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FGWAS: Functional genome wide association analysis

Chao Huang, Paul Thompson, Yalin Wang, Yang Yu, Jingwen Zhang, Dehan Kong, Rivka R. Colen, Rebecca C. Knickmeyer, Hongtu Zhu
2017 NeuroImage  
. * Data used in preparation of this article were obtained from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database (adni.loni.usc.edu).  ...  As such, the investigators within the ADNI contributed to the design and implementation of ADNI and/or provided data but did not participate in analysis or writing of this report.  ...  Acknowledgments The collection and sharing of data that we analyzed for this project were funded by the Alzheimer's Disease Neuroimaging Initiative (ADNI) (National Institutes of Health Grant U01 AG024904  ... 
doi:10.1016/j.neuroimage.2017.07.030 pmid:28735012 pmcid:PMC5984052 fatcat:r5oyvirwg5gipl77ganlr73gpe

Small Animal Multivariate Brain Analysis (SAMBA): A High Throughput Pipeline with a Validation Framework [article]

Robert J Anderson, James J Cook, Natalie A Delpratt, John C Nouls, Bin Gu, James O McNamara, Brian B Avants, G Allan Johnson, Alexandra Badea
2018 arXiv   pre-print
We have used this framework to inform the VBA workflow parameters in a VBA study for a mouse model of epilepsy.  ...  While voxel-based analysis (VBA) of preclinical magnetic resonance images is widely-used, a thorough examination of the statistical robustness, stability, and error rates is hindered by high computational  ...  Acknowledgments The Duke University Center for In Vivo Microscopy is an NIH/NIBIB national Biomedical Technology Resource Center supported by P41 EB015897 1S10OD010683 (Johnson).  ... 
arXiv:1709.10483v2 fatcat:y2zk5cae2fgt5lhj7txfynhg4e

Small Animal Multivariate Brain Analysis (SAMBA) – a High Throughput Pipeline with a Validation Framework

Robert J. Anderson, James J. Cook, Natalie Delpratt, John C. Nouls, Bin Gu, James O. McNamara, Brian B. Avants, G. Allan Johnson, Alexandra Badea
2018 Neuroinformatics  
We have used this framework to inform the VBA workflow parameters in a VBA study for a mouse model of epilepsy.  ...  While voxel-based analysis (VBA) of preclinical magnetic resonance images is widely-used, a thorough examination of the statistical robustness, stability, and error rates is hindered by high computational  ...  Acknowledgments The Duke University Center for In Vivo Microscopy is an NIH/NIBIB national Biomedical Technology Resource Center supported by P41 EB015897 1S10OD010683 (Johnson).  ... 
doi:10.1007/s12021-018-9410-0 pmid:30565026 pmcid:PMC6584586 fatcat:vezm3lc5vrhhdkwxxifzofclmu

Automated ventricular mapping with multi-atlas fluid image alignment reveals genetic effects in Alzheimer's disease

Yi-Yu Chou, Natasha Leporé, Greig I. de Zubicaray, Owen T. Carmichael, James T. Becker, Arthur W. Toga, Paul M. Thompson
2008 NeuroImage  
First, we used a set of parameterized surfaces to represent the ventricles in four subjects' manually labeled brain MRI scans (atlases).  ...  We developed and validated a new method to create automated 3D parametric surface models of the lateral ventricles in brain MRI scans, providing an efficient approach to monitor degenerative disease in  ...  The authors are grateful to Stephen Rose at the University of Queensland Center for Magnetic Resonance for his work acquiring the MRI scan data.  ... 
doi:10.1016/j.neuroimage.2007.11.047 pmid:18222096 pmcid:PMC2720413 fatcat:s6rrvfeahfdzvcqugilaw6ehsq

Sex is a defining feature of neuroimaging phenotypes in major brain disorders

Lauren E Salminen, Meral A Tubi, Joanna Bright, Sophia I Thomopoulos, Alyssa Wieand, Paul M Thompson
2021 Human Brain Mapping  
Neuroimaging studies of population-based samples have identified normative differences in brain structure between males and females, many of which are exacerbated in psychiatric and neurological conditions  ...  We discuss commonalities and sources of variance in study designs, analysis procedures, disease subtype effects, and the impact of these factors on MRI interpretation.  ...  In one of the only studies we could find, Tremblay et al. (2020) used DTI and deformation-based morphometry (DBM-an alternative to VBM that maps regional atrophy patterns and has heightened sensitivity  ... 
doi:10.1002/hbm.25438 pmid:33949018 pmcid:PMC8805690 fatcat:4y3ufbxppjg3bobnvysm7cwd7q

Abstracts

2012 Dementia and Geriatric Cognitive Disorders  
MRI voxel-based morphometry analyses revealed that famous tunes recognition deficits correlated with right ATL atrophy, a region which overlapped with that involved in the recognition of famous faces.  ...  Task performance was correlated with changes in grey matter signal intensity using voxel-based morphometry.  ...  The case is presented for its rarity of relatively late onset of FTD with possible temporal association with a parasagittal meningioma, and the challenges faced in management.  ... 
doi:10.1159/000342903 pmid:23007027 fatcat:io2rfqz7hndlddkrquqhkjhm7m

Final Program, Fortieth Annual Meeting International Neuropsychological Society February 15–18, 2012 Montréal, Québec, Canada

2012 Journal of the International Neuropsychological Society  
Students of INS (SINS) Workshop: Writing Successful Grants in Neuropsychology.  ...  In this symposium a panel of neuropsychologists will provide direction and insights towards developing a program of sustained externally funded research.  ...  The current study uses a data-driven method of measuring brain volume (voxel based morphometry, VBM) to determine whether atrophy in frontalsubcortical regions are related to depression in MS.  ... 
doi:10.1017/s1355617712000537 fatcat:4p2fkgxxzna3vcf3uxxgac6rsi

Final Program Forty Second Annual Meeting International Neuropsychological Society February 12–15, 2014 Seattle, Washington, USA

2014 Journal of the International Neuropsychological Society  
interventions that are widely used in neuropsychological rehabilitation.  ...  T. HART & J. WHYTE. Clinical Trials in Neuropsychological Rehabilitation: Challenges and Solutions.  ...  The subjects (N = 75) with complete data sets were selected from the NIH MRI Study of Normal Development.  ... 
doi:10.1017/s1355617714000381 pmid:24666775 fatcat:6bwv7b2wjjez3beb3z5bryms6i

Robust multi-structure segmentation of magnetic resonance brain images

Christian Ledig, Daniel Rueckert, European Union
2016
The presented methodology is robust in the presence of disease-related atrophy or severe brain deformation. The proposed algorithms are evaluated on widely used reference datasets.  ...  In particular an approach is presented that quantifies the volume of more than 100 individual structures within the whole brain.  ...  The ADNIMERGE package is updated daily and summarises commonly used data from all three ADNI studies (ADNI-1/-GO/-2).  ... 
doi:10.25560/28959 fatcat:c63ztanfoja7dg7mucveidfggi

Machine learning approaches to model cardiac shape in large-scale imaging studies

Carlo Biffi, Daniel Rueckert, Declan O'Regan, Stuart Cook, British Heart Foundation
2020
Recent improvements in non-invasive imaging, together with the introduction of fully-automated segmentation algorithms and big data analytics, has paved the way for large-scale population-based imaging  ...  Finally, a preliminary analysis of a deep learning system capable of reconstructing 3D high-resolution cardiac segmentations from a sparse set of 2D views segmentations is reported.  ...  Deep networks parameters θ, which consists of all the weights ω and biases b i used by a neural network to model f f θ , are learned from data via the optimization of an objective function g(θ).  ... 
doi:10.25560/83742 fatcat:uvilmm5fx5h6xd46ccmtxhbqa4

In this issue Motor Control-Paul Pope and Chris Miall-How Might the Cerebellum Participate in Motor Control, if Life Without One is Possible? Clinical Dilemmas in Neuropsychiatry-Simon Fleminger-Is Post Concussional Syndrome Due to Brain Damage?

Thomas Cope, William Sedley, Timothy Griffiths, Neurosurgery -Pharrah Debono, Shawn Agius, Sohail Ansari
unpublished
Dr Parkkinen is Career development fellow, Oxford Parkinson's disease Centre funded by Monument Trust Discovery Award from Parkinson's UK.  ...  their CSF.Analysis of the longitudinal data obtained from 1.5 T MRI scans using Freesurfer software showed evidence of hippocampal volume loss in both groups with a statistically significant greater degree  ...  The authors used two different methods for examining brain structure in Tourette Syndrome (TS); cortical thickness estimation and voxel-based morphometry.  ... 
fatcat:2crnzzzy6zfr3gaxq2x2ngo5a4