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Neuroendocrine tumor presenting like lymphoma: a case report

Riccardo Del Vescovo, Roberto Luigi Cazzato, Sofia Battisti, Francesco D'Agostino, Bruno Vincenzi, Rosario Francesco Grasso, Bruno Beomonte Zobel
2011 Journal of Medical Case Reports  
Neuroendocrine tumors are a rare but diverse group of malignancies that arise in a wide range of organ systems, including the mediastinum. Differential diagnosis includes other masses arising in the middle mediastinum such as lymphoma, pericardial, bronchogenic and enteric cysts, metastatic tumors, xanthogranuloma, systemic granuloma, diaphragmatic hernia, meningocele and paravertebral abscess. Case presentation: We present a case of 42-year-old Caucasian man with a neuroendocrine tumor of the
more » ... iddleposterior mediastinum and liver metastases, which resembled a lymphoma on magnetic resonance imaging. Conclusion: The differential diagnosis in patients with mediastinal masses and liver lesions should include neuroendocrine tumor.
doi:10.1186/1752-1947-5-506 pmid:21974797 pmcid:PMC3195764 fatcat:ulzhb7tcarau5g7l2cfqb6neyu

Osteofibrous dysplasia: A case report and review of the literature

Paolo Simoni, Laura Scarciolla, Eugene Mutijima, Bruno Beomonte Zobel
2011 Radiology Case Reports  
Osteofibrous dysplasia (OFD) is a rare bone tumor affecting young individuals. The differential diagnosis between OFD and adamantinoma may be challenging in some cases on imaging. We present a case of OFD and discuss the key imaging and histological findings. We also discuss the differential diagnosis between OFD and classical adamantinoma on the basis of recent literature.
doi:10.2484/rcr.v6i4.546 pmid:27307931 pmcid:PMC4899941 fatcat:a6qtwbikhng6jklmf7w2zwqtcq

Imaging of Renal Angiomyolipomatosis

Federico Greco, Carlo Augusto Mallio, Vincenzo Cirimele, Pasquale D'Alessio, Bruno Beomonte Zobel, Rosario Francesco Grasso
2018 Journal of Renal and Hepatic Disorders  
Angiomyolipoma is a type of benign renal tumor. It is sporadic and isolated in 80% of cases. The remaining 20% is associated with tuberous sclerosis complex or pulmonary lymphangioleiomyomatosis. Generally, angiomyolipomas manifest themselves as angiomyolipomatosis, in which the angiomyolipomas are larger, bilateral, and widespread. Understanding whether angiomyolipomas are present in the context of angiomyolipomatosis is of considerable importance because it might be associated with malignant
more » ... esions. This article provides an overview of the radiological features of renal angiomyolipomatosis under different imaging techniques such as ultrasound, computed tomography, and magnetic resonance.
doi:10.15586/jrenhep.2018.37 fatcat:lv4ns52lznb35fleerdq2v4n5m

Azygo-Tracheal Fistula in a Complete Implantable Central Venous System

Carlo Cosimo Quattrocchi, Matteo Sammarra, Massimiliano Carassiti, Bruno Vincenzi, Giuseppe Tonini, Rosario Francesco Grasso, Bruno Beomonte Zobel
2006 Journal of Clinical Oncology  
Carlo Cosimo Quattrocchi, Matteo Sammarra, Massimiliano Carassiti, Bruno Vincenzi, Giuseppe Tonini, Rosario Francesco Grasso, and Bruno Beomonte Zobel Biomedica esearct epartn est 120:1 DOI: 10.1200/JCO  ... 
doi:10.1200/jco.2006.05.6440 pmid:16921059 fatcat:3cwnhqum6zccrg4nlr27uifeoi

Unilateral Blepharoptosis From Renal Cell Carcinoma

Federico Greco, Lorenzo Sabatino, Francesco Sabatino, Manuele Casale, Carlo Cosimo Quattrocchi, Bruno Beomonte Zobel
2016 Journal of Kidney Cancer and VHL  
<p>Blepharoptosis is the drooping or inferior displacement of the upper eyelid. Blepharoptosis can be either congenital or acquired. Tumour metastasis is one of the acquired causes of blepharoptosis. The lungs, locoregional lymph nodes, bone and liver are the usual sites of metastases of renal cell carcinoma (RCC); however, unusual locations of RCC have also been reported. Herein, we describe a case of a 47-year-old man with unilateral ptosis and blurred vision due to metastatic RCC. We
more » ... the different causes of blepharopstosis, the path that led to the diagnosis, and how RCC can metastasize to unusual anatomical regions such as the orbit. Symptoms such as exophthalmos, lid edema, diplopia, ptosis, cranial nerve paralysis or blurred vision may mime a benign disease; however, they could also be the symptoms of a systemic malignancy.</p>
doi:10.15586/jkcvhl.2016.61 pmid:28326282 pmcid:PMC5345509 fatcat:uz6p7ouo2raudhn5ijkx2c7x2a

Vocal Cord Metastasis From Breast Cancer

Rosario Francesco Grasso, Carlo Cosimo Quattrocchi, Sara Piciucchi, Giuseppe Perrone, Fabrizio Salvinelli, Carla Rabitti, Bruno Beomonte Zobel
2007 Journal of Clinical Oncology  
O.0TY Carla Rabitti, and Bruno Beomonte Zobel Interdisciplinary Center for Biomedical Research, Department of Radiology, Otolaryngology-Head and Neck Surgery and Pathology, Universita Campus Bio- Medico  ... 
doi:10.1200/jco.2007.10.7268 pmid:17470873 fatcat:rsf47y4lrreyfmjkq3gdo3e4ly

Ultrasound Imaging of Cystic Nephroma

Federico Greco, Eliodoro Faiella, Domiziana Santucci, Delia De Lisi, Gianguido Lo Vullo, Bruno Beomonte Zobel, Rosario Francesco Grasso
2017 Journal of Kidney Cancer and VHL  
<p>Cystic nephroma is a rare, benign multicystic lesion of the kidney. This tumor occurs both in children and in adults. In children, it is highly prevalent in males; in adults, it is more frequent in women. The term "cystic nephroma" represents two apparently different entities: pediatric cystic nephroma, a benign form thought to originate from metanephric tissue, and adult cystic nephroma, considered as a lesion of mixed epithelial stromal tumor. The clinical presentation may be a palpable
more » ... s or nonspecific symptoms such as abdominal pain, hematuria, and urinary tract infections. In this review, we summarize the ultrasound imaging features of cystic nephroma and describe the characteristics of the most common renal cystic lesions and the differential diagnosis of cystic nephroma with other renal cystic lesions.</p>
doi:10.15586/jkcvhl.2017.79 pmid:28752022 pmcid:PMC5519771 fatcat:yklpwdtxezc67hafzsacbqxva4

Imaging of Renal Medullary Carcinoma

Federico Greco, Eliodoro Faiella, Domiziana Santucci, Carlo Augusto Mallio, Marco Nezzo, Carlo Cosimo Quattrocchi, Bruno Beomonte Zobel, Rosario Francesco Grasso
2017 Journal of Kidney Cancer and VHL  
<p>Renal medullary carcinoma (RMC) is a rare, highly aggressive tumor recognized as an independent pathological entity. African-descent adolescents and young adults with sickle cell hemoglobinopathy are the most affected groups. This rare subtype of renal cell carcinoma has its own morphogenetic and pathological characteristics. The major clinical manifestations include gross hematuria, abdominal or flank pain, and weight loss. The prognosis is very poor, with 95% of cases diagnosed at an
more » ... ed stage of the disease. In this review, we summarize the morphologic and dynamic characteristics of RMC under various imaging modalities such as ultrasound, computed tomography, and magnetic resonance. Differential diagnosis and management strategies are also discussed.</p>
doi:10.15586/jkcvhl.2017.62 pmid:28405543 pmcid:PMC5364331 fatcat:okqurdekmvetnihveqfnjl5lpe

Portomesenteric Venous System Gas after CT Colonography: A Case Report

Ilaria Sansoni, Claudia Lucia Piccolo, Ilenia Di Giampietro, Matteo Polacco, Bruno Beomonte Zobel
2012 Case Reports in Radiology  
Portomesenteric vein gas can occur owing to a variety of interraleted factors such as loss of mucosal integrity and intraluminal overpressure, and the most common and serious cause is bowel ischemia, which requires urgent laparotomy. Nevertheless, when portal venous gas is caused by nonischemic causes, surgery is not required and it can be treated conservatively. So, its features should be carefully evaluated at CT scan, together with clinical findings. The authors report a case of an old male
more » ... ith portomesenteric venous system gas after CT colonography, without evidence of pneumatosis intestinalis or colonic perforation. A CT scan without enema was required after 24 hours in absence of worsened patient conditions, revealing the disappearance of gas in mesenteric vein and in the portal venous system.
doi:10.1155/2012/420901 pmid:23050186 pmcid:PMC3461289 fatcat:ezqfhqllb5cvfnfmnkg6cwljpq

Diffuse Alveolar Hemorrhage After Leflunomide Therapy in a Patient With Rheumatoid Arthritis

Angelo Carloni, Sara Piciucchi, Kostantinos Giannakakis, Gianrenato Nori, Bruno Beomonte Zobel, Venerino Poletti
2008 Journal of thoracic imaging  
We report the case of a young man, affected by rheumatoid arthritis who developed a rapid-onset shortof-breath, hemoptysis, and severe weakness, about 2 weeks after the administration of leflunomide. Chest radiography showed central bilateral opacities and pleural effusion as confirmed by the high-resolution computed tomography that demonstrated diffuse ground-glass and interlobular septal thickening as well. On admission at the Emergency Department, a microhematuria and a severe anemia were
more » ... o documented. On the basis of the clinico-radiologic presentation, a pulmonary hemorrhage was likely to occur; so to clarify the origin of this process, a complete serologic examination was performed but all the antibodies were negative. Finally a renal biopsy was performed and it showed a pauci-immunologic glomerulonephritis and the bronchioloalveolar lavage confirmed the diffuse alveolar hemorrhage. In conclusion, the diagnosis of leflunomide-pulmonary-renal syndrome was rendered. The treatment with leflunomide was suspended; the conditions of the patient gradually improved and he became completely asymptomatic 1 week later.
doi:10.1097/rti.0b013e3181598d40 pmid:18347524 fatcat:gwchhke6tnf57nwystm35rr6ue

Gender-based differences of abdominal adipose tissue distribution in non-small cell lung cancer patients

Carlo Augusto Mallio, Federico Greco, Giuseppina Pacella, Emiliano Schena, Bruno Beomonte Zobel
2018 Shanghai Chest  
Lung cancer is a malignant tumor with high lethality, responsible for about 28% of all cancer deaths. In this study, using a quantitative CT imaging-based approach, we aimed to investigate the differences of abdominal adipose tissue distribution in patients with non-small cell lung cancer (NSCLC) according to gender. Methods: A group of 66 patients with NSCLC at first diagnosis [male: 45, mean age: 67.3 years (range, 51.0-88.0 years); female: 21, mean age: 62.4 years (range, 44.0-84.0 years)]
more » ... s included. As a control group, 70 patients without history of malignancies who have undergone a chest-abdomen CT for pre-operative cardiovascular surgery planning [male: 42, mean age: 62.7 years (range, 40.0-83.0 years); female: 28, mean age: 66.4 years (range, 39.0-83.0 years)] was included. We calculated total adipose area (TAA), visceral adipose area (VAA) and subcutaneous adipose area (SAA) using OsiriX to analyze cross-sectional CT images. The differences were analyzed using the Student's t-test (P<0.05). The Pearson's correlation coefficient (r) and the significance of the simple regressions (ρ) were calculated. Results: In the female group, the visceral/subcutaneous (V/S) ratio was higher in the control group than in patients. Conversely, in the male group we found a higher V/S ratio in patients then controls. Considering male and female together, the age parameter showed a significant positive correlation with the amount of visceral (r=0.390; P=0.001) and total (r=0.270; P=0.030) fat in the patients. Dividing the groups between male and female, the age parameter showed a significant positive correlation with the amount of visceral fat in the female patients (r=0.440; P=0.049), visceral fat in the male patients (r=0.320; P=0.030), subcutaneous fat in the female patients (r=0.480; P=0.030) and total fat in the female patients (r=0.490; P=0.020). Conclusions: The results of this study are in line with the concept of differential gender-based relationships among abdominal fat distribution, age and NSCLC.
doi:10.21037/shc.2018.03.03 fatcat:kvfzokdidfba7hyc7vvbp4ziwq

Different Treatments of Symptomatic Angiomyolipomas of the Kidney

Giuseppina Pacella, Eliodoro Faiella, Carlo Altomare, Flavio Andresciani, Gennaro Castiello, Caterina Bernetti, Bruno Beomonte Zobel, Rosario Francesco Grasso
2021 Journal of Kidney Cancer and VHL  
Development of more sensitive imaging techniques has caused an increase in the number of diagnosed small renal tumors. Approximately 2–3% of these lesions are proved to be angiomyolipomas (AML), a rare benign tumor of the kidney sometimes causing pain and hematuria. The most required approach is observation, but in the case of recurrent symptoms or larger tumors, which may cause bleeding, a more active treatment is required. We present two cases of symptomatic AML tumors of different sizes in
more » ... e kidney: one treated with transarterial embolization (TAE), and the other with percutaneous cryoablation (CRA). The lesions were diagnosed on the basis of contrast-enhanced computed tomography (CT) scan and magnetic resonance imaging (MRI). Both treatments proved to be effective and safe for treating renal AMLs. A follow-up carried out, based on contrast-enhanced CT scan, confirmed complete treatment of AML and decreased lesion size. There are myriad minimally invasive approaches for the treatment of renal AMLs, and the preservation of renal function remains a priority. The most popular treatment option is the selective renal artery embolization. Owing to its limited invasiveness, CRA could be an attractive option for the preventive treatment of AML.
doi:10.15586/jkcvhl.v8i4.181 pmid:34722129 pmcid:PMC8532053 fatcat:mabkwr2onfh7foloq3uthg7v4m

Brain microischemic phenomena in a woman receiving bevacizumab treatment: a case report

Carlo C Quattrocchi, Andrea M Alexandre, Giuseppe Tonini, Yuri Errante, Rosario F Grasso, Bruno Beomonte Zobel
2011 Journal of Medical Case Reports  
Several adverse events have been associated with the use of bevacizumab during the treatment of neoplasms such as colorectal cancer, breast cancer, non-small cell lung cancer, pancreatic cancer and renal cell carcinoma. The present case demonstrates how focal neurological symptoms lead to the magnetic resonance imaging-based differential diagnosis between focal parenchymal metastases and microischemic phenomena, with crucial implications for patient management. Case presentation: We describe
more » ... case of a 37-year-old Italian Caucasian woman with metastatic colon cancer who developed focal neurological symptoms during a chemotherapy regimen involving the use of bevacizumab. Brain magnetic resonance imaging examination revealed millimetric lesions with restricted diffusion without perilesional edema or contrast enhancement after gadodiamide intravenous injection, suggestive of acute microischemic phenomena. This complication is very rare but clinically significant. Conclusion: The differential diagnosis in patients with cancer undergoing bevacizumab treatment should include microischemic phenomena.
doi:10.1186/1752-1947-5-84 pmid:21352580 pmcid:PMC3058088 fatcat:ebozb2asd5ajnne4i53vuwinhm

Treatment of Early-Stage Pressure Ulcers by Using Autologous Adipose Tissue Grafts

Giovanni Francesco Marangi, Tiziano Pallara, Barbara Cagli, Emiliano Schena, Francesco Giurazza, Elio Faiella, Bruno Beomonte Zobel, Paolo Persichetti
2014 Plastic Surgery International  
Assessing pressure ulcers (PUs) in early stages allows patients to receive safer treatment. Up to now, in addition to clinical evaluation, ultrasonography seems to be the most suitable technique to achieve this goal. Several treatments are applied to prevent ulcer progression but none of them is totally effective. Furthermore, the in-depth knowledge of fat regenerative properties has led to a wide use of it. With this study the authors aim at introducing a new approach to cure and prevent the
more » ... rsening of early-stage PUs by using fat grafts. The authors selected 42 patients who showed clinical and ultrasonographic evidence of early-stage PUs. Values of skin thickness, fascial integrity, and subcutaneous vascularity were recorded both on the PU area and the healthy trochanteric one, used as control region. Fat grafting was performed on all patients. At three months, abnormal ultrasonographic findings, such as reduction of cutaneous and subcutaneous thickness, discontinuous fascia, and decrease in subcutaneous vascularity, all were modified with respect to almost all the corresponding parameters of the control region. Results highlight that the use of fat grafts proved to be an effective treatment for early-stage PUs, especially in the care of neurological and chronic bedridden patients.
doi:10.1155/2014/817283 pmid:24818019 pmcid:PMC4003771 fatcat:ztp6ofhbprembdmyu4xspqkm34

Computed Tomography Imaging in Lemmel Syndrome A Report of Two Cases

Giulia Frauenfelder, Annamaria Maraziti, Vincenzo Ciccone, Giuliano Maraziti, Oliviero Caleo, Francesco Giurazza, Bruno Beomonte Zobel, Mattia Carbone
2019 Journal of Clinical Imaging Science  
Lemmel syndrome is a rare and misdiagnosed cause of acute abdominal pain due to a juxtapapillary duodenal diverticulum causing mechanical obstruction of the common bile duct. Frequently, patients suffering from Lemmel syndrome have a history of recurrent access to the emergency room for acute abdominal pain referable to a biliopancreatic obstruction, in the absence of lithiasis nuclei or solid lesions at radiological examinations. Ultrasonography (US) may be helpful in evaluation of upstream
more » ... atation of extra-/intra-hepatic biliary duct, but computed tomography (CT) is the reference imaging modality for the diagnosis of periampullary duodenal diverticula compressing the intrapancreatic portion of the common bile duct. Recognition of this entity is crucial for targeted, timely therapy avoiding mismanagement and therapeutic delay. The aim of this paper is to report CT imaging findings and our experience in two patients affected by Lemmel syndrome.
doi:10.25259/jcis-17-2019 pmid:31448174 pmcid:PMC6702893 fatcat:ld7zm7ejdrepbo4itzu74vpixi
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