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This article describes the biocuration process and methods used in the structure-function linkage database (SFLD) to help address some of the challenges. ... With ever-increasing amounts of sequence data available in both the primary literature and sequence repositories, there is a bottleneck in annotating molecular function to a sequence. ... The Structure-Function Linkage Database (9) (SFLD, available from http://sfld.rbvi.ucsf.edu/) aims to catalogue the specific sequence and structural attributes reflected in SFs of enzymes, with a key focus ...doi:10.1093/database/bax006 pmid:28365730 pmcid:PMC5467563 fatcat:kiw2cgnrkzhtvjzjv45h5347j4
Tissues within complex multi-cellular organisms have historically been defined in terms of their anatomy and function. ... Molecular and cellular structure Understanding the structure of a molecule is key to understanding how it may function. ...doi:10.1038/nbt.3918 pmid:28700551 fatcat:oqiurm5cgzec7lfenvjvlemxoy
More importantly, it illustrates how the biocurated genes in the database may represent a reliable starting point for divulging transcriptional regulation, diagnostic markers and the biology related to ... This thesis reports on the development of a novel comprehensive database (Dragon Database of Genes Implicated in Esophageal Cancer, DDEC) as an integrated knowledge database aimed at representing a gateway ... V The biocurated ESCC genes in the database were additionally used to expand on the current knowledge of the transcriptional circuitry of ESCC. ...fatcat:3ajvudqcjvcodhby3abthpbzji