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Menopausal status and risk factors for cardiovascular disease

H. W. Peters, I. C. D. Westendorp, A. E. Hak, D. E. Grobbee, C. D. A. Stehouwer, A. Hofman, J. C. M. Witteman
1999 Journal of Internal Medicine  
The difference was present within 3 years after onset of menopause and did not show a trend towards an increase with the number of postmenopausal years.  ...  Therefore we examined cardiovascular risk factors in a meticulously selected population in which the contrast in oestrogen status between preand postmenopausal women of the same age was maximized.  ...  The study was supported by a grant from the Netherlands Heart Foundation.  ... 
doi:10.1046/j.1365-2796.1999.00547.x pmid:10620095 fatcat:2u2jw4ah5ncgxcabw2umqtdlne

Increased plasma endothelin in diabetes: an atherosclerosis marker?

R. Pati�o, C. D. A. Stehouwer
1994 Diabetologia  
Yours sincerely, C. D. A. Stehouwer Corresponding author: Dr. R.  ...  Further research is indicated to classify the role of endothelin as a marker of vascular dysfunction. Yours sincerely, R. Patifio, J. Ibarra, A. Molino, R. Fernandez-Durango, J. Moya, A.  ... 
doi:10.1007/bf00398065 pmid:8174852 fatcat:yxo5nxemc5fyfk2m73lncpgi54

Endothelial Dysfunction Precedes Development of Microalbuminuria in IDDM

C. D. A. Stehouwer, H. R. Andreas Fischer, A. W. R. Van Kuijk, B. C. P. Polak, A. J. M. Donker
1995 Diabetes  
We examined a cohort of 17 IDDM pa tients at baseline and on three occasions during a follow-up of (median) 64 months (range 51-89).  ...  In patients with insulin-dependent diabetes niellitus (IDDM), microalbuminuria is a predictor of widespread severe microangiopathy and maeroangiopathy.  ...  ACKNOWLEDGMENTS C.D.A.S. is suppozted by a fellowship from the Diabetes Fonds Nederland (Diabetes Research Fund) and the Nether lands Organisation for Scientific Research (NWO). We thank W.  ... 
doi:10.2337/diab.44.5.561 pmid:7729616 fatcat:v2wrlq5mf5filkcvwa43z4cccy

Excess Cardiovascular Risk in Diabetic Women: A Case for Intensive Treatment

C. Recarti, S. J. S. Sep, C. D. A. Stehouwer, T. Unger
2015 Current Hypertension Reports  
Several studies have demonstrated a significant diabetes-associated excess risk of cardiovascular disease in women.  ...  Diabetes is a common and rapidly growing disease that affects more than 380 million people worldwide and is an established risk factor for cardiovascular disease with differential effects on women compared  ...  Interest C. Recarti, S.J.S. Sep, C.D.A. Stehouwer and T. Unger declare that they have no conflicts of interest.  ... 
doi:10.1007/s11906-015-0554-0 pmid:25903071 pmcid:PMC4408368 fatcat:2wsywuowgzh5hkf7h5d35vxjja

Complement C3: an emerging risk factor in cardiometabolic disease

E. Hertle, M. M. J. van Greevenbroek, C. D. A. Stehouwer
2012 Diabetologia  
C3 may play a role in the macrovascular, as well as microvascular, complications of diabetes.  ...  Recent data suggest a diabetesdependent incorporation of C3 into fibrin clots, with concomitant effects on clot characteristics.  ...  They propose a mechanism in which C3 participates in a hypofibrinolytic, and thus prothrombotic, state.  ... 
doi:10.1007/s00125-012-2462-z pmid:22282163 pmcid:PMC3295998 fatcat:cwbbk2nwsjan7lujyjmn5giud4

Arterial stiffness in diabetes and the metabolic syndrome: a pathway to cardiovascular disease

C. D. A. Stehouwer, R. M. A. Henry, I. Ferreira
2008 Diabetologia  
Meyer C, Milat F, McGrath BP, Cameron J, Kotsopoulos D, Teede HJ (2004) Vascular dysfunction and autonomic neuropathy in type 2 diabetes. Diabet Med 21:746-751 48.  ...  Parikh A, Sochett EB, McCrindle BW, Dipchand A, Daneman A, Daneman D (2000) Carotid artery distensibility and cardiac function in adolescents with type 1 diabetes. J Pediatr 137:465-469 19.  ... 
doi:10.1007/s00125-007-0918-3 pmid:18239908 fatcat:wnunynauzrdlllsxbnqzev2cvi

Evidence for Genetic Factors Explaining the Birth Weight-Blood Pressure Relation : Analysis in Twins

R. G. IJzerman, C. D. A. Stehouwer, D. I. Boomsma
2000 Hypertension  
; monozygotic twins: blood pressure at rest, 117.4Ϯ6.4 versus 118.4Ϯ9.0, Pϭ0.4, and during a reaction time task, 122.9Ϯ8.4 versus 124.2Ϯ10.8, Pϭ0.2).  ...  The dizygotic but not the monozygotic twins with the lowest birth weight from each pair had a systolic blood pressure measured at rest and during the reaction time experiment that was higher compared with  ...  "yes" button when a high tone and a "no" button when a low tone was heard over the earphones.  ... 
doi:10.1161/01.hyp.36.6.1008 pmid:11116116 fatcat:kbn6zfldivbxhdhvfn4wnhh4ru

Metformin: A Narrative Review of Its Potential Benefits for Cardiovascular Disease, Cancer and Dementia

Wiebe M. C. Top, Adriaan Kooy, Coen D. A. Stehouwer
2022 Pharmaceuticals  
Coupled with a favorable side effect profile and low cost, metformin has become the cornerstone in the treatment of T2DM worldwide.  ...  AMPK, as a cellular energy sensor, is activated by a decrease in ATP and an increase in AMP.  ...  AMPK, as a cellular energy sensor, is activated by a decrease in ATP and an increase in AMP.  ... 
doi:10.3390/ph15030312 pmid:35337110 pmcid:PMC8951049 fatcat:cgk6ae6glvgzbbpkvued4zdyiq

Treatment of Hypertension in the Oldest Old: A Critical Role for Frailty?

M. Muller, Y. M. Smulders, P. W. de Leeuw, C. D. A. Stehouwer
2013 Hypertension  
well tolerated (Class IIb; Level of Evidence C) 3 .  ...  In addition, she experienced 2 falls in the past 2 years; calcium/vitamin D and alendronate were started for the management of osteoporosis.  ... 
doi:10.1161/hypertensionaha.113.00911 pmid:24324042 fatcat:6itqtj5zsfdq7akkgosipkl3g4

The pathogenesis of vascular complications of diabetes mellitus: one voice or many?

C. D. A. Stehouwer, N. C. Schaper
1996 European Journal of Clinical Investigation  
C. D. A. STEHOUWER & N. C.  ...  D. ASTEHOUWER & N. C. SCHAPER Acknowledgments We thank Professor A. J. M. Donker for helpful comments. C. D. A.  ... 
doi:10.1046/j.1365-2362.1996.1780527.x pmid:8864414 fatcat:im65tyzmindaject4cy4j37aem

Risk of a Recurrent Cardiovascular Event in Individuals With Type 2 Diabetes or Intermediate Hyperglycemia: The Hoorn Study

A. A. W. A. van der Heijden, E. van't Riet, S. D. M. Bot, S. C. Cannegieter, C. D. A. Stehouwer, C. A. Baan, J. M. Dekker, G. Nijpels
2013 Diabetes Care  
OBJECTIVEdTo investigate risk of a recurrent cardiovascular event and its predictors in a population-based cohort.  ...  RESULTSdDuring a median follow-up of 4.1 years, 44% (n = 148) of the population developed a recurrent vascular event.  ...  D ue to aging, the increasing prevalence of obesity and diabetes worldwide, and improved care after a first cardiovascular event, the number of people at risk for a recurrent cardiovascular event is increasing  ... 
doi:10.2337/dc12-2691 pmid:23877981 pmcid:PMC3816885 fatcat:omur2j2verfxtfbkrok6rwdp4m

Effects of insulin infusion on endothelium-derived vasoactive substances

K. H. Polderman, C. D. A. Stehouwer, G. J. van Kamp, L. J. G. Gooren
1996 Diabetologia  
Short-term hyperinsulinaemia in women is associated with a decline in levels of immunoreactive endothelin, and possibly with a rise in production of nitric oxide and prostacyclin.  ...  We also assessed urinary excretion of 6-keto PGF-1a (a degradation product of prostacyclin reflecting prostacyclin production). Blood pressure was monitored in all subjects throughout the experiment.  ...  Stehouwer is supported by a fellowship from the Diabetes Fonds Nederland and the Netherlands Organisation for Scientific Research (NWO).  ... 
doi:10.1007/s001250050571 pmid:8932993 fatcat:dccwtr6xbng4zgpz57wbujcmsq

Inflammation and endothelial dysfunction are associated with retinopathy: the Hoorn Study

M. V. van Hecke, J. M. Dekker, G. Nijpels, A. C. Moll, R. J. Heine, L. M. Bouter, B. C. P. Polak, C. D. A. Stehouwer
2005 Diabetologia  
Methods: As part of a population-based cohort study, 625 individuals aged 50-74 years, stratified according to age, sex and glucose tolerance status, underwent an extensive physical examination.  ...  Levels of C-reactive protein (CRP), soluble intercellular adhesion molecule-1 (sICAM-1), von Willebrand factor, and soluble vascular adhesion molecule-1 (sVCAM-1) were assessed, together with the urinary  ...  We did not include HbA 1 c in the multivariate model because it is likely that hyperglycaemia causes endothelial dysfunction and inflammation, which means that analyses adjusted for HbA 1 c are probably  ... 
doi:10.1007/s00125-005-1799-y pmid:15918015 fatcat:2qbyx2qsg5adlil4r2en4lwv3i

Social network characteristics are associated with depressive symptoms: The Maastricht Study

V Gianfredi, N C Schaper, S J P M Eussen, A Odone, C Signorelli, N Dukers, A Koster, C D A Stehouwer, A Wasselius, M T Schram
2020 European Journal of Public Health  
Less social support was associated with a higher risk of depressive symptoms.  ...  Social network characteristics were assessed through a name generator questionnaire.  ...  Less social support was associated with a higher risk of depressive symptoms.  ... 
doi:10.1093/eurpub/ckaa165.198 fatcat:wa6xembchnc7ph3evgnumib4ze

Biomarker Research in Glucose Disorders: Current Concepts and Clinical Applications

D. R. Webb, K. Herbert, Melanie J. Davies, K. Khunti, N. Sattar, C. D. A. Stehouwer
2013 Journal of Diabetes Research  
Acknowledgment This paper is supported by the NIHR Leicester-Loughborough Diet, Lifestyle and Physical Activity Biomedical Research Unit which is a partnership between University Hospitals of Leicester  ...  The National Institute for Health working group broadly define a "biomarker" as an objectively quantifiable characteristic reflecting normal biological action, a specific pathogenic process, or pharmacologic  ...  should enable detailed characterisation of the "metabotype. " In this special issue we see examples of relevance to diabetes, including state-of-the-art tandem mass spectrometry measurement of L(+) and D(  ... 
doi:10.1155/2013/290671 pmid:23844372 pmcid:PMC3703428 fatcat:bnabdeayxzegzirnd35sje63ym
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