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Biocuration in the structure–function linkage database: the anatomy of a superfamily

Gemma L. Holliday, Shoshana D. Brown, Eyal Akiva, David Mischel, Michael A. Hicks, John H. Morris, Conrad C. Huang, Elaine C. Meng, Scott C.-H. Pegg, Thomas E. Ferrin, Patricia C. Babbitt
2017 Database: The Journal of Biological Databases and Curation  
This article describes the biocuration process and methods used in the structure-function linkage database (SFLD) to help address some of the challenges.  ...  With ever-increasing amounts of sequence data available in both the primary literature and sequence repositories, there is a bottleneck in annotating molecular function to a sequence.  ...  The Structure-Function Linkage Database (9) (SFLD, available from http://sfld.rbvi.ucsf.edu/) aims to catalogue the specific sequence and structural attributes reflected in SFs of enzymes, with a key focus  ... 
doi:10.1093/database/bax006 pmid:28365730 pmcid:PMC5467563 fatcat:kiw2cgnrkzhtvjzjv45h5347j4

Unlocking Big Data for better health

Steven Munevar
2017 Nature Biotechnology  
Tissues within complex multi-cellular organisms have historically been defined in terms of their anatomy and function.  ...  Molecular and cellular structure Understanding the structure of a molecule is key to understanding how it may function.  ... 
doi:10.1038/nbt.3918 pmid:28700551 fatcat:oqiurm5cgzec7lfenvjvlemxoy

Transcription Regulation and Candidate Diagnostic Markers of Esophageal Cancer

Magbubah Essack, B Vladimir, Bajic
2009 unpublished
More importantly, it illustrates how the biocurated genes in the database may represent a reliable starting point for divulging transcriptional regulation, diagnostic markers and the biology related to  ...  This thesis reports on the development of a novel comprehensive database (Dragon Database of Genes Implicated in Esophageal Cancer, DDEC) as an integrated knowledge database aimed at representing a gateway  ...  V The biocurated ESCC genes in the database were additionally used to expand on the current knowledge of the transcriptional circuitry of ESCC.  ... 
fatcat:3ajvudqcjvcodhby3abthpbzji