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Application of bioreactor technology in plant propagation and secondary metabolite production
Приложение на биореакторната технология в размножаването на растенията и производството на вторични метаболити

Svetla Yancheva, Liliya Georgieva, Ilian Badjakov, Ivayla Dincheva, Mariya Georgieva, Vasil Georgiev, Violeta Kondakova
2019 Journal of Central European Agriculture  
Some applications of modified bioreactor systems and their importance for the advancement of plant biotechnology in the fields of agriculture, medicine, and pharmacy are discussed in this review.  ...  In the past decades, the progress in plant tissue culture technology was directed towards the introduction of the liquid medium for cultivation under submerged conditions in different bioreactor types,  ...  With the in vitro cultivated plants in bioreactors, such problems could be avoided by the precisely controlled microenvironment.  ... 
doi:10.5513/jcea01/20.1.2224 fatcat:2sltm6ulmrfrvklskik5whk7t4

The omnistat: a flexible continuous‐culture system for prolonged experimental evolution

David M. Ekkers, Filipe Branco dos Santos, Cyrus A. Mallon, Frank Bruggeman, G. Sander van Doorn
2020 Methods in Ecology and Evolution  
Third, bioreactor modules can be coupled by uni- or bi-directional flows to induce spatiotemporal variation in selection.  ...  Second, the bioreactor is small (25-250 ml), which makes it feasible to run many replicates in parallel.  ...  A broad range of culturing modes can be induced by programming control loops between the measured variable and control parameters ( Figure 6 ).  ... 
doi:10.1111/2041-210x.13403 pmid:32999708 pmcid:PMC7508058 fatcat:uzvsdyvm7jak5ojdb5krgp3tsi

Optimization of invertase production in a fed-batch bioreactor using simulation based dynamic programming coupled with a neural classifier

Catalina Valencia, Gabriela Espinosa, Jaume Giralt, Francesc Giralt
2007 Computers and Chemical Engineering  
A controller based on neuro-dynamic programming coupled with a fuzzy ARTMAP neural network for a fed-batch bioreactor was developed to produce cloned invertase in Saccharomyces cerevisiae yeast in a fed-batch  ...  The controller updated in time an optimal control action that incremented the fed-batch bioreactor profitability.  ...  Another alternative is to use genetic algorithms for the optimization problem (Sarkar & Modak, 2004 , 2005 .  ... 
doi:10.1016/j.compchemeng.2006.10.002 fatcat:7yp2cphyebbqxaynfzipwoikom

Bioreactors and molecular analysis in berry crop micropropagation – A review

Samir Debnath
2011 Canadian Journal of Plant Science  
for the assessment of genetic fidelity, uniformity, stability and trueness-to-type among donor plants and tissue culture regenerants.  ...  Bioreactors and molecular analysis in berry crop micropropagation Á A review. Can. J. Plant Sci. 91: 147Á157.  ...  To overcome some of these problems, two major solutions for malformation control include the use of growth retardants to control rapid proliferation and temporary immersion bioreactors (TIB; Ziv et al  ... 
doi:10.4141/cjps10131 fatcat:vmbxcasia5c6jaaw2qozl3bvye

Gene-activated and cell-migration guiding PEG matrices based on three dimensional patterning of RGD peptides and DNA complexes

Silvia Orsi, Daniela Guarnieri, Antonia De Capua, Paolo A. Netti
2012 Acta Biomaterialia  
Therefore, the system, acting as a genetic bioreactor potentially useful for the regulation of biology at a distance, could be used to directly control cell trafficking and activation in the human body  ...  Essential to the design of genetic bioreactors used in the human body is a consideration of how the properties of biomaterials can combine to envelope, spatially guide, reprogramme by gene transfer, and  ...  a b s t r a c t Essential to the design of genetic bioreactors used in the human body is a consideration of how the properties of biomaterials can combine to envelope, spatially guide, reprogramme by gene  ... 
doi:10.1016/j.actbio.2012.05.010 pmid:22633968 fatcat:cmgqajm6tra23ehysylmcbhhiq

The new role of the microchemostat in the bioengineering revolution

F.K. Balagadde
2009 2009 Annual International Conference of the IEEE Engineering in Medicine and Biology Society  
The microfluidic chemostat prolonged the lifetime of the programmed circuit by an order of magnitude compared macroscale characterization schemes.  ...  This concept was demonstrated by characterizing the dynamics of Escherichia coli cells carrying a synthetic "population control" circuit, which regulates cell density through a feedback mechanism based  ...  The killer gene regulated cell density by controlling the cell death rate. The circuit, under control of a synthetic promoter, was inducible with isopropyl-β-Dthiogalactopyranoside (IPTG).  ... 
doi:10.1109/iembs.2009.5335037 pmid:19965138 fatcat:7etxtkbmw5dldabimxtb3crb5a

Transgenic hairy roots

Archana Giri, M.Lakshmi Narasu
2000 Biotechnology Advances  
The neoplastic roots produced by A. rhizogenes infection is characterized by high growth rate and genetic stability.  ...  Development of bioreactor models for hairy root cultures is still a recent phenomenon.  ...  Acknowledgments The financial support to A.G. by Council of Scientific and Industrial Research (CSIR) Govt. of India is duly acknowledged. The authors thank Dr C.C.  ... 
doi:10.1016/s0734-9750(99)00016-6 pmid:14538116 fatcat:vt7y6xygavcz5kxcky3ugx3jde

An evolutionary strategy for fed-batch bioreactor optimization; concepts and performance

J.A. Roubos, G. van Straten, A.J.B. van Boxtel
1999 Journal of Biotechnology  
An evolutionary program, based on a real-code genetic algorithm (GA), is applied to calculate optimal control policies for bioreactors.  ...  The performance and optimal trajectories obtained by the extended GA are compared with those calculated with two common methods: (i) dynamic programming, and (ii) a Hamiltonian based gradient algorithm  ...  Variation in the population is achieved by genetic cross-over and mutation.  ... 
doi:10.1016/s0168-1656(98)00174-6 fatcat:l3qpei4ownf73eutuola44rnze

Commercial delivery of genetic improvement to conifer plantations using somatic embryogenesis

Ben Sutton
2002 Annals of Forest Science  
In view of these limitations many organizations have initiated programs to produce control-pollinated seed.  ...  The precise control of these variables can be achieved efficiently using liquid medium supplied to developing embryos in bioreactors [4] .  ... 
doi:10.1051/forest:2002052 fatcat:vst2uwgz2rdofcqdz67u3xkkvq

Biological and biophysical principles in extracorporal bone tissue engineering

H.P Wiesmann, U Joos, U Meyer
2004 International Journal of Oral & Maxillofacial Surgery  
Furthermore an enhancement of bone regeneration by application of chemical stimulation factors is discussed.  ...  Sophisticated bioreactor systems are those that mimic the three-dimensional morphology and the mechanical situation of bones.  ...  With the understanding of how programmed cell death is controlled 69 in vivo, combined with the improved ability to effectively influence the process of apoptosis, apoptosis is gaining clinical relevance  ... 
doi:10.1016/j.ijom.2004.04.005 pmid:15308249 fatcat:5kgkveankndalcyow4yz43hnci

Biochemical reactor modeling and control

2006 IEEE Control Systems  
Penicillin production was revolutionized by the combination of genetically engineered cell strains and large-scale fermentation, as illustrated in "Penicillin Production."  ...  Further enhancements in penicillin production were achieved by introducing random genetic mutations into this Penicillium chrysogenum strain through the application of X-ray and ultraviolet irradiation  ... 
doi:10.1109/mcs.2006.1657876 fatcat:pldvbbu4irhqjepneb3y7iqzny

Fractional-Order PID Controllers for Temperature Control: A Review

Adeel Ahmad Jamil, Wen Fu Tu, Syed Wajhat Ali, Yacine Terriche, Josep M. Guerrero
2022 Energies  
, and the improvement achieved by temperature control systems.  ...  In this paper, fractional-order proportional integral derivative controllers are discussed in the context of controlling the temperature in ambulances, induction heating systems, control of bioreactors  ...  PID controls with genetic algorithms and particle swarm optimization; (4) Adjustment of PID and fractional-order PID controls by GA.  ... 
doi:10.3390/en15103800 fatcat:w7t7louqjbfwlpfc2vgli2jfsu

Regulation on Genetically Modified Animals: Proposed and Its Possible Application in Indonesia

Bess Tiesnamurti, Sri Muharsini, M I Shiddieqy
2021 Wartazoa  
European countries and USA have regulations to control genetically modified animals. Malaysia also has applied a similar regulation since 2007.  ...  This paper is aimed to propose the regulation for genetically modified animal that may be entering Indonesia and or be researched by Indonesian scientists.  ...  amandmend of that regulation to No. 6/2018 of food control genetically modified organism.  ... 
doi:10.14334/wartazoa.v31i4.2972 fatcat:263cir3zibfxrlxiuejo4rqmmi

ambr™ Mini-bioreactor as a high-throughput tool for culture process development to accelerate transfer to stainless steel manufacturing scale: comparability study from process performance to product quality attributes

Frédéric Delouvroy, Gaetan Siriez, An-Vy Tran, Larissa Mukankurayija, Nadine Kochanowski, Laetitia Malphettes
2015 BMC Proceedings  
Data was analysed using JMP statistical (SAS) program.  ...  with Biostat B-DCUII control systems (Sartorius Stedim), 80L and 400L stainless-steel bioreactors (Zeta).  ... 
doi:10.1186/1753-6561-9-s9-p78 fatcat:55ljyswpmfdanc64mt3j2od5ui

Clinical scale rapid expansion of lymphocytes for adoptive cell transfer therapy in the WAVE® bioreactor

Robert PT Somerville, Laura Devillier, Maria R Parkhurst, Steven A Rosenberg, Mark E Dudley
2012 Journal of Translational Medicine  
Results: TIL and genetically modified PBL were rapidly expanded to clinically relevant scales in both static bags and the WAVE bioreactor.  ...  Both bioreactors produced comparable numbers of cells; however the cultures generated in the WAVE bioreactor had a higher percentage of CD4+ cells and had a less activated phenotype.  ...  Acknowledgements This research was supported in part by the intramural research program of the National Cancer Institute. Robert Somerville is supported by the Adelson Medical Research Foundation.  ... 
doi:10.1186/1479-5876-10-69 pmid:22475724 pmcid:PMC3402993 fatcat:ufwwbj7m7vhyfcv5df3z4m4mua
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