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Broadband Local Field Potentials Correlate with Spontaneous Fluctuations in Functional Magnetic Resonance Imaging Signals in the Rat Somatosensory Cortex Under Isoflurane Anesthesia

Wen-Ju Pan, Garth Thompson, Matthew Magnuson, Waqas Majeed, Dieter Jaeger, Shella Keilholz
2011 Brain Connectivity  
Results show that low-frequency blood oxygen level-dependent (BOLD) fluctuations (< 0.1 Hz) correlate significantly with slow power modulations ( < 0.1 Hz) of local field potentials (LFPs) in a broad frequency  ...  Resting-state functional magnetic resonance imaging (fMRI) is widely used for exploring spontaneous brain activity and large-scale networks; however, the neural processes underlying the observed resting-state  ...  Acknowledgment The work was supported by NIH R21NS057718-01. Author Disclosure Statement No competing financial interests exist.  ... 
doi:10.1089/brain.2011.0014 pmid:22433008 pmcid:PMC3621847 fatcat:ozbs4hrmmvgndgj6zd75zaapji

Functional connectivity in blood oxygenation level-dependent and cerebral blood volume-weighted resting state functional magnetic resonance imaging in the rat brain

Matthew Magnuson, Waqas Majeed, Shella D. Keilholz
2010 Journal of Magnetic Resonance Imaging  
Further experiments should address the relationship between spontaneous neural activity, local changes in metabolism, and hemodynamic fluctuations to elucidate the origins of the BOLD and CBV signals.  ...  Purpose-To directly compare functional connectivity and spatiotemporal dynamics acquired with BOLD and CBV-weighted fMRI in anesthetized rats.  ...  Acknowledgments We would like to thank the NIH (NIH T32EB005969 and NIH 1R21NS057718-01) for supporting Matthew Magnuson throughout the duration of this work.  ... 
doi:10.1002/jmri.22295 pmid:20815055 pmcid:PMC2936716 fatcat:4m4jelfsjzeg3dhwsktru36qpe

Effects of severing the corpus callosum on electrical and BOLD functional connectivity and spontaneous dynamic activity in the rat brain

Matthew E Magnuson, Garth John Thompson, Wen-Ju Pan, Shella Dawn Keilholz
2013 Brain Connectivity  
Results indicated a significant reduction in interhemispheric connectivity in the full callosotomy group as compared with the sham group in primary somatosensory cortex and caudate-putamen regions.  ...  This work represents a robust finding indicating the corpus callosum's influence on maintaining integrity in bilateral functional networks; further, functional magnetic resonance imaging (fMRI) and electrophysiological  ...  We would also like to thank the NIH for two primary funding sources used to fund the research presented in this article (R21NS057718 and T32EB005969).  ... 
doi:10.1089/brain.2013.0167 pmid:24117343 pmcid:PMC3931437 fatcat:sfgtny7wl5g25cdgr4z4sal3em

The Neural Basis of Time-Varying Resting-State Functional Connectivity

Shella Dawn Keilholz
2014 Brain Connectivity  
Dynamic network analysis based on resting-state magnetic resonance imaging (rsMRI) is a fairly new and potentially powerful tool for neuroscience and clinical research.  ...  However, the appearance of time-varying connectivity can also arise in signals that share no temporal information, complicating the interpretation of dynamic functional connectivity studies.  ...  with spontaneous BOLD fluctuations Pan et al. (2011) Rat Isoflurane anesthesia LFP Voxel-by-voxel correlation with LFP, seed-based correlation Broadband LFP power correlation with local BOLD  ... 
doi:10.1089/brain.2014.0250 pmid:24975024 pmcid:PMC4268576 fatcat:inzw42pkvva4ndor2du65fm3vu

Functional Connectivity of the Brain Across Rodents and Humans

Nan Xu, Theodore J. LaGrow, Nmachi Anumba, Azalea Lee, Xiaodi Zhang, Behnaz Yousefi, Yasmine Bassil, Gloria P. Clavijo, Vahid Khalilzad Sharghi, Eric Maltbie, Lisa Meyer-Baese, Maysam Nezafati (+2 others)
2022 Frontiers in Neuroscience  
Resting-state functional magnetic resonance imaging (rs-fMRI), which measures the spontaneous fluctuations in the blood oxygen level-dependent (BOLD) signal, is increasingly utilized for the investigation  ...  Rodents, as a typical animal model in neuroscience, play an important role in the studies that examine the neuronal processes that underpin the spontaneous fluctuations in the BOLD signal and the functional  ...  are linked to the time points with high local field potential broadband power.  ... 
doi:10.3389/fnins.2022.816331 pmid:35350561 pmcid:PMC8957796 fatcat:kkfqmlxlyncbzinrgrqtu6p4ia

Quasi-periodic patterns (QPP): Large-scale dynamics in resting state fMRI that correlate with local infraslow electrical activity

Garth John Thompson, Wen-Ju Pan, Matthew Evan Magnuson, Dieter Jaeger, Shella Dawn Keilholz
2014 NeuroImage  
Recent work in anesthetized rats has shown that the spontaneous BOLD fluctuations are tightly linked to infraslow local field potentials (LFPs) that are seldom recorded but comparable in frequency to the  ...  Functional connectivity measurements from resting state blood-oxygen level dependent (BOLD) functional magnetic resonance imaging (fMRI) are proving a powerful tool to probe both normal brain function  ...  Acknowledgments The authors would like to thank Josh Grooms, Alessio Medda, Jeremy Edgerton, Collin Lobb, Mac Merritt and Martha Willis for their valuable help and suggestions.  ... 
doi:10.1016/j.neuroimage.2013.09.029 pmid:24071524 pmcid:PMC3869452 fatcat:2iymlihgv5b7rb2744n4gfu6de

Functional Connectivity of the Brain Across Rodents and Humans [article]

Nan Xu, Theodore J. LaGrow, Nmachi Anumba, Azalea Lee, Xiaodi Zhang, Behnaz Yousefi, Yasmine Bassil, Gloria Perrin Clavijo, Vahid Khalilzad Sharghi, Eric Maltbie, Lisa Meyer-Baese, Maysam Nezafati (+2 others)
2022 arXiv   pre-print
Resting-state functional magnetic resonance imaging (rs-fMRI), which measures the spontaneous fluctuations in the blood oxygen level-dependent (BOLD) signal, is increasingly utilized for the investigation  ...  Rodents, as a typical animal model in neuroscience, play an important role in the studies that examine the neuronal processes that underpin the spontaneous fluctuations in the BOLD signal and the functional  ...  TJL would like to thank the financial support from the George R. Riley Fellowship.  ... 
arXiv:2111.05912v5 fatcat:6vqseyf5qvgdjdbhy5esnpjrse

Gastric stimulation drives fast BOLD responses of neural origin

Jiayue Cao, Kun-Han Lu, Steven T. Oleson, Robert J. Phillips, Deborah Jaffey, Christina L. Hendren, Terry L. Powley, Zhongming Liu
2019 NeuroImage  
Functional magnetic resonance imaging (fMRI) is commonly thought to be too slow to capture any neural dynamics faster than 0.1 Hz.  ...  Local field potentials recorded during the same gastric stimuli revealed transient and phase-locked broadband neural responses, preceding the fMRI responses by as short as 0.5 s.  ...  Acknowledgements: The authors thank Prof. Mark Sayles for his initial assistance in electrophysiological recording.  ... 
doi:10.1016/j.neuroimage.2019.04.064 pmid:31029867 pmcid:PMC6594550 fatcat:6dx4c3ir35fnrigk6ddtklm66u

Layer-specific interhemispheric functional connectivity in the somatosensory cortex of rats: resting state electrophysiology and fMRI studies

Kwangyeol Baek, Woo Hyun Shim, Jaeseung Jeong, Harsha Radhakrishnan, Bruce R. Rosen, David Boas, Maria Franceschini, Bharat B. Biswal, Young R. Kim
2015 Brain Structure and Function  
The spontaneous cerebral hemodynamic fluctuations observed during the resting state have been frequently visualized using functional magnetic resonance imaging (rsfMRI).  ...  We investigated the characteristics of bihemispheric functional connectivity via electrophysiology and rsfMRI in the primary sensory cortex of rats anesthetized by a-chloralose.  ...  Delta and broadband (1-100 Hz) power modulation was found to be correlated with rsfMRI signals of rats under isoflurane anesthesia (Pan et al. 2010 (Pan et al. , 2011 .  ... 
doi:10.1007/s00429-015-1073-0 pmid:26077581 pmcid:PMC4681693 fatcat:f6ovcrie6fbz3brpv4d5xwvzxe

The Relationship Between Local Field Potentials and the Blood-Oxygenation-Level Dependent MRI Signal Can Be Non-linear

Xiaodi Zhang, Wen-Ju Pan, Shella Keilholz
2019 Frontiers in Neuroscience  
Functional magnetic resonance imaging (fMRI) is currently one of the most important neuroimaging methods in neuroscience.  ...  Simultaneous local field potential (LFP) and fMRI recordings provide a method to study neurovascular coupling.  ...  The authors would like to thank Chinese Scholarship Council (CSC) for financial support and Center for Systems Imaging Core.  ... 
doi:10.3389/fnins.2019.01126 pmid:31708727 pmcid:PMC6823197 fatcat:ygvfsvygfrdundeawls6y636ia

Task-Induced Modulation of Intrinsic Functional Connectivity Networks in the Behaving Rat

J. Li, S. Martin, M. D. Tricklebank, A. J. Schwarz, G. Gilmour
2015 Journal of Neuroscience  
Rats were implanted with CPEs in two nodes of the default mode network (DMN) and two nodes in a lateral cortical network, revealing amperometric oxygen correlation patterns consistent with imaging studies  ...  While resting-state functional magnetic resonance imaging can probe intrinsic network connectivity in both human and rodent brain, behavioral modulation of these connectivity patterns has not yet been  ...  Introduction Correlated low-frequency oscillations in the blood oxygen (O 2 ) level-dependent (BOLD) resting-state functional magnetic resonance imaging (rsfMRI) signal are now an established means of  ... 
doi:10.1523/jneurosci.3488-14.2015 pmid:25589760 fatcat:a3kef5qlffcwtagurmllgnlywa

Cerebral functional connectivity and Mayer waves in mice: Phenomena and separability

Jonathan R Bumstead, Adam Q Bauer, Patrick W Wright, Joseph P Culver
2016 Journal of Cerebral Blood Flow and Metabolism  
In this study, we analyze spontaneous hemodynamic fluctuations over the mouse cortex using optical intrinsic signal imaging.  ...  We found spontaneous occurrence of oscillatory hemodynamics $0.2 Hz consistent with the properties of Mayer waves reported in the literature.  ...  Acknowledgements The authors would like to thank Dr. Ben Palanca, Dr. Abraham Z. Snyder, and Dr. Beau M. Ances for fruitful discussion.  ... 
doi:10.1177/0271678x16629977 pmid:26868180 pmcid:PMC5381445 fatcat:r4lbvtsouvds5fi6ococ57fywu

Anesthesia differentially modulates spontaneous network dynamics by cortical area and layer

Kristin K. Sellers, Davis V. Bennett, Axel Hutt, Flavio Fröhlich
2013 Journal of Neurophysiology  
To address this gap in knowledge, we recorded spontaneous mesoscopic (local field potential) and microscopic (multiunit activity) network dynamics in primary visual cortex (V1) and prefrontal cortex (PFC  ...  In contrast, anesthesia profoundly altered spectral power in PFC, with more uniform modulation across cortical layers.  ...  Jennifer Bizley for invaluable insight on recording in awake ferrets and the members of the Fröhlich lab for support, particularly Michael Boyle, Steve Schmidt, Stephanie Belhorn, and Helen Powell.  ... 
doi:10.1152/jn.00404.2013 pmid:24047911 fatcat:4tdflcexkzdltja7lib5mbo4cm

The Relationship between BOLD and Neural Activity Arises from Temporally Sparse Events [article]

Xiaodi Zhang, Wen-Ju Pan, Shella Keilholz
2019 bioRxiv   pre-print
Resting state functional magnetic resonance (rs-fMRI) imaging offers insights into how different brain regions are connected into functional networks.  ...  To provide more direct evidence that the neuronal co-activation events produce the time-varying network patterns seen in rs-fMRI studies, we examined the simultaneous rs-fMRI and local field potential  ...  The authors would like to thank Chinese Scholarship Council (CSC) for financial support.  ... 
doi:10.1101/644419 fatcat:a3ldhuydxfhcnezdf4fredgake

Distinct structure-function relationships across cortical regions and connectivity scales in the rat brain [article]

Milou Straathof, Michel R.T. Sinke, Theresia J.M. Roelofs, Erwin L.A. Blezer, R. Angela Sarabdjitsingh, Annette van der Toorn, Oliver Schmitt, Willem M. Otte, Rick M. Dijkhuizen
2019 bioRxiv   pre-print
depiction of the structure-function relationship in the rat brain.  ...  Our main goal was to identify to what extent structural and functional connectivity strengths are correlated, macro- and meso-scopically, across the cortex.  ...  Broadband Local Field Potentials Correlate with Spontaneous Fluctuations in All rights reserved. No reuse allowed without permission.  ... 
doi:10.1101/742833 fatcat:rwquezu4urh2jlutlwe76ehv5i
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