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Brain Network Connectivity and Executive Function in Long-Term Survivors of Childhood Acute Lymphoblastic Leukemia

Shelli R. Kesler, Robert Ogg, Wilburn E. Reddick, Nicholas Phillips, Matthew Scoggins, John O. Glass, Yin Ting Cheung, Ching-Hon Pui, Leslie L. Robison, Melissa M. Hudson, Kevin R. Krull
<span title="">2018</span> <i title="Mary Ann Liebert Inc"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/v4t2k6us4zdn7imahrf7iujoiq" style="color: black;">Brain Connectivity</a> </i> &nbsp;
Brain Connectivity Brain network connectivity and executive function in long-term survivors of childhood acute lymphoblastic leukemia (Abstract Chemotherapeutic agents used to treat acute lymphoblastic  ...  Brain network connectivity and executive function in long-term survivors of childhood acute lymphoblastic leukemia (This paper has been peer-reviewed and accepted for publication, but has yet to undergo  ...  Acknowledgements This research was supported by grants from the National Institutes of Health (MH085849 to KRK; CA195547 to MMH and LLR; Cancer Center Support [CORE] grant CA21765; 1R01NR014195 and 1R01CA172145  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1089/brain.2017.0574">doi:10.1089/brain.2017.0574</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/29936880">pmid:29936880</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC6103246/">pmcid:PMC6103246</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/5g4puhiifnhfbd3w3svspfs4e4">fatcat:5g4puhiifnhfbd3w3svspfs4e4</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190305102933/http://pdfs.semanticscholar.org/d195/396f3853ef34cf3cec030a98ce642d4761f1.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/d1/95/d195396f3853ef34cf3cec030a98ce642d4761f1.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1089/brain.2017.0574"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6103246" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Structural and Functional Brain Imaging in Long-Term Survivors of Childhood Acute Lymphoblastic Leukemia Treated with Chemotherapy: A Systematic Review

Kellen Gandy, Matthew A Scoggins, Lisa M Jacola, Molly Litten, Wilburn E Reddick, Kevin R Krull
<span title="2021-08-11">2021</span> <i title="Oxford University Press (OUP)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/5toe7jruirb6degrpnzntm5rei" style="color: black;">JNCI Cancer Spectrum</a> </i> &nbsp;
Background The effect of chemotherapy on brain development in long-term survivors of pediatric acute lymphoblastic leukemia (ALL) was systematically reviewed.  ...  Survivors also had impaired brain function including lower brain network efficiency and altered resting state connectivity.  ...  Acknowledgments: We thank the researcher investigators who published their studies in the public domain.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1093/jncics/pkab069">doi:10.1093/jncics/pkab069</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/34514328">pmid:34514328</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC8421809/">pmcid:PMC8421809</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/6xbbmjj7xbhofoqxureun6pyxe">fatcat:6xbbmjj7xbhofoqxureun6pyxe</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20210824155058/https://watermark.silverchair.com/pkab069.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAuEwggLdBgkqhkiG9w0BBwagggLOMIICygIBADCCAsMGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMvb5Ca0UKOoqaAepEAgEQgIIClK_0003v7MrXFXBtH5YZBZKty2U3e4-TKi-86n9IAvfUXnV0IuWblZeauylvV6256oloPxp4vuVKDISeC0kk1DqgrH7GdFFqraXHh-14sBJVh1VxP0ZYH0RoJV4gYEcHsV2MIOB5SjVmWns-yYi9APmLgzoXTYqLgHHTBtvYjA4RFMMhKTWbZ-i2ml7otDS1Ems1AC8fPNSDaOaZFwDQjV44HBTUmJjXcnoT9VYA_F87THCftO7cXE4R4BddIzFjn7WWXsA9nvjYVrjQ4ya2NgKeuTwF-OjHRYPoJ67LcfISGl8yGNbeSqNsDphz-TFIMVwSNYXvzUMkij0uc1m0TCx6nPoLLH1DeZc5PTAJnNGrV34bYbDve3EhtiplOpXPfPPWaQSwN3Rvl1-t3kqIOELuqaZSoVUc487V10bvbfEQrvfkHwEhIYz7aqXYcIHC_u3lFi4R4n8vY9h-Rlu7pwFH0Nl-odmP61fGf25Fs7akJUxDqh2a47ho3yoto0KxIuaSp5OD8vQEFUwzS0uOeHlI2sNQfFCnzOSXo0ngxYXmDuUmKfbrm32BVzGxdLtO1NqHbpNx5tU2gxr0VT1j9vtGjzsEReQRGo_Ted_BkjY0VdkEK1-JqRglOWrDvScazqLHoiFVz08h7KL-eQh68l_6ZW5NcPwVxZbxDrP0TuTbyFW9iqojXtSqNo92at-SU5GmOE_J18OqsxV1QyWo_6i0VnULLwi7LZpqdl0jfL-Szwb0uhWyEKpVr7ohtY75HZIVOkhdRfmQNeTdE_LdTdQWzYfXWBjqboEwrOBdSG9YI7YSyObt2yOOkQxle26-nasoNrV2nHY5FVd9wBawRB4xm9NrHLU9sjWoSPDMte_2kBkDDw" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/ec/a0/eca03aa7f360d022bb1037dfc0911aab4da11578.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1093/jncics/pkab069"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> oup.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8421809" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Neurocognitive Outcomes and Interventions in Long-Term Survivors of Childhood Cancer

Kevin R. Krull, Kristina K. Hardy, Lisa S. Kahalley, Ilse Schuitema, Shelli R. Kesler
<span title="2018-07-20">2018</span> <i title="American Society of Clinical Oncology (ASCO)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/lwab7jq3mnfefomyfiv6nvc6su" style="color: black;">Journal of Clinical Oncology</a> </i> &nbsp;
We discuss the patterns and prevalence of neurocognitive problems commonly experienced by survivors of CNS tumors and acute lymphoblastic leukemia, the two most commonly researched cancer diagnoses.  ...  Long-term survivors of childhood cancer are also at risk for physical morbidity (eg, cardiac, pulmonary, endocrine) and problems with health behaviors (eg, sleep); research is reviewed that demonstrates  ...  Krull KR, Cheung YT, Liu W, et al: Chemotherapy pharmacodynamics and neuroimaging and neurocognitive outcomes in long-term survivors of childhood acute lymphoblastic leukemia.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1200/jco.2017.76.4696">doi:10.1200/jco.2017.76.4696</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/29874137">pmid:29874137</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC6553837/">pmcid:PMC6553837</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/xlrz7ml7hvbiro25ddaeeazjgm">fatcat:xlrz7ml7hvbiro25ddaeeazjgm</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190428041010/https://openaccess.leidenuniv.nl/bitstream/handle/1887/69148/Neurocognitive_outcomes.pdf?sequence=1" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/de/87/de871e58a0f9547c52e1b4d38ae3d154e3317241.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1200/jco.2017.76.4696"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6553837" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Chemotherapy Pharmacodynamics and Neuroimaging and Neurocognitive Outcomes in Long-Term Survivors of Childhood Acute Lymphoblastic Leukemia

Kevin R. Krull, Yin Ting Cheung, Wei Liu, Slim Fellah, Wilburn E. Reddick, Tara M. Brinkman, Cara Kimberg, Robert Ogg, Deokumar Srivastava, Ching-Hon Pui, Leslie L. Robison, Melissa M. Hudson
<span title="">2016</span> <i title="American Society of Clinical Oncology (ASCO)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/lwab7jq3mnfefomyfiv6nvc6su" style="color: black;">Journal of Clinical Oncology</a> </i> &nbsp;
Conclusion Survivors of childhood acute lymphoblastic leukemia treated on contemporary chemotherapy-only protocols demonstrate executive dysfunction.  ...  A higher plasma concentration of methotrexate was associated with executive dysfunction as well as with a thicker cortex and higher activity in frontal brain regions, regions often associated with executive  ...  Acknowledgment We thank the laboratory of Mary Relling at St Jude Children's Research Hospital for providing results of pharmacokinetic studies conducted during the therapeutic trial.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1200/jco.2015.65.4574">doi:10.1200/jco.2015.65.4574</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/27269941">pmid:27269941</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC5321052/">pmcid:PMC5321052</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/e3vkhjpfwrf4hnyxocn7z3cgri">fatcat:e3vkhjpfwrf4hnyxocn7z3cgri</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200504152708/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC5321052&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/5c/ee/5cee09ce45a7d50607bea28d920629b09e9ab174.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1200/jco.2015.65.4574"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5321052" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Altered Functional Connectivity Density in Young Survivors of Acute Lymphoblastic Leukemia Using Resting-State fMRI

Linglong Chen, Yaru Zhan, Fei He, Shouhua Zhang, Lin Wu, Honghan Gong, Fuqing Zhou, Xianjun Zeng, Haibo Xu
<span title="2020-08-07">2020</span> <i title="Informa UK Limited"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/6t76u6ys3nartbykmz3tjwjufy" style="color: black;">Cancer Management and Research</a> </i> &nbsp;
abnormalities in neural activity of young survivors of acute lymphoblastic leukemia (ALL) and to explore the neuropathological evidence of chemotherapy-related cognitive impairment of patients.  ...  Our results suggest the altered functional connectivity of young survivors of ALL in the posterior region of the brain and posterior lobe of the cerebellum.  ...  Introduction Acute lymphoblastic leukemia (ALL) is the most common malignancy in childhood.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.2147/cmar.s253202">doi:10.2147/cmar.s253202</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/32821168">pmid:32821168</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC7425087/">pmcid:PMC7425087</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/p75va6566ne4jhvnorsybhhmam">fatcat:p75va6566ne4jhvnorsybhhmam</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200814153736/https://www.dovepress.com/front_end/cr_data/cache/pdf/download_1597419455_5f36afbfad372/cmar-253202-altered-functional-connectivity-density-in-young-survivors-o.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/1a/ca/1acad3f7ed2e0e914e15e5ce27a621cf9f3f230f.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.2147/cmar.s253202"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7425087" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Connectivity of the Cerebello-Thalamo-Cortical Pathway in Survivors of Childhood Leukemia Treated With Chemotherapy Only

Nicholas S. Phillips, Shelli R. Kesler, Matthew A. Scoggins, John O. Glass, Yin Ting Cheung, Wei Liu, Pia Banerjee, Robert J. Ogg, Deokumar Srivastava, Ching-Hon Pui, Leslie L. Robison, Wilburn E. Reddick (+2 others)
<span title="2020-11-20">2020</span> <i title="American Medical Association (AMA)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/aj4ubaiwqfeknejtsyuk2st4su" style="color: black;">JAMA Network Open</a> </i> &nbsp;
Treatment with contemporary chemotherapy-only protocols is associated with risk for neurocognitive impairment among survivors of childhood acute lymphoblastic leukemia (ALL).  ...  of executive function in female survivors.  ...  Introduction Among survivors of childhood acute lymphoblastic leukemia (ALL), treatment with contemporary chemotherapy-only protocols, which include high doses of methotrexate and glucocorticoids (ie,  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1001/jamanetworkopen.2020.25839">doi:10.1001/jamanetworkopen.2020.25839</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/33216140">pmid:33216140</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC7679952/">pmcid:PMC7679952</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/fwpsptyakjfbjogtxpnk5z76ea">fatcat:fwpsptyakjfbjogtxpnk5z76ea</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20201122004435/https://jamanetwork.com/journals/jamanetworkopen/articlepdf/2773165/phillips_2020_oi_200845_1605213453.47315.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/23/ed/23edbadebe92cc1d9625d108494ae4d7b420aa03.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1001/jamanetworkopen.2020.25839"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7679952" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Cognitive Impairment in Survivors of Adolescent and Early Young Adult Onset Non-CNS Cancers: Does Chemotherapy Play a Role?

Tami D. John, Leonard S. Sender, Daniela A. Bota
<span title="">2016</span> <i title="Mary Ann Liebert Inc"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/vepze5x5x5d2xmm4hl5r675e6a" style="color: black;">Journal of Adolescent and Young Adult Oncology</a> </i> &nbsp;
Adolescent brain reorganization begins during puberty and slows by age 25 years. 15 This reorganization primarily involves maturation of functional connectivity of white matter networks, which is especially  ...  , particular for memory, processing speed, and executive function. 31 Challenges with participation and long-term follow-up for aging survivors of AYA-onset cancers may hinder our ability to investigate  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1089/jayao.2015.0025">doi:10.1089/jayao.2015.0025</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/27078009">pmid:27078009</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/prqo6tqgu5ejhlfwtyrdgyuko4">fatcat:prqo6tqgu5ejhlfwtyrdgyuko4</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20180725060112/https://cloudfront.escholarship.org/dist/prd/content/qt4jp8888z/qt4jp8888z.pdf?t=p6xivh" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/ae/b5/aeb54255156185f22b1aa6b4244b84a9550bfd24.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1089/jayao.2015.0025"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a>

Functional and structural differences in the hippocampus associated with memory deficits in adult survivors of acute lymphoblastic leukemia

Michelle Monje, Moriah E. Thomason, Laura Rigolo, Yalin Wang, Deborah P. Waber, Stephen E. Sallan, Alexandra J. Golby
<span title="2012-08-08">2012</span> <i title="Wiley"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/ilrunatnkra4hjvcdbjhcpdd6q" style="color: black;">Pediatric Blood &amp; Cancer</a> </i> &nbsp;
Procedure-In the present study, we explored episodic memory and its neuroimaging correlates in 10 adult survivors of childhood acute lymphoblastic leukemia (ALL) treated with cranial radiation therapy  ...  Results-We report behavioral, structural and functional changes in the brains of the adult survivors.  ...  Acknowledgments The authors gratefully acknowledge the support of the Hagerty Foundation (M.M.), the National Institute of Mental Health (MH081583, M.E.T.,) and a NARSAD Young Investigator Award (MET.)  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1002/pbc.24263">doi:10.1002/pbc.24263</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/22887801">pmid:22887801</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC3612582/">pmcid:PMC3612582</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/26qtz6txhnf5zafrxewu3zwo64">fatcat:26qtz6txhnf5zafrxewu3zwo64</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200502105345/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC3612582&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/75/09/75090e57fff6b63962319b205e4449ec2fd904ba.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1002/pbc.24263"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> wiley.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3612582" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Regional Brain Glucose Metabolism and Neurocognitive Function in Adult Survivors of Childhood Cancer Treated with Cranial Radiation

K. R. Krull, S. Minoshima, M. Edelmann, B. Morris, N. D. Sabin, T. M. Brinkman, G. T. Armstrong, L. L. Robison, M. M. Hudson, B. Shulkin
<span title="2014-10-14">2014</span> <i title="Society of Nuclear Medicine"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/es34xtfdxrgybg2kmdq2n5xqry" style="color: black;">Journal of Nuclear Medicine</a> </i> &nbsp;
The objective of this study was to examine associations between regional brain metabolism, as measured by (18)F-FDG PET, and neurocognitive outcomes in adult survivors of childhood acute lymphoblastic  ...  leukemia (ALL) treated with cranial radiation.  ...  Neurocognitive impairment, particularly in executive function, is relatively common in adult survivors of childhood acute lymphoblastic leukemia (ALL) treated with cranial radiation therapy (CRT) (3)  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.2967/jnumed.114.142950">doi:10.2967/jnumed.114.142950</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/25315244">pmid:25315244</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC4366940/">pmcid:PMC4366940</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/ioebmkk4nfax5f7fu2uigd7wkm">fatcat:ioebmkk4nfax5f7fu2uigd7wkm</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20180719202931/http://jnm.snmjournals.org/content/55/11/1805.full.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/3a/5e/3a5e139c701c85e1bcfc21c8f74eacd4576021c1.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.2967/jnumed.114.142950"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4366940" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Methylene tetrahydrofolate reductase A1298C polymorphisms influence the adult sequelae of chemotherapy in childhood-leukemia survivors

Iris Elens, Sabine Deprez, Thibo Billiet, Charlotte Sleurs, Veerle Labarque, Anne Uyttebroeck, Stefaan Van Gool, Jurgen Lemiere, Rudi D'Hooge
<span title="2021-04-30">2021</span> <i title="Public Library of Science"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/s3gm7274mfe6fcs7e3jterqlri" style="color: black;">PLoS ONE</a> </i> &nbsp;
This retrospective correlation study investigated the putative link between methylene tetrahydrofolate reductase (MTHFR) A1298C mutations and chemotherapy-related brain function changes in adult childhood-leukemia  ...  at the time of treatment, (2) their adult performance intelligence quotient (PIQ), and (3) their regional brain connectivity using diffusion magnetic resonance imaging (dMRI) and resting-state functional  ...  Altered functional connectivity of the DMN in non-irradiated childhood-leukemia survivors has been described by others as an adult marker of chemotherapy-induced brain damage [10] [11] [12] .  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1371/journal.pone.0250228">doi:10.1371/journal.pone.0250228</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/33930029">pmid:33930029</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC8087097/">pmcid:PMC8087097</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/zc5nehowcnbbfbq34zfmawj5hm">fatcat:zc5nehowcnbbfbq34zfmawj5hm</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20210717155644/https://lirias2repo.kuleuven.be/bitstream/handle/123456789/675924/Elens_2021_MTHFR.pdf;jsessionid=C1545C2CAC509B52FB32414B8C54181C?sequence=2" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/1a/7b/1a7b5407402b11cf7877536ad5bfda9dbe247b27.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1371/journal.pone.0250228"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> plos.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8087097" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

The Psychoneuroimmunology of Stress Regulation in Pediatric Cancer Patients

Gillian E. White, Jessica E. Caterini, Victoria McCann, Kate Rendall, Paul C. Nathan, Shawn G. Rhind, Heather Jones, Greg D. Wells
<span title="2021-09-18">2021</span> <i title="MDPI AG"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/2zwku6u6nfdcri773tpisi6ldi" style="color: black;">Cancers</a> </i> &nbsp;
To date, there has been minimal study of stress reactivity patterns in childhood illness populations. Nor has the role of stress regulation in long-term health and function been elucidated.  ...  We conclude that consideration of stress regulation in childhood cancer may be crucial in understanding and treating the disease.  ...  Indeed, in a recent study of childhood Acute Lymphoblastic Leukemia (ALL) survivors, correlations were found between low levels of physical activity and inattention [77] .  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3390/cancers13184684">doi:10.3390/cancers13184684</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/34572911">pmid:34572911</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC8468382/">pmcid:PMC8468382</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/sgqaxgfikbayzfihnf4qdc7otm">fatcat:sgqaxgfikbayzfihnf4qdc7otm</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20211002064715/https://mdpi-res.com/d_attachment/cancers/cancers-13-04684/article_deploy/cancers-13-04684-v2.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/3c/93/3c937169e19169dec59085077b9c26b1997809a9.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3390/cancers13184684"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> mdpi.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8468382" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Long-term brain structural magnetic resonance imaging and cognitive functioning in children treated for acute lymphoblastic leukemia with high-dose methotrexate chemotherapy alone or combined with CNS radiotherapy at reduced total dose to 12 Gy

Olga Zając-Spychała, Mikołaj A. Pawlak, Katarzyna Karmelita-Katulska, Jakub Pilarczyk, Katarzyna Derwich, Jacek Wachowiak
<span title="2017-01-10">2017</span> <i title="Springer Nature"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/na5fvete3zgchm7q2aibnq2yhm" style="color: black;">Neuroradiology</a> </i> &nbsp;
The control group consisted of 12 children newly diagnosed with acute lymphoblastic leukemia.  ...  Introduction The aim of this study was to assess the long-term side effects of central nervous system prophylaxis (high-dose chemotherapy alone vs chemotherapy and CNS radiotherapy) according to the ALL  ...  Introduction Acute lymphoblastic leukemia (ALL) is the most common malignancy in children [1] [2] [3] .  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/s00234-016-1777-8">doi:10.1007/s00234-016-1777-8</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/28074235">pmid:28074235</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC5371615/">pmcid:PMC5371615</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/zt34jdujhfanvk3rygcmmqza3y">fatcat:zt34jdujhfanvk3rygcmmqza3y</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20181030085824/https://link.springer.com/content/pdf/10.1007%2Fs00234-016-1777-8.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/4d/8c/4d8cf311a11fdedfd95abbccc9bfc42ce1710770.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/s00234-016-1777-8"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> springer.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5371615" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Developing Interventions for Cancer-Related Cognitive Dysfunction in Childhood Cancer Survivors

S. M. Castellino, N. J. Ullrich, M. J. Whelen, B. J. Lange
<span title="2014-07-30">2014</span> <i title="Oxford University Press (OUP)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/jnejgjvotvh5boads34hitrvlu" style="color: black;">Journal of the National Cancer Institute</a> </i> &nbsp;
Survivors of childhood cancer frequently experience cancer-related cognitive dysfunction, commonly months to years after treatment for pediatric brain tumors, acute lymphoblastic leukemia (ALL), or tumors  ...  The increased years of life saved after childhood cancer warrants continued study toward the prevention and remediation of cancer-related cognitive dysfunction, using uniform assessments anchored in functional  ...  Cognitive dysfunction varies in severity. It is most common in survivors of brain tumors or acute lymphoblastic leukemia (ALL).  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1093/jnci/dju186">doi:10.1093/jnci/dju186</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/25080574">pmid:25080574</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC4155432/">pmcid:PMC4155432</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/twvsnqle6fc7fdmmwd4oypbhwm">fatcat:twvsnqle6fc7fdmmwd4oypbhwm</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190304065940/http://pdfs.semanticscholar.org/d769/20b16bdbde725ebf62f99657fd93546da52e.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/d7/69/d76920b16bdbde725ebf62f99657fd93546da52e.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1093/jnci/dju186"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> oup.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4155432" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Future Considerations for Pediatric Cancer Survivorship: Translational Perspectives from Developmental Neuroscience

Rebecca M. Jones, Siobhan S. Pattwell
<span title="2019-05-24">2019</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/d6mayixwtng25h4i22gqinj7em" style="color: black;">Developmental Cognitive Neuroscience</a> </i> &nbsp;
Despite enhanced cure rates, a subset of pediatric cancer survivors exhibit life-long psychological side effects.  ...  Yet, absent from many studies are the ways in which cancer treatment can impact the developing brain.  ...  Ruberry for helpful discussions and feedback in preparing this review.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.dcn.2019.100657">doi:10.1016/j.dcn.2019.100657</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/31158802">pmid:31158802</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC6697051/">pmcid:PMC6697051</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/v5dcaajcfrewtkqrtodsypjwii">fatcat:v5dcaajcfrewtkqrtodsypjwii</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200511103138/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC6697051&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/80/6f/806f46928ef52c63faa32ec1110d44e897f2834c.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.dcn.2019.100657"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> elsevier.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6697051" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Cerebrospinal Fluid Biomarkers in Childhood Leukemias

Chrysanthy Ikonomidou
<span title="2021-01-24">2021</span> <i title="MDPI AG"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/2zwku6u6nfdcri773tpisi6ldi" style="color: black;">Cancers</a> </i> &nbsp;
Involvement of the central nervous system (CNS) in childhood leukemias remains a major cause of treatment failures.  ...  This review presents an overview of studies demonstrating that cerebrospinal fluid biomarkers can be utilized in tracing both CNS disease and neurotoxicity of administered treatments in childhood leukemias  ...  Conflicts of Interest: The author declares no conflict of interest. Cancers 2021, 13, 438  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3390/cancers13030438">doi:10.3390/cancers13030438</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/33498882">pmid:33498882</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/mwqk7cpfnreytke7n2ebpzqxou">fatcat:mwqk7cpfnreytke7n2ebpzqxou</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20210129095035/https://res.mdpi.com/d_attachment/cancers/cancers-13-00438/article_deploy/cancers-13-00438.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/f1/cf/f1cf5f6f257d5294d0518bd6bb66ed7806172e15.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3390/cancers13030438"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> mdpi.com </button> </a>
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