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New Evidence of Association Between COMT Gene and Prefrontal Neurocognitive Function in Healthy Individuals From Sibling Pairs Discordant for Psychosis
2004
American Journal of Psychiatry
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Conclusions: These results seem to confirm the role of COMT genotype in the modulation of executive functions related to frontal lobe function in healthy individuals but not in schizophrenia patients. ...
Objective: Using a sample of sibling pairs discordant for psychosis, the authors attempted to replicate the findings of previous studies suggesting that the functional genetic polymorphism Val158Met in ...
Supported by funding from the Vada and Stanley Foundation, a Ph.D. grant from the University of Barcelona to Araceli Rosa, and an award from the Fondo de Investigación Sanitaria (Spain, FIS 00/0132) to ...
doi:10.1176/appi.ajp.161.6.1110
pmid:15169701
fatcat:62syjnxphves7fkhxu5c76zimy
COMT-by-Sex Interaction Effect on Psychosis Proneness
2015
BioMed Research International
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Catechol-O-methyltransferase (COMT) is a candidate susceptibility gene for schizophrenia that is involved in the regulation of dopamine in the prefrontal cortex. ...
The present study investigated the association of COMT Val158Met (rs4680) with psychometric positive and negative schizotypy and psychotic experiences in a sample of 808 nonclinical young adults. ...
Comissionat per a Universitats i Recerca of the Generalitat de Catalunya (2014SGR1070 and 2014SGR1636). ...
doi:10.1155/2015/829237
pmid:25722988
pmcid:PMC4334622
fatcat:dpkadk6h7zhpzkzwfabxo5lv74
Lack of Meta-Analytic Evidence for an Impact of COMT Val158Met Genotype on Brain Activation During Working Memory Tasks
2015
Biological Psychiatry
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Acknowledgments and Disclosures The authors report no biomedical financial interests or potential conflicts of interest. ...
Within this framework, schizophrenia risk genes and, in particular, the effect of the Val158Met (rs4680) single nucleotide polymorphism in the catechol-O-methyltransferase (COMT) gene on activations related ...
Subthreshold analyses revealed that the highest likelihoods for activation differences due to the Val158Met polymorphism across both healthy controls and schizophrenia patients were located ( Figure 1 ...
doi:10.1016/j.biopsych.2015.02.030
pmid:25861704
fatcat:3ea5odjbtnbrhmn7gbvbuex27u
Balance between Transmitter Availability and Dopamine D2 Receptors in Prefrontal Cortex Influences Memory Functioning
2019
Cerebral Cortex
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The Catechol-O-Methyltransferase polymorphism served as genetic proxy for endogenous prefrontal DA availability, and D2DRs in dorsolateral prefrontal cortex (dlPFC) were measured with [11C]raclopride-PET ...
Our data suggest that the inverted-U-shaped function relating DA signaling to cognition is modulated by a dynamic association between DA availability and receptor status. ...
This is in line with the hypothesis that excessive D2DR activation contributes to prefrontal dysfunction in schizophrenia (Winterer and Weinberger 2004; Durstewitz and Seamans 2008) . ...
doi:10.1093/cercor/bhz142
pmid:31504282
fatcat:onn5wv4dlrhqpksccoaowonkza
Catechol-O-methyl transferase and schizophrenia
2010
Psychiatria Danubina
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Given the association between schizophrenia and decreased dopamine activity in the prefrontal cortex, it is not surprising that Val108/158Met polymorphism is among the most extensively investigated polymorphisms ...
The most commonly examined polymorphism within the COMT gene is Val108/158Met polymorphism, which results in three to fourfold difference in COMT enzyme activity. ...
In contrast to these pathways, dopamine transporters are sparse in prefrontal cortex (PFC) and therefore, COMT activity is the most important regulator of the prefrontal dopamine function. ...
pmid:20562760
fatcat:cs5jkzy4kbbc7lus6fuqoiy5re
Catechol-O-methyltransferase (COMT) polymorphisms modulate working memory in individuals with schizophrenia and healthy controls
2017
Revista Brasileira de Psiquiatria
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Objective: Cognitive impairment is a core feature of schizophrenia, related to dopaminergic dysfunction in the prefrontal cortex (PFC). ...
Conclusion: These data support the hypothesis that COMT polymorphisms may be associated with schizophrenia and modulate cognition in patients and controls. ...
The authors gratefully acknowledge the enormous contributions made to this project by the patients, their families, and staff at UNIFESP. ...
doi:10.1590/1516-4446-2016-1987
pmid:28273278
fatcat:k2zzu5khpjcuxa7ww2d3gopqle
The modulatory influence of the functional COMT Val158Met polymorphism on lexical decisions and semantic priming
2009
Frontiers in Human Neuroscience
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ACKNOWLEDGEMENT We would like to thank Dr. Luke Smilllie, Department of Psychology,Goldsmith Institute, London, for his help and intellectual input. ...
In support for the hypothesis that lexical-semantic processing depends on prefrontal DA activity, patients with schizophrenia showed increased semantic priming for directly-(hen-egg) and indirectly-(lemon ...
In support of this view, schizophrenia patients suffer from low prefrontal dopamine activity (e.g., Dolan the distractor trials were not analyzed. ...
doi:10.3389/neuro.09.020.2009
pmid:19738929
pmcid:PMC2737487
fatcat:kn5lwj72onfa7czxvw2ob7rjny
Impact of Catechol-O-Methyltransferase on Prefrontal Brain Functioning in Schizophrenia Spectrum Disorders
2006
Neuropsychopharmacology
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A common SNP in the COMT gene causes a Val to Met transition at AA158/AA108 (Val158Met), resulting in reduced COMT activity in Met allele carriers. ...
The aim of this study was to determine whether COMT genotype affects an electrophysiological marker of prefrontal activation and neuropsychological frontal lobe measures in schizophrenia. ...
This study was supported by the Deutsche Forschungsgemeinschaft (Grant RE1632/1-1 to AR, KFO 125/1-1 to AR, AJF, and KPL, SFB 581 to KPL, and FA 361/8-1 + 2 to ...
doi:10.1038/sj.npp.1301151
pmid:16823382
fatcat:2rgz43vrjbel5mq5bvifqgfudu
Oppositional COMT Val158Met effects on resting state functional connectivity in adolescents and adults
2014
Brain Structure and Function
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Val158Met polymorphism in
Circular analysis in systems neuroscience: the dangers of double relation to activation and de-activation in the prefrontal cortex: a
dipping. ...
Nat Neurosci 12:535–540. doi:10.1038/nn.2303 study in patients with schizophrenia and healthy subjects. ...
doi:10.1007/s00429-014-0895-5
pmid:25319752
pmcid:PMC4667398
fatcat:fkaj637eynhmnmgk4lrsle4n6q
Smoking and schizophrenia
2009
Psychiatria Danubina
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The reasons for high frequency of both smoking prevalence and heavy smoking in schizophrenic patients is thought to be at least partially related to enhancement of brain dopaminergic activity, which, in ...
There is also evidence that cigarette smoking can reduce deficits relative to dopamine hypofunction in prefrontal cortex. ...
Namely, variations in COMT Val158Met polymorphism result in a three to fourfold difference in COMT enzyme activity. ...
pmid:19794359
fatcat:7eexpsinwzdpbcpiv2ckqepdrq
The val158met COMT polymorphism's effect on atrophy in healthy aging and Parkinson's disease
2010
Neurobiology of Aging
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We investigated whether the val 158 met functional polymorphism of catechol-o-methyltransferase influenced age-related changes in grey matter density and volume, both in healthy individuals (n = 80, ages ...
Since the val 158 met polymorphism is associated with differences in cortical dopamine metabolism, our data suggest a role for dopamine in cortical development followed by differential vulnerability to ...
In summary, our data indicate age-related changes in global and regional grey matter with the val 158 met polymorphism of COMT. ...
doi:10.1016/j.neurobiolaging.2008.07.009
pmid:18755526
pmcid:PMC3898476
fatcat:m57btutxezeqnndyynvg5l7ape
Polymorphisms of Catechol-O-Methyl Transferase (COMT) Gene in Vulnerability to Levodopa-Induced Dyskinesia
2018
Journal of Pharmacy & Pharmaceutical Sciences
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The aim of this study is to investigate the association between seven COMT gene single-nucleotide polymorphisms (SNPs) and the development of LID in patients with PD. ...
The results failed to clearly support a contribution of the studied polymorphisms; this may be related to a dominant relationship with the disease duration confounding the effect on the prevalence of LID ...
vs. 127 healthy controls. 40 De Lau et al described the existence of a prospectively assessed correlation between the A-allele of the COMT Val158Met polymorphism and an increased risk of developing ...
doi:10.18433/jpps29903
pmid:30075828
fatcat:z4upy6ildbdg3amze3r4ihftey
Prefrontal-Hippocampal Coupling During Memory Processing Is Modulated by COMT Val158Met Genotype
2006
Biological Psychiatry
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Methods: Using fMRI in healthy humans matched for a series of demographic and genetic variables, we studied the effect of the COMT val158met polymorphism on function of HF and VLPFC as well as on their ...
This network includes the hippocampal formation (HF) as well as the ventrolateral prefrontal cortex (VLPFC). ...
Further studies in healthy humans with fMRI have also demonstrated that the COMT Val158Met genotype modulates neuronal activity in anterior cingulate during effortful attention (Blasi et al 2005) , as ...
doi:10.1016/j.biopsych.2006.03.078
pmid:16950222
fatcat:cxy6sehajvbyhgmmhonpit76pq
Prefrontal executive function and D1, D3, 5-HT2A and 5-HT6 receptor gene variations in healthy adults
2008
Journal of Psychiatry & Neuroscience
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The Val158Met polymorphism of the catechol-O-methyltransferase gene has been demonstrated to be associated with prefrontal executive function explaining 4% of variance in perseverative errors on the Wisconsin ...
A sample of 216 healthy Han Chinese adults were measured with the WCST and genotyped for the 4 genetic polymorphisms. ...
Acknowledgements: This study was supported by the National Sci- ...
pmid:18197272
pmcid:PMC2186374
fatcat:e2b6dtkvgvbhjavxai2yh5sxpe
Genetic influence on the working memory circuitry: Behavior, structure, function and extensions to illness
2011
Behavioural Brain Research
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(PKU), and schizophrenia. ...
This has implications for our understanding of the transmission of working memory deficits in both healthy and disordered populations. ...
There is an evolutionarily recent functional single nucleotide polymorphism (SNP), known as the Val158Met polymorphism [42], with the Met form of COMT having lower activity at body temperature [43] and ...
doi:10.1016/j.bbr.2011.08.016
pmid:21878355
pmcid:PMC3545474
fatcat:6hfegvxglvahvh7xjyxk4otlpy
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