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Recent Literature Aids to Materia Medica and Therapeutics. Part II. (Double Part.) The Vegetable and Animal Substances . By C. E. Armand Semple, R. A., M. B. Cantab., M. R. C. P. Lond. New York: G. P. Putnam's Sons. 1880. 32mo, pp. 152

1880 Boston Medical and Surgical Journal  
By C. E. Armand Semple, R. A., M. B. Cantab., M. R. C. P. Lond. New York : G. P. Putnam's Sons. 1880. 32mo, pp. 152. John Green.  ...  Shaffer relates a number of interesting cases where he was able to form a diagnosis, and where the result substantiated the opinion ; in a few instances, however, the impression left on the reader's mind  ... 
doi:10.1056/nejm188006171022508 fatcat:teiouucuijetdle5fflh6nuizu

Meet the parents: bioinformatics and computational biology

C A M Semple
2003 Heredity  
The hope is that much of the activity in bioinformatics can be redirected to form something approaching a theoretical branch of molecular biology that constitutes a predictive science in its own right  ...  Underlining the distance, we have to go to reach a full set of reliable gene predictions, let alone a predictive theory of how the structures of genes relate to alternative splicing and regulation.  ...  Reviewed by CAM Semple The term bioinformatics is most often used to describe the development of software to process, store and visualize sequence data.  ... 
doi:10.1038/sj.hdy.6800366 fatcat:n47ufjjyerhdtb3f6fptw6qcxe

Insulin-induced hypoglycemia induces a rise in C-reactive protein

P. J. Galloway, G. A. Thomson, B. M. Fisher, C. G. Semple
2000 Diabetes Care  
PATRICIA M.  ...  Fukushima M, Taniguchi A, Sakai M, Doi K, Nagata I, Nagasaka S, Tokuyama K, Nakai Y: Effect of bezafibrate on insulin sensitivity in nonobese Japanese type 2 diabetic patients (Letter).  ...  A Japanese version of the Well-Being Questionnaire was used with a sample of people with diabetes attending the Tenri Hospital diabetes clinic.  ... 
doi:10.2337/diacare.23.6.861 pmid:10841013 fatcat:npdy7vi6lfh7jowdqiwrbu77sm

Recovering a phylogenetic tree using pairwise closure operations

K.T. Huber, V. Moulton, C. Semple, M. Steel
2005 Applied Mathematics Letters  
A fundamental task in evolutionary biology is the amalgamation of a collection P of leaf-labelled trees into a single parent tree.  ...  For unrooted trees, deciding if there is such a tree is NP-complete.  ...  The quartet with leaves a, b, c, d is denoted ab|cd if the path from a to b does not intersect the path from c to d.  ... 
doi:10.1016/j.aml.2004.01.007 fatcat:6mx77vdhdrd6vlw2tstjrlduzm

Pernicious anaemia in a young man presenting with dyspepsia

C. G. Semple, J. M. Williamson
1982 Postgraduate medical journal  
An otherwise healthy 17-year-old male presented with a 6-month history of nausea and vomiting.  ...  Case report A 17-year-old man presented to a general medical out-patient clinic with a 6-month history of nausea and vomiting occurring at any time of day.  ...  We describe a case of pernicious anaemia in a young man presenting solely with upper gastrointestinal symptoms.  ... 
doi:10.1136/pgmj.58.681.439 pmid:7122391 pmcid:PMC2426502 fatcat:bfncs35w2zh5jhyg27txv34hsy

A bioinformatic screen for novel A-I RNA editing sites reveals recoding editing in BC10

D. R. Clutterbuck, A. Leroy, M. A. O'Connell, C. A. M. Semple
2005 Bioinformatics  
A novel multiply edited transcript, BC10, was identified and experimentally verified. BC10 is highly conserved across a range of metazoa and has been implicated in two forms of cancer.  ...  Here we present a bioinformatic approach to identify novel sites based on these shared features.  ...  This analysis was not applicable to C-U, U-C or U-A editing as the known edited sites could not be identified owing to a lack of expressed sequence data or their absence from Ensembl genes.  ... 
doi:10.1093/bioinformatics/bti411 pmid:15797904 fatcat:xnol5dty4rbffkshzdnh3wwyxm

Identifying the Role of Novel Protein Kinase C Isoforms in Mediating Paclitaxel-Induced Peripheral Neuropathy

A. L. Blaker, C. M. Mitchell, E. A. Semple
2015 Journal of Neuroscience  
Multiple second messenger signaling molecules have been implicated in the pathophysiology of PIPN, including cAMP, protein kinase A, and protein kinase C (PKC) (Hucho and Levine, 2007).  ...  Based on these results, it is reasonable to speculate that PKC␤II may have a different role than other isoforms in mediating pain  ...  Multiple second messenger signaling molecules have been implicated in the pathophysiology of PIPN, including cAMP, protein kinase A, and protein kinase C (PKC) (Hucho and Levine, 2007) .  ... 
doi:10.1523/jneurosci.1903-15.2015 pmid:26180187 fatcat:bn5alvuyfnci5jg6kpsp6gebze

Nature Reserve Selection Problem: A Tight Approximation Algorithm

M. Bordewich, C. Semple
2008 IEEE/ACM Transactions on Computational Biology & Bioinformatics  
Nature reserve selection problem : a tight approximation algorithm.', IEEE/ACM transactions on computational biology and bioinformatics., 5 (2). pp. 275-280.  ...  'Nature reserve selection problem : a tight approximation algorithm.', IEEE/ACM transactions on computational biology and bioinformatics., 5 (2). pp. 275-280.  ...  ACKNOWLEDGMENTS Magnus Bordewich was supported by the EPSRC, and Charles Semple was supported by the New Zealand Marsden Fund.  ... 
doi:10.1109/tcbb.2007.70252 pmid:18451436 fatcat:7fda57phnfettcsshuvfdnroqq

Corrigendum of 'High throughput analysis of epistasis in genome-wide association studies with BiForce'

A. Gyenesei, C. A. M. Semple, C. S. Haley, W.-H. Wei
2013 Bioinformatics  
Table 2 . 2 Previous genome-wide significant epistatic pairs identified from the NFBC199 cohort a (update) Trait SNP 1 SNP 2 P int distance LD (r 2 ) c o r r e c tP int CRP rs1811472 b (1q23.2  ...  In summary, the issue only affects a small part of *To whom correspondence should be addressed.  ... 
doi:10.1093/bioinformatics/btt444 pmcid:PMC3873004 fatcat:6mw7577nwrfwfjfj2aun4ffnoq

Disruption of Ledgf/Psip1 Results in Perinatal Mortality and Homeotic Skeletal Transformations

H. G. Sutherland, K. Newton, D. G. Brownstein, M. C. Holmes, C. Kress, C. A. Semple, W. A. Bickmore
2006 Molecular and Cellular Biology  
The resulting Psip1-␤geo fusion protein retains chromatin-binding activity and the PWWP and AT hook domains of the wild-type protein but is missing the highly conserved C terminus.  ...  fat pads, and a tendency to develop blepharitis.  ...  Bars, 50 m. (C) H&E staining of eyes from WT (ϩ/ϩ) and Psip1 Ϫ/Ϫ mutant mice showing a normal lens epithelium (le). (D) Chronic ulcerative blepharitis in Psip1 Ϫ/Ϫ mutant mice.  ... 
doi:10.1128/mcb.00459-06 pmid:16980622 pmcid:PMC1592893 fatcat:kxh6goi325bsrckr26huh5fbje

An Outbreak of Trichinosis in Liverpool in 1953

A. B. Semple, J. B. M. Davies, W. E. Kershaw, C. A. St. Hill
1954 BMJ (Clinical Research Edition)  
Methods of Infection Anderson and Arnstein (1953) state that heating to a temperature of 58°C. for a few minutes kills the Trichinella larvae in pork, and that freezing to a temperature of l18°C . for  ...  Another patient died from a pulmonary embolism during the third week of the disease. Report of Fatal C-ase.  ... 
doi:10.1136/bmj.1.4869.1002 pmid:13149888 pmcid:PMC2084966 fatcat:y73smm5wl5cb7b45z7vmrnmpce

Hierarchical folding and reorganization of chromosomes are linked to transcriptional changes in cellular differentiation

J. Fraser, C. Ferrai, A. M. Chiariello, M. Schueler, T. Rito, G. Laudanno, M. Barbieri, B. L. Moore, D. C. Kraemer, S. Aitken, S. Q. Xie, K. J. Morris (+10 others)
2015 Molecular Systems Biology  
Here, we investigate TAD higher-order interactions with Hi-C through neuronal differentiation and show that they form a hierarchy of domains-within-domains (metaTADs) extending across genomic scales up  ...  Using polymer modelling, we demonstrate that hierarchical folding promotes efficient chromatin packaging without the loss of contact specificity, highlighting a role far beyond the simple need for packing  ...  of published ChIP-seq data sets and Robert A.  ... 
doi:10.15252/msb.20156492 pmid:26700852 pmcid:PMC4704492 fatcat:66r3qbym7bdmdf3ltpxzjswtvm

Angiotensin II, aldosterone and arterial pressure: a quantitative approach. Arthur C. Corcoran Memorial Lecture

J J Brown, J Casals-Stenzel, A M Cumming, D L Davies, R Fraser, A F Lever, J J Morton, P F Semple, M Tree, J I Robertson
1979 Hypertension  
M were able to recover the octapeptide unchanged. They conclude that such a conversion is not obligatory.  ...  M Normal volunteers were fed a fixed diet containing known and constant quantities of sodium and potassium.  ...  ., less trypsin was required for complete activation at pH 7.4:200 Mg/ml at 25°C and 100 Mg/ml at -4°C.  ... 
doi:10.1161/01.hyp.1.3.159 pmid:399234 fatcat:fk4lg6ygfvhdrefxin36btthaa

ETO/MTG8 Is an Inhibitor of C/EBP Activity and a Regulator of Early Adipogenesis

J. J. Rochford, R. K. Semple, M. Laudes, K. B. Boyle, C. Christodoulides, C. Mulligan, C. J. Lelliott, S. Schinner, D. Hadaschik, M. Mahadevan, J. K. Sethi, A. Vidal-Puig (+1 others)
2004 Molecular and Cellular Biology  
The pMT2-C/EBP␤ expression vector and the pGL3-C/EBP␣ promoter reporter construct were generously provided by Q.-Q. Tang and M. D. Lane. Cell culture and transfection.  ...  These findings define, for the first time, a molecular role for ETO in normal physiology as an inhibitor of C/EBP␤ and a novel regulator of early adipogenesis. on July 21, 2018 by guest http://mcb.asm.org  ...  Tang and M. D. Lane generously provided C/EBP␣ promoter and C/EBP␤ expression constructs. The C/EBPwt-LUC construct was kindly provided by S. Smola-Hess.  ... 
doi:10.1128/mcb.24.22.9863-9872.2004 pmid:15509789 pmcid:PMC525461 fatcat:vpt2hoiwpvbbzfmc5vqhuf2jsy

A review of a facility for the admission of mothers with babies to psychiatric care

M. M. Semple, C. B. Ballinger
1995 Psychiatric bulletin of the Royal College of Psychiatrists  
The advantages and disadvantages of a mother and baby facility as part of a general hospital psychiatric admission unit were explored.  ...  A questionnaire was sent to 60 women who had been admitted to the unit with their babies over a ten-year period asking about their psychological health following discharge from hospital, the welfare of  ...  Interestingly, in two cases, a mother was admitted on two separate occasions with a different baby each time.  ... 
doi:10.1192/pb.19.6.346 fatcat:yvpf344jlnakddaq4ojca6ilem
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