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Leukodystrophies: a proposed classification system based on pathological changes and pathogenetic mechanisms

Marjo S. van der Knaap, Marianna Bugiani
<span title="2017-06-21">2017</span> <i title="Springer Nature"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/fu2v5yy75zfitiwkzgznutnkvq" style="color: black;">Acta Neuropathologica</a> </i> &nbsp;
Given the complex molecular and cellular interplay underlying white matter pathology, recognition of the cellular pathology behind a disease becomes crucial in addressing possible treatment strategies.  ...  Following this classification, we illustrate the neuropathology and disease mechanisms of some leukodystrophies taken as example for each category.  ...  Acknowledgements The authors are grateful to the patients and  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/s00401-017-1739-1">doi:10.1007/s00401-017-1739-1</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/28638987">pmid:28638987</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC5563342/">pmcid:PMC5563342</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/gsoi3fwp5bdhxgf7rkelt3p4y4">fatcat:gsoi3fwp5bdhxgf7rkelt3p4y4</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20181030073225/https://link.springer.com/content/pdf/10.1007%2Fs00401-017-1739-1.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/76/14/761422457b79efe8107b0fd6413f6fc19984ca89.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/s00401-017-1739-1"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> springer.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5563342" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Toward 20 T magnetic resonance for human brain studies: opportunities for discovery and neuroscience rationale

Thomas F. Budinger, Mark D. Bird, Lucio Frydman, Joanna R. Long, Thomas H. Mareci, William D. Rooney, Bruce Rosen, John F. Schenck, Victor D. Schepkin, A. Dean Sherry, Daniel K. Sodickson, Charles S. Springer (+3 others)
<span title="2016-05-18">2016</span> <i title="Springer Nature"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/nmniume7n5f3jkrtvblj5hbf2e" style="color: black;">Magnetic Resonance Materials in Physics, Biology and Medicine</a> </i> &nbsp;
for the nuclear fusion endeavors support the feasibility of a human brain MRI and MRS system with 1 ppm homogeneity over at least a 16-cm diameter volume and a bore size of 68 cm.  ...  Twelve neuroscience opportunities are presented as well as an analysis of the biophysical and physiological effects to be investigated before exposing human subjects to the high fields of 14 T and beyond  ...  A second powerful use of 13 C MRS/MRI at ultrahigh fields is the potential to image glucose oxidation regionally in the human brain.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/s10334-016-0561-4">doi:10.1007/s10334-016-0561-4</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/27194154">pmid:27194154</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC5538368/">pmcid:PMC5538368</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/sbjidd4fyjfojiszbcbbbq2jea">fatcat:sbjidd4fyjfojiszbcbbbq2jea</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20191121083226/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC5538368&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/e2/84/e28414bf408e7e57be974fb2899823fe6f569623.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/s10334-016-0561-4"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> springer.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5538368" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Power of a Metabonomic Approach to Investigate an Unknown Nervous Disease [chapter]

Celine Domange, Alain Paris, Henri Schroeder, Nathalie Priymenko
<span title="2011-12-09">2011</span> <i title="InTech"> Neurodegenerative Diseases - Processes, Prevention, Protection and Monitoring </i> &nbsp;
Each behavioural manifestation in animal model tends to reflect a specific human behavioural alteration or cognitive effect like depression, anxiety, fear or schizophrenia.  ...  In case of the lack of any behavioural manifestation in animals, the conclusion isn't that there is a lack of effect but only that there is an impossibility to give an interpretation of this lack of effect  ...  Contrary to other organs in mammals, brain is isolated from the rest of organism by the blood-brain barrier, with consequences on the passage of some metabolites.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.5772/30963">doi:10.5772/30963</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/cyme4xg5uba2lhpycuoidft4na">fatcat:cyme4xg5uba2lhpycuoidft4na</a> </span>
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Channelopathies

June-Bum Kim
<span title="">2014</span> <i title="Korean Pediatric Society"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/s3kcpc7t2zhb5h7p2yrq34tfli" style="color: black;">Korean Journal of Pediatrics</a> </i> &nbsp;
Channelopathies are a heterogeneous group of disorders resulting from the dysfunction of ion channels located in the membranes of all cells and many cellular organelles.  ...  These include diseases of the ner vous system (e.g., generalized epilepsy with febrile seizures plus, familial hemiplegic migraine, episodic ataxia, and hyperkalemic and hypokalemic periodic paralysis)  ...  Acknowledgements This work was supported by the 12th Seokcheon Research Award funded by the Korean Pediatric Society. The author thanks Moon-Yong Park for assistance with illustrations.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3345/kjp.2014.57.1.1">doi:10.3345/kjp.2014.57.1.1</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/24578711">pmid:24578711</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC3935107/">pmcid:PMC3935107</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/mxvgjrmptzagzhhlt52kn7mopq">fatcat:mxvgjrmptzagzhhlt52kn7mopq</a> </span>
<a target="_blank" rel="noopener" href="https://archive.org/download/pubmed-PMC3935107/PMC3935107-kjp.2014.57.1.1.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> File Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/34/ce/34ce44d327f3dec39d66a1b56c710345db1f08ce.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3345/kjp.2014.57.1.1"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3935107" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Imaging and spectroscopic approaches to probe brain energy metabolism dysregulation in neurodegenerative diseases

Gilles Bonvento, Julien Valette, Julien Flament, Fanny Mochel, Emmanuel Brouillet
<span title="2017-03-09">2017</span> <i title="SAGE Publications"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/zh7dem5jnfbevczyfq7zr6yhme" style="color: black;">Journal of Cerebral Blood Flow and Metabolism</a> </i> &nbsp;
Furthermore, energy defects have often been discussed solely in the context of their probable neuronal origin without considering the cellular heterogeneity of the brain.  ...  The purpose of this review is to offer a brief overview of the broad spectrum of methodological approaches that have emerged in recent years to probe energy metabolism in more detail.  ...  Acknowledgements The authors wish to thank warmly Pierre-Gilles Henry for his great contribution on the development of our MR spectroscopy approaches in humans and Morwena Latouche and Bruno Stankoff for  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1177/0271678x17697989">doi:10.1177/0271678x17697989</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/28276944">pmid:28276944</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC5464722/">pmcid:PMC5464722</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/cjioqpwqf5brzo5r5yyzvpbqlu">fatcat:cjioqpwqf5brzo5r5yyzvpbqlu</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200208153804/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC5464722&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/1f/a8/1fa89ca62e686a6edcd4db4e3a63ac9de48cf5a4.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1177/0271678x17697989"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> sagepub.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5464722" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Review: Central nervous system involvement in mitochondrial disease

N. Z. Lax, G. S. Gorman, D. M. Turnbull
<span title="2016-07-07">2016</span> <i title="Wiley"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/4xnndzuhkvghrpc7pi2qfkpavy" style="color: black;">Neuropathology and Applied Neurobiology</a> </i> &nbsp;
regions of the brain.  ...  Mitochondrial abnormalities have been detected in both human tissues and animal models of temporal lobe epilepsy with detection of mitochondrial ultrastructural pathology, impairment of complex I in the  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1111/nan.12333">doi:10.1111/nan.12333</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/27287935">pmid:27287935</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC5363248/">pmcid:PMC5363248</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/idhj54cxbzcs3pkd7dzjjoyaxu">fatcat:idhj54cxbzcs3pkd7dzjjoyaxu</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200211215526/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC5363248&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/a1/70/a1705e53e2c610f4441c506da49d3e570dafa924.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1111/nan.12333"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363248" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Dynamic regulation of aquaporin-4 water channels in neurological disorders

Ying Hsu, Minh Tran, Andreas A. Linninger
<span title="">2015</span> <i title="Croatian Medical Journal"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/msfca5ttqzhrfjo7vht7f3zbam" style="color: black;">Croatian Medical Journal</a> </i> &nbsp;
In light of current evidence, we still do not have a complete understanding of the role of aquaporin-4 in brain water transport.  ...  However, measurements of aquaporin-4 levels in animal models of brain injury often report opposite trends of change at the injury core and the penumbra.  ...  The importance of AQP4-mediated water flux in potassium homeostasis is established in epilepsy (3, 4) .  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3325/cmj.2015.56.401">doi:10.3325/cmj.2015.56.401</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/26526878">pmid:26526878</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC4655926/">pmcid:PMC4655926</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/gsu5tyuchrfonbftbhiysj5t7a">fatcat:gsu5tyuchrfonbftbhiysj5t7a</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20170829085215/http://neuron.mefst.hr/docs/CMJ/issues/2015/56/5/cmj_56_5_lininger_26526878.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/0a/eb/0aeb6a07530402f95fd6901239cfa147853d0f39.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3325/cmj.2015.56.401"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4655926" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

The Therapeutic Potential and Limitations of Ketones in Traumatic Brain Injury

Savannah Anne Daines
<span title="2021-10-22">2021</span> <i title="Frontiers Media SA"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/4kchoxo3jrfubkck3y7nfncina" style="color: black;">Frontiers in Neurology</a> </i> &nbsp;
However, studies evaluating the effectiveness of ketones in human TBI are limited.  ...  Further research and improvements in metabolic monitoring technology are also needed to determine if ketone supplementation can improve TBI recovery outcomes in humans.  ...  ACKNOWLEDGMENTS The author thanks Dr. Brett Adams, Dr. Tye Harrison, and Dr. Nina Jorgensen for their support with this project.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3389/fneur.2021.723148">doi:10.3389/fneur.2021.723148</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/34777197">pmid:34777197</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC8579274/">pmcid:PMC8579274</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/zknfdwbknzdihjwq4m7g5nfvo4">fatcat:zknfdwbknzdihjwq4m7g5nfvo4</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20211116122102/https://fjfsdata01prod.blob.core.windows.net/articles/files/723148/pubmed-zip/.versions/3/.package-entries/fneur-12-723148-r2/fneur-12-723148.pdf?sv=2018-03-28&amp;sr=b&amp;sig=Tnm17OYgqV65WBpHbUnhX0493OyvETYxpi7Xtku7CNs%3D&amp;se=2021-11-16T12%3A21%3A32Z&amp;sp=r&amp;rscd=attachment%3B%20filename*%3DUTF-8&#39;&#39;fneur-12-723148.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/2e/56/2e561c60532c0cac7b3e3842fe28a186f08e5bd6.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3389/fneur.2021.723148"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> frontiersin.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8579274" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

A blood–brain barrier overview on structure, function, impairment, and biomarkers of integrity

Hossam Kadry, Behnam Noorani, Luca Cucullo
<span title="2020-11-18">2020</span> <i title="Springer Science and Business Media LLC"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/o7tyfoms2jcrbialut4jkepwoy" style="color: black;">Fluids and Barriers of the CNS</a> </i> &nbsp;
Thus, the functional and structural integrity of the BBB is pivotal to maintain the homeostasis of the brain microenvironment.  ...  AbstractThe blood–brain barrier is playing a critical role in controlling the influx and efflux of biological substances essential for the brain's metabolic activity as well as neuronal function.  ...  Microglial activation and infiltration of different plasma components and immune cells into the brain parenchyma result in disturbance of CNS homeostasis and variable damage to the surrounding brain.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1186/s12987-020-00230-3">doi:10.1186/s12987-020-00230-3</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/33208141">pmid:33208141</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC7672931/">pmcid:PMC7672931</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/wvzzgaveqzbxhdcfy7gq5htkru">fatcat:wvzzgaveqzbxhdcfy7gq5htkru</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20201119124109/https://fluidsbarrierscns.biomedcentral.com/track/pdf/10.1186/s12987-020-00230-3.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/f1/30/f13016a771a6bf82075b954bf1b02047c8c8fa96.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1186/s12987-020-00230-3"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> springer.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7672931" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

The role of brain barriers in fluid movement in the CNS: is there a 'glymphatic' system?

N. Joan Abbott, Michelle E. Pizzo, Jane E. Preston, Damir Janigro, Robert G. Thorne
<span title="2018-02-10">2018</span> <i title="Springer Nature"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/fu2v5yy75zfitiwkzgznutnkvq" style="color: black;">Acta Neuropathologica</a> </i> &nbsp;
The interstitial fluid (ISF) of the brain tissue and the cerebrospinal fluid (CSF) bathing the CNS are integral to this homeostasis and the idea of a glia-lymph or 'glymphatic' system for waste clearance  ...  This review discusses studies which question the role of AQP4 in ISF flow and the lack of evidence for its ability to transport solutes; summarizes attributes of brain ECS that strongly favour the diffusion  ...  Acknowledgements This work was supported by the University of  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/s00401-018-1812-4">doi:10.1007/s00401-018-1812-4</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/29428972">pmid:29428972</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/yxr6osugsndybpjuhcp6jpjn5q">fatcat:yxr6osugsndybpjuhcp6jpjn5q</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20180729085426/https://link.springer.com/content/pdf/10.1007%2Fs00401-018-1812-4.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/03/dd/03dd8c010d84b729a93199190f688ae46deaaa11.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/s00401-018-1812-4"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> springer.com </button> </a>

Peripheral markers of blood–brain barrier damage

Nicola Marchi, Marco Cavaglia, Vincent Fazio, Sunil Bhudia, Kerri Hallene, Damir Janigro
<span title="">2004</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/36vasqfx4nemtc5jnzkgzhnqde" style="color: black;">Clinica Chimica Acta</a> </i> &nbsp;
On the one hand, a leaky BBB may lead to brain disease by allowing extravasation of cells and molecules normally segregated in the periphery, while on the other hand an intact BBB may hamper drug delivery  ...  to the ailing brain.  ...  Acknowledgements The authors would like to thank Anne-Charlotte Aronsson for her helpful comments and support.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.cccn.2003.12.008">doi:10.1016/j.cccn.2003.12.008</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/15026262">pmid:15026262</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/nnkxu2oei5arjfb3qluyof3rfu">fatcat:nnkxu2oei5arjfb3qluyof3rfu</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20170811120017/http://users.zoominternet.net/~vfazio2/index_files/Ref11_CCA_342_2004_p1-12.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/99/a4/99a420343339f8d60cf48a647d9b68e3bc8b77c3.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.cccn.2003.12.008"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> elsevier.com </button> </a>

Chloride Dysregulation, Seizures, and Cerebral Edema: A Relationship with Therapeutic Potential

Joseph Glykys, Volodymyr Dzhala, Kiyoshi Egawa, Kristopher T. Kahle, Eric Delpire, Kevin Staley
<span title="">2017</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/53wtswjt2balnct24ywxu4bzzu" style="color: black;">Trends in Neurosciences</a> </i> &nbsp;
In the adult brain, [Cl − ] i is 10 -20 times lower than the extracellular Cl − concentration, leading to a large driving force for inward Cl − diffusion.  ...  If the membrane potential is more negative than E Cl −, GABA A R activation will result in outward flow of Cl − from the neuron and membrane depolarization.  ...  KE was supported by the Takeda Science Foundation, the Japan Health Foundation and the Ministry of Education, Science, Sports, Culture and Technology 40450829 and 15H05871.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.tins.2017.03.006">doi:10.1016/j.tins.2017.03.006</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/28431741">pmid:28431741</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC5473173/">pmcid:PMC5473173</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/z2kjmqrscjbfpbnivlae6lqe6e">fatcat:z2kjmqrscjbfpbnivlae6lqe6e</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200208055040/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC5473173&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/aa/94/aa9426832b1b86ea74f33a13263e32612df5eccd.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.tins.2017.03.006"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> elsevier.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5473173" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

The Quest for Neuroprotection for Injuries in the Developing Brain

Fatima Yousif Ismail, Ali Fatemi, Michael Johnston
<span title="2017-09-21">2017</span> <i title="The International Child Neurology Association (ICNA)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/6pjokxdjgfbv3hw4pnhoen3eiq" style="color: black;">Journal of International Child Neurology Association</a> </i> &nbsp;
In the field of pediatric neurology, one of the best illustrative examples is our quest for finding neuroprotective therapies in the setting of neonatal hypoxic-ischemic encephalopathy.  ...  We trace the relentless efforts to emulate the pathogenesis in animal models to testing potential therapies in clinical trials that made the transfer of this knowledge back to the bedside possible in order  ...  Hypoxia and energy failure in astrocytes lead to a disturbance of neuronal ionic and pH homeostasis and a decrease in glutamate re-uptake from the synapse, contributing to glutamate excitotoxicity.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.17724/jicna.2017.79">doi:10.17724/jicna.2017.79</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/6tymhrschrftlmavo2xwngzcny">fatcat:6tymhrschrftlmavo2xwngzcny</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200213154119/https://jicna.org/index.php/journal/article/download/jicna-2017-79/pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/62/86/6286c2027ae4338539b8997fc89ff1acf2bc7865.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.17724/jicna.2017.79"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> Publisher / doi.org </button> </a>

In Situ Imaging of Metals in Cells and Tissues

Reagan McRae, Pritha Bagchi, S. Sumalekshmy, Christoph J. Fahrni
<span title="2009-10-14">2009</span> <i title="American Chemical Society (ACS)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/3jiv5gamdrch7lswaebpzyrjmi" style="color: black;">Chemical Reviews</a> </i> &nbsp;
physiology of trace metals in biological systems.  ...  Acknowledgments We gratefully thank the National Institutes of Health (NIGMS/NIDDK, GM067169, DK68096) for funding our research on developing fluorescence probes and imaging tools for elucidating the inorganic  ...  or in cases of genetic-linked disturbances of metal homeostasis.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1021/cr900223a">doi:10.1021/cr900223a</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/19772288">pmid:19772288</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC3812694/">pmcid:PMC3812694</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/jjqjkxhl2fdn3f7rfhkh4us7r4">fatcat:jjqjkxhl2fdn3f7rfhkh4us7r4</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200208124736/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC3812694&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/96/fc/96fca5c2da437b6cba2c26a356e47d60f991539e.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1021/cr900223a"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> acs.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3812694" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Cerebrovascular Function in Pregnancy and Eclampsia

M. J. Cipolla
<span title="2007-06-04">2007</span> <i title="Ovid Technologies (Wolters Kluwer Health)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/6t3rln3635aixh4anfuytsyl6i" style="color: black;">Hypertension</a> </i> &nbsp;
Sources of Funding We gratefully acknowledge the support of the National Institute of Neurologic Disorders and Stroke (grant NS045940) and the American Heart Association Established Investigator Award  ...  We also acknowledge the continued support of the Totman Medical Research Trust. Disclosures None.  ...  In addition, because of the regional heterogeneity in edema formation during eclampsia, being more prominent in the posterior region of the brain, how BBB permeability may be regionally affected by acute  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1161/hypertensionaha.106.079442">doi:10.1161/hypertensionaha.106.079442</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/17548723">pmid:17548723</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/yokpqe24efhtfjbcoulcz4hcdm">fatcat:yokpqe24efhtfjbcoulcz4hcdm</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20180719183838/http://hyper.ahajournals.org/content/hypertensionaha/50/1/14.full.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/e2/07/e207054ece48c43b363f194bb2ab34c9e5ab6534.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1161/hypertensionaha.106.079442"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a>
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