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Brain activation patterns in medicated versus medication-naïve adults with attention-deficit hyperactivity disorder during fMRI tasks of motor inhibition and cognitive switching

Jatta Berberat, Ruth Huggenberger, Margherita Montali, Philipp Gruber, Achmed Pircher, Karl-Olof Lövblad, Hanspeter E. Killer, Luca Remonda
2021 BMC Medical Imaging  
We hypothesized that ADHD-adults with and without medication would show different fMRI pattern compared to healthy controls while testing tasks of motor inhibition and cognitive switching.  ...  However, fMRI revealed statistically significant differences between the ADHD+, ADHD− and control groups on tasks of motor inhibition and cognitive switching on adults in bilateral fronto-striatal brain  ...  Discussion This fMRI study demonstrated a statistically significant differences in the brain activation patterns during motor task inhibition and cognitive switching in adults with and without ADHD, as  ... 
doi:10.1186/s12880-021-00579-3 pmid:33740903 pmcid:PMC7977301 fatcat:nzdyyealmrhmnjetgmg6qtmnym

Task-Specific Hypoactivation in Prefrontal and Temporoparietal Brain Regions During Motor Inhibition and Task Switching in Medication-Naive Children and Adolescents With Attention Deficit Hyperactivity Disorder

Anna B. Smith, Eric Taylor, Mick Brammer, Brian Toone, Katya Rubia
2006 American Journal of Psychiatry  
Objective: A relatively small number of functional imaging studies of attention deficit hyperactivity disorder (ADHD) have shown abnormal prefrontal and striatal brain activation during tasks of motor  ...  Conclusion: Abnormal brain activation was observed in medication-naive children and adolescents with ADHD during tasks involving motor inhibition and task switching, suggesting that hypoactivation in this  ...  Objective: A relatively small number of functional imaging studies of attention deficit hyperactivity disorder (ADHD) have shown abnormal prefrontal and striatal brain activation during tasks of motor  ... 
doi:10.1176/ajp.2006.163.6.1044 pmid:16741205 fatcat:fzochdaeuvacvomrikohh62n7m

Effects of Stimulants on Brain Function in Attention-Deficit/Hyperactivity Disorder: A Systematic Review and Meta-Analysis

Katya Rubia, Analucia A. Alegria, Ana I. Cubillo, Anna B. Smith, Michael J. Brammer, Joaquim Radua
2014 Biological Psychiatry  
We tested methylphenidate effects relative to placebo in functional magnetic resonance imaging (fMRI) during three disorder-relevant tasks in medication-naïve ADHD adolescents.  ...  Psychostimulant medication, most commonly the catecholamine agonist methylphenidate, is the most effective treatment for attention-deficit/hyperactivity disorder (ADHD).  ...  Attention-deficit/hyperactivity disorder is associated with inhibition, attention, working memory (WM), and timing deficits (2) (3) (4) (5) , underpinned by functional magnetic resonance imaging (fMRI  ... 
doi:10.1016/j.biopsych.2013.10.016 pmid:24314347 pmcid:PMC4183380 fatcat:kxytudm6znd2tieiy7fy4rbyj4

Functional Neuroimaging in Obsessive-Compulsive Disorder

A. Del Casale, G.D. Kotzalidis, C. Rapinesi, D. Serata, E. Ambrosi, A. Simonetti, M. Pompili, S. Ferracuti, R. Tatarelli, P. Girardi
2011 Neuropsychobiology  
Improvements in spatial resolution of neuroimaging techniques may contribute to a better understanding of the neurocircuitry of OCD and other anxiety disorders.  ...  eral studies have targeted brain regions hypothesised to be involved in the pathogenesis of OCD, showing the existence of dysfunctional connectivity in the corticostriatothalamocortical circuitry.  ...  All other authors of this paper have no relevant affiliations or financial involvement with any organisation or entity with a financial interest in, or financial conflict with, the subject matter or materials  ... 
doi:10.1159/000325223 pmid:21701225 fatcat:h7xr2ixhcjh43kdpcf6srntiue

Functional Magnetic Resonance Imaging Evidence for Abnormalities in Response Selection in Attention Deficit Hyperactivity Disorder: Differences in Activation Associated with Response Inhibition but Not Habitual Motor Response

Stacy J. Suskauer, Daniel J. Simmonds, Sunaina Fotedar, Joanna G. Blankner, James J. Pekar, Martha B. Denckla, Stewart H. Mostofsky
2008 Journal of Cognitive Neuroscience  
., & Rubia, K. lask-specific hypoactivation in prefrontal and Tavlor, E temporoparietal brain regions during motor inhibition and task switching in medication-naive children and adolescents with attention  ...  , J., Event-related fMRI Tamm, | & Reiss, A. | of frontotemporal involvement (2004) evidence in aberrant response inhibition and task switching in attention-deficit/ hyperactivity disorder.  ... 
doi:10.1162/jocn.2008.20032 pmid:18004945 pmcid:PMC2896028 fatcat:djvucvhjjffr5pnub63pcdxutm

Different Neural Patterns Are Associated With Trials Preceding Inhibitory Errors in Children With and Without Attention-Deficit/Hyperactivity Disorder

Simona Spinelli, Suresh Joel, Tess E. Nelson, Roma A. Vasa, James J. Pekar, Stewart H. Mostofsky
2011 Journal of the American Academy of Child and Adolescent Psychiatry  
Objective-Attention-deficit/hyperactivity disorder (ADHD) is associated with difficulty inhibiting impulsive, hyperactive, and off-task behavior.  ...  Keywords ADHD; children; functional magnetic resonance imaging; commission error; go/no-go task Difficulties in response inhibition and attentional deficits have been widely reported in children with attention-deficit  ...  with ADHD during task switching. 43 In contrast, increased precuneus/PCC activity was found during unsuccessful response inhibition during the stopsignal task in TD adolescents compared with medication-naive  ... 
doi:10.1016/j.jaac.2011.03.014 pmid:21703498 pmcid:PMC3971481 fatcat:ydbwtocvfvesbaoxyz46ojo63u

Neurobiological Circuits Regulating Attention, Cognitive Control, Motivation, and Emotion: Disruptions in Neurodevelopmental Psychiatric Disorders

Amy F.T. Arnsten, Katya Rubia
2012 Journal of the American Academy of Child and Adolescent Psychiatry  
Children with attention-deficit/hyperactivity disorder show prominent abnormalities in the inferior PFC and its connections to striatal, cerebellar, and parietal regions, whereas children with conduct  ...  Results: The PFC provides "top-down" regulation of attention, inhibition/cognitive control, motivation, and emotion through connections with posterior cortical and subcortical structures.  ...  Arnsten and Yale University receive royalties from Shire Pharmaceuticals from the sales of extended release guanfacine (Intuniv™) for the treatment of attention-deficit/hyperactivity disorder. Dr.  ... 
doi:10.1016/j.jaac.2012.01.008 pmid:22449642 fatcat:bjwpkj5juzesxfn4aotj6pdaya

Toward Systems Neuroscience of ADHD: A Meta-Analysis of 55 fMRI Studies

Samuele Cortese, Clare Kelly, Camille Chabernaud, Erika Proal, Adriana Di Martino, Michael P. Milham, F. Xavier Castellanos
2012 American Journal of Psychiatry  
Objective-To perform a comprehensive meta-analysis of task-based functional MRI studies of Attention-Deficit/Hyperactivity Disorder (ADHD).  ...  Significant differences in activation of brain regions between individuals with ADHD and comparisons were detected using activation likelihood estimation meta-analysis (p<0.05, corrected).  ...  This work was also supported by NIH grants MH083246, MH081218, HD065282, and K23M087770.  ... 
doi:10.1176/appi.ajp.2012.11101521 pmid:22983386 pmcid:PMC3879048 fatcat:j5spj5odejcqbhcbxwd3pvjcka

Meta-analysis of fMRI studies of timing in attention-deficit hyperactivity disorder (ADHD)

Heledd Hart, Joaquim Radua, David Mataix-Cols, Katya Rubia
2012 Neuroscience and Biobehavioral Reviews  
Attention-deficit hyperactivity disorder (ADHD) is associated with deficits in timing functions with, however, inconclusive findings on the underlying neurofunctional deficits.  ...  The findings of left fronto-parieto-cerebellar deficits during timing functions contrast with well documented right fronto-striatal dysfunctions for inhibitory and attention functions, suggesting cognitive  ...  typically switched off during cognitively demanding tasks in healthy subjects (Weissman et al., 2006) , and which in turn is associated with optimal task performance and fewer attention lapses in healthy  ... 
doi:10.1016/j.neubiorev.2012.08.003 pmid:22922163 fatcat:pgjnrglcnnaq3bz3i4tf3p7ewy

Cognitive Inflexibility and Frontal-Cortical Activation in Pediatric Obsessive-Compulsive Disorder

Jennifer C. Britton, Scott L. Rauch, Isabelle M. Rosso, William D.S. Killgore, Lauren M. Price, Jennifer Ragan, Anne Chosak, Dianne M. Hezel, Daniel S. Pine, Ellen Leibenluft, David L. Pauls, Michael A. Jenike (+1 others)
2010 Journal of the American Academy of Child and Adolescent Psychiatry  
Objective-Deficits in cognitive flexibility and response inhibition have been linked to perturbations in cortico-striatal-thalamic circuitry in adult obsessive-compulsive disorder (OCD).  ...  Method-In this functional magnetic resonance imaging (fMRI) study, a pediatric sample of 10to 17-year-old subjects, 15 with OCD and 20 HC, completed a set-shifting task.  ...  Acknowledgments The authors acknowledge the contributions of Adriane Alpern, Elizabeth Flamm, Sarah Glaser, and Elizabeth Sadock from Massachusetts General Hospital for their assistance in conducting assessments  ... 
doi:10.1016/j.jaac.2010.05.006 pmid:20732630 pmcid:PMC4196669 fatcat:l4a42zxc25enroz7mrgoemluzy

Are Motor Skills and Motor Inhibitions Impaired in Tourette Syndrome? A Review

Navkiran Kalsi, Renata Tambelli, Paola Aceto, Carlo Lai
2015 Journal of Experimental Neuroscience  
This article reviews research on the execution and inhibition of voluntary motor movements in TS.  ...  Over last two decades, a number of studies have addressed the structural and functional deficits associated with this syndrome.  ...  of control: decreased motor cortex engagement during a Go/ noGo task in tourette's syndrome 15 patients with pure tourette's syndrome; medication-naïve 34 (9) fmri Go/noGo reaction time paradigm  ... 
doi:10.4137/jen.s25095 pmid:26279630 pmcid:PMC4517831 fatcat:dolpzehsxneh5bb56npcc3htdm

Functional MRI in ADHD: a systematic literature review

Yannis Paloyelis, Mitul A Mehta, Jonna Kuntsi, Philip Asherson
2007 Expert Review of Neurotherapeutics  
Every study appears to show differences in patterns of brain activation between cases and controls, but the interpretation of such differences is not as straightforward as it may seem.  ...  We present here a systematic review of the fMRI literature in ADHD; areas covered include executive functions, reward processing, the effects of methylphenidate, comorbidity and spontaneous brain activity  ...  function in children, adolescents and adults with attention deficit hyperactivity disorder (ADHD).  ... 
doi:10.1586/14737175.7.10.1337 pmid:17939771 pmcid:PMC3763932 fatcat:gmqi4zgww5d7bj2cp42i4swxxu

Comparative Multimodal Meta-analysis of Structural and Functional Brain Abnormalities in Autism Spectrum Disorder and Obsessive-Compulsive Disorder

Christina O. Carlisi, Luke J. Norman, Steve S. Lukito, Joaquim Radua, David Mataix-Cols, Katya Rubia
2017 Biological Psychiatry  
Inhibitory control is typically measured in motor and interference inhibition or switching tasks(9).  ...  While in Stop, GNG and interference inhibition tasks, a pre-potent motor response has to be inhibited, switching requires, in addition to motor inhibition, reengagement in a different response.  ...  -S4) for further details Abbreviations: ASD, autism spectrum disorders; fMRI, functional magnetic resonance imaging; OCD, obsessive compulsive disorder; SD, standard deviation; VBM, voxel-based morphometry  ... 
doi:10.1016/j.biopsych.2016.10.006 pmid:27887721 fatcat:y6xefxbyj5cqdjut2zxbliacy4

Neuroimaging of cognitive brain function in paediatric obsessive compulsive disorder: a review of literature and preliminary meta-analysis

Silvia Brem, Tobias U. Hauser, Reto Iannaccone, Daniel Brandeis, Renate Drechsler, Susanne Walitza
2012 Journal of neural transmission  
during cognitive task performance.  ...  during cognitive task performance.  ...  Conflict of interest S. Walitza received speakers honoraria from Eli Lilly, Janssen-Cilag and AstraZeneca in the last five years. The other authors declare no competing financial interests.  ... 
doi:10.1007/s00702-012-0813-z pmid:22678698 fatcat:t5s522ezarh6zonidh6eil66hy

Neural correlates of tic severity and cognitive control in children with Tourette syndrome

C. L. Baym, B. A. Corbett, S. B. Wright, S. A. Bunge
2007 Brain  
It has been unclear whether TS is associated with cognitive control deficits as well as pure motor control deficits, or whether cognitive deficits are associated with the presence of comorbid conditions  ...  Furthermore, little is known about the neural underpinnings of TS in childhood, prior to the long-term effects of medication on brain function.  ...  Acknowledgements This study was supported by a Merck Scholarship in the Biology of Developmental Disorders. Additional support for Blythe A.  ... 
doi:10.1093/brain/awm278 pmid:18056159 fatcat:cpcd7ngucncdxnv6ua5vquhl6y
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