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We have developed the BiForce Toolbox to address the demand for high-throughput analysis of pairwise epistasis in GWAS of quantitative and disease traits across all commonly used computer systems. ... Genome-wide association studies (GWAS) have discovered many loci associated with common disease and quantitative traits. ... We are grateful for assistance from the authors of the BOOST software. ...doi:10.1093/nar/gks550 pmid:22689639 pmcid:PMC3394281 fatcat:pw2c5igunjcophffnuuhgtw7dy