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Rain Noise

Brian Donohue, John Pearse
2019 Proceedings of the ICA congress  
In this paper we discuss the requirements of the generic international standard (ISO, BS EN ISO 10140) for testing of sound transmission through sample roofs exposed to simulated rainfall and of lessons learned during a recent test program. The test data forms the basis for calculating in -situ sound levels in rooms beneath the roof and we discuss the differences in sound produced by simulated rain to that of natural rain. The differences in impact velocity and raindrop distribution between
more » ... lated and natural rain are key factors that are not addressed by the Standard. In addition, an optional normalization test using a pane of glass is included, for the explicit comparison of products tested and as quality control for test laboratories, and its results have been incorrectly shown in some manufacturer's publicity material as the basis for calculating room sound levels. The Standard does not specify whether the normalization test should be carried out as a skylight or as glazing but the two tests have different requirements. Being optional and intended for inter-lab comparison suggests that the normalization data should not be released to clients as it is misleading and thus should be excluded from reporting.
doi:10.18154/rwth-conv-239914 fatcat:lpaambe3oncole5ogwsuv57akq

Technology is Changing What's "Fair Use" in Teaching

Linda Howe-Steiger, Brian C. Donohue
2002 Education Policy Analysis Archives  
The Doctrine of Fair Use was established by the courts to exempt certain activities such as teaching and research from the legal requirements of the copyright law. Before the 1976 Revision of the Copyright Act, only two cases were brought against teachers for copyright infringements. In both cases the teachers lost because their extensive copying was found to impact the copyright owner's market for legally published copies. Although the 1976 Act explicitly recognizes the existence of
more » ... Fair Uses, the act makes application of the principle highly situational. Classroom Guidelines attached to the Act make application even more murky and constrained. After 1976 photocopy technology and the advent of the coursepack began a trend towards circumscribing situations in which Fair Use may be applied. Potential impact on a new, lucrative market for sale of rights to copy portions of books and journals appears to dominate contemporary case law. Desktop publishing and Internet and web-based teaching, the authors believe, will further erode traditional applications of Fair Use for educational purposes. They argue that instructors and researchers should assume that there is no Fair Use on the Internet. Guidelines are provided for faculty and others considering dissemination of potentially copyrighted materials to students via digital technologies.
doi:10.14507/epaa.v10n4.2002 fatcat:pfyubahya5bslgjb5hb37kivxu

Failure analysis of an MVR (mechanical vapor recompressor) Impeller

Keith Alexander, Brian Donohue, Troy Feese, Gordon Vanderlinden, Milo Kral
2010 Engineering Failure Analysis  
This article describes the root cause failure analysis of a mechanical vapor recompressor (MVR) impeller used in a dairy processing plant. An impeller blade was thrown during commissioning after approximately 150 h of service. Visual examination of the blade's fracture surface indicated that the crack growth mechanism was fatigue and this was confirmed by scanning electron microscope (SEM) examinations. A detailed investigation was commissioned to determine the source of the oscillatory
more » ... that must have been present to cause fatigue. A vibration analysis indicated large torsional oscillatory stresses, leading to fatigue, were induced by excitation of the 1st and 2nd torsional vibration modes of the MVR impeller and motor system. The excitation was induced by the control system for the motor variable speed drive (VSD).
doi:10.1016/j.engfailanal.2010.03.009 fatcat:d6hwcyxdbneedkrcb7nf25gl5i

Tranquillity mapping in New Zealand national parks – a pilot study

Greg Watts, John Pearse, Ioannis Delikostidis, Johann Kissick, Brian Donohue, Jeff Dalley
2020 Noise Mapping  
AbstractThe tranquillity in national parks worldwide is currently under threat from intrusion of anthropogenic noise of a growing tourism industry and activity related to park management. This was addressed by creating informative tranquillity maps, where perceived tranquillity can be considered a key indicator of soundscape quality in natural areas. Tranquillity of an area can be assessed using TRAPT (Tranquillity Rating Prediction Tool), that has been developed and refined for assessing urban
more » ... green spaces, national parks and wilderness areas in the United Kingdom. The subjective response to helicopter noise levels of a sample group of 35 people representing the general New Zealand population was obtained, based on visual and audio stimuli that were collected in Aoraki/Mt Cook National Park. These results were used to produce a revised TRAPT equation. It was discovered that levels under 32 dBA correspond to an excellent level of tranquillity. This threshold was used to produce a noise level exposure calculation for two national parks using noise prediction model AEDT (Aviation Environmental Development Tool). Contours representing tranquillity duration were then calculated and plotted, to serve as a planning tool for use by the Department of Conservation. A similar approach could be used for other national parks worldwide.
doi:10.1515/noise-2020-0025 fatcat:kcxpvpx3iraofn24ea4ltw2y2y

Continuous Femoral Nerve Blocks

Brian M. Ilfeld, Vanessa J. Loland, NavParkash S. Sandhu, Preetham J. Suresh, Michael J. Bishop, Michael C. Donohue, Eliza J. Ferguson, Sarah J. Madison
2012 Anesthesia and Analgesia  
BACKGROUND: During a continuous femoral nerve block, the influence of catheter tip position relative to the femoral nerve on infusion characteristics remains unknown. METHODS: We inserted bilateral femoral perineural catheters in volunteers (ultrasound-guided, needle in-plane). Subjects' dominant side was randomized to have the catheter tip placed either anterior or posterior to the femoral nerve. The contralateral limb received the alternative position. Ropivacaine 0.1% was administered
more » ... both catheters concurrently for 6 hours (4 mL/h). Outcome measures included the maximum voluntary isometric contraction (MVIC) of the quadriceps femoris muscle and tolerance to cutaneous electrical current over to the distal quadriceps tendon. Measurements were performed at hour 0 (baseline), and on the hour until hour 9, as well as hour 22. The primary end point was the MVIC of the quadriceps at hour 6. RESULTS: As a percentage of the baseline measurement, quadriceps MVIC for limbs with anterior (n ϭ 16) and posterior (n ϭ 16) catheter tip placement did not differ to a statistically significant degree at hour 6 (mean [SD] 29% [26] vs 30% [28], respectively; 95% confidence interval: Ϫ22% to 20%; P ϭ 0.931), or at any other time point. However, the maximum tolerance to cutaneous electrical current was higher in limbs with anterior compared with posterior catheter tip placement at hour 6 (20 [23] mA vs 6 [4] mA, respectively; 95% confidence interval: 1-27 mA; P ϭ 0.035), as well as at hours 1, 7, 8, and 9 (P Ͻ 0.04). CONCLUSIONS: This study documents the significant (70%-80%) quadriceps femoris weakness induced by a continuous femoral nerve block infusion at a relatively low dose of ropivacaine (4 mg/h) delivered through a perineural catheter located both anterior and posterior to the femoral nerve. In contrast, an anterior placement increases cutaneous sensory block compared with a posterior insertion, without a concurrent relative increase in motor block. (Anesth Analg 2012; 115:721-7)
doi:10.1213/ane.0b013e318261f326 pmid:22745116 pmcid:PMC3425725 fatcat:ow74iannjnehpjcslpvlakn23q

Nutrient enrichment alters the consequences of species loss

Nessa E. O'Connor, Matthew E. S. Bracken, Tasman P. Crowe, Ian Donohue, Brian Silliman
2015 Journal of Ecology  
doi:10.1111/1365-2745.12415 fatcat:eawjwahwmzanjjp2soprdzvhxy

Continuous Peripheral Nerve Blocks

Brian M. Ilfeld, Lisa K. Moeller, Edward R. Mariano, Vanessa J. Loland, Jennifer E. Stevens-Lapsley, Adam S. Fleisher, Paul J. Girard, Michael C. Donohue, Eliza J. Ferguson, Scott T. Ball
2010 Anesthesiology  
,25 With an SD of each group of 17 (based on unpublished data, Brian Ilfeld, M.D., M.S., San Diego, California, March 2008) and assuming a two-sided type I error protection of 0.05 and a power of 0.80  ... 
doi:10.1097/aln.0b013e3181ca4e5d pmid:20098137 fatcat:tg42os5nejakxdfv7jarw7rgqi

Continuous Femoral Nerve Blocks

Matthew T. Charous, Sarah J. Madison, Preetham J. Suresh, NavParkash S. Sandhu, Vanessa J. Loland, Edward R. Mariano, Michael C. Donohue, Pascual H. Dutton, Eliza J. Ferguson, Brian M. Ilfeld
2011 Anesthesiology  
Whether the method of local anesthetic administration for continuous femoral nerve blocks-basal infusion versus repeated hourly bolus doses-influences block effects remains unknown. Methods: Bilateral femoral perineural catheters were inserted in volunteers (n ϭ 11). Ropivacaine 0.1% was concurrently administered through both catheters: a 6-h continuous 5 ml/h basal infusion on one side and 6 hourly bolus doses on the contralateral side. The primary endpoint was the maximum voluntary isometric
more » ... ontraction (MVIC) of the quadriceps femoris muscle at hour 6. Secondary endpoints included quadriceps MVIC at other time points, hip adductor MVIC, and cutaneous sensation 2 cm medial to the distal quadriceps tendon in the 22 h after initiation of local anesthetic administration. Results: Quadriceps MVIC for limbs receiving 0.1% ropivacaine as a basal infusion declined by a mean (SD) of 84% (19) compared with 83% (24) for those receiving 0.1% ropivacaine as repeated bolus doses between baseline and hour 6 (paired t test P ϭ 0.91). Intrasubject comparisons (left vs. right) also reflected a lack of difference: the mean basal-bolus difference in quadriceps MVIC at hour 6 was Ϫ1.1% (95% CI Ϫ22.0 -19.8%). The similarity did not reach the a priori threshold for concluding equivalence, which was the 95% CI decreasing within Ϯ 20%. There were similar minimal differences in the secondary endpoints during local anesthetic administration. Conclusions: This study did not find evidence to support the hypothesis that varying the method of local anesthetic administration-basal infusion versus repeated bolus doses-influences continuous femoral nerve block effects to a clinically significant degree. A CONTINUOUS femoral nerve block (cFNB)-also termed "perineural local anesthetic infusion"-is frequently used to provide analgesia after major knee surgery. 1 • Whether the method of local anesthetic administration (repeated bolus or continuous infusion) alters safety and efficacy of continuous femoral nerve blocks after surgery is not clear What This Article Tells Us That Is New • In 11 healthy volunteers receiving femoral nerve block with ropivacaine continuously or by hourly boluses, there was no difference in the degree of motor block of the quadriceps, suggesting no advantage of one method over the other for this unwanted effect Anesthesiology, V 115 • No 4 October 2011 774 Downloaded From: on 07/19/2018 PERIOPERATIVE MEDICINE Anesthesiology 2011; 115:774 -81 Charous et al. PERIOPERATIVE MEDICINE Anesthesiology 2011; 115:774 -81 Charous et al. 779 Downloaded From: on 07/19/2018
doi:10.1097/aln.0b013e3182124dc6 pmid:21394001 pmcid:PMC3116995 fatcat:ocrvbfplmfemnlnkxw6gf63hgi

Liposomal Bupivacaine as a Single-Injection Peripheral Nerve Block

Brian M. Ilfeld, Nisha Malhotra, Timothy J. Furnish, Michael C. Donohue, Sarah J. Madison
2013 Anesthesia and Analgesia  
Conflicts of Interest: Brian M.  ...  DISCLOSURES Name: Brian M. Ilfeld, MD, MS (Clinical Investigation). Contribution: This author helped design and conduct the study, analyze the data, and write the manuscript. Attestation: Brian M.  ... 
doi:10.1213/ane.0b013e31829cc6ae pmid:24108252 pmcid:PMC3808480 fatcat:lznbaatorza3ravuab7afkh5zu

Anaerobic degradation of syringic acid by an adapted strain of Rhodopseudomonas palustris [article]

Julian Zachary Oshlag, Yanjun Ma, Kaitlin Morse, Brian T Burger, Rachelle A Lemke, Steven D Karlen, Kevin Myers, Timothy J Donohue, Daniel R Noguera
2019 bioRxiv   pre-print
Tavano CL, Podevels AM, Donohue TJ. 2005. Identification of genes required for 579 recycling reducing power during photosynthetic growth.  ... doi: bioRxiv preprint 384 385 387 594 Table 1 . 5941 Kontur W, Ulbrich A, Oshlag JZ, Higbee A, Zhang Y, Coon JJ, Hodge DB, Donohue TJ, Noguera DR. 2015.  ... 
doi:10.1101/740985 fatcat:hummb62ktjbp5cismextaurqee

Continuous Femoral Nerve Blocks

Maria Bauer, Lu Wang, Olusegun K. Onibonoje, Chad Parrett, Daniel I. Sessler, Loran Mounir-Soliman, Sherif Zaky, Viktor Krebs, Leonard T. Buller, Michael C. Donohue, Jennifer E. Stevens-Lapsley, Brian M. Ilfeld
2012 Anesthesiology  
Whether decreasing the local anesthetic concentration during a continuous femoral nerve block results in less quadriceps weakness remains unknown. Methods: Preoperatively, bilateral femoral perineural catheters were inserted in subjects undergoing bilateral knee arthroplasty (n ϭ 36) at a single clinical center. Postoperatively, right-sided catheters were randomly assigned to receive perineural ropivacaine of either 0.1% (basal 12 ml/h; bolus 4 ml) or 0.4% (basal 3 ml/h; bolus 1 ml), with the left catheter receiving the alterna-
doi:10.1097/aln.0b013e3182475c35 pmid:22293719 pmcid:PMC3288409 fatcat:ptmx6e4cpfhltalynyudfmia4u

Continuous Femoral Nerve Blocks

Maria Bauer, Lu Wang, Olusegun K. Onibonoje, Chad Parrett, Daniel I. Sessler, Loran Mounir-Soliman, Sherif Zaky, Viktor Krebs, Leonard T. Buller, Michael C. Donohue, Jennifer E. Stevens-Lapsley, Brian M. Ilfeld
2013 Survey of Anesthesiology  
Whether decreasing the local anesthetic concentration during a continuous femoral nerve block results in less quadriceps weakness remains unknown. Methods: Preoperatively, bilateral femoral perineural catheters were inserted in subjects undergoing bilateral knee arthroplasty (n ϭ 36) at a single clinical center. Postoperatively, right-sided catheters were randomly assigned to receive perineural ropivacaine of either 0.1% (basal 12 ml/h; bolus 4 ml) or 0.4% (basal 3 ml/h; bolus 1 ml), with the left catheter receiving the alterna-
doi:10.1097/sa.0b013e3182911f3b fatcat:ld2d3kkoyzaj3i2j43uudevgfu

Continuous Transversus Abdominis Plane Nerve Blocks

Bahareh Khatibi, Engy T. Said, Jacklynn F. Sztain, Amanda M. Monahan, Rodney A. Gabriel, Timothy J. Furnish, Johnathan T. Tran, Michael C. Donohue, Brian M. Ilfeld
2017 Anesthesia and Analgesia  
Background-It remains unknown whether continuous or scheduled intermittent bolus local anesthetic administration is preferable for transversus abdominis plane (TAP) catheters. We therefore tested the hypothesis that when using TAP catheters, providing local anesthetic in repeated bolus doses increases the cephalad-caudad cutaneous effects compared with a basal-only infusion. Methods-Bilateral TAP catheters (posterior approach) were inserted in 24 healthy volunteers followed by ropivacaine 2
more » ... L administration for a total of 6 hours. The right side was randomly assigned to either a basal infusion (8 mL/h) or bolus doses (24 mL administered every 3 hours for a total of 2 bolus doses) in a double-masked manner. The left side received the alternate treatment. The primary endpoint was the extent of sensory deficit as measured by cool roller along the axillary line at Hour 6 (6 hours after the local anesthetic administration was initiated). Secondary endpoints included the extent of sensory deficit as measured by cool roller and Von Frey filaments along the axillary line and along a transverse line at the level of the anterior superior iliac spine at Hours 0-6.
doi:10.1213/ane.0000000000001939 pmid:28319550 pmcid:PMC5362121 fatcat:m5a2cvgt3bb35ktz7azrqymaxq

Fast and Powerful Genome Wide Association Analysis of Dense Genetic Data with High Dimensional Imaging Phenotypes [article]

Habib Ganjgahi, Anderson M. Winkler, David C. Glahn, John Blangero, Brian Donohue, Peter Kochunov, Thomas E. Nichols
2017 bioRxiv   pre-print
Donohue, P. Kochunov, T. E.  ... 
doi:10.1101/179150 fatcat:2fvzpxytyvgj5er2koahyvghpe

The Role of Methylation in the Intrinsic Dynamics of B- and Z-DNA

Nuri A. Temiz, Duncan E. Donohue, Albino Bacolla, Brian T. Luke, Jack R. Collins, Claudine Mayer
2012 PLoS ONE  
Methylation of cytosine at the 5-carbon position (5mC) is observed in both prokaryotes and eukaryotes. In humans, DNA methylation at CpG sites plays an important role in gene regulation and has been implicated in development, gene silencing, and cancer. In addition, the CpG dinucleotide is a known hot spot for pathologic mutations genome-wide. CpG tracts may adopt left-handed Z-DNA conformations, which have also been implicated in gene regulation and genomic instability. Methylation facilitates
more » ... this B-Z transition but the underlying mechanism remains unclear. Herein, four structural models of the dinucleotide d(GC) 5 repeat sequence in B-, methylated B-, Z-, and methylated Z-DNA forms were constructed and an aggregate 100 nanoseconds of molecular dynamics simulations in explicit solvent under physiological conditions was performed for each model. Both unmethylated and methylated B-DNA were found to be more flexible than Z-DNA. However, methylation significantly destabilized the BII, relative to the BI, state through the Gp5mC steps. In addition, methylation decreased the free energy difference between B-and Z-DNA. Comparisons of a/c backbone torsional angles showed that torsional states changed marginally upon methylation for B-DNA, and Z-DNA. Methylation-induced conformational changes and lower energy differences may contribute to the transition to Z-DNA by methylated, over unmethylated, B-DNA and may be a contributing factor to biological function.
doi:10.1371/journal.pone.0035558 pmid:22530050 pmcid:PMC3328458 fatcat:edrmd2erynbybiz37a4wugr27m
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