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CCFold: Rapid And Accurate Prediction Of Coiled-Coil Structures And Application To Modelling Intermediate Filaments [article]

Dmytro Guzenko, Sergei Strelkov
2017 bioRxiv   pre-print
Accurate molecular structure of the protein dimer representing the elementary building block of intermediate filaments (IFs) is essential towards the understanding of the filament assembly, rationalizing  ...  Here we present CCFold, a generally applicable threading-based algorithm which produces coiled-coil models from protein sequence only.  ...  Introduction Intermediate filaments (IFs) are an important example of a protein assembly based on α-helical coiled coils (CCs).  ... 
doi:10.1101/123869 fatcat:xamsdnczujexjn6f2ar5g6mlka

CCFold: rapid and accurate prediction of coiled-coil structures and application to modelling intermediate filaments

Dmytro Guzenko, Sergei V Strelkov, Alfonso Valencia
2017 Bioinformatics  
S1 : Distributions of distances between Cα atoms of the aligned residues in both chains of a CC dimer, per amino acid, obtained from the CC+ database.  ...  S7 : S7 Ribbon diagram of a CCFold model (green) for a trimer CC superposed to the true structure (red) from PDB entry 2QIH.  ...  to the corresponding part of the crystal structure (PDB entry 1X8Y).  ... 
doi:10.1093/bioinformatics/btx551 pmid:28968723 fatcat:7puu66mrjzf4hi3cun5pwisgha

TROVE: a user-friendly tool for visualizing and analyzing cancer hallmarks in signaling networks

Huey Eng Chua, Sourav S Bhowmick, Jie Zheng, Jonathan Wren
2017 Bioinformatics  
scanning M.Tiberti, A.Pandini, F.Fraternali and A.Fornili CCFold: rapid and accurate prediction of coiled-coil structures and application to modelling intermediate filaments D.Guzenko and S.V.Strelkov  ...  IntPred: a structure-based predictor of protein-protein interaction sites T.C.Northey, A.Barešić and A.C.R.Martin MemBrain-contact 2.0: a new two-stage machine learning model for the prediction enhancement  ... 
doi:10.1093/bioinformatics/btx600 pmid:29028982 fatcat:xgf3ijfm4nfxnn3gl3y3zxfcum