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Application of Novel Quantitative Proteomic Technologies to Identify New Serological Biomarkers in Autoimmune Diseases [chapter]

Soyoung Lee, Satoshi Serada, Minoru Fujimoto, Tetsuji Nak
2011 Autoimmune Disorders - Current Concepts and Advances from Bedside to Mechanistic Insights  
Disorders -Current Concepts and Advances from Bedside to Mechanistic Insights  ...  Leucin-rich-α-2 glycoprotein as a novel biomarker We reported for the first time that the iTRAQ technology is applicable to identify novel biomarkers in sera from patients with autoimmune diseases .  ...  Application of Novel Quantitative Proteomic Technologies to Identify New Serological Biomarkers in Autoimmune Diseases, Autoimmune Disorders -Current Concepts and Advances from Bedside to Mechanistic Insights  ... 
doi:10.5772/20726 fatcat:holko5a7tzgytoue6lntxuwxwi

Immunologic Biomarkers and Biomarkers for Immunotherapies in Gastrointestinal Cancer

Benedikt Martin, Bruno Märkl
2019 Visceral Medicine  
This immunologic biomarker was shown to be impressively prognostic and predictive in colorectal cancer.  ...  In conclusion, there is increasing evidence of immunologic as well as predictive biomarkers for immunotherapies in GI cancers.  ...  Statement of Ethics The authors have no ethical conflicts to disclose. Disclosure Statement All authors declare that no conflict of interests exists.  ... 
doi:10.1159/000496565 pmid:31312644 pmcid:PMC6597909 fatcat:ervyy42nvzhn5oajq3jdnw5kci

Gold Nanozymes: From Concept to Biomedical Applications

Javier Lou-Franco, Bhaskar Das, Christopher Elliott, Cuong Cao
2020 Nano-Micro Letters  
Likewise, further toxicity studies are required to ensure the applicability of gold nanozymes in vivo.  ...  Yet, real applications often require specific biorecognition elements to be immobilized onto the nanozymes, leading to unexpected positive or negative effects on their activity.  ...  immunological assays (i.e., ELISA).  ... 
doi:10.1007/s40820-020-00532-z pmid:34138170 pmcid:PMC8187695 fatcat:ooiib5dhovflngxw65ap7tuahu

New Immuno-Epidemiological Biomarker of Human Exposure to Aedes Vector Bites: From Concept to Applications

André Sagna, Mabo Yobo, Emmanuel Elanga Ndille, Franck Remoue
2018 Tropical Medicine and Infectious Disease  
Potential applications of such antibody-based biomarkers of exposure to Aedes vector bites in the field of operational research are also discussed.  ...  This review focuses on studies highlighting the concept, techniques, and methods used to develop and validate specific candidate biomarkers of human exposure to Aedes bites.  ...  Figure 2 . 2 The concept of salivary biomarkers to vector bites. Figure 2 . 2 The concept of salivary biomarkers to vector bites. Figure 3 . 3 Figure 3.  ... 
doi:10.3390/tropicalmed3030080 pmid:30274476 pmcid:PMC6161005 fatcat:fopgl5roezculpvpyhpafwdkhi

Editorial: Novel Immunological Biomarkers for Allogeneic HSCT Outcome

Raffaella Greco, Jacopo Peccatori, Francesca Bonifazi, John A. Snowden, Fabio Ciceri
2021 Frontiers in Immunology  
ACKNOWLEDGMENTS We would like to thank all authors that generously contributed to this topic, and the staff of Frontiers for the precious help and assistance.  ...  AUTHOR CONTRIBUTIONS All authors listed have made a substantial, direct and intellectual contribution to the work, and approved it for publication.  ...  Recently, several potential immunological biomarkers have been identified in the setting of allogeneic HSCT, ranging from serum proteins and other small molecules to immune cell subsets.  ... 
doi:10.3389/fimmu.2021.670822 pmid:33777058 pmcid:PMC7994590 fatcat:t62ky4ie4zc6xfug3goehwbgou

The Identification of Immunological Biomarkers in Kidney Cancers

Antonio Lopez-Beltran, Vanessa Henriques, Alessia Cimadamore, Matteo Santoni, Liang Cheng, Thomas Gevaert, Ana Blanca, Francesco Massari, Marina Scarpelli, Rodolfo Montironi
2018 Frontiers in Oncology  
Thus, there is need for improved knowledge and application of PD-1/PD-L1 IHC biomarkers in daily practice. IHC staining appears in membranous fashion.  ...  PD-L1 expression is a poor prognostic factor and predictive of better responses from both PD-1 and PD-L1 inhibitors in a variety of tumor types including RCC.  ...  Thus, there is need for improved knowledge and application of PD-1/PD-L1 IHC biomarkers in daily practice. IHC staining appears in membranous fashion.  ... 
doi:10.3389/fonc.2018.00456 pmid:30450335 pmcid:PMC6225533 fatcat:25vtyiqj4fbldpe3gabitcxat4

Biomarkers in Severe Asthma

Xiao Chloe Wan, Prescott G. Woodruff
2016 Immunology and allergy clinics of North America  
There are several potential applications of biomarkers in the study and management of severe asthma (Box 2).  ...  Of these potential applications, significant advances have been made in biomarkers of endotypes (ie, biologically related subtypes) of asthma and in those that are predictive of response to therapy.  ... 
doi:10.1016/j.iac.2016.03.004 pmid:27401625 pmcid:PMC6057475 fatcat:nebcx22jabcurl6ueawryu6mty

Biomarkers in Hereditary Angioedema

Grzegorz Porebski, Mateusz Kwitniewski, Avner Reshef
2021 Clinical reviews in allergy and immunology  
Pathophysiologic pathways involved in HAE reveal a plethora of molecules from the complement, coagulation, and fibrinolysis systems or from the vascular endothelium, which may serve as biomarkers.  ...  Additionally, major advances in high-throughput omics-based technologies may facilitate the discovery of new candidate biomarkers in the future.  ...  To view a copy of this licence, visit http://creat iveco mmons .org/licen ses/by/4.0/. Fig. 1 1 Biomarkers in hereditary angioedema-future applications and research directions.  ... 
doi:10.1007/s12016-021-08845-6 pmid:33560480 pmcid:PMC8272698 fatcat:3zh4xdk56fcrnoiogl64sl3k7y

Seeking Relevant Biomarkers in Common Variable Immunodeficiency

Hsi-en Ho, Charlotte Cunningham-Rundles
2022 Frontiers in Immunology  
The implementation of high throughput profiling techniques may accelerate the search of relevant biomarker profiles in CVID and lead to better clinical risk stratification, revealing disease insights,  ...  More than 50% of patients in some series suffer from autoimmune or inflammatory complications (the "CVID+" phenotype), and these are not adequately addressed by current treatments.  ...  In a proof-of-concept study, this technique was capable of segregating CVID patients from healthy participants based on serum or plasma samples with high sensitivity and specificity.  ... 
doi:10.3389/fimmu.2022.857050 pmid:35359997 pmcid:PMC8962738 fatcat:lyhbaulvgbgjnb3zooyrvycxqm

Immunologic Biomarkers in Peripheral Blood of Persons With Tuberculosis and Advanced HIV

Artur T. L. Queiroz, Mariana Araújo-Pereira, Beatriz Barreto-Duarte, Adriano Gomes-Silva, Allyson G. Costa, Alice M. S. Andrade, João Pedro Miguez-Pinto, Renata Spener-Gomes, Alexandra B. Souza, Aline Benjamin, Flavia Sant'Anna, Marina C. Figueiredo (+7 others)
2022 Frontiers in Immunology  
We used neural network analysis, based on machine learning, to identify biomarkers (single or in combination) that best distinguished cases from controls.  ...  We assessed soluble factors to identify biomarkers associated with TB among persons with advanced HIV.MethodsA case-control (1:1) study was conducted, with participants from Rio de Janeiro and Manaus,  ...  ACKNOWLEDGMENTS We thank the patients and the teams involved in this study. We also thank the teams of clinical and laboratory platforms of RePORT Brazil.  ... 
doi:10.3389/fimmu.2022.890003 pmid:35757685 pmcid:PMC9226490 fatcat:rag6j6plyrc5lhmxdizvbxcgzm

Minimally invasive biomarker studies in eosinophilic esophagitis

Brittany T. Hines, Matthew A. Rank, Benjamin L. Wright, Lisa A. Marks, John B. Hagan, Alex Straumann, Matthew Greenhawt, Evan S. Dellon
2018 Annals of Allergy, Asthma & Immunology  
Objective: To identify promising minimally-invasive EoE biomarkers and remaining gaps in biomarker validation.  ...  Methods: We performed a systematic review of EMBASE, Ovid Medline, PubMed, and Web of Science from inception to June 6, 2017.  ...  , rare disease supplementary concept word, Asthma Immunol.  ... 
doi:10.1016/j.anai.2018.05.005 pmid:29753832 pmcid:PMC6104633 fatcat:jraecgv63vb2nc27gvanjwh7vu

GPC2 Is a Potential Diagnostic, Immunological, and Prognostic Biomarker in Pan-Cancer

Guoming Chen, Dongqiang Luo, Nan Zhong, Danyun Li, Jiyuan Zheng, Hui Liao, Zhuoyao Li, Xiaoxiao Lin, Qiqi Chen, Cheng Zhang, Yuanjun Lu, Yau-Tuen Chan (+3 others)
2022 Frontiers in Immunology  
However, no systematic pan-cancer analysis has been conducted to explore its function in diagnosis, prognosis, and immunological prediction.MethodsBy comprehensive use of datasets from The Cancer Genome  ...  The expression level of GPC2 in a variety of tumors is significantly different from that of normal tissues.  ...  DISCUSSION Hitherto, cancer-related research has always been a research focus in the current medical domain. 33 cancer-related data from TCGA and CCLE platforms were used to explore biomarkers suitable  ... 
doi:10.3389/fimmu.2022.857308 pmid:35345673 pmcid:PMC8957202 fatcat:nc7lwr5gcrcjfmboxub2nmui4u

Biomarkers for antigen immunotherapy in allergy and type 1 diabetes

Jared M. Odegard, Gerald T. Nepom, Erik Wambre
2015 Clinical Immunology  
In the setting of antigen-specific therapy in allergy and type 1 diabetes, assays to monitor the immunological mechanisms of disease have been improving in recent years, and we are getting closer to an  ...  Understanding changes in frequency and phenotype of these cells is critical to improve assessment of disease diagnosis and prognosis and effectively assess immunological response to therapy.  ...  The authors thank their colleagues and clinical collaborators at Benaroya Research Institute, who contributed to the work described in this review.  ... 
doi:10.1016/j.clim.2015.05.023 pmid:26122171 pmcid:PMC4628579 fatcat:wxwa5xr3cnbobobul76kv3y6zi

Advances in Biomarker-Guided Therapy for Pediatric- and Adult-Onset Neuroinflammatory Disorders: Targeting Chemokines/Cytokines

Michael R. Pranzatelli
2018 Frontiers in Immunology  
The concept of CKRs as biomarkers was studied in MS (47) .  ...  The biomarker-guided approach helps advance preclinical studies to clinical proof-of-concept studies in targeted drug development (2) .  ... 
doi:10.3389/fimmu.2018.00557 pmid:29670611 pmcid:PMC5893838 fatcat:wgjc4gfvfbhqhkkdwoyzui3lkm

Understanding Fatigue in Sjögren's Syndrome: Outcome Measures, Biomarkers and Possible Interventions

Elisabeth Mæland, Samira T. Miyamoto, Daniel Hammenfors, Valeria Valim, Malin V. Jonsson
2021 Frontiers in Immunology  
Symptoms range from dryness to severe extra-glandular disease involving manifestations in the skin, lungs, nervous system, and kidney.  ...  This study briefly reviews fatigue in pSS, with special attention to outcome measures, biomarkers, and possible treatment options.  ...  The overall aim was to briefly review fatigue in SS with special attention to outcome measures, biomarkers and current treatment options.  ... 
doi:10.3389/fimmu.2021.703079 pmid:34249008 pmcid:PMC8267792 fatcat:piig5yky35hm3ez55aqpd7ifpe
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