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To detect robust cis-mediated trans-associations at the gene-level and for specific single nucleotide polymorphisms (SNPs), we proposed two Cross-Condition Mediation methods -- CCmed-gene and CCmed-GWAS ... Many trans-effects are mediated by cis-gene expression and some of those effects are shared across tissue types/conditions. ... Francois Aguet, Kristin Ardlie for providing cis-eQTL summary statistics. ...doi:10.1101/803106 fatcat:mdxvs4jaw5dctosnwc2k3hgbny