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Brain development and aging: Overlapping and unique patterns of change
2013
NeuroImage
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The pattern of lateral cortical changes was similar across development and aging, but the pronounced medial temporal reduction in aging was not precast in development. ...
Developmental origins of neurocognitive late-life functions are acknowledged, but detailed longitudinal magnetic resonance imaging studies of brain maturation and direct comparisons with aging are lacking ...
A comparison of relative rates of cortical change in development and in elderly revealed a mixture of overlapping and unique characterizing changes in maturation and senescence. ...
doi:10.1016/j.neuroimage.2012.11.039
pmid:23246860
pmcid:PMC5378867
fatcat:4bghuj2ugfg27klada4b5jjx2y
Widespread splicing changes in human brain development and aging
2014
Molecular Systems Biology
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and aging. ...
While splicing differences between tissues, sexes and species are well documented, little is known about the extent and the nature of splicing changes that take place during human or mammalian development ...
Acknowledgements We thank the NICHD Brain and Tissue Bank for Developmental Disorders, the Netherlands Brain Bank, and Dr HR Zielke in particular for providing the human samples; Suzhou Drug Safety Evaluation ...
doi:10.1038/msb.2012.67
pmid:23340839
pmcid:PMC3564255
fatcat:nr662my2nbezraewp2yae4nfri
The temporal expression patterns of brain transcriptome during chicken development and ageing
2018
BMC Genomics
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The transcriptional profiles of mammals during brain development and ageing have been characterized. ...
However the global expression patterns of transcriptome in the chicken brain have not been explored. ...
Availability of data and materials All the data supporting our findings are contained within the manuscript. ...
doi:10.1186/s12864-018-5301-x
fatcat:ivbiejn725dq5klv5keedrkvkq
Stress-associated H3K4 methylation accumulates during postnatal development and aging of rhesus macaque brain
2012
Aging Cell
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Epigenetic modifications are critical determinants of cellular and developmental states. ...
In support of this, we also observed increased expression of two H3K4 methyltransferases, SETD7 and DPY30, in aged macaque brain. These authors contributed equally to this work. ...
Acknowledgments We are indebted to Drs Teng Fei and Yeguang Chen for the use of equipments. This work was supported by grants from the China Natural National Science Foundation (Grant #30890033 and ...
doi:10.1111/acel.12007
pmid:22978322
fatcat:qclcfsg7kzf4fhx47rk3k4w2ea
Genome-wide expression and methylation profiling in the aged rodent brain due to early-life Pb exposure and its relevance to aging
2012
Mechanisms of Ageing and Development
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Acknowledgments This research was supported by the Intramural Research Program of the National Institutes of Health (NIH), National Institute of Environmental Health Sciences (NIEHS) and by grants (ES013022 ...
and AG027246) from the NIH awarded to NHZ. ...
Shown through heat maps is the expression patterns of significant two fold differential gene expression (p ≤ 0.01) in the normal aging brain and in aged brains developmentally exposed to Pb. ...
doi:10.1016/j.mad.2012.05.003
pmid:22613225
pmcid:PMC3389195
fatcat:aeogkt57bvezxbkfvk64lkdomi
Development and heritability of subcortical brain volumes at ages 9 and 12
2014
Genes, Brain and Behavior
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Brain scans were acquired for 112 and 89 twin pairs at 9 and 12 years of age. ...
The heritability of development of subcortical brain volumes during adolescence has not been studied comprehensively. ...
Acknowledgments We thank the twins and their parents for making this study possible. ...
doi:10.1111/gbb.12182
pmid:25311829
fatcat:jhkxyhzo7rb57db4dniqwc7ywa
CircRNAs in the tree shrew (Tupaia belangeri) brain during postnatal development and aging
2018
Aging
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ACKNOWLEDGEMENTS
CONFLICTS OF INTEREST The authors declare no conflicts of interest. ...
These findings demonstrated the involvement of pathways related to brain development and aging. ...
In general, the regulation of brain development and aging is complex and multifaceted, and many of the details remain unknown. ...
doi:10.18632/aging.101437
pmid:29723158
pmcid:PMC5940110
fatcat:fhyxqbkqejc5rd25kiytfuijh4
DNA damage in the oligodendrocyte lineage and its role in brain aging
2017
Mechanisms of Ageing and Development
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Delineating the relationships between early myelin loss and DNA damage in brain aging will offer an additional dimension outside the neurocentric view of neurodegenerative disease. ...
Myelin is only formed by fully differentiated oligodendrocytes, but the entire oligodendrocyte lineage are clear targets of the altered chemistry of the aging brain. ...
Support was also received from the National Key Basic Research Program of China (2013CB530900) and the National Institutes of Health of the United States (NS71022) ...
doi:10.1016/j.mad.2016.05.006
pmid:27235538
pmcid:PMC5124419
fatcat:qavejpbuu5fg5hrjl5shwbyyqu
Experience and Brain Development
1987
Child Development
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.; and WALLACE, GHRISTOPHER S. Experience and Brain Development. GHILD DEVELOPMENT, 1987, 58, 539-559. ...
This article considers how experience can influence the developing and mature brain and proposes a new categorization scheme based upon the type of information stored and the brain mechanisms that appear ...
, the System Development Foundation, and the University of Illinois Research Board. ...
doi:10.2307/1130197
pmid:3038480
fatcat:p4tjoz6srndeletls77q7jo2iq
Experience and Brain Development
1987
Child Development
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.; and WALLACE, GHRISTOPHER S. Experience and Brain Development. GHILD DEVELOPMENT, 1987, 58, 539-559. ...
This article considers how experience can influence the developing and mature brain and proposes a new categorization scheme based upon the type of information stored and the brain mechanisms that appear ...
, the System Development Foundation, and the University of Illinois Research Board. ...
doi:10.1111/j.1467-8624.1987.tb01400.x
pmid:3038480
fatcat:gwo6eek7dfgvjiohzvoujp2yom
Autism and Brain Development
2008
Cell
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Autism is classified as a "pervasive developmental disorder"-pervasive because it affects many aspects of cognition and behavior and developmental because autistic symptoms emerge during development from ...
Language acquisition, at ~2 years of age is one of the last developmental milestones, whereas learning about social relationships continues into adulthood. ...
doi:10.1016/j.cell.2008.10.015
pmid:18984148
pmcid:PMC2701104
fatcat:4lmdimvckvfntbsexvhpibjj2y
MicroRNA, mRNA, and protein expression link development and aging in human and macaque brain
2010
Genome Research
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Instead, the vast majority of miRNA and gene expression changes that occur in aging represent reversals or extensions of developmental patterns. ...
Although development is tightly regulated, the transition between development and aging, as well as regulation of post-developmental changes, are not well understood. ...
Acknowledgments We thank the NICHD Brain and Tissue Bank for Developmental Disorders, the Chinese Brain Bank Center, and, in particular, H. ...
doi:10.1101/gr.106849.110
pmid:20647238
pmcid:PMC2928499
fatcat:6qtgkv7b35eqdkgegcyr6j3dbm
Brain Regions for Perceiving and Reasoning About Other People in School-Aged Children
2009
Child Development
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We thank Elizabeth Spelke for suggesting the psychological ⁄ pragmatic interpretation of the effect of age. We thank the children and their families who made this research possible. ...
This study was funded by a Career Development Award from the National Insti- ...
We therefore examined changes in response patterns with age. ...
doi:10.1111/j.1467-8624.2009.01325.x
pmid:19630902
fatcat:nfvyj5t3vbbarbpc2nfjq5pcb4
Germline mitochondrial DNA mutations aggravate ageing and can impair brain development
2013
Nature
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n=3 animals). d, Proportions of unique and repeated mtDNA mutations of wt N −2 animals from G1 and G4. ...
Some mtDNA mutator mice (n=4) had widespread bilateral brain malformations, which included cortical and hippocampal lamination disturbances, hypertrophic/hyperplastic changes in hippocampus and cerebral ...
doi:10.1038/nature12474
pmid:23965628
pmcid:PMC3820420
fatcat:jt3mnfjhgbbcbbtfybswffrnpe
Differential expression of sirtuin family members in the developing, adult, and aged rat brain
2014
Frontiers in Aging Neuroscience
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Spatial and temporal expression of sirtuins in brain we examined the endogenous mRNA and protein expression patterns of the seven sirtuin family members in the adult, developing and aged rat brain, and ...
In the present study, we examined the regional mRNA and protein expression patterns of individual sirtuin family members in the developing, adult, and aged rat brain. ...
ACKNOWLEDGMENTS The authors declare no conflict of interest with this study. We wish to thank Richard Logan and Jamie Fong for technical assistance, Dr. ...
doi:10.3389/fnagi.2014.00333
pmid:25566066
pmcid:PMC4270178
fatcat:kxzkcxfvjvcajilfs3ag2nvreu
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