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Bow-tie signaling in c-di-GMP: Machine learning in a simple biochemical network

Jinyuan Yan, Maxime Deforet, Kerry E. Boyle, Rayees Rahman, Raymond Liang, Chinweike Okegbe, Lars E. P. Dietrich, Weigang Qiu, Joao B. Xavier, Oleg A. Igoshin
2017 PLoS Computational Biology  
how Machine learning in c-di-GMP network PLOS Computational Biology | https://doi.  ...  The c-di-GMP network has a bow-tie shaped architecture that integrates many signals from the outside world-the input stimuli-into intracellular c-di-GMP levels that then regulate genes for biofilm formation  ...  Signal integration in a bow-tie network has therefore many advantages.  ... 
doi:10.1371/journal.pcbi.1005677 pmid:28767643 pmcid:PMC5555705 fatcat:buccwim4ffhs7irbzgluwgmxm4