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New Evidence of Association Between COMT Gene and Prefrontal Neurocognitive Function in Healthy Individuals From Sibling Pairs Discordant for Psychosis

Araceli Rosa, Víctor Peralta, Manuel J. Cuesta, Amalia Zarzuela, Fermín Serrano, Alfredo Martínez-Larrea, Lourdes Fañanás
2004 American Journal of Psychiatry  
Conclusions: These results seem to confirm the role of COMT genotype in the modulation of executive functions related to frontal lobe function in healthy individuals but not in schizophrenia patients.  ...  Objective: Using a sample of sibling pairs discordant for psychosis, the authors attempted to replicate the findings of previous studies suggesting that the functional genetic polymorphism Val158Met in  ...  Supported by funding from the Vada and Stanley Foundation, a Ph.D. grant from the University of Barcelona to Araceli Rosa, and an award from the Fondo de Investigación Sanitaria (Spain, FIS 00/0132) to  ... 
doi:10.1176/appi.ajp.161.6.1110 pmid:15169701 fatcat:62syjnxphves7fkhxu5c76zimy

COMT-by-Sex Interaction Effect on Psychosis Proneness

Marta de Castro-Catala, Neus Barrantes-Vidal, Tamara Sheinbaum, Artal Moreno-Fortuny, Thomas R. Kwapil, Araceli Rosa
2015 BioMed Research International  
Catechol-O-methyltransferase (COMT) is a candidate susceptibility gene for schizophrenia that is involved in the regulation of dopamine in the prefrontal cortex.  ...  The present study investigated the association of COMT Val158Met (rs4680) with psychometric positive and negative schizotypy and psychotic experiences in a sample of 808 nonclinical young adults.  ...  Comissionat per a Universitats i Recerca of the Generalitat de Catalunya (2014SGR1070 and 2014SGR1636).  ... 
doi:10.1155/2015/829237 pmid:25722988 pmcid:PMC4334622 fatcat:dpkadk6h7zhpzkzwfabxo5lv74

Lack of Meta-Analytic Evidence for an Impact of COMT Val158Met Genotype on Brain Activation During Working Memory Tasks

Thomas Nickl-Jockschat, Hildegard Janouschek, Simon B. Eickhoff, Claudia R. Eickhoff
2015 Biological Psychiatry  
Acknowledgments and Disclosures The authors report no biomedical financial interests or potential conflicts of interest.  ...  Within this framework, schizophrenia risk genes and, in particular, the effect of the Val158Met (rs4680) single nucleotide polymorphism in the catechol-O-methyltransferase (COMT) gene on activations related  ...  Subthreshold analyses revealed that the highest likelihoods for activation differences due to the Val158Met polymorphism across both healthy controls and schizophrenia patients were located ( Figure 1  ... 
doi:10.1016/j.biopsych.2015.02.030 pmid:25861704 fatcat:3ea5odjbtnbrhmn7gbvbuex27u

Balance between Transmitter Availability and Dopamine D2 Receptors in Prefrontal Cortex Influences Memory Functioning

2019 Cerebral Cortex  
The Catechol-O-Methyltransferase polymorphism served as genetic proxy for endogenous prefrontal DA availability, and D2DRs in dorsolateral prefrontal cortex (dlPFC) were measured with [11C]raclopride-PET  ...  Our data suggest that the inverted-U-shaped function relating DA signaling to cognition is modulated by a dynamic association between DA availability and receptor status.  ...  This is in line with the hypothesis that excessive D2DR activation contributes to prefrontal dysfunction in schizophrenia (Winterer and Weinberger 2004; Durstewitz and Seamans 2008) .  ... 
doi:10.1093/cercor/bhz142 pmid:31504282 fatcat:onn5wv4dlrhqpksccoaowonkza

Catechol-O-methyl transferase and schizophrenia

Marina Sagud, Dorotea Mück-Seler, Alma Mihaljević-Peles, Bjanka Vuksan-Cusa, Maja Zivković, Miro Jakovljević, Nela Pivac
2010 Psychiatria Danubina  
Given the association between schizophrenia and decreased dopamine activity in the prefrontal cortex, it is not surprising that Val108/158Met polymorphism is among the most extensively investigated polymorphisms  ...  The most commonly examined polymorphism within the COMT gene is Val108/158Met polymorphism, which results in three to fourfold difference in COMT enzyme activity.  ...  In contrast to these pathways, dopamine transporters are sparse in prefrontal cortex (PFC) and therefore, COMT activity is the most important regulator of the prefrontal dopamine function.  ... 
pmid:20562760 fatcat:cs5jkzy4kbbc7lus6fuqoiy5re

Catechol-O-methyltransferase (COMT) polymorphisms modulate working memory in individuals with schizophrenia and healthy controls

Camila T. Matsuzaka, Denise Christofolini, Vanessa K. Ota, Ary Gadelha, Arthur A. Berberian, Cristiano Noto, Diego R. Mazzotti, Leticia M. Spindola, Patricia N. Moretti, Marilia A.C. Smith, Maria I. Melaragno, Sintia I. Belangero (+1 others)
2017 Revista Brasileira de Psiquiatria  
Objective: Cognitive impairment is a core feature of schizophrenia, related to dopaminergic dysfunction in the prefrontal cortex (PFC).  ...  Conclusion: These data support the hypothesis that COMT polymorphisms may be associated with schizophrenia and modulate cognition in patients and controls.  ...  The authors gratefully acknowledge the enormous contributions made to this project by the patients, their families, and staff at UNIFESP.  ... 
doi:10.1590/1516-4446-2016-1987 pmid:28273278 fatcat:k2zzu5khpjcuxa7ww2d3gopqle

The modulatory influence of the functional COMT Val158Met polymorphism on lexical decisions and semantic priming

Martin Reuter
2009 Frontiers in Human Neuroscience  
ACKNOWLEDGEMENT We would like to thank Dr. Luke Smilllie, Department of Psychology,Goldsmith Institute, London, for his help and intellectual input.  ...  In support for the hypothesis that lexical-semantic processing depends on prefrontal DA activity, patients with schizophrenia showed increased semantic priming for directly-(hen-egg) and indirectly-(lemon  ...  In support of this view, schizophrenia patients suffer from low prefrontal dopamine activity (e.g., Dolan the distractor trials were not analyzed.  ... 
doi:10.3389/neuro.09.020.2009 pmid:19738929 pmcid:PMC2737487 fatcat:kn5lwj72onfa7czxvw2ob7rjny

Impact of Catechol-O-Methyltransferase on Prefrontal Brain Functioning in Schizophrenia Spectrum Disorders

Ann-Christine Ehlis, Andreas Reif, Martin J Herrmann, Klaus-Peter Lesch, Andreas J Fallgatter
2006 Neuropsychopharmacology  
A common SNP in the COMT gene causes a Val to Met transition at AA158/AA108 (Val158Met), resulting in reduced COMT activity in Met allele carriers.  ...  The aim of this study was to determine whether COMT genotype affects an electrophysiological marker of prefrontal activation and neuropsychological frontal lobe measures in schizophrenia.  ...  This study was supported by the Deutsche Forschungsgemeinschaft (Grant RE1632/1-1 to AR, KFO 125/1-1 to AR, AJF, and KPL, SFB 581 to KPL, and FA 361/8-1 + 2 to  ... 
doi:10.1038/sj.npp.1301151 pmid:16823382 fatcat:2rgz43vrjbel5mq5bvifqgfudu

Oppositional COMT Val158Met effects on resting state functional connectivity in adolescents and adults

Bernhard M. Meyer, Julia Huemer, Ulrich Rabl, Roland N. Boubela, Klaudius Kalcher, Andreas Berger, Tobias Banaschewski, Gareth Barker, Arun Bokde, Christian Büchel, Patricia Conrod, Sylvane Desrivières (+26 others)
2014 Brain Structure and Function  
Val158Met polymorphism in Circular analysis in systems neuroscience: the dangers of double relation to activation and de-activation in the prefrontal cortex: a dipping.  ...  Nat Neurosci 12:535–540. doi:10.1038/nn.2303 study in patients with schizophrenia and healthy subjects.  ... 
doi:10.1007/s00429-014-0895-5 pmid:25319752 pmcid:PMC4667398 fatcat:fkaj637eynhmnmgk4lrsle4n6q

Smoking and schizophrenia

Marina Sagud, Alma Mihaljević-Peles, Dorotea Mück-Seler, Nela Pivac, Bjanka Vuksan-Cusa, Tomo Brataljenović, Miro Jakovljević
2009 Psychiatria Danubina  
The reasons for high frequency of both smoking prevalence and heavy smoking in schizophrenic patients is thought to be at least partially related to enhancement of brain dopaminergic activity, which, in  ...  There is also evidence that cigarette smoking can reduce deficits relative to dopamine hypofunction in prefrontal cortex.  ...  Namely, variations in COMT Val158Met polymorphism result in a three to fourfold difference in COMT enzyme activity.  ... 
pmid:19794359 fatcat:7eexpsinwzdpbcpiv2ckqepdrq

The val158met COMT polymorphism's effect on atrophy in healthy aging and Parkinson's disease

J.B. Rowe, L. Hughes, C.H. Williams-Gray, S. Bishop, S. Fallon, R.A. Barker, A.M. Owen
2010 Neurobiology of Aging  
We investigated whether the val 158 met functional polymorphism of catechol-o-methyltransferase influenced age-related changes in grey matter density and volume, both in healthy individuals (n = 80, ages  ...  Since the val 158 met polymorphism is associated with differences in cortical dopamine metabolism, our data suggest a role for dopamine in cortical development followed by differential vulnerability to  ...  In summary, our data indicate age-related changes in global and regional grey matter with the val 158 met polymorphism of COMT.  ... 
doi:10.1016/j.neurobiolaging.2008.07.009 pmid:18755526 pmcid:PMC3898476 fatcat:m57btutxezeqnndyynvg5l7ape

Polymorphisms of Catechol-O-Methyl Transferase (COMT) Gene in Vulnerability to Levodopa-Induced Dyskinesia

Anton J.M. Loonen, Svetlana A. Ivanova, Valentina M. Alifirova, Ivan V. Pozhidaev, Maxim B. Freidin, Irina A. Zhukova, Diana Z. Osmanova, Natalia G. Zhukova, Yulia A. Mironova, Vladimir V. Tiguntsev, Olga Yu. Fedorenko, Nikolay A. Bokhan (+2 others)
2018 Journal of Pharmacy & Pharmaceutical Sciences  
The aim of this study is to investigate the association between seven COMT gene single-nucleotide polymorphisms (SNPs) and the development of LID in patients with PD.  ...  The results failed to clearly support a contribution of the studied polymorphisms; this may be related to a dominant relationship with the disease duration confounding the effect on the prevalence of LID  ...  vs. 127 healthy controls. 40 De Lau et al described the existence of a prospectively assessed correlation between the A-allele of the COMT Val158Met polymorphism and an increased risk of developing  ... 
doi:10.18433/jpps29903 pmid:30075828 fatcat:z4upy6ildbdg3amze3r4ihftey

Prefrontal-Hippocampal Coupling During Memory Processing Is Modulated by COMT Val158Met Genotype

Alessandro Bertolino, Valeria Rubino, Fabio Sambataro, Giuseppe Blasi, Valeria Latorre, Leonardo Fazio, Grazia Caforio, Vittoria Petruzzella, Bhaskar Kolachana, Ahmad Hariri, Andreas Meyer-Lindenberg, Marcello Nardini (+2 others)
2006 Biological Psychiatry  
Methods: Using fMRI in healthy humans matched for a series of demographic and genetic variables, we studied the effect of the COMT val158met polymorphism on function of HF and VLPFC as well as on their  ...  This network includes the hippocampal formation (HF) as well as the ventrolateral prefrontal cortex (VLPFC).  ...  Further studies in healthy humans with fMRI have also demonstrated that the COMT Val158Met genotype modulates neuronal activity in anterior cingulate during effortful attention (Blasi et al 2005) , as  ... 
doi:10.1016/j.biopsych.2006.03.078 pmid:16950222 fatcat:cxy6sehajvbyhgmmhonpit76pq

Prefrontal executive function and D1, D3, 5-HT2A and 5-HT6 receptor gene variations in healthy adults

Hsien-Yuan Lane, Yi-Ching Liu, Chieh-Liang Huang, Ching-Liang Hsieh, Yi-Lin Chang, Lauren Chang, Yue-Cune Chang, Wen-Ho Chang
2008 Journal of Psychiatry & Neuroscience  
The Val158Met polymorphism of the catechol-O-methyltransferase gene has been demonstrated to be associated with prefrontal executive function explaining 4% of variance in perseverative errors on the Wisconsin  ...  A sample of 216 healthy Han Chinese adults were measured with the WCST and genotyped for the 4 genetic polymorphisms.  ...  Acknowledgements: This study was supported by the National Sci-  ... 
pmid:18197272 pmcid:PMC2186374 fatcat:e2b6dtkvgvbhjavxai2yh5sxpe

Genetic influence on the working memory circuitry: Behavior, structure, function and extensions to illness

Katherine H. Karlsgodt, Peter Bachman, Anderson M. Winkler, Carrie E. Bearden, David C. Glahn
2011 Behavioural Brain Research  
(PKU), and schizophrenia.  ...  This has implications for our understanding of the transmission of working memory deficits in both healthy and disordered populations.  ...  There is an evolutionarily recent functional single nucleotide polymorphism (SNP), known as the Val158Met polymorphism [42], with the Met form of COMT having lower activity at body temperature [43] and  ... 
doi:10.1016/j.bbr.2011.08.016 pmid:21878355 pmcid:PMC3545474 fatcat:6hfegvxglvahvh7xjyxk4otlpy
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