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The Use of Bioinformatics for Studying HIV Evolutionary and Epidemiological History in South America

Gonzalo Bello, Marcelo A. Soares, Carlos G. Schrago
2011 AIDS Research and Treatment  
geographical dissemination and the current molecular scenario of the HIV epidemic in the continent, particularly in the countries of Southern Cone.  ...  the circulating HIV-1 lineages.  ...  this CRF, but still higher than those reported for Brazilian HIV-1 subtypes B, F1, and C.  ... 
doi:10.1155/2011/154945 pmid:22162803 pmcid:PMC3226295 fatcat:hlom7oz2e5bere4wyz6v452ify

Multiple clades of Husavirus in South America revealed by next generation sequencing

Endrya do Socorro Fôro Ramos, Ulisses Alves Rosa, Geovani de Oliveira Ribeiro, Fabiola Villanova, Flávio Augusto de Pádua Milagres, Rafael Brustulin, Vanessa dos Santos Morais, Emerson Luiz Lima Araújo, Ramendra Pati Pandey, V. Samuel Raj, Ester Cerdeira Sabino, Xutao Deng (+5 others)
2021 PLoS ONE  
In particular, 251 fecal samples obtained from individuals were sequenced in southern, northeastern, and northern Brazil. all samples were also analyzed using culture methods and parasitological tests  ...  The study showed that Brazilian sequences are closely related to the HuV defined in Viet Nam in 2013, further characterization based on phylogenetics.  ...  the donation of reagents for this project.  ... 
doi:10.1371/journal.pone.0248486 pmid:33755700 fatcat:5bqcj35k65dohjyasnremyrqni

Estimating HIV-1 Genetic Diversity in Brazil Through Next-Generation Sequencing

Brunna M. Alves, Juliana D. Siqueira, Isabel M. Prellwitz, Ornella M. Botelho, Vanusa P. Da Hora, Sabri Sanabani, Patrícia Recordon-Pinson, Hervé Fleury, Esmeralda A. Soares, Marcelo A. Soares
2019 Frontiers in Microbiology  
In the pooled analysis depicted in this report, HIV subtypes have been determined from HIV-positive patients in five states of Brazil with some of the highest HIV prevalence, three in the Southeast (Rio  ...  These data unveiled unprecedented high rates of viral recombination and highlighted that novel recombinants are continually arising in the Brazilian epidemic.  ...  We focused on the HIV-1 subtype classification, identification of HIV recombinants and multiple infection investigation for our novel patients.  ... 
doi:10.3389/fmicb.2019.00749 pmid:31024510 pmcid:PMC6465556 fatcat:qdy2nxioafen7anjzmqthnd4ze

Molecular epidemiology of tuberculosis in Brazil: a translational research perspective*

Emilyn Costa Conceição, Karla Valéria Batista Lima, Harrison Magdinier Gomes, Rafael Silva Duarte
2017 Revista Pan-Amazônica de Saúde  
In other words, WGS data-analysis, using bioinformatic tools, is suggested to replace the genotypic techniques, and in a long-term perspective, also the phenotypic tests.  ...  Ideally, molecular tools should be applied in routine diagnosis and epidemiological investigation of TB cases, as observed in Singapore, a city-state in Southeast Asia with a very high Human Development  ... 
doi:10.5123/s2176-62232017000400003 fatcat:weum7zgdgbaehioq4nbh5nrttq

Epidemiological and Molecular Characteristics of HIV-1 Infection in a Sample of Men Who Have Sex With Men in Brazil: Phylogeography of Major Subtype B and F1 Transmission Clusters

Ágabo Macêdo da Costa e Silva, Mônica Nogueira da Guarda Reis, Thaís Augusto Marinho, Nara Rúbia de Freitas, Sheila Araújo Teles, Márcia Alves Dias de Matos, Megmar Aparecida dos Santos Carneiro, Gonzalo Bello, Mariane Martins Araújo Stefani, Regina Maria Bringel Martins
2020 Frontiers in Microbiology  
Most HIV-1 subtype B sequences (67%; 34 out of 51) branched within 12 monophyletic clusters of variable sizes, which probably arose in the State of Goiás between the 1980s and 2010s.  ...  Overall, HIV-1 prevalence was 17.6% (95% CI: 12.6–23.5).  ...  HIV-1 Molecular Epidemiology in Brazilian MSM sequencing and submitted sequence information to GenBank. ÁS, MR, and GB performed the bioinformatics analyses.  ... 
doi:10.3389/fmicb.2020.589937 pmid:33329467 pmcid:PMC7732656 fatcat:ftwjxh57urbaxjfxjdefzoccoe

Molecular characterization of HTLV-1 gp46 glycoprotein from health carriers and HAM/TSP infected individuals

Aline C A Mota-Miranda, Fernanda K Barreto, Maria F C Amarante, Everton Batista, Joana P Monteiro-Cunha, Lourdes Farre, Bernardo Galvão-Castro, Luiz C J Alcantara
2013 Virology Journal  
The molecular characterization was performed using bioinformatics tools.  ...  Human T-cell Leukemia Virus type 1 (HTLV-1) is the etiological agent of tropical spastic paraparesis/ HTLV-associated myelopathy (HAM/TSP) that can be identified in around 0.25%-3.8% of the infected population  ...  Despite the scarcity of data on the real prevalence of HAM/TSP in the Brazilian population, the individual risk of disease development is of considerable importance for HTLV-1 endemic areas such as southern  ... 
doi:10.1186/1743-422x-10-75 pmid:23510700 pmcid:PMC3599561 fatcat:qondybuljnainn5hqt73wr363m

Genomic epidemiology of Mycobacterium tuberculosis in Santa Catarina, Southern Brazil

Mirela Verza, Mara Cristina Scheffer, Richard Steiner Salvato, Marcos André Schorner, Fernando Hartmann Barazzetti, Hanalydia de Melo Machado, Taiane Freitas Medeiros, Darcita Buerger Rovaris, Isabel Portugal, Miguel Viveiros, João Perdigão, Afrânio Kritski (+1 others)
2020 Scientific Reports  
Florianópolis, the state capital of Santa Catarina (SC) in south Brazil, shows a high TB incidence (46.0/100,000).  ...  Besides, resistance to pyrazinamide and ethambutol was detected in 0.7% (n = 1) and reistance to ethionamide and fluoroquinolone (FQ) in 1.3% (n = 2), while a single (0.7%) multidrug-resistant (MDR) strain  ...  infrastructure in bioinformatics analysis.  ... 
doi:10.1038/s41598-020-69755-9 pmid:32732910 fatcat:674pb4ym2vg77nwzelgq6sldki

Biotechnology to improve health in developing countries: a review

Tara Acharya, Robyn Kennedy, Abdallah S Daar, Peter A Singer
2004 Memórias do Instituto Oswaldo Cruz  
In 2002, the University of Toronto published a report on the "Top 10 Biotechnologies for Improving Health in Developing Countries".  ...  The fight to improve global health needs, in addition to effective public health measures, requires rapid and efficient diagnostic tools; new vaccines and drugs, efficient delivery methods and novel approaches  ...  Determine® HIV-1/2 is another easy-to-use, rapid test for HIV-1 and HIV-2 antibodies developed by Abbott Laboratories that does not require instrumentation (http:// www.pmtctdonations.org/en/products/determine.cfm  ... 
doi:10.1590/s0074-02762004000400001 fatcat:srdu2eg73za4hfxei7brideneq

A highly rifampicin resistant Mycobacterium tuberculosis strain emerging in Southern Brazil [article]

Maria Lucia Rossetti, Pedro Eduardo Almeida da Silva, Richard Steiner Salvato, Ana Julia Reis, Sun Hee Schiefelbein, Andrea von Groll, Regina Barcellos, Raquel Maschmann, Leonardo Esteves, Fernanda Spies, Rubia Trespach, Elis Regina Dalla Costa (+1 others)
2020 bioRxiv   pre-print
Here we described phenotypical, molecular and epidemiological features of a highly rifampicin-resistant Mycobacterium tuberculosis strain emerging in Southern Brazil, that carries an uncommon insertion  ...  Nine of these 16 strains were available to minimum inhibitory concentration determination and for all of them was found a high rifampicin-resistance level (≥ to 32 mg/L).  ...  Figure 4 4 Rio Grande do Sul is a high burden TB state in Southern Brazil with elevated 3 2 9 rates of MDR-TB.  ... 
doi:10.1101/2020.09.03.282194 fatcat:vdxg55r56zao7p7sdnndr2d7g4

Microbial Symbionts of Insects are the Focus of the First International Cooperative Biodiversity Group (ICBG) in Brazil

Mônica Pupo, Cameron Currie, Jon Clardy
2016 Journal of the Brazilian Chemical Society  
The first ICBG in Brazil is jointly supported by the Fogarty International Center of the National Institutes of Health (FIC/NIH) in the USA and by the São Paulo Research Foundation (FAPESP) in Brazil.  ...  In this article we describe the rationale of the ICBG and the legal requirements to develop this type of international collaborative project in Brazil.  ...  Pupo graduated in Figure 1 . 1 ICBG work flow and roles for each Associate Program (AP).  ... 
doi:10.21577/0103-5053.20160284 fatcat:er5rrmhdfzbdrigapoblfn432q

Serological Expression Cloning and Immunological Evaluation of MTB48, a Novel Mycobacterium tuberculosis Antigen

M. J. Lodes, D. C. Dillon, R. Mohamath, C. H. Day, D. R. Benson, L. D. Reynolds, P. McNeill, D. P. Sampaio, Y. A. W. Skeiky, R. Badaro, D. H. Persing, S. G. Reed (+1 others)
2001 Journal of Clinical Microbiology  
Southern and Western blot analyses indicate that this sequence is present in a single copy and is conserved in the M. tuberculosis and M. bovis isolates tested but not in other mycobacterial species tested  ...  Improved diagnostics are needed for the detection of Mycobacterium tuberculosis, especially for patients with smear-negative disease.  ...  DNA for Southern blot analysis.  ... 
doi:10.1128/jcm.39.7.2485-2493.2001 pmid:11427558 pmcid:PMC88174 fatcat:kcwhqox6w5grbilkb2y3lhgkzu

Between a bug and a hard place:Trypanosoma cruzigenetic diversity and the clinical outcomes of Chagas disease

Louisa A Messenger, Michael A Miles, Caryn Bern
2015 Expert Review of Anti-Infective Therapy  
ND Acute: 4 TcII (Brazilian ZII), 4 TcVI (Paraguayan ZII) IND: 1 TcII (Brazilian ZII), 1 TcV (Bolivian ZII) CCM: 1 TcII (Brazilian ZII) Congenital: 1 TcV (Bolivian ZII) MLEE (15 loci) [325  ...  novemcinctus, Nasua nasua, Procyon lotor Southern USA and northern South America Secondary agent in Venezuela Sporadic oral outbreaks in Brazilian Amazon [16,66,68,93,95-99] TcV Rare in  ... 
doi:10.1586/14787210.2015.1056158 pmid:26162928 pmcid:PMC4784490 fatcat:j6n4gikj65ff7c2dhuajrr2wwy

CURRENT STRATEGIES AND RECENT ADVANCES IN NANOSTRUCTURED DELIVERY SYSTEMS FOR MANAGING LEISHMANIASIS-A REVIEW

Rahul Chaurasia, Neelam Jain
2022 Journal of advanced scientific research  
Among these diseases, deadly, prevalent parasitic infection such as leishmaniasis, presents a significant global burden which is responsible for high morbidity/mortality rate especially in low-and middle-income  ...  The lack of cheap, portable, easy to use diagnostic tools exhibiting high efficiency and specificity impede the early diagnosis of the disease.  ...  tools and better drug delivery for various infectious diseases in the near future [113] .  ... 
doi:10.55218/jasr.202213104 fatcat:svjuch3bxfh6nhlxtp5ewbtcjq

Abstract for the 8th International congress, Molecular Epidemiology and Evolutionary Genetics of Infectious Diseases

2008 Infection, Genetics and Evolution  
These emerging issues will be discussed with emphasis on how molecular tools and epidemiological studies can help resolve these questions.  ...  Although they have been the subject of research for many years, recent studies have raised fundamental questions concerning our understanding of the epidemiology of infections with these parasites.  ...  Study on iron uptake regulation in Agrobacterium tumefaciens  ... 
doi:10.1016/j.meegid.2008.01.008 fatcat:dnu5go3mcragdcgejfyyrw42tm

Faecal Virome Analysis of Wild Animals from Brazil

Matheus A. Duarte, João M. F. Silva, Clara R. Brito, Danilo S. Teixeira, Fernando L. Melo, Bergmann M. Ribeiro, Tatsuya Nagata, Fabrício S. Campos
2019 Viruses  
Based on this scenario, high-throughput sequencing contributes a robust tool for the identification of known and unknown virus species in this environment.  ...  We demonstrate that the metagenomics approach applied in this work was effective for identification of known and putative new viruses in faeces samples from Brazilian Cerrado fauna.  ...  Acknowledgments: The authors thank Veterinary Hospital at UnB for providing the samples of animals. Conflicts of Interest: The authors declare no conflict of interest.  ... 
doi:10.3390/v11090803 pmid:31480274 pmcid:PMC6784175 fatcat:fpajo5ve7zeqlnq5oxevqosyei
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