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Breeze: an integrated quality control and data analysis application for high-throughput drug screening
2020
Bioinformatics
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Here, we have implemented an open-source analysis application, Breeze, an integrated quality control and data analysis application for HTS data. ...
High throughput screening (HTS) enables systematic testing of thousands of chemical compounds for potential use as investigational and therapeutic agents. ...
Acknowledgements We would like to thank all FIMM Breeze application users for valuable input and beta testing. ...
doi:10.1093/bioinformatics/btaa138
pmid:32119072
pmcid:PMC7267830
fatcat:kqstvjud3jcafgfafs33vnntly
NEW PRODUCTS
2005
Science
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Glyco-Stain detects both glycosylated and non-glycosylated proteins. G-Biosciences/Genotech For information 314-911-6034 www.GBiosciences.com ...
technique, it offers nanogram levels of sensitivity, with greater than twofold increase in glycoprotein and proteoglycan detection. ...
Automated Sample Processing With a footprint of just 2 m by 1.2 m, the BioCel 1200 is a compact system capable of automating a wide range of applications, from compound plate replication and high-throughput ...
doi:10.1126/science.310.5750.1035
fatcat:fnkdynnav5e7bjs6ar65fwrwf4
Abstracts of papers presented at the 2002 Pittsburgh Conference
2002
Journal of automated methods & management in chemistry (Print)
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For example, consolidation of synthetic compounds that pass quality control or positive hits from biological screening are applications. ...
Improving throughput for stability analysis, quality control assays and dissolution testing are all key motivations for improvement in separation speed in the pharmaceutical industry. ...
doi:10.1155/s1463924602000196
pmid:18924747
pmcid:PMC2562979
fatcat:5j4eagxgc5bj5h2qnxcpxw2ama
Affinity-based, biophysical methods to detect and analyze ligand binding to recombinant proteins: Matching high information content with high throughput
2010
Journal of Structural Biology
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This paper discusses some of the theoretical and experimental aspects of the most common affinity-based methods, what type of information can be gained from each one of those approaches, and what requirements ...
Affinity-based technologies have become impactful tools to detect, monitor and characterize molecular interactions using recombinant target proteins. ...
We would like to thank Tomas Lundqvist and Alex Breeze for critical feedback on the content and form of this manuscript and all the researchers whose work has been well documented and published so we could ...
doi:10.1016/j.jsb.2010.06.024
pmid:20609391
fatcat:2mwy6pr72ra5lglvwyg7wj3iuy
Highlights from the 11th ISCB Student Council Symposium 2015
2016
BMC Bioinformatics
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Student presentations The student presentations were begun by Griet Laenen, who shared a new method for identifying drug targets [8]. ...
Nagarajan Raju reported the identification of different modes of protein-RNA interaction in different organisms, based on structural analysis and molecular dynamics simulation [9]. ...
We are very grateful to all the volunteer reviewers for their work on ensuring the quality of the scientific program, and to the program and travel fellowship committees for coordinating the reviewing ...
doi:10.1186/s12859-016-0901-4
pmid:26986007
pmcid:PMC4895264
fatcat:vxzbcsulqfdctoylhyoebrbzpm
Association of tamoxifen resistance and lipid reprogramming in breast cancer
2018
BMC Cancer
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Conclusion: Altogether, our findings highlight a major role of LMP prevention in tamoxifen resistance, and suggest novel drug vulnerabilities associated with this phenotype. ...
In the tamoxifen-resistant T-47D cell variants we observed a striking increase of neutral lipids in lipid droplets as well as an accumulation of free cholesterol in the lysosomes. ...
High Throughput Biomedicine (HTB) unit (Laura Turunen, Maria Nurmi and Swapnil Podar), Sequencing unit (Pirkko Mattila), and High Content Imaging and Analysis (HCA) unit at the Institute for Molecular ...
doi:10.1186/s12885-018-4757-z
pmid:30143015
pmcid:PMC6109356
fatcat:cnzktuwumbhanhwaf5m66q35dy
Novel pharmacological actions of Trequinsin Hydrochloride improve human sperm cell motility and function
2019
British Journal of Pharmacology
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We have demonstrated that a high-throughput screening (HTS) strategy and established in vitro tests can identify and characterise compounds that improve sperm motility. ...
A validated HTS fluorometric [Ca2+ ]i assay was used to screen an in-house library of compounds. ...
All assay plates in the screen were subject to quality control analysis. ...
doi:10.1111/bph.14814
pmid:31368510
pmcid:PMC6932944
fatcat:eg3xybn4zzawpoemtumxkcgclu
Network-guided identification of cancer-selective combinatorial therapies in ovarian cancer
2021
Briefings in Bioinformatics
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In this case study, we show how the platform enables prediction of cancer-selective drug combinations for patients with high-grade serous ovarian cancer using single-cell imaging cytometry drug response ...
RNA-sequencing data to deconvolute cell population-specific transcriptome profiles from bulk RNA-seq data, (iii) and whether multi-patient or patient-specific predictive models lead to better predictive ...
High-throughput drug screening (HTS) of the phenotypic effects of drug combinations in preclinical cancer models is often used for unbiased exploration of candidate drug combinations. ...
doi:10.1093/bib/bbab272
pmid:34343245
pmcid:PMC8574973
fatcat:nejdkbbqp5bwhjrahqnzb3tgf4
State-of-the-art of 3D cultures (organs-on-a-chip) in safety testing and pathophysiology
2014
ALTEX: Alternatives to Animal Experimentation
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Moreover, they refer to the application in disease modeling, drug discovery and safety assessment. ...
Integrated approaches using different in vitro methods in combination with bioinformatics can (i) increase the success rate and speed of drug development; (ii) improve the accuracy of toxicological risk ...
Acknowledgement We are grateful to many participants of the CAAt-europe workshop and information day on 3D models for sharing their ideas and for giving input. the valuable help of many members of the ...
doi:10.14573/altex.1406111
pmid:25027500
pmcid:PMC4783151
fatcat:6i4pxhi2a5fuhjmqqw3lk7fe54
Molecular networks in Network Medicine: Development and applications
2020
Wiley Interdisciplinary Reviews: Systems Biology and Medicine
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Successful applications of molecular network analysis have been reported in pulmonary arterial hypertension, coronary heart disease, diabetes mellitus, chronic lung diseases, and drug development. ...
Network Medicine applies these integrated approaches to Omics Big Data (including genetics, epigenetics, transcriptomics, metabolomics, and proteomics) using computational biology tools and, thereby, has ...
Gerasch et al. (2014) proposed a system for visually analyzing high-throughput Omics data in the context of networks; in particular, for differential analysis between groups of subjects and the analysis ...
doi:10.1002/wsbm.1489
pmid:32307915
fatcat:ps5v2yzn3ncidcf7avay6f5xli
State-of-the-art of 3D cultures (organs-on-a-chip) in safety testing and pathophysiology
2014
ALTEX: Alternatives to Animal Experimentation
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Moreover, they refer to the application in disease modeling, drug discovery and safety assessment. ...
Finally, consensus recommendations indicate a roadmap for the successful implementation of 3D models in routine screening. ...
Acknowledgement We are grateful to many participants of the CAAt-europe workshop and information day on 3D models for sharing their ideas and for giving input. the valuable help of many members of the ...
doi:10.14573/altex1406111
fatcat:h2373gjoirg6hj2qv556jlliya
The Promises and Challenges of Toxico-Epigenomics: Environmental Chemicals and Their Impacts on the Epigenome
2020
Environmental Health Perspectives
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Until recently, efforts to apply epigenomic data in toxicology and risk assessment were restricted by an incomplete understanding of epigenomic variability across tissue types and populations. ...
We present an overview of epigenetic regulation and a summary of reported evidence of environmental toxicants as epigenetic disruptors. ...
The authors certify that their freedom to design, conduct, interpret, and publish research was not compromised by any controlling sponsor. ...
doi:10.1289/ehp6104
pmid:31950866
pmcid:PMC7015548
fatcat:6gfmg755xveunn4rmhtpzhmafa
Activated Surfaces for Laser Desorption Mass Spectrometry: Application for Peptide and Protein Analysis
2005
Current pharmaceutical design
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This review will discuss the various surface modifications used in combination with laser desorption mass spectrometry and their application for the analysis of peptides and proteins. ...
In an other hand chemical and biochemical modified surfaces developed to isolate species with more or less specific interactions can be used for onslide sample clean-up before MALDI-MS analysis. ...
The MALDI process can be miniaturised and fully automated for high throughput analysis. ...
doi:10.2174/1381612054546888
pmid:16101459
fatcat:fyafo7ncwjan5gmnrq26w2jmsi
Programme Booklet Of The 11Th Iscb Student Council Symposium, Dublin, 2015
[article]
2015
Zenodo
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To understand cross-talk we developed pipelines and methods for the analysis of high throughput data to survey the direct and indirect association of several families of repetitive elements with known ...
In particular we show strategic analysis of high throughput data for ERVs which reveals the differential cross regulation of subsets of HERVs by host factors and vice-versa in vivo and in vitro stem cells ...
Manuel Corpas gave an excellent keynote talk along with 7 student presentations. The chairs for this meeting were Yassine Souilmi and Chinmay Kumar Dwibedi. ...
doi:10.5281/zenodo.1253018
fatcat:b75h2xdwmralzfqdhs6jd6k4vm
Tuesday posters
2010
Journal of the American Society for Mass Spectrometry
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Analysis of Compounds for Early Drug Discovery: Quantitative and Qualitative Screening in One Pass; Xiaojie C. ...
, CT TP 498 Evaluation of Accurate Mass TOF-MS for Use in High Throughput PAMPA Screening; Michelle Romm; Nikunj Parikh; Vaughn Miller; William A. ...
doi:10.1016/j.jasms.2010.03.020
fatcat:vkjwc7lrgzebvf467q7sh2ny74
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