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Progress in Research of Flexible MEMS Microelectrodes for Neural Interface

Long-Jun Tang, Ming-Hao Wang, Hong-Chang Tian, Xiao-Yang Kang, Wen Hong, Jing-Quan Liu
2017 Micromachines  
channels and electrode-tissue interface modification technology for performance improvement.  ...  With the rapid development of Micro-electro-mechanical Systems (MEMS) fabrication technologies, many microelectrodes with various structures and functions have been designed and fabricated for applications  ...  In their study, thirty electrodes from three electrode arrays were stimulated for stability evaluation.  ... 
doi:10.3390/mi8090281 pmid:30400473 pmcid:PMC6190450 fatcat:u5poyqz3yrgijonlvdy26v4dra

A Nonenzymatic Amperometric Glucose Sensor Based on a RuO2/Graphene Sheet Composite Electrode

2014 Sensors and materials  
The experimental results revealed that the type of electrode was critical for enhancing output voltage.  ...  The positioning accuracy of the displacement sensor was 600 μm; thus, the sensor could successfully determine positioning, confirming the feasibility of the displacement sensing mechanism.  ...  Acknowledgments The authors would like to thank the Ministry of Science and Technology (MOST) and  ... 
doi:10.18494/sam.2014.1034 fatcat:xmz5v3ng5rdpxprekfebzq7pem

Neural Interfaces for Intracortical Recording: Requirements, Fabrication Methods, and Characteristics

Katarzyna M. Szostak, Laszlo Grand, Timothy G. Constandinou
2017 Frontiers in Neuroscience  
In this review, we identify the key requirements for neural interfaces for intracortical recording, describe the three different types of probes-microwire, micromachined, and polymer-based probes; their  ...  Although the trend is promising, the long-term reliability of such devices has not yet met the required criteria for chronic human application.  ...  (D) Polyimide-based three dimensional multichannel electrode . (E) Three-dimensional thermoformed Parylene-C-based cone polymer sheath electrode .  ... 
doi:10.3389/fnins.2017.00665 pmid:29270103 pmcid:PMC5725438 fatcat:4fuzxkhz4rc45ds2px2557m46q

BioMEMS –Advancing the Frontiers of Medicine

Teena James, Manu Mannoor, Dentcho Ivanov
2008 Sensors  
Integration of biology and microtechnology has resulted in the development of a number of platforms for improving biomedical and pharmaceutical technologies.  ...  Biological and medical application of micro-electro-mechanical-systems (MEMS) is currently seen as an area of high potential impact.  ...  Neural probes for precision mapping of activity in the central nervous system have evolved from simple acute structures to complex three-dimensional electrode arrays capable of both stimulation and recording  ... 
doi:10.3390/s8096077 pmid:27873858 pmcid:PMC3705549 fatcat:3fzotnbw7bglthjrzyf6m636zm

Flexible polyimide-based intracortical electrode arrays with bioactive capability

P.J. Rousche, D.S. Pellinen, D.P. Pivin, J.C. Williams, R.J. Vetter, D.R. Kipke
2001 IEEE Transactions on Biomedical Engineering  
The use of polyimide provides a mechanically flexible substrate which can be manipulated into unique three-dimensional designs.  ...  Results suggest that these arrays could be a candidate device for long-term neural implants.  ...  Preliminary three-dimensional (3-D) structures have been created by appropriately placing bends in suitable two-dimensional (2-D) planar structures (see Fig. 1 (f)).  ... 
doi:10.1109/10.914800 pmid:11327505 fatcat:m33dknbrebcpnax4d7awa5kwyq

Recent Progress in Technologies for Tactile Sensors

Cheng Chi, Xuguang Sun, Ning Xue, Tong Li, Chang Liu
2018 Sensors  
This paper starts with an introduction of human tactile systems, followed by a presentation of the basic demands of tactile sensors.  ...  State-of-the-art tactile sensors are reviewed in terms of their diverse sensing mechanisms, design consideration, and material selection.  ...  Conflicts of Interest: The authors declare no conflict of interest.  ... 
doi:10.3390/s18040948 pmid:29565835 pmcid:PMC5948515 fatcat:buh3sbgbjffadgua3tiy47xq5a

Implantable Thin Film Devices as Brain-Computer Interfaces: Recent Advances in Design and Fabrication Approaches

Yuhao Zhou, Bowen Ji, Minghao Wang, Kai Zhang, Shuaiqi Huangfu, Huicheng Feng, Honglong Chang, Xichen Yuan
2021 Coatings  
Remarkable progress has been made in the high resolution, biocompatibility, durability and stretchability for the implantable brain-computer interface (BCI) in the last decades.  ...  In addition, an overview of the fabrication approaches is also presented. Traditional lithography and state-of-the-art processing methods are discussed for the key issue of high-resolution.  ...  Acknowledgments: The authors thank to partial financial support from the project funded by China Postdoctoral Science Foundation (2020TQ0246), the Fundamental Research Funds for the Central  ... 
doi:10.3390/coatings11020204 fatcat:7d6rviowcjguram3xg2o3wkvly

Research Progress on the Flexibility of an Implantable Neural Microelectrode

Huiqing Zhao, Ruping Liu, Huiling Zhang, Peng Cao, Zilong Liu, Ye Li
2022 Micromachines  
In recent years, the choice of flexible materials and design of electrode structures can achieve modulus matching between electrode and biological tissue, and tissue damage is decreased.  ...  Young's modulus of the traditional rigid electrode probe is not matched well with that of biological tissue, and tissue immune rejection is easy to generate, resulting in the electrode not being able to  ...  For example, the mesh electrode has a more flexible nature, has a three-dimensional (3D) structure (the structure of nerve tissue is usually 3D [106] ), and less damage to nerve cells. Xiang et al.  ... 
doi:10.3390/mi13030386 pmid:35334680 pmcid:PMC8954487 fatcat:ki6dcjm43vfaddwt4bxs7llcmm

In Vivo Neural Interfaces—From Small- to Large-Scale Recording

Bingjie Zhang, Chunshan Deng, Chunzhi Cai, Xiaojian Li
2022 Frontiers in Nanotechnology  
In this review, we focused on the neural interfaces developed for small- to large-scale recordings and discussed the developmental challenges and strategies in microsystem, electrode device, and interface  ...  material levels for the future larger-scale neural ensemble recordings.  ...  One-dimensional narrow bar multi-electrode probes are expanded into high electrode density two-dimensional electrode arrays, which in turn are stacked into three-dimensional electrode matrices (often expanded  ... 
doi:10.3389/fnano.2022.885411 fatcat:57hbgemuxzcphpteqqjrzr5cga

Large area flexible pressure/strain sensors and arrays using nanomaterials and printing techniques

Chithra Parameswaran, Dipti Gupta
2019 Nano Convergence  
Exhaustive study for process advancement towards miniaturization from the advent of MEMS technology has been going on and progressing at high pace and has reached a highly advanced level wherein batch  ...  Sensors are becoming more demanding in all spheres of human activities for their advancement in terms of fabrication and cost.  ...  This sensor was additionally attached with an SU-8 bumpy layer enabling for three dimensional strain sensing which is peculiar for the bump layer.  ... 
doi:10.1186/s40580-019-0198-x pmid:31495907 pmcid:PMC6732266 fatcat:7j2cfarr4vh2pgsl7lfoobu7dm

Integration of Different Graphene Nanostructures with PDMS to Form Wearable Sensors

Shan He, Yang Zhang, Jingrong Gao, Anindya Nag, Abdul Rahaman
2022 Nanomaterials  
Different kinds of electrochemical and strain-sensing applications have been carried out to detect the physiological signals and parameters of the human body.  ...  This paper presents a substantial review of the fabrication and implementation of graphene-PDMS-based composites for wearable sensing applications.  ...  The second layer acted as the top electrode array for these triboelectric sensors.  ... 
doi:10.3390/nano12060950 pmid:35335764 pmcid:PMC8949288 fatcat:cy3ll3g7gbdspklqz2psfhoeyi

Implantable Sensors for Regenerative Medicine

Brett S. Klosterhoff, Melissa Tsang, Didi She, Keat Ghee Ong, Mark G. Allen, Nick J. Willett, Robert E. Guldberg
2017 Journal of Biomechanical Engineering  
Determining mechanistic reasons for impaired treatment efficacy is challenging after a regenerative therapy is implanted due to technical limitations in longitudinally measuring the progression of key  ...  In this perspective article, we discuss the need for longitudinal measurements in TE/RM research, technical progress in MEMS and magnetoelastic approaches to implantable sensors, the potential application  ...  The integration of these approaches, along with addressing physiological constraints and representative testing, will be necessary for the development of next-generation, implantable sensors for smart  ... 
doi:10.1115/1.4035436 pmid:27987300 pmcid:PMC5253675 fatcat:iv2zzm4ebzdxfjlw56rzm6tsw4

Degradation Study of Thin-Film Silicon Structures in a Cell Culture Medium

Huachun Wang, Jingjing Tian, Bingwei Lu, Yang Xie, Pengcheng Sun, Lan Yin, Yuguang Wang, Xing Sheng
2022 Sensors  
Finally, in vitro cell culture studies demonstrate desirable biocompatibility of corroded Si pillars.  ...  The results provide a guideline for the use of thin-film Si materials and devices as transient implants in biomedicine.  ...  (A,B) Three-dimensional AFM images showing the surface morphologies of (A) planar Si and (B) Si pillars during degradation in DMEM.  ... 
doi:10.3390/s22030802 pmid:35161547 pmcid:PMC8838160 fatcat:baj6wgjsiffcno7iwtyeztzxwm

Research Progress of Biomimetic Memristor Flexible Synapse

Huiling Zhang, Ruping Liu, Huiqing Zhao, Zhicheng Sun, Zilong Liu, Liang He, Ye Li
2021 Coatings  
However, they still face many problems, especially in the application of artificial bionic synapses, which call for higher requirements in the mechanical properties of the device.  ...  The use of a flexible memristor to simulate nerve synapses will provide new methods for neural network computing and bionic sensing systems.  ...  Conflicts of Interest: The authors declare no conflict of interest.  ... 
doi:10.3390/coatings12010021 fatcat:4eqc7amr2fb6xmgtmn3bota3mq

A Review of Organic and Inorganic Biomaterials for Neural Interfaces

Pouria Fattahi, Guang Yang, Gloria Kim, Mohammad Reza Abidian
2014 Advanced Materials  
Finally, technical and scientific challenges are discussed regarding biocompatibility, mechanical mismatch, and electrical properties faced by these nanomaterials for the development of long-lasting functional  ...  An ideal neural interface should create seamless integration into the nervous system and performs reliably for long periods of time.  ...  Kim et al. implanted three different arrays of surface electrodes (30 electrodes per array) in cats for neural recording from the visual cortex ( Figure 4b ) (i.e., (1) PI thick electrodes (75 μm); (2  ... 
doi:10.1002/adma.201304496 pmid:24677434 pmcid:PMC4373558 fatcat:4oln5mhjmbdj3h3pdl7v27zfmi
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