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Brain development and aging: Overlapping and unique patterns of change

Christian K. Tamnes, Kristine B. Walhovd, Anders M. Dale, Ylva Østby, Håkon Grydeland, George Richardson, Lars T. Westlye, J. Cooper Roddey, Donald J. Hagler, Paulina Due-Tønnessen, Dominic Holland, Anders M. Fjell
2013 NeuroImage  
The pattern of lateral cortical changes was similar across development and aging, but the pronounced medial temporal reduction in aging was not precast in development.  ...  Developmental origins of neurocognitive late-life functions are acknowledged, but detailed longitudinal magnetic resonance imaging studies of brain maturation and direct comparisons with aging are lacking  ...  A comparison of relative rates of cortical change in development and in elderly revealed a mixture of overlapping and unique characterizing changes in maturation and senescence.  ... 
doi:10.1016/j.neuroimage.2012.11.039 pmid:23246860 pmcid:PMC5378867 fatcat:4bghuj2ugfg27klada4b5jjx2y

Widespread splicing changes in human brain development and aging

P. Mazin, J. Xiong, X. Liu, Z. Yan, X. Zhang, M. Li, L. He, M. Somel, Y. Yuan, Y.-P. Phoebe Chen, N. Li, Y. Hu (+7 others)
2014 Molecular Systems Biology  
and aging.  ...  While splicing differences between tissues, sexes and species are well documented, little is known about the extent and the nature of splicing changes that take place during human or mammalian development  ...  Acknowledgements We thank the NICHD Brain and Tissue Bank for Developmental Disorders, the Netherlands Brain Bank, and Dr HR Zielke in particular for providing the human samples; Suzhou Drug Safety Evaluation  ... 
doi:10.1038/msb.2012.67 pmid:23340839 pmcid:PMC3564255 fatcat:nr662my2nbezraewp2yae4nfri

The temporal expression patterns of brain transcriptome during chicken development and ageing

Zhongxian Xu, Tiandong Che, Feng Li, Kai Tian, Qing Zhu, Shailendra Kumar Mishra, Yifei Dai, Mingzhou Li, Diyan Li
2018 BMC Genomics  
The transcriptional profiles of mammals during brain development and ageing have been characterized.  ...  However the global expression patterns of transcriptome in the chicken brain have not been explored.  ...  Availability of data and materials All the data supporting our findings are contained within the manuscript.  ... 
doi:10.1186/s12864-018-5301-x fatcat:ivbiejn725dq5klv5keedrkvkq

Stress-associated H3K4 methylation accumulates during postnatal development and aging of rhesus macaque brain

Yixing Han, Dali Han, Zheng Yan, Jerome D. Boyd-Kirkup, Christopher D. Green, Philipp Khaitovich, Jing-Dong J. Han
2012 Aging Cell  
Epigenetic modifications are critical determinants of cellular and developmental states.  ...  In support of this, we also observed increased expression of two H3K4 methyltransferases, SETD7 and DPY30, in aged macaque brain. These authors contributed equally to this work.  ...  Acknowledgments We are indebted to Drs Teng Fei and Yeguang Chen for the use of equipments. This work was supported by grants from the China Natural National Science Foundation (Grant #30890033 and  ... 
doi:10.1111/acel.12007 pmid:22978322 fatcat:qclcfsg7kzf4fhx47rk3k4w2ea

Genome-wide expression and methylation profiling in the aged rodent brain due to early-life Pb exposure and its relevance to aging

Remi Dosunmu, Hany Alashwal, Nasser H. Zawia
2012 Mechanisms of Ageing and Development  
Acknowledgments This research was supported by the Intramural Research Program of the National Institutes of Health (NIH), National Institute of Environmental Health Sciences (NIEHS) and by grants (ES013022  ...  and AG027246) from the NIH awarded to NHZ.  ...  Shown through heat maps is the expression patterns of significant two fold differential gene expression (p ≤ 0.01) in the normal aging brain and in aged brains developmentally exposed to Pb.  ... 
doi:10.1016/j.mad.2012.05.003 pmid:22613225 pmcid:PMC3389195 fatcat:aeogkt57bvezxbkfvk64lkdomi

Development and heritability of subcortical brain volumes at ages 9 and 12

S. C. Swagerman, R. M. Brouwer, E. J. C. de Geus, H. E. Hulshoff Pol, D. I. Boomsma
2014 Genes, Brain and Behavior  
Brain scans were acquired for 112 and 89 twin pairs at 9 and 12 years of age.  ...  The heritability of development of subcortical brain volumes during adolescence has not been studied comprehensively.  ...  Acknowledgments We thank the twins and their parents for making this study possible.  ... 
doi:10.1111/gbb.12182 pmid:25311829 fatcat:jhkxyhzo7rb57db4dniqwc7ywa

CircRNAs in the tree shrew (Tupaia belangeri) brain during postnatal development and aging

CaiXia Lu, XiaoMei Sun, Na Li, WenGuang Wang, DeXuan Kuang, PinFen Tong, YuanYuan Han, JieJie Dai
2018 Aging  
ACKNOWLEDGEMENTS CONFLICTS OF INTEREST The authors declare no conflicts of interest.  ...  These findings demonstrated the involvement of pathways related to brain development and aging.  ...  In general, the regulation of brain development and aging is complex and multifaceted, and many of the details remain unknown.  ... 
doi:10.18632/aging.101437 pmid:29723158 pmcid:PMC5940110 fatcat:fhyxqbkqejc5rd25kiytfuijh4

DNA damage in the oligodendrocyte lineage and its role in brain aging

Kai-Hei Tse, Karl Herrup
2017 Mechanisms of Ageing and Development  
Delineating the relationships between early myelin loss and DNA damage in brain aging will offer an additional dimension outside the neurocentric view of neurodegenerative disease.  ...  Myelin is only formed by fully differentiated oligodendrocytes, but the entire oligodendrocyte lineage are clear targets of the altered chemistry of the aging brain.  ...  Support was also received from the National Key Basic Research Program of China (2013CB530900) and the National Institutes of Health of the United States (NS71022)  ... 
doi:10.1016/j.mad.2016.05.006 pmid:27235538 pmcid:PMC5124419 fatcat:qavejpbuu5fg5hrjl5shwbyyqu

Experience and Brain Development

William T. Greenough, James E. Black, Christopher S. Wallace
1987 Child Development  
.; and WALLACE, GHRISTOPHER S. Experience and Brain Development. GHILD DEVELOPMENT, 1987, 58, 539-559.  ...  This article considers how experience can influence the developing and mature brain and proposes a new categorization scheme based upon the type of information stored and the brain mechanisms that appear  ...  , the System Development Foundation, and the University of Illinois Research Board.  ... 
doi:10.2307/1130197 pmid:3038480 fatcat:p4tjoz6srndeletls77q7jo2iq

Experience and Brain Development

William T. Greenough, James E. Black, Christopher S. Wallace
1987 Child Development  
.; and WALLACE, GHRISTOPHER S. Experience and Brain Development. GHILD DEVELOPMENT, 1987, 58, 539-559.  ...  This article considers how experience can influence the developing and mature brain and proposes a new categorization scheme based upon the type of information stored and the brain mechanisms that appear  ...  , the System Development Foundation, and the University of Illinois Research Board.  ... 
doi:10.1111/j.1467-8624.1987.tb01400.x pmid:3038480 fatcat:gwo6eek7dfgvjiohzvoujp2yom

Autism and Brain Development

Christopher A. Walsh, Eric M. Morrow, John L.R. Rubenstein
2008 Cell  
Autism is classified as a "pervasive developmental disorder"-pervasive because it affects many aspects of cognition and behavior and developmental because autistic symptoms emerge during development from  ...  Language acquisition, at ~2 years of age is one of the last developmental milestones, whereas learning about social relationships continues into adulthood.  ... 
doi:10.1016/j.cell.2008.10.015 pmid:18984148 pmcid:PMC2701104 fatcat:4lmdimvckvfntbsexvhpibjj2y

MicroRNA, mRNA, and protein expression link development and aging in human and macaque brain

M. Somel, S. Guo, N. Fu, Z. Yan, H. Y. Hu, Y. Xu, Y. Yuan, Z. Ning, Y. Hu, C. Menzel, H. Hu, M. Lachmann (+3 others)
2010 Genome Research  
Instead, the vast majority of miRNA and gene expression changes that occur in aging represent reversals or extensions of developmental patterns.  ...  Although development is tightly regulated, the transition between development and aging, as well as regulation of post-developmental changes, are not well understood.  ...  Acknowledgments We thank the NICHD Brain and Tissue Bank for Developmental Disorders, the Chinese Brain Bank Center, and, in particular, H.  ... 
doi:10.1101/gr.106849.110 pmid:20647238 pmcid:PMC2928499 fatcat:6qtgkv7b35eqdkgegcyr6j3dbm

Brain Regions for Perceiving and Reasoning About Other People in School-Aged Children

Rebecca R. Saxe, Susan Whitfield-Gabrieli, Jonathan Scholz, Kevin A. Pelphrey
2009 Child Development  
We thank Elizabeth Spelke for suggesting the psychological ⁄ pragmatic interpretation of the effect of age. We thank the children and their families who made this research possible.  ...  This study was funded by a Career Development Award from the National Insti-  ...  We therefore examined changes in response patterns with age.  ... 
doi:10.1111/j.1467-8624.2009.01325.x pmid:19630902 fatcat:nfvyj5t3vbbarbpc2nfjq5pcb4

Germline mitochondrial DNA mutations aggravate ageing and can impair brain development

Jaime M. Ross, James B. Stewart, Erik Hagström, Stefan Brené, Arnaud Mourier, Giuseppe Coppotelli, Christoph Freyer, Marie Lagouge, Barry J. Hoffer, Lars Olson, Nils-Göran Larsson
2013 Nature  
n=3 animals). d, Proportions of unique and repeated mtDNA mutations of wt N −2 animals from G1 and G4.  ...  Some mtDNA mutator mice (n=4) had widespread bilateral brain malformations, which included cortical and hippocampal lamination disturbances, hypertrophic/hyperplastic changes in hippocampus and cerebral  ... 
doi:10.1038/nature12474 pmid:23965628 pmcid:PMC3820420 fatcat:jt3mnfjhgbbcbbtfybswffrnpe

Differential expression of sirtuin family members in the developing, adult, and aged rat brain

Elena Sidorova-Darmos, Robert G. Wither, Natalya Shulyakova, Carl Fisher, Melanie Ratnam, Michelle Aarts, Lothar Lilge, Philippe P. Monnier, James H. Eubanks
2014 Frontiers in Aging Neuroscience  
Spatial and temporal expression of sirtuins in brain we examined the endogenous mRNA and protein expression patterns of the seven sirtuin family members in the adult, developing and aged rat brain, and  ...  In the present study, we examined the regional mRNA and protein expression patterns of individual sirtuin family members in the developing, adult, and aged rat brain.  ...  ACKNOWLEDGMENTS The authors declare no conflict of interest with this study. We wish to thank Richard Logan and Jamie Fong for technical assistance, Dr.  ... 
doi:10.3389/fnagi.2014.00333 pmid:25566066 pmcid:PMC4270178 fatcat:kxzkcxfvjvcajilfs3ag2nvreu
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