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CCmed: cross-condition mediation analysis for identifying robust trans-eQTLs and assessing their effects on human traits [article]

Fan Yang, Kevin J Gleason, Jiebiao Wang, Jubao Duan, Xin He, Brandon L. Pierce, Lin S. Chen, The GTEx Consortium
2019 bioRxiv   pre-print
To detect robust cis-mediated trans-associations at the gene-level and for specific single nucleotide polymorphisms (SNPs), we proposed two Cross-Condition Mediation methods -- CCmed-gene and CCmed-GWAS  ...  Many trans-effects are mediated by cis-gene expression and some of those effects are shared across tissue types/conditions.  ...  Francois Aguet, Kristin Ardlie for providing cis-eQTL summary statistics.  ... 
doi:10.1101/803106 fatcat:mdxvs4jaw5dctosnwc2k3hgbny