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Wilkerson and Brian L. Scott S1. ... Related literature For related literature, see: Hall et al. (1966) ; Watkin et al. (1991) ; Wilkerson et al. (2004) ; Wilkerson et al. (2007) ; Bean et al. (2004 Bean et al. ( , 2005 ; Grenthe et ...doi:10.1107/s1600536807066354 pmid:21200455 pmcid:PMC2914883 fatcat:326wlh2qlrgcziew2r4tjtnynu
Haskell Indian Nations University is the sole 4-year intertribal university in America and their athletics department is called The Fightin' Indians. Their logo and name seem to contradict most of the research describing the negative impacts of Native imagery. Interviews were conducted with current students at Haskell University to understand their feelings towards Native imagery overall. When exploring the usage of Native imagery by Haskell it was apparent the students felt as an all-Nativedoi:10.17161/jas.v7i2.14806 fatcat:thaftcwxgffrbfvtmpnasypebu
more »... titution there was a sense of ownership to utilize the imagery but were aware it misrepresented some Native people. The students also discussed how their imagery may influence outsiders' perspectives. This study helps us understand a unique situation and should lead to future research around Native American imagery in sport.
doi:10.15171/hpp.2017.32 pmid:29085793 pmcid:PMC5647351 fatcat:xpq365v7irayngui3fjhesghiy
Mark Ballard was a major contributor to the initia1 language design and along with Brian Wilkerson built the first experimental implementation. ...doi:10.1145/62083.62095 dblp:conf/oopsla/Wirfs-BrockW88 fatcat:kh5wrtgohfhprn2i6bhmbe4moi
Parasites & Vectors
Background Some of the most important malaria vectors in South America belong to the Albitarsis Complex (Culicidae; Anophelinae; Anopheles). Understanding the origin, nature, and geographical distribution of species diversity in this important complex has important implications for vector incrimination, control, and management, and for modelling future responses to climate change, deforestation, and human population expansion. This study attempts to further explore species diversity anddoi:10.1186/s13071-021-05090-w pmid:34838107 pmcid:PMC8627034 fatcat:itesnkqryfby5fso3nywiu4qjm
more »... nary history in the Albitarsis Complex by undertaking a characterization and phylogenetic analysis of the mitogenome of all 10 putative taxa in the Albitarsis Complex. Methods Mitogenome assembly and annotation allowed for feature comparison among Albitarsis Complex and Anopheles species. Selection analysis was conducted across all 13 protein-coding genes. Maximum likelihood and Bayesian inference methods were used to construct gene and species trees, respectively. Bayesian methods were also used to jointly estimate species delimitation and species trees. Results Gene composition and order were conserved across species within the complex. Unique signatures of positive selection were detected in two species—Anopheles janconnae and An. albitarsis G—which may have played a role in the recent and rapid diversification of the complex. The COI gene phylogeny does not fully recover the mitogenome phylogeny, and a multispecies coalescent-based phylogeny shows that considerable uncertainty exists through much of the mitogenome species tree. The origin of divergence in the complex dates to the Pliocene/Pleistocene boundary, and divergence within the distinct northern South American clade is estimated at approximately 1 million years ago. Neither the phylogenetic trees nor the delimitation approach rejected the 10-species hypothesis, although the analyses could not exclude the possibility that four putative species with scant a priori support (An. albitarsis G, An. albitarsis H, An. albitarsis I, and An. albitarsis J), represent population-level, rather than species-level, splits. Conclusion The lack of resolution in much of the species tree and the limitations of the delimitation analysis warrant future studies on the complex using genome-wide data and the inclusion of additional specimens, particularly from two putative species, An. albitarsis I and An. albitarsis J. Graphical Abstract
Characterization of the chemical speciation and morphologies of products formed from hydrolysis of uranium hexafluoride (UF 6 ) is important for predicting dispersion and contamination of released material, or health consequences from inhalation of air-borne particles. We report products of hydrolysis of UF 6 in which the quantity of water was insufficient for complete formation of UO 2 F 2 . Material was deposited onto carbon tape and aluminum. Scanning Electron Microscopy was employed todoi:10.1016/j.jfluchem.2015.07.004 fatcat:jqfqf2v7ezcbxkwpihtx76yuma
more »... cterize textures and particle sizes, and powder X-ray diffraction analysis and μ-Fourier Transform Infrared Absorption spectroscopy were used to characterize chemical speciation. These results revealed that the ratio of H 2 O to UF 6, depository substrate composition, and storage conditions must be considered when evaluating chemical speciation, morphologic textures and particles size of UF 6 hydrolysis products. LA-UR-15-23846.
Brian Lee, PharmD is the principle and Medical Director of Horizon CME, Inc., a medical education company that develops continuing education programs for health care professionals. ... Cara Williams, PharmD and Elizabeth Wilkerson are employees of Horizon CME, Inc., a medical education company that develops continuing Steven Haimowitz, MD is the Chief Executive Officer of RealCME, an ...doi:10.1007/s13300-016-0176-9 pmid:27272527 pmcid:PMC5014783 fatcat:p7z5bsn37zd4tahhf5fjk6itra
We describe the construction of a high-resolution radiation hybrid (RH) map of the domestic cat genome, which includes 2662 markers, translating to an estimated average intermarker distance of 939 kilobases (kb). Targeted marker selection utilized the recent feline 1.9x genome assembly, concentrating on regions of low marker density on feline autosomes and the X chromosome, in addition to regions flanking interspecies chromosomal breakpoints. Average gap (breakpoint) size between cat-humandoi:10.1016/j.ygeno.2008.09.010 pmid:18951970 pmcid:PMC2656592 fatcat:uxkiauyeibc5rbrei6a24jbgya
more »... ed conserved segments is less than 900 kb. The map was used for a fine-scale comparison of conserved syntenic blocks with the human and canine genomes. Corroborative fluorescence in situ hybridization (FISH) data were generated using 129 domestic cat BAC clones as probes, providing independent confirmation of the long-range correctness of the map. Cross-species hybridization of BAC probes on divergent felids from the genera Profelis (serval) and Panthera (snow leopard) provides further evidence for karyotypic conservation within felids, and demonstrates the utility of such probes for future studies of chromosome evolution within the cat family and in related carnivores. The integrated map constitutes a comprehensive framework for identifying genes controlling feline phenotypes of interest, and to aid in assembly of a higher coverage feline genome sequence.
Cell growth and differentiation are controlled by growth factor receptors coupled to the GTPase Ras. Oncogenic mutations disrupt GTPase activity, leading to persistent Ras signaling and cancer progression. Recent evidence indicates that monoubiquitination of Ras leads to Ras activation. Mutation of the primary site of monoubiquitination impairs the ability of activated K-Ras (one of the three mammalian isoforms of Ras) to promote tumor growth. To determine the mechanism of human Ras activation,doi:10.1038/nsmb.2430 pmid:23178454 pmcid:PMC3537887 fatcat:k5sl4elbpvcprejkgvamdlchie
more »... we chemically ubiquitinated the protein and analyzed its function by NMR, computational modeling and biochemical activity measurements. We established that monoubiquitination has little effect on the binding of Ras to guanine nucleotide, GTP hydrolysis or exchange-factor activation but severely abrogates the response to GTPase-activating proteins in a site-specific manner. These findings reveal a new mechanism by which Ras can trigger persistent signaling in the absence of receptor activation or an oncogenic mutation.
Wilkerson-Jerde, Wagh & Wilensky (Under Review) argue that modifiable computational simulation construction kits that accomodate a group's emergent goals and shared understandings can better support productive ... Krajcik, & Soloway, 1998; Schwartz & White, 2005) , and explore the causal aspects of the phenomena under study (Blikstein & Wilensky, 2009; Papert, 1996; Sherin, 2001; Sherin, diSessa & Hammer, 1993; Wilkerson-Jerde ...doi:10.1007/s10956-014-9497-5 fatcat:aurebw4wmfbjrgdidxlm34v554
Introduction Chronic insomnia is a common and debilitating disease that increases risk for significant morbidity and workplace difficulties. Cognitive behavioral therapy for insomnia (CBT-I) is the first-line treatment, but there is a critical lack of behavioral health providers trained in CBT-I because, in part, of a bottleneck in training availability and costs. The current project developed and evaluated a web-based provider training course for CBT-I: CBTIweb.org. Materials and Methodsdoi:10.1093/milmed/usaa359 pmid:33499510 fatcat:pc5s5e3uabftxp7ftp5z7guyje
more »... t matter experts developed the content for CBTIweb.org. Then, trainees completed alpha testing (n = 24) and focus groups, and the site was improved. Next, licensed behavioral health providers and trainees completed beta testing (n = 41) and the site underwent another round of modifications. Finally, to compare CBTIweb.org to an in-person workshop, licensed behavioral health providers were randomly assigned to CBTIweb.org (n = 21) or an in-person workshop (n = 23). All participants were CBT-I naïve and completed the following assessments: Computer System Usability Questionnaire, Website Usability Satisfaction Questionnaire, Website Content Satisfaction Questionnaire, and Continuing Education knowledge acquisition questionnaires. Results Alpha and beta testers of CBTIweb.org reported high levels of usability and satisfaction with the site and showed significant within-group knowledge acquisition. In the pilot comparison study, linear fixed-effects modeling on the pre-/postquestionnaires revealed a significant main effect for time, indicating a significant increase in knowledge acquisition from 69% correct at baseline to 92% correct at posttraining collapsed across in-person and CBTIweb.org groups. The interaction effect of Time by Condition was nonsignificant, indicating equivalence in knowledge gains across both groups. Conclusion CBTIweb.org appears to be an engaging, interactive, and concise provider training that can be easily navigated by its users and produce significant knowledge gains that are equivalent to traditional in-person workshops. CBTIweb.org will allow for worldwide dissemination of CBT-I to any English-speaking behavioral health providers. Future research will work on translating this training to other languages and extending this web-based platform to the treatment of other sleep disorders (e.g., nightmares) and populations (e.g., pediatric populations with insomnia).
Despite being preventable, more than 15% of all cancer cases in Iran occur in the skin, making them the most commonly diagnosed malignancy in the country. The purpose of this study is to gain an insight into the current skin cancer related knowledge, attitudes, beliefs, and practices among the Iranian population. A systematic computer based literature search was conducted using databases for articles published through April 2017. Research studies included those that measured skin cancer or sundoi:10.1155/2017/4934108 pmid:29348940 pmcid:PMC5733983 fatcat:qpiss553evddzpaakl6sw6ogym
more »... rotection related knowledge, attitudes, beliefs, and behaviors in different Iranian population groups. Exclusion criteria for the articles included (1) irrelevant topics to the review article's aim, (2) articles that focused on the treatment of skin cancers instead of prevention practices, and (3) similar studies conducted on populations not indigenous to Iran. A total of 25 articles that met the eligibility criteria were included in the review. Predominant data were collected via questionnaires. Skin cancer related knowledge varied from low to high across the studies. Moreover, there was a pattern of low perceived skin cancer susceptibility and severity. Overall, there was low usage of sun protection methods among the Iranian population. The findings of this study show that efforts to prevent skin cancer are needed. Education concerning the dangers of sun exposure as well as strategies used to prevent or lower the risk of developing skin cancer should be stressed.
We report the construction of a 1.5-Mb-resolution radiation hybrid map of the domestic cat genome. This new map includes novel microsatellite loci and markers derived from the 2X genome sequence that target previous gaps in the feline-human comparative map. Ninety-six percent of the 1793 cat markers we mapped have identifiable orthologues in the canine and human genome sequences. The updated autosomal and X-chromosome comparative maps identify 152 cat-human and 134 cat-dog homologous syntenydoi:10.1016/j.ygeno.2006.08.007 pmid:16997530 pmcid:PMC3760348 fatcat:67ibvq6kcrh7jfv2wuw3igeabi
more »... cks. Comparative analysis shows the marked change in chromosomal evolution in the canid lineage relative to the felid lineage since divergence from their carnivoran ancestor. The canid lineage has a 30-fold difference in the number of interchromosomal rearrangements relative to felids, while the felid lineage has primarily undergone intrachromosomal rearrangements. We have also refined the pseudoautosomal region and boundary in the cat and show that it is markedly longer than those of human or mouse. This improved RH comparative map provides a useful tool to facilitate positional cloning studies in the feline model. Genomics 89 (2007) 189 -196 www.elsevier.com/locate/ygeno ⁎ Corresponding authors. W.J. Murphy is to be contacted at fax: +1 979 845 9972. M. Menotti-Raymond,
Study of the neutrinoless double beta decay and searches for the manifestation of the neutrino mass in ordinary beta decay are the main sources of information about the absolute neutrino mass scale, and the only practical source of information about the charge conjugation properties of the neutrinos. Thus, these studies have a unique role in the plans for better understanding of the whole fast expanding field of neutrino physics.arXiv:hep-ph/0412300v1 fatcat:wqoxscdz5rc5vojkp2rovpk2ne
Pathogenic mutations in fumarate hydratase (FH) drive hereditary leiomyomatosis and renal cell cancer (HLRCC) and increase the risk of developing uterine leiomyomas (ULMs). An integrated proteogenomic analysis of ULMs from HLRCC (n = 16; FH-mutation confirmed) and non-syndromic (NS) patients (n = 12) identified a significantly higher protein:transcript correlation in HLRCC (R = 0.35) vs. NS ULMs (R = 0.242, MWU p = 0.0015). Co-altered proteins and transcripts (228) included antioxidant responsedoi:10.1038/s41598-021-88585-x pmid:33931688 pmcid:PMC8087684 fatcat:vkvmkaqfqrhh3lwqq5u4udg574
more »... element (ARE) target genes, such as thioredoxin reductase 1 (TXNRD1), and correlated with activation of NRF2-mediated oxidative stress response signaling in HLRCC ULMs. We confirm 185 transcripts previously described as altered between HLRCC and NS ULMs, 51 co-altered at the protein level and several elevated in HLRCC ULMs are involved in regulating cellular metabolism and glycolysis signaling. Furthermore, 367 S-(2-succino)cysteine peptides were identified in HLRCC ULMs, of which sixty were significantly elevated in HLRCC vs. NS ULMs (LogFC = 1.86, MWU p < 0.0001). These results confirm and define novel proteogenomic alterations in uterine leiomyoma tissues collected from HLRCC patients and underscore conserved molecular alterations correlating with inactivation of the FH tumor suppressor gene.
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