis

Yan Zhang, Jan Awrejcewicz, Julien S Baker, Yaodong Gu
2018 Frontiers in Physiology  
As the Young's modulus of cartilage increased, the peak von Mises stress in the fifth metatarsal increased obviously, while that in the calcaneus remains unchanged.  ...  The cartilage stiffening also caused a general increase of contact pressure at mid- and forefoot joints.  ...  YZ, JA, JB, and YG analyzed the data, interpreted results of research, wrote the paper and involved in the editing process of the manuscript.  ... 
doi:10.3389/fphys.2018.01434 pmid:30364272 pmcid:PMC6193066 fatcat:bnwze2sfpvgzfogmr2b5znm7i4

ST-246 is a key antiviral to inhibit the viral F13L phospholipase, one of the essential proteins for orthopoxvirus wrapping

Sophie Duraffour, María M. Lorenzo, Gudrun Zöller, Dimitri Topalis, Doug Grosenbach, Dennis E. Hruby, Graciela Andrei, Rafael Blasco, Hermann Meyer, Robert Snoeck
2015 Journal of Antimicrobial Chemotherapy  
Conclusions: Besides demonstrating that F13L is a direct target of ST-246, we also identified novel F13L residues involved in the interaction with ST-246.  ...  These findings are important for ST-246 use in the clinic and crucial for future drug-resistance surveillance programmes.  ...  the engineering of deleted recombinant viruses, the help of Annabel Rector in processing F13L nucleotide sequences and the support given by Robert Jordan when this project was initiated.  ... 
doi:10.1093/jac/dku545 pmid:25630650 fatcat:ptzu4srtvjhbdbze7vhlm4stz4

Relating whole-brain functional connectivity to self-reported negative emotion in a large sample of young adults using group regularized canonical correlation analysis

Leonardo Tozzi, Elena Tuzhilina, Matthew F Glasser, Trevor J Hastie, Leanne M Williams
2021 NeuroImage  
Here, we present the first neuroimaging application of GRCCA, a novel algorithm for regularized canonical correlation analyses that takes into account grouping of the variables during the regularization  ...  To identify the relationship between functional connectivity in these two conditions and self-reports of negative emotion, we introduce group regularized canonical correlation analysis (GRCCA), a novel  ...  ., 2020 ) for similar implementations): rather than computing canonical coefficients in 71,631 column space we did all the computations in 652 row space. To achieve this, we proceeded as follows.  ... 
doi:10.1016/j.neuroimage.2021.118137 pmid:33951512 pmcid:PMC8536403 fatcat:25na7ux6fnfwpm77szlzmy7ko4

Paurush Praveen, Erfan Younesi and Martin Hofmann-Apitius [article]

Modeling inter-species molecular cross-talks in three host- parasite systems by expansion of their sparse information space
2012 arXiv   pre-print
Enrichment of these maps with drug-target informations showed a plethora of drug space to be explored and led to proposal of two new targets for each malaria and sleeping sickness.  ...  Comprehensive modelling can capture such interactions and could be useful to understand their pathophysiology and assist in identifying novel drug targets.  ...  Vinod Kasam for his fruitful advice in developing rationales for drug target discovery and Theo Mevissen for his support in text-mining.  ... 
arXiv:1209.5588v1 fatcat:juy6bvsjivgv3ndblgssomakhu

Genomic Analysis of the Vaccinia Virus Strain Variants Found in Dryvax Vaccine

L. Qin, C. Upton, B. Hazes, D. H. Evans
2011 Journal of Virology  
Over 85% of insertion and deletion mutations are associated with repeats, and a rare new isolate bearing a large deletion in the right telomere was identified.  ...  We used genome-sequencing technology to examine the genetic diversity of the population of viruses present in a sample of Dryvax.  ...  We also thank the staff at the Genome Québec Innovation Centre for their guidance and the reviewers for helpful comments.  ... 
doi:10.1128/jvi.05779-11 pmid:21976639 pmcid:PMC3233142 fatcat:vpgwrwprjjgkzndjw7wrlpjwyy

International review panel

2011 2011 6th International Conference on Industrial and Information Systems  
creativity comes from Sean Hanna 45 Beyond Binary Choices: Understanding and exploiting trade-offs to enhance creativity Gerhard Fisher 71 COMPUTATIONAL CREATIVITY 93 Creativity as disruptive adaption: A  ...  Acknowledgements I would like to thank Alan Penn for spatially related advice, and Peter Bentley for insights while developing the model presented in this paper.  ...  The research was supported by (1) the National Science Foundation, grants (a) REC-0106976 'Social Creativity and Meta-Design in Lifelong Learning Communities,' and (b) CCR-0204277 'A Social-Technical Approach  ... 
doi:10.1109/iciinfs.2011.6038027 fatcat:olgp74wayzadfb7n7f7mtx2jyi

Genome Scale Patterns of Recombination between Coinfecting Vaccinia Viruses

L. Qin, D. H. Evans
2014 Journal of Virology  
Recombination plays a critical role in virus evolution. It helps avoid genetic decline and creates novel phenotypes.  ...  An attractive feature of this approach is that when it is combined with selection for a particular phenotype, it provides a way of mapping and dissecting more complex virus traits.  ...  This work was supported by operating grants from the Canadian Institutes for Health Research and the Alberta Cancer Foundation and by an infrastructure award from the Canada Foundation for Innovation.  ... 
doi:10.1128/jvi.00022-14 pmid:24574414 pmcid:PMC4019122 fatcat:d5k6vnorqbgq3a3u5zaxg2b2qy

Abstracts from the 3rd International Genomic Medicine Conference (3rd IGMC 2015)

Jerry W. Shay, Noriko Homma, Ruyun Zhou, Muhammad Imran Naseer, Adeel G. Chaudhary, Mohammed Al-Qahtani, Nobutaka Hirokawa, Maryam Goudarzi, Albert J. Fornace, Saleh Baeesa, Deema Hussain, Mohammed Bangash (+992 others)
2016 BMC Genomics  
The authors would like to thank all the IVF team of the Assisted Conception Unit at King Khalid University Hospital in Saudi Arabia for their dedication and professionalism in serving our patients.  ...  Acknowledgements This study was performed in support of the King Abdulaziz City for Science and Technology (KACST) grant 09-BIO2289-03.  ...  A NAS storage unit of total 22 TB usable space acts as home directory and application space for users.  ... 
doi:10.1186/s12864-016-2858-0 pmid:27454254 pmcid:PMC4959372 fatcat:tukrmp73jbgnncl7ryif4pds6y

Concept and application of a computational vaccinology workflow

Johannes Söllner, Andreas Heinzel, Georg Summer, Raul Fechete, Laszlo Stipkovits, Susan Szathmary, Bernd Mayer
2010 Immunome Research  
a Systems Biology assessment of central aspects in host-pathogen interaction.  ...  Joining these advancements, further complemented by novel vaccine formulation and delivery aspects, have paved the way for implementing computational vaccinology for rational vaccine design tackling presently  ...  Paul Perco for his helpful suggestions and support concerning Systems Biology analyses.  ... 
doi:10.1186/1745-7580-6-s2-s7 pmid:21067549 pmcid:PMC2981879 fatcat:lfr5gkryknc53kur32zufyiyga

Efficient Intelligent Systems for Healthcare Data Management and Delivery

Dr Krishna Prasad K
2021 Zenodo  
Efficient Intelligent Systems for Healthcare Data Management and Delivery: PDF  ...  The model designed in this paper is a conceptual one and the implementation issues related to the same are yet to be explored.  ...  INTRODUCTION : The COVID-19 is caused by 'Novel Coronavirus'. The first case of COVID-19 was reported at the end of December 2019 in China.  ... 
doi:10.5281/zenodo.5148783 fatcat:zabqdvbnkbacrgritgzu2sedsy

Postmodernism: style and subversion, 1970-1990

2012 ChoiceReviews  
site) is the basis for a stage-set-like accumulation of fragments which form a map of Italy, with a fountain in the middle of the space.  ...  The same went for Disneyland, which Moore was prepared to settle for as a latter-day version of civic space, saying: 'Curiously, for a public place, Disneyland is not free.  ... 
doi:10.5860/choice.49-6680 fatcat:4qi4ws472bceni7tpkv3mllmjm

Using genomic sequencing to explore vaccinia virus diversity, recombination and evolution

Li Qin
vaccine used exclusively in China.  ...  Smallpox was eradicated using vaccinia viruses (VACV) as vaccines, including Dryvax, a calf-lymph vaccine derived from the New York City Board of Health (NYCBH) strain, and TianTan, a chicken egg cultured  ...  This is not a novel approach of course; related methods have been used for decades to map complex genetic traits in many different organisms.  ... 
doi:10.7939/r30c4st2d fatcat:4yjlilxdizegtprosz5d6oqy54

Automatic Recognition of the Unconscious Reactions from Physiological Signals [chapter]

Leonid Ivonin, Huang-Ming Chang, Wei Chen, Matthias Rauterberg
2013 Lecture Notes in Computer Science  
Besides cognitive and social psychology, the domain of consumer psychology may be in the position to play an important role in exploring the unconscious space.  ...  (cop- ing potential) 4. What is the significance of this even for my self-concept and to social norms and values?  ...  bringing a lot of fun.  ... 
doi:10.1007/978-3-642-39062-3_2 fatcat:bk3cu2ue5jd7lauofs6mz7nj7y

Epidemic-Associated Neisseria meningitidis Detected by Multilocus Enzyme Electrophoresis

Michael Reeves
1995 Emerging Infectious Diseases  
This case clinically resembled that of a woman in Finland infected during week 11 of pregnancy while traveling in Mexico, Guatemala, and Belize (5); in that case, Zika virus was detected in the brain of  ...  In addition, we acknowledge Thierry Carage for his assistance.  ...  AF482758), and VACV COP (accession no. 35027) for comparison.  ... 
doi:10.3201/eid0102.950203 pmid:8903159 pmcid:PMC2626839 fatcat:73vig66uc5bfjbb2ddrk5dvumm
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