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Bioinformatics in the Netherlands: the value of a nationwide community

Celia W. G. van Gelder, Rob W. W. Hooft, Merlijn N. van Rijswijk, Linda van den Berg, Ruben G. Kok, Marcel Reinders, Barend Mons, Jaap Heringa
2017 Briefings in Bioinformatics  
This review provides a historical overview of the inception and development of bioinformatics research in the Netherlands.  ...  The Dutch bioinformatics community is accustomed to facing the ever-changing landscape of data challenges and working towards solutions together.  ...  The authors would also like to acknowledge the Dutch bioinformatics community at large for its commitment and energy to drive the field further.  ... 
doi:10.1093/bib/bbx087 pmid:28968694 fatcat:smni2ho7gjdujkxivarmgqqbpi

Tobacco Control Legislation in the Netherlands

Brigit Toebes, Willem Bantema
2016 Social Science Research Network  
L Tobacco Control Legislation in the Netherlands By Prof.  ...  predictive value of a positive screen and reduce medical resource utilization at the likely expense of missed or delays in diagnosis of lung cancer. 12, 13 Mathematical models have been developed that  ...  Over 80% of the categories of evidence and consensus in the NCCN NSCLC guidelines are Category 2A unless otherwise noted.  ... 
doi:10.2139/ssrn.3054095 fatcat:qgfdn3o625ahfjjmb3pybc7g5y

3PNotable variation of molecular testing in metastatic lung cancer in the Netherlands

C Kuijpers, M Van den Heuvel, L Overbeek, A Van Lindert, R Damhuis, S Willems
2019 Annals of Oncology  
This translates into a significantly fewer number of high PD-L1 expressors (>49%) in cases with high MET CN (>2.2; P ¼ 0.06; Table) .  ...  Methods: 80 cases of pleomorphic carcinoma were identified from the biobank and diagnostic archives of Royal Brompton Hospital and Imperial College Healthcare NHS trust.  ...  On a nationwide basis, we aimed to assess the performance of molecular testing for EGFR and/or KRAS mutation, and ALK and ROS rearrangement in a cohort of metastatic NSCLC.  ... 
doi:10.1093/annonc/mdz072.002 pmid:32131156 fatcat:cu5wttf2jbh3pfdmpemkfp7zue

ISNS 9th International Symposium, The Hague, The Netherlands, September 11–14, 2016

Gerard Loeber
2016 International Journal of Neonatal Screening  
and a positive predictive value of 82.5%.  ...  In the Netherlands a monitoring program is in place to ensure that quality is maintained or even improved.  ... 
doi:10.3390/ijns2030005 fatcat:7ad7pzbvjjgufo7zawl2ifcuve

10th World Congress 15-18 October 2017 Rotterdam, The Netherlands

2017 Journal of Developmental Origins of Health and Disease  
in a human setting.  ...  GCs can become elevated in the fetus as a result of stress (maternal or fetal) or maternal treatment with GCs. The latter occurs in cases of threatened preterm birth (>10% of all pregnancies).  ...  In Japan, the Ministry of the Environment started a nationwide 100,000-scale birth cohort study named Japan Environment and Children's Study (JECS) in 2011.  ... 
doi:10.1017/s2040174417000848 fatcat:qhzb6wwwrjb3tnmrxryqdeajzi

The Contribution of DNA Metabarcoding to Fungal Conservation: Diversity Assessment, Habitat Partitioning and Mapping Red-Listed Fungi in Protected Coastal Salix repens Communities in the Netherlands

József Geml, Barbara Gravendeel, Kristiaan J. van der Gaag, Manon Neilen, Youri Lammers, Niels Raes, Tatiana A. Semenova, Peter de Knijff, Machiel E. Noordeloos, Zhengguang Zhang
2014 PLoS ONE  
Red-Listed Fungi in Protected Coastal Salix repens Communities in the Netherlands.  ...  Communities of the creeping willow (Salix repens) represent one of the most characteristic and diverse vegetation types in the dunes.  ...  Acknowledgments The authors also thank Marcel Eurlings for support with initial labwork, and Shawn Houston and Rob Cermak at the University of Alaska Fairbanks for bioinformatics support.  ... 
doi:10.1371/journal.pone.0099852 pmid:24937200 pmcid:PMC4061046 fatcat:3cl7lazux5g4bdirhj3yxqbf7u

204th ENMC International Workshop on Biomarkers in Duchenne Muscular Dystrophy 24–26 January 2014, Naarden, The Netherlands

Alessandra Ferlini, Kevin M. Flanigan, Hanns Lochmuller, Francesco Muntoni, Peter A.C. 't Hoen, Elizabeth McNally
2015 Neuromuscular Disorders  
Work by the authors was supported by the European Community Framework Programme 7 grant agreement no. 241665 (BIO-NMD), no. 305444 (RD-Connect) and no. 305121 (Neuromics).  ...  Acknowledgments This workshop was made possible by the financial support of the European Neuromuscular Centre (ENMC) and its main sponsors: Association Française contre les Myopathies (France), Deutsche  ...  Global harmonisation of regulatory perspective on the use of biomarkers is needed. There is a lot of confusion in the Duchenne Community about the role of different biomarkers in drug development.  ... 
doi:10.1016/j.nmd.2014.09.004 pmid:25529833 pmcid:PMC4534085 fatcat:rlz6mczoprfpbavdjfbnkpjrge

Oral abstracts of the 22nd International AIDS Conference, 23-27 July 2018, Amsterdam, the Netherlands

2018 Journal of the International AIDS Society  
The development of soluble native-like HIV-1 envelope trimers (SOSIP trimers) has enabled the induction of neutralizing antibodies against neutralization-resistant (Tier-2) primary HIV-1 strains in several  ...  Rates of antibody decay after the fourth vaccination exhibited regimen-independent decrease in magnitude.  ...  Matrices were used as a post-coding technique to map emergent themes at each level of the SEM including individual, network, community, and public policy levels.  ... 
doi:10.1002/jia2.25148 pmid:30051631 pmcid:PMC6062436 fatcat:gkb5i2cdy5cbnhrivubxaf7fde

Abstracts from the 9th Meeting of The European Association of NeuroOncology, September 16-19, 2010, Maastricht, The Netherlands

2010 Neuro-Oncology  
After establishing a cut-off value of 2.12 for rCBV, pMRI could differentiate between the two entities with a positive predictive value of 96% for the presence of true progression (PD).  ...  Sensitivity was 88% and specificity was 83% with a negative predictive value of 63% (P , .002, Fisher's exact test).  ...  the most commonly reported symptoms in the community.  ... 
doi:10.1093/neuonc/noq085 fatcat:gjf6gsrup5derot25vxenj6tvy

How to kickstart a national biobanking infrastructure – experiences and prospects of BBMRI-NL

M. Brandsma, F. Baas, P.I.W. De Bakker, E.P. Beem, D.I. Boomsma, J. Bovenberg, B. Bueno-de-Mesquita, C. Van Duijn, L.A. Kiemeney, O. Klungel, P.W. De Leeuw, F.E. Van Leeuwen (+6 others)
2012 Norsk Epidemiologi  
In 2006 the Royal Netherlands Academy of Arts and Sciences published the results of a foresight study on Multifactorial Diseases in the Genomics Era.  ...  in biobanking: how a national network of biobanks, BBMRI-NL, was set up in the Netherlands and the results achieved since its initiation in 2009.  ... 
doi:10.5324/nje.v21i2.1485 fatcat:knuwoibgyncvbbeooaqnc4n2t4

A genome-wide association study yields five novel thyroid cancer risk loci

Julius Gudmundsson, Gudmar Thorleifsson, Jon K. Sigurdsson, Lilja Stefansdottir, Jon G. Jonasson, Sigurjon A. Gudjonsson, Daniel F. Gudbjartsson, Gisli Masson, Hrefna Johannsdottir, Gisli H. Halldorsson, Simon N. Stacey, Hannes Helgason (+28 others)
2017 Nature Communications  
The great majority of thyroid cancers are of the non-medullary type.  ...  In combination, these results raise several opportunities for future studies of the pathogenesis of thyroid cancer.  ...  This work was supported in part by The University of Texas MD Anderson Cancer  ... 
doi:10.1038/ncomms14517 pmid:28195142 pmcid:PMC5316879 fatcat:e7j36s3v5ffn3cxe4y3yal4p3m

The potential use of big data in oncology

Stefan M. Willems, Sanne Abeln, K. Anton Feenstra, Remco de Bree, Egge F. van der Poel, Robert J. Baatenburg de Jong, Jaap Heringa, Michiel W.M. van den Brekel
2019 Oral Oncology  
It discusses some initiatives in linking of such datasets on a nation-wide scale in the Netherlands.  ...  In this commentary, the main sources of big data are explained, especially in (head and neck) oncology.  ...  Acknowledgements The authors thank Martine D'Herdt for carefully reading and commenting the manuscript.  ... 
doi:10.1016/j.oraloncology.2019.09.003 pmid:31521885 fatcat:db3x4cskavgbpepvmjsfkhwg6u

Ecoinformatics and global change - an overdue liaison

Jürgen Dengler, Jörg Ewald, Ingolf Kühn, Robert K. Peet
2011 Journal of Vegetation Science  
In this editorial, introducing the Special Feature 'Ecoinformatics and global change', we reflect on the development of ecoinformatics and explore its importance for future global change research with  ...  The field of ecoinformatics provides concepts, methods and standards to guide management and analysis of ecological data with particular emphasis on exploration of co-occurrences of organisms and their  ...  (FlorSoz) for their financial support of the meeting in Hamburg where the included articles were presented, and the Chief Editors of the Journal of Vegetation Science for making this Special Feature possible  ... 
doi:10.1111/j.1654-1103.2011.01313.x fatcat:krvkp6egmff2zlzmx3m3nykncm

Report on the Dutch Consensus Development Meeting for Implementation and Further Development of Population Screening for Colorectal Cancer Based on FOBT

M. de Visser, M. van Ballegooijen, S. M. Bloemers, S. J. H. van Deventer, J. B. M. J. Jansen, J. Jespersen, C. Kluft, G. A. Meijer, J. Stoker, G. A. de Valk, M. F. Verweij, F. A. Vlems
2005 Analytical Cellular Pathology  
A consensus development meeting was held to evaluate whether or not in the Netherlands all requirements were fulfilled for implementation of population screening with FOBT for colorectal cancer, or whether  ...  Consequently, it was concluded that a national population screening for colorectal cancer should be implemented and carried out in the Netherlands in line with current national and European cancer screening  ...  Together, these products constitute a road map towards a nationwide CRC screening programme in the Netherlands and its continuous improvement.  ... 
doi:10.1155/2005/260692 fatcat:upfbt4labnaarmfir7qdvdgelq

Report on the Dutch consensus development meeting for implementation and further development of population screening for colorectal cancer based on FOBT

M de Visser, M van Ballegooijen, S M Bloemers, S J H van Deventer, J B M J Jansen, J Jespersen, C Kluft, G A Meijer, J Stoker, G A de Valk, M F Verweij, F A Vlems
2005 Cellular Oncology  
A consensus development meeting was held to evaluate whether or not in the Netherlands all requirements were fulfilled for implementation of population screening with FOBT for colorectal cancer, or whether  ...  Consequently, it was concluded that a national population screening for colorectal cancer should be implemented and carried out in the Netherlands in line with current national and European cancer screening  ...  Together, these products constitute a road map towards a nationwide CRC screening programme in the Netherlands and its continuous improvement.  ... 
pmid:15750204 pmcid:PMC4612259 fatcat:uhfuyykls5dwnj3qa7sn2i4m34
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