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The plant cytoskeleton: a key tool for agro-biotechnology
2009
Annals of Botany
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g-tubulins and intermediate filaments only -such a reduced list of cytoskeletal components that the term 'fundamentals' seems difficult to justify); (2) cytoskeleton and development (featuring one of ...
s The plant cytoskeleton: a key tool for agro-biotechnology (abbreviated hereafter to TPC). ...
doi:10.1093/aob/mcp084
pmcid:PMC2685313
fatcat:vpbdtzijazaopivgyv6bdgewsy
Identification of a Novel Keratin 9 Missense Mutation in a Chinese Family with Epidermolytic Palmoplantar Keratoderma
2018
Cellular Physiology and Biochemistry
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We wish to thank our clinical colleagues for their efforts in collecting clinical and genetic data. ...
Acknowledgements We are grateful to the proband and his family; without their cooperation and contribution, this work would not have been performed. ...
Bioinformatics tools predicted that the variant was "disease-causing". ...
doi:10.1159/000489381
pmid:29719290
fatcat:qnlbmoipybeyzbglgqtrd5xbxi
Integrating mass spectrometry and genomics for cyanobacterial metabolite discovery
2015
Journal of Industrial Microbiology & Biotechnology
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this discussion the use of genomics, mass spectrometric networking, biochemical characterization, and isolation and structure elucidation techniques. ...
, mass spectrometry, and biochemical studies has provided effective tools for understanding their fundamental pathways. ...
While the development of more robust heterologous expression tools would usher a transformative approach to studying cyanobacterial natural products, it is clear that the combination of genome analysis ...
doi:10.1007/s10295-015-1705-7
pmid:26578313
pmcid:PMC5065021
fatcat:kec4w2pqbvfkzhaqpuffntj3pm
Bioinformatics analysis of genes associated with the patchy-type alopecia areata: CD2 may be a new therapeutic target
2019
Biomedical Papers of the Faculty of Medicine of Palacky University
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The up-regulated DEGs were related to the immune response and chemokine signaling pathway. Meanwhile, down-regulated DEGs were enriched in keratin filament and intermediate filament. ...
Further study is needed to explore the value of CD2 in the treatment of alopecia areata. ...
and intermediate filament. ...
doi:10.5507/bp.2019.049
pmid:31558844
fatcat:frg6o5733fgq3haa7i7kxmm7l4
Cell structure and dynamics
2005
Current Opinion in Cell Biology
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proteins, also contains relatives of intermediate filaments. ...
of structural and single-molecule studies. ...
doi:10.1016/j.ceb.2004.12.013
fatcat:6b2x3vgbtzcetkdpbf2duesyca
Electron Cryomicroscopy of Biological Machines at Subnanometer Resolution
2005
Structure
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Bridging the information gap: computational tools for intermediate resolution structure interpretation. 10, 131-135. King, J., and Chiu, W. (1997). ...
the crystal structures of the individual components. two distinct types of machines amenable to cryo-EM However, cryo-EM can be the sole structural tool in the investigations at subnanometer resolutions ...
Acknowledgments groundwork for using cryo-EM density maps to build and assess homology models based on low sequence ...
doi:10.1016/j.str.2004.12.016
pmid:15766537
fatcat:7q33fiifdvevxohmpkmey2om4m
A Missense Mutation within the Helix Termination Motif of KRT25 Causes Autosomal Dominant Woolly Hair/Hypotrichosis
2018
Journal of Investigative Dermatology
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ACKNOWLEDGMENTS We thank all patients and their families for their ongoing participation in this study. We thank Dr. Yutaka Shimomura for providing the pCXN2.1-Wt-K25-Flag expression vector. ...
Leu residue at position 376 is
In order to predict the potential effect of p.Leu376Arg variant on the function of human K25，we integrated multiple bioinformatics tools. ...
filament
IF: intermediate filaments
HS: hair shaft
). ...
doi:10.1016/j.jid.2017.08.035
pmid:28899683
fatcat:2xwdwzmo6zadxemmvuyaoly6dm
Expression of Vimentin Intermediate Filament for Vascular Development in Olive Flounder (Paralichthys olivaceus)
2014
Development & Reproduction
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In addition, in the myoplasm, intermediate filaments connect to dense bodies to which actin filaments also attach (Fuchs & Cleveland, 1998; Prahlad et al., 1998) . ...
filaments in flatfish developmental stages has not been sufficiently studied. ...
doi:10.12717/dr.2014.18.2.107
pmid:25949178
pmcid:PMC4282252
fatcat:2f5lib42dvbofkx6uuul7ghbcq
Capturing Natural Product Biosynthetic Pathways from Uncultivated Symbiotic Bacteria of Marine Sponges Through Metagenome Mining: A Mini-Review
2015
Squalen
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Metagenome mining is a powerful cultivation-independent tool that can be used to search for new natural product biosynthetic pathways from highly complex bacterial consortia. ...
be predicted with high accuracy through bioinformatic analysis and sometimes combined with functional proof. ...
Structural studies of AT's binding pocket have been used to create predictive tools for the specificity of malonyl-CoA (MCoA), methylmalonyl-CoA (MMCoA), and other less common substrates (Anand et al. ...
doi:10.15578/squalen.v10i1.131
fatcat:aplgdsquhjcd5jg7jqh7x55qqy
Ultrastructural Organization of Budding Yeast Septin Filaments Both in vitro and in situ, Analyzed by Electron Microscopy
2010
Biophysical Journal
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Here, we used electron cryo-microscopy (Cryo-EM) and image analysis to study the structures of LDL and LDLLDLr complex. ...
We are performing structural studies on purified DHPRs and RyRs to understand structural details involved in the gating mechanism. The DHPR is a heteropentamer with total molecular weight of~450 kDa. ...
Here, we used electron cryo-microscopy (Cryo-EM) and image analysis to study the structures of LDL and LDLLDLr complex. ...
doi:10.1016/j.bpj.2009.12.2069
fatcat:dhksnrarindnhbvzhkwzaftlyi
Novel origin of lamin-derived cytoplasmic intermediate filaments in tardigrades
2016
eLife
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Intermediate filament (IF) proteins, including nuclear lamins and cytoplasmic IF proteins, are essential cytoskeletal components of bilaterian cells. ...
These results suggest that a lamin derivative has been co-opted to enhance tissue stability in tardigrades, a function otherwise served by cytoplasmic IF proteins in all other bilaterians. ...
Intermediate 497 filament structure: the bottom-up approach. Curr. Opin. Cell. Biol. 32, 65-72.
, H., and Aebi, U. (2004). ...
doi:10.7554/elife.11117
pmid:26840051
pmcid:PMC4829535
fatcat:rdpjuc2ogvgfnhoj4rzl7jftjm
mycelyso – high-throughput analysis of Streptomyces mycelium live cell imaging data
2019
BMC Bioinformatics
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Results: We present the tool mycelyso (MYCElium anaLYsis SOftware), an image analysis system tailored to fully automated hyphae-level processing of image stacks generated by time-lapse microscopy. ...
Streptomycetes are filamentous microorganisms of high biotechnological relevance, especially for the production of antibiotics. ...
Graph data structures and intermediate segmentation results are visualized for checking the processed results. ...
doi:10.1186/s12859-019-3004-1
fatcat:4lvgiqsg7jesfo3gkut7xkmrgq
Simultaneous Multicomponent Registration of High-Resolution X-Ray Structures into Electron Microscopy Maps
2010
Biophysical Journal
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Here, we used electron cryo-microscopy (Cryo-EM) and image analysis to study the structures of LDL and LDLLDLr complex. ...
We are performing structural studies on purified DHPRs and RyRs to understand structural details involved in the gating mechanism. The DHPR is a heteropentamer with total molecular weight of~450 kDa. ...
Here, we used electron cryo-microscopy (Cryo-EM) and image analysis to study the structures of LDL and LDLLDLr complex. ...
doi:10.1016/j.bpj.2009.12.2066
fatcat:h5kfswthjfcf5hp3w5fltrwlfq
The Desmin (DES) Mutation p.A337P Is Associated with Left-Ventricular Non-Compaction Cardiomyopathy
2021
Genes
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DES encodes the muscle-specific intermediate filament protein desmin and DSP encodes desmoplakin, which is a cytolinker protein connecting desmosomes with the intermediate filaments. ...
Because the majority of DES mutations cause severe filament assembly defects and because this mutation was found in both affected patients, we analyzed this DES mutation in vitro by cell transfection experiments ...
Several bioinformatic prediction tools suggested a high probability for a damaging effect of DES-p.A337P (Table 2 ). ...
doi:10.3390/genes12010121
pmid:33478057
fatcat:dyrdnaftkbe5hktftkq3rrgfju
Calcium Gating by the DHPR-RyR1 Pair
2010
Biophysical Journal
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Here, we used electron cryo-microscopy (Cryo-EM) and image analysis to study the structures of LDL and LDLLDLr complex. ...
We are performing structural studies on purified DHPRs and RyRs to understand structural details involved in the gating mechanism. The DHPR is a heteropentamer with total molecular weight of~450 kDa. ...
Here, we used electron cryo-microscopy (Cryo-EM) and image analysis to study the structures of LDL and LDLLDLr complex. ...
doi:10.1016/j.bpj.2009.12.2068
fatcat:77n5cvrjsngqtnatjem4hgjgpy
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