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Biomimetic in Silico Devices [chapter]

C. Anthony Hunt, Glen E. P. Ropella, Michael S. Roberts, Li Yan
2005 Lecture Notes in Computer Science  
We introduce biomimetic in silico devices, and means for validation along with methods for testing and refining them.  ...  An assembly of lobule-mimetic devices represents an in silico liver. We validate against outflow profiles for sucrose administered as a bolus to isolated, perfused rat livers.  ...  The process produces in silico devices [6] capable of biomimetic behaviors. Of course, these devices are also models.  ... 
doi:10.1007/978-3-540-25974-9_4 fatcat:nyxuvb6apfds7ovd7wvllznxxe

In silico drug absorption tract: An agent-based biomimetic model for human oral drug absorption

Jianyuan Deng, Anika Jhandey, Xiao Zhu, Zhibo Yang, Kin Fu Patrick Yik, Zhong Zuo, Tai Ning Lam, Luis Eduardo M. Quintas
2018 PLoS ONE  
Methods An agent-based biomimetic model, in silico drug absorption tract (ISDAT), was built to mimic oral drug absorption in humans.  ...  This project demonstrates that a biomimetic agent-based model can adequately describe the absorption and disposition kinetics both of midazolam and clonazepam.  ...  Overall significance In summary, we have developed a prototypical ISDAT, an in silico device which is capable of modeling oral drug absorption in human.  ... 
doi:10.1371/journal.pone.0203361 pmid:30169515 pmcid:PMC6118387 fatcat:xgkekqldtjbdznb6cpw2v4w4yi

Food Oral Processing—An Industry Perspective

Marine Devezeaux De Lavergne, Ashley K. Young, Jan Engmann, Christoph Hartmann
2021 Frontiers in Nutrition  
We illustrate how scientific understanding of Food Oral Processing enables food product development with specific benefits for several target populations. in vivo, in vitro, and in silico approaches are  ...  discussed in the context of their ability to quantify oral processing from the molecular to the macroscopic scale.  ...  Similarly to our insights on biomimetic devices, we believe that in-silico approaches, validated thoroughly with in-vivo data, and in combination with in vitro tools, will allow inherently coupled processes  ... 
doi:10.3389/fnut.2021.634410 pmid:33634161 pmcid:PMC7899988 fatcat:ymttl75ltffj5h246nwefqbubq

Studies of intestinal drug transport using an in silico epithelio-mimetic device

Yu Liu, C. Anthony Hunt
2005 Biosystems (Amsterdam. Print)  
We demonstrate that this device can generate behaviors similar to those observed in the in vitro Caco-2 transwell system.  ...  We demonstrate that this device can generate behaviors similar to those observed in the in vitro Caco-2 transwell system.  ...  Acknowledgements This research was done by Yu Liu in partial fulfillment of the Ph.D. degree requirements. It was supported in part by the CDH Research Foundation (R21-CDH-00101).  ... 
doi:10.1016/j.biosystems.2005.06.008 pmid:16135397 fatcat:yx2ceucyibcp3p7lymeve2plim

Parametric Modeling of Biomimetic Cortical Bone Microstructure for Additive Manufacturing

José Robles-Linares, Erick Ramírez-Cedillo, Hector Siller, Ciro Rodríguez, J. Martínez-López
2019 Materials  
In this work we present a novel algorithm for generating in-silico biomimetic models of a cortical bone microstructure towards manufacturing biomimetic bone via additive manufacturing.  ...  Modeling based on the density, inclination and size range of the osteon and Haversian and Volkmann´s canals granted the development of a dynamic in-silico porosity (13.37–21.49%) that matches with models  ...  List of inputs for the models used for the algorithm in-silico validation.  ... 
doi:10.3390/ma12060913 pmid:30893894 pmcid:PMC6471362 fatcat:tc6zkttx7rcovo4w7ec5kcniqa

Using hydrodynamic focusing to predictably alter the diameter of synthetic silk fibers

Bradley Hoffmann, Catherine Gruat-Henry, Pranothi Mulinti, Long Jiang, Benjamin D. Brooks, Amanda E. Brooks, Mohammad Reza Abidian
2018 PLoS ONE  
Mirroring in silico fluid flow simulations using a hydrodynamic microfluidic spinning technique, we have developed a model correlating spinning rates, solution viscosity and fiber diameter outputs that  ...  In this study, the use of hydrodynamic fluid focusing within a 3D printed biomimetic spinning system to recapitulate the biological spinneret is explored and shown to produce predictable, small diameter  ...  While rheological analysis provides insight into protein behavior under increasing fluidic shear within the artificial biomimetic device (Fig 2) , in silico simulations in which fluid flow rates can be  ... 
doi:10.1371/journal.pone.0195522 pmid:29649239 pmcid:PMC5896967 fatcat:cdq72di6nrfhnh65rytzqdyviq

Hybrid Ceramo-Polymeric Nanocomposite for Biomimetic Scaffolds Design and Preparation

Raffaella Aversa, Relly Victoria V. Petrescu, Roberto Sorrentino, Florian Ion T. Petrescu, Antonio Apicella
2016 American Journal of Engineering and Applied Sciences  
Since testing and mathematical methods are closely interlaced, a promising approach seemed to be the combination of in vitro and in vivo experiments with computer simulations (in silico).  ...  Biomimetics, biomechanics and tissue engineering are three multidisciplinary fields that have been contemplated in this research to attain the objective of improving prosthetic implants reliability.  ...  Biomimetic/Biomechanical Approach: Hybrid Ceramo-Polymeric Surface and Bulk Properties Design for Osteointegration Improvement Bio-prosthetic devices represent a reconstructive therapy widely used in clinical  ... 
doi:10.3844/ajeassp.2016.1096.1105 fatcat:q7r7qettbzadxor3vpag6em6n4

Biologically structured materials

Raffaella Aversa, Relly Victoria Virgil Petrescu, Antonio Apicella, Florian Ion Tiberiu Petrescu
2020 Independent Journal of Management & Production  
Since testing and mathematical methods are closely interlaced, a promising approach seemed to be the combination of in vitro and in vivo experiments with computer simulations (in silico).  ...  Biomimetics, biomechanics, and tissue engineering are three multidisciplinary fields that have been contemplated in this research to attain the objective of improving prosthetic implants reliability.  ...  Biomimetic/Biomechanical approach: Hybrid ceramo-polymeric surface and bulk properties design for osteointegration improvement Bio-prosthetic devices represent a reconstructive therapy widely used in clinical  ... 
doi:10.14807/ijmp.v11i4.950 fatcat:akc6hb53uvcphhda3yvpcmqrse

Microfluidic-Based Multi-Organ Platforms for Drug Discovery

Ahmad Rezaei Kolahchi, Nima Khadem Mohtaram, Hassan Pezeshgi Modarres, Mohammad Mohammadi, Armin Geraili, Parya Jafari, Mohsen Akbari, Amir Sanati-Nezhad
2016 Micromachines  
Recent advances in physiologically-based pharmacokinetic and pharmacodynamic (PBPK-PD) modeling, micro-and nanotechnology, and in silico modeling have enabled single-and multi-organ platforms for investigation  ...  Despite significant efforts that have been recently made to develop biomimetic in vitro tissue models, the clinical application of such platforms is still far from reality.  ...  In vitro and in silico models instead have been developed to overcome such limitations [5, 6] .  ... 
doi:10.3390/mi7090162 pmid:30404334 pmcid:PMC6189912 fatcat:ba53b5cncndd7ki6iavpp4slme

Biomimetic molecular design tools that learn, evolve, and adapt

David A Winkler
2017 Beilstein Journal of Organic Chemistry  
This paper describes new developments in biomimetic adaptive, evolving, learning computational molecular design methods and their potential impacts in chemistry, engineering, and medicine.  ...  Automation, robotics, artificial intelligence, and evolutionary algorithms are now converging to generate what might broadly be called in silico-based adaptive evolution of materials.  ...  Biomimetic in silico evolutionary methods and their synergy with high throughput materials synthesis technologies (materials defined very broadly) are then briefly described.  ... 
doi:10.3762/bjoc.13.125 pmid:28694872 pmcid:PMC5496546 fatcat:idnflg4i35azzpg7vibdbaqgce

Towards real-time communication between in vivo neurophysiological data sources and simulator-based brain biomimetic models

Giljae Lee, Andréa Matsunaga, Salvador Dura-Bernal, Wenjie Zhang, William W Lytton, Joseph T Francis, José A B Fortes
2014 Journal of Computational Surgery  
These then must be connected as hybrid systems in order to interface the BMM with in vivo data acquisition devices and prosthetic devices.  ...  One approach is to utilize brain biomimetic models (BMMs) to develop and instantiate these algorithms.  ...  In the second data flow, simulation results are fed back into the system via the in silico interface and interconnection modules and are used to control a prosthetic device through the in vivo interface  ... 
doi:10.1186/s40244-014-0012-3 pmid:26702394 pmcid:PMC4685709 fatcat:uvsawqtucfbstf4ubfv4owjdju

Biomimetic and Evolutionary Design Driven Innovation in Sustainable Products Development

Raffaella Aversa, Relly Victoria V. Petrescu, Florian Ion T. Petrescu, Antonio Apicella
2016 American Journal of Engineering and Applied Sciences  
An innovative, design-driven, sustainable approach in conceiving, developing, producing, using new materials can be effective in strengthening the competiveness and success of creative industries linked  ...  holistic view of the industrial design process in the field of biomedical application.  ...  Biomechanics, Biomimetic and Biofidelity cooperative path: An "in silico" tool for new prostheses design Osteointegrative and osteinductive Biomimetic properties of hybrid ceramo-polymeric nanocomposites  ... 
doi:10.3844/ajeassp.2016.1027.1036 fatcat:twljumik2zd4xmeeaktmy7pmgu

A bio-inspired spatial patterning circuit

Kai-Yuan Chen, Danial J. Joe, James B. Shealy, Bruce R. Land, Xiling Shen
2014 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society  
We built an in silico genetic circuit model to analyze the dynamic properties of LI.  ...  This biomimetic system serve as a physical model to elucidate the design principle of generating robust patterning through spatial feedback, regardless of the underlying devices being biological or electrical  ...  Here, using in silico models and biomimetic electrical circuits, we demonstrate that LI forms robust cell fate patterns by acting as an intercellular bistable switch that amplify differences between neighboring  ... 
doi:10.1109/embc.2014.6943535 pmid:25569903 pmcid:PMC4304701 dblp:conf/embc/ChenJSLS14 fatcat:asa6iuxbgjbpbc3pargzf5oe6a

Computational and bioengineered lungs as alternatives to whole animal, isolated organ, and cell-based lung models

Brijeshkumar Patel, Robert Gauvin, Shahriar Absar, Vivek Gupta, Nilesh Gupta, Kamrun Nahar, Ali Khademhosseini, Fakhrul Ahsan
2012 American Journal of Physiology - Lung cellular and Molecular Physiology  
and efficacy of these models. bioengineered lung; computational modeling; in silico; lung models; tissue engineering  ...  To address the complexity and limitations associated with in vivo and in vitro models, attempts have been made to develop in silico and tissue-engineered lung models that allow incorporation of various  ...  In this in silico model of particle deposition in asthma, Martonen et al.  ... 
doi:10.1152/ajplung.00076.2012 pmid:22886505 fatcat:peyqj5efbfbuznsdmjpa7d3cfm

The Genealogy of Biomimetics: Half a Century's Quest for Dynamic IT [chapter]

Mikkel Holm Sørensen
2004 Lecture Notes in Computer Science  
Whereas 1) and 2) concern the creation of fait accompli products, a biomimetic IT design methodology 3) instead creates dynamic 'produces', i.e. evolutionary processes involving IT devices that adapt in  ...  Mimicking biological processes in creating life-like products.  ...  in IT devices [2, 3, 4, 29] .  ... 
doi:10.1007/978-3-540-27835-1_36 fatcat:74ltmu6kzzbnjl7oqd6vavxpky
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