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Brain network interactions in transgender individuals with gender incongruence

Carme Uribe, Carme Junque, Esther Gómez-Gil, Alexandra Abos, Sven C. Mueller, Antonio Guillamon
2020 NeuroImage  
Functional brain organization in transgender persons remains unclear.  ...  Our aims were to investigate global and regional connectivity differences within functional networks in transwomen and transmen with early-in-life onset gender incongruence; and to test the consistency  ...  Brain imaging studies on transgender populations are usually focused on individuals in which the intensity of gender discrepancy is extreme, their experienced gender is with the opposite sex, and apply  ... 
doi:10.1016/j.neuroimage.2020.116613 pmid:32057995 fatcat:ehbbv5wekngazefbeik7qjck4q

A New Theory of Gender Dysphoria Incorporating the Distress, Social Behavioral, and Body-Ownership Networks

Stephen V. Gliske
2019 eNeuro  
I find that the brain networks that give individuals their ownership of body parts, that influence gender typical behavior, and that are involved in chronic distress are different in individuals with and  ...  I hypothesize that in individuals with gender dysphoria, the aspects of chronic distress, gender atypical behavior, and incongruence between perception of gender identity and external primary sex characteristics  ...  The incongruence was then specifically stated to be that transgender individuals have brain sex opposite to their gender assigned at birth.  ... 
doi:10.1523/eneuro.0183-19.2019 pmid:31792116 pmcid:PMC6911960 fatcat:glfmpctkojbzfmpwhgf6cstlr4

Sex Matters: A Multivariate Pattern Analysis of Sex- and Gender-Related Neuroanatomical Differences in Cis- and Transgender Individuals Using Structural Magnetic Resonance Imaging

2019 Cerebral Cortex  
The neuroanatomical signature of sex in cisgender did not interact with depressive features (BAC = 74.7%) but was affected by hormone therapy when applied in transgender women (P < 0.001).  ...  Gender identity and gender incongruence could not be reliably identified (all pFDR > 0.05).  ...  Further studies need to be performed to fully understand the interaction between biological sex and gender incongruence.  ... 
doi:10.1093/cercor/bhz170 pmid:31368487 pmcid:PMC7132951 fatcat:ivq6n575o5ccpoafo7tppbzvvy

Gene Variants and Epigenetics That Lead to Gender Dysphoria

Matanalai Buayam
2022 Zenodo  
ABSTRACT: These days, the rate of gender dysphoria among transgender individuals has increased drastically.  ...  Ultimately, understanding the mechanism of gender dysphoria will promote a better quality of life for individuals experiencing gender dysphoria.  ...  Individuals with gender incongruence who experience difficulties or significant burdens might develop gender dysphoria [7, 9] .  ... 
doi:10.5281/zenodo.6944356 fatcat:dkwcxuawlffpjeyhlfdoyzngcy

Transsexualism: A Different Viewpoint to Brain Changes

Mohammad Reza Mohammadi, Ali Khaleghi
2018 Clinical Psychopharmacology and Neuroscience  
In summary, transgender individuals experience change in lifestyle, context of beliefs and concepts and, as a result, their culture and behaviors.  ...  Transsexualism refers to a condition or belief which results in gender dysphoria in individuals and makes them insist that their biological gender is different from their psychological and experienced  ...  In another study, Kranz et al. 40) investigated the white matter microstructure pattern of untreated transgender individuals with early-onset gender incongruence using DTI.  ... 
doi:10.9758/cpn.2018.16.2.136 pmid:29739126 pmcid:PMC5953012 fatcat:czvtn4ypjbcmtco4crdzgzoq24

Predicting outcomes of cross-sex hormone therapy in transgender individuals with gender incongruence based on pre-therapy resting-state brain connectivity

Teena D Moody, Jamie D Feusner, Nicco Reggente, Jonathan Vanhoecke, Mats Holmberg, Amirhossein Manzouri, Behzad Sorouri Khorashad, Ivanka Savic
2020 NeuroImage: Clinical  
Individuals with gender incongruence (GI) experience serious distress due to incongruence between their gender identity and birth-assigned sex.  ...  Twenty-five trans women and trans men with gender incongruence participated.  ...  Acknowledgement We thank Natalie Rotstein for assistance with data validation.  ... 
doi:10.1016/j.nicl.2020.102517 pmid:33340976 pmcid:PMC7750413 fatcat:kl2fv32y3fbzldm4u33pmifaxm

Altered White Matter and Sensory Response to Bodily Sensation in Female-to-Male Transgender Individuals

Laura K. Case, David Brang, Rosalynn Landazuri, Pavitra Viswanathan, Vilayanur S. Ramachandran
2016 Archives of Sexual Behavior  
These findings suggest that dysphoria related to gender-incongruent body parts in FtM individuals may be tied to differences in neural representation of the body and altered white matter connectivity.  ...  Similarly, many transgender individuals describe their untreated sexed body parts as incongruent and aversive, and many experience phantom body parts of the sex they identify with (Ramachandran, 2008)  ...  Tao Song, for support in collecting the MEG data and Dr. Eric Halgren and Burke Rosen for assistance in processing the MEG data.  ... 
doi:10.1007/s10508-016-0850-z pmid:27646840 pmcid:PMC5357597 fatcat:k3axt7tf6bczpeyzwsmp2wm3sq

Neuroimaging studies in people with gender incongruence

Baudewijntje P.C. Kreukels, Antonio Guillamon
2016 International Review of Psychiatry  
The brain phenotypes of people with feelings of gender incongruence may help us to figure out whether sex differentiation of the brain is atypical in these individuals, and shed light on gender identity  ...  First, we describe studies into the aetiology of feelings of gender incongruence, primarily addressing the sexual differentiation hypothesis: does the brain of transgender individuals resemble that of  ...  We have already seen above that people with gender incongruence show differences in their connectivity profiles while watching erotic interactions (Ku et al., 2013) .  ... 
doi:10.3109/09540261.2015.1113163 pmid:26766406 fatcat:pzohrax4lzbdnpdixm5m2casfa

Gender incongruence and gender dysphoria in childhood and adolescence-current insights in diagnostics, management, and follow-up

Hedi Claahsen-van der Grinten, Chris Verhaak, Thomas Steensma, Tim Middelberg, Joep Roeffen, Daniel Klink
2020 European Journal of Pediatrics  
Gender incongruence (GI) is defined as a condition in which the gender identity of a person does not align with the gender assigned at birth.  ...  treatment can be effectively used in adolescence with gender dysphoria.  ...  Recent studies have focused on brain connectivity between people with and without GI, showing differences in brain networks related to body image [15] .  ... 
doi:10.1007/s00431-020-03906-y pmid:33337526 fatcat:zncfp2p4njfariz2vzpccyqvtq

Replication of Previous Findings? Comparing Gray Matter Volumes in Transgender Individuals with Gender Incongruence and Cisgender Individuals

Benjamin Clemens, Mikhail Votinov, Andrei Alexandru Puiu, Andre Schüppen, Philippa Hüpen, Josef Neulen, Birgit Derntl, Ute Habel
2021 Journal of Clinical Medicine  
The brain structural changes related to gender incongruence (GI) are still poorly understood.  ...  The primary aim is to replicate previous findings and identify anatomical regions which differ between transgender individuals with GI and cisgender individuals.  ...  The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.  ... 
doi:10.3390/jcm10071454 pmid:33916288 pmcid:PMC8037365 fatcat:xv4wlh3wufhangx3rq3ddbkgpa

How gender dysphoria and incongruence became medical diagnoses – a historical review

Marc-Antoine Crocq
2021 Dialogues in Clinical Neuroscience  
This article is a historical review of the medical and psychiatric diagnoses associated with transgender people across epochs. Ancient Greek and Roman writings already mention gender change.  ...  In the nineteenth century, most authors conflated questions of sexual orientation and gender.  ...  Individuals with transvestic disorder do not report an incongruence between their experienced gender and assigned gender or desire to be of the other gender.  ... 
doi:10.1080/19585969.2022.2042166 pmid:35860172 pmcid:PMC9286744 fatcat:bawegkbgfbgvnhbypyph2knvgq

Data for functional MRI connectivity in transgender people with gender incongruence and cisgender individuals

Carme Uribe, Carme Junque, Esther Gómez-Gil, Alexandra Abos, Sven C. Mueller, Antonio Guillamon
2020 Data in Brief  
Data from three different techniques that describe global and regional connectivity differences within functional resting-state networks in transwomen and transmen with early-in-life onset gender incongruence  ...  We provide T2*-weighted and T1-weighted images acquired on a 3T MRI scanner obtained from 17 transwomen and 29 transmen with gender incongruence; and 22 ciswomen and 19 cismen that identified themselves  ...  Conflict of Interest The authors declare that they have no known competing financial interests or personal relationships which have, or could be perceived to have, influenced the work reported in this  ... 
doi:10.1016/j.dib.2020.105691 pmid:32490070 pmcid:PMC7262419 fatcat:vlgswdbjdfcqrk2twxb5xf5tty

Regional Grey Matter Structure Differences between Transsexuals and Healthy Controls—A Voxel Based Morphometry Study

Lajos Simon, Lajos R. Kozák, Viktória Simon, Pál Czobor, Zsolt Unoka, Ádám Szabó, Gábor Csukly, Gaolang Gong
2013 PLoS ONE  
Gender identity disorder (GID) refers to transsexual individuals who feel that their assigned biological gender is incongruent with their gender identity and this cannot be explained by any physical intersex  ...  There is growing scientific interest in the last decades in studying the neuroanatomy and brain functions of transsexual individuals to better understand both the neuroanatomical features of transsexualism  ...  However, there is a group of individuals who do not show such known genetic or somatic abnormality and yet experience strong incongruency between their assigned biological gender and their gender identity  ... 
doi:10.1371/journal.pone.0083947 pmid:24391851 pmcid:PMC3877116 fatcat:gyckw6jhlbgylaaz6ebqe4wkxu

The influence of sex steroid treatment on insular connectivity in gender dysphoria [article]

Murray Bruce Reed, Patricia Anna Handschuh, Manfred Kloebl, Melisande Elisabeth Konadu, Ulrike Kaufmann, Andreas Hahn, Georg Kranz, Marie Spies, Rupert Lanzenberger
2022 medRxiv   pre-print
Thereby, gender-dysphoric individuals receiving gender-affirming hormone therapy represent an interesting cohort to address this gap in available knowledge.  ...  These findings suggest a considerable influence of long-term estrogen administration and androgen suppression on brain networks implicated in interoception, own-body perception and higher-level cognition  ...  Transgender (TX) individuals seeking GHT were recruited from the Unit for Gender Identity Disorder at the General Hospital in Vienna.  ... 
doi:10.1101/2022.01.21.22269471 fatcat:epd2c5vdhrf3njqgysaxijf5hy


Wylie C. Hembree, Peggy T. Cohen-Kettenis, Louis Gooren, Sabine E. Hannema, Walter J. Meyer, M. Hassan Murad, Stephen M. Rosenthal, Joshua D. Safer, Vin Tangpricha, Guy G. T'Sjoen
2017 Endocrine Practice  
Studies focusing on brain structure suggest that the brain phenotypes of people with GD/gender incongruence differ in various ways from control males and females, but that there is not a complete sex reversal  ...  Recommendations for Those Involved in the Gender-Affirming Hormone Treatment of Individuals With GD/Gender Incongruence 1.1.  ... 
doi:10.4158/1934-2403-23.12.1437 pmid:29320642 fatcat:ybrdme6ltjbbfa227ecxbdivyi
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