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Integrating Argument Mapping with Systems Thinking Tools: Advancing Applied Systems Science [chapter]

Michael Hogan, Owen Harney, Benjamin Broome
2014 Advanced Information and Knowledge Processing  
1995b Broome & Christakis, 1988; Broome & Cromer, 1991) , and training facilitators (Broome & Fulbright, 1995) .  ...  Department of Defense's acquisition process (Alberts, 1992) , promoting world peace (Christakis, 1987) , improving Tribal governance process in Native American communities (Broome, 1995a (Broome, ,  ... 
doi:10.1007/978-1-4471-6470-8_18 fatcat:y5ny2lkwrjegjk6572qnsqnpqq

Zinc protects against shiga-toxigenic Escherichia coli by acting on host tissues as well as on bacteria

John K Crane, Jackie E Broome, Ryan M Reddinger, Benjamin B Werth
2014 BMC Microbiology  
Zinc supplements can treat or prevent enteric infections and diarrheal disease. Many articles on zinc in bacteria, however, highlight the essential nature of this metal for bacterial growth and virulence, suggesting that zinc should make infections worse, not better. To address this paradox, we tested whether zinc might have protective effects on intestinal epithelium as well as on the pathogen. Results: Using polarized monolayers of T84 cells we found that zinc protected against damage induced
more » ... by hydrogen peroxide, as measured by trans-epithelial electrical resistance. Zinc also reduced peroxide-induced translocation of Shiga toxin (Stx) across T84 monolayers from the apical to basolateral side. Zinc was superior to other divalent metals to (iron, manganese, and nickel) in protecting against peroxide-induced epithelial damage, while copper also showed a protective effect. The SOS bacterial stress response pathway is a powerful regulator of Stx production in STEC. We examined whether zinc's known inhibitory effects on Stx might be mediated by blocking the SOS response. Zinc reduced expression of recA, a reliable marker of the SOS. Zinc was more potent and more efficacious than other metals tested in inhibiting recA expression induced by hydrogen peroxide, xanthine oxidase, or the antibiotic ciprofloxacin. The close correlation between zinc's effects on recA/SOS and on Stx suggested that inhibition of the SOS response is one mechanism by which zinc protects against STEC infection. Conclusions: Zinc's ability to protect against enteric bacterial pathogens may be the result of its combined effects on host tissues as well as inhibition of virulence in some pathogens. Research focused solely on the effects of zinc on pathogenic microbes may give an incomplete picture by failing to account for protective effects of zinc on host epithelia.
doi:10.1186/1471-2180-14-145 pmid:24903402 pmcid:PMC4072484 fatcat:t3d3rmldpvgybbytlxaeji3nfe

Collaborative learning: the effects of trust and open and closed dynamics on consensus and efficacy

Owen Harney, Michael J. Hogan, Benjamin J. Broome
2012 Social Psychology of Education  
Cooperative learning and collaborative inquiry have been used in various fields including education (Johnson et al. 2001) , business (Alavi et al. 1995) and conflict resolution (Broome 2004) using  ...  Benjamin Broome is Professor in the School of Human Communication at Arizona State University, USA. Dr.  ... 
doi:10.1007/s11218-012-9202-6 fatcat:zwd4peobojb5vmky7zehyg7hdm

Are neurocognitive factors associated with repetition of self-harm? A systematic review

Angharad N. de Cates, Karen Rees, Fabrice Jollant, Benjamin Perry, Karina Bennett, Katie Joyce, Eimear Leyden, Catherine Harmer, Keith Hawton, Kees van Heeringen, Matthew R. Broome
2017 Neuroscience and Biobehavioral Reviews  
impair the functioning of the amygdalo-orbitofrontal-cingulate network, thereby preventing the amygdala from inhibiting the OFC and PFC, and the OFC from inhibiting the ACC appropriately (de Cates and Broome  ...  targeted treatment of individual neurocognitive deficits, potentially using tailored cognitive therapy, targeted neurophysiological techniques (e.g. brain stimulation) or pharmacotherapy (de Cates and Broome  ... 
doi:10.1016/j.neubiorev.2016.10.032 pmid:27923730 fatcat:i2fuxjixi5ejffpfn5xkr7zivu

Pyridoxamine Dihydrochloride in Diabetic Nephropathy (PIONEER-CSG-17): Lessons Learned from a Pilot Study

Jamie P. Dwyer, Barbara A. Greco, Kausik Umanath, David Packham, J. Wesley Fox, Robert Peterson, Benjamin R. Broome, Laura E. Greene, Mohammed Sika, Julia B. Lewis
2014 Nephron  
>3 months. Thus, subjects in the pivotal trial must be on ACE/ ARB for 6 months. Frequent antihypertensive adjustment could engender SCr changes unrelated to CKD progression. Thus, we will require subjects to have BP ≤ 150/90 mm Hg and on stable antihypertensives for 26 weeks, or ≤ 140/90 mm Hg and on stable antihypertensives for 13 weeks. Since ΔSCr over 52 weeks is limited as a surrogate outcome, the pivotal trial uses a time-to-event analysis of baseline SCr to at least a 50% increase in SCr
more » ... or ESRD as the primary outcome. This substantial ΔSCr is protected from noise and is clinically relevant. The pyridoxamine pilot provided critical information to inform the design of PIONEER-CSG-17, which we conducted under the SPA agreement with FDA. Introduction Despite the role of inhibition of the renin-angiotensin aldosterone system (RAAS) in delaying the progression of diabetic nephropathy (DN) [1-3] , many patients still progress to end-stage renal disease (ESRD). With the increasing prevalence of diabetes mellitus, the potential rise in incident ESRD due to DN is costly to our healthcare systems and it negatively impacts the quality of life of our Abstract Background/Aims: Pyridoxamine dihydrochloride (Pyridorin TM ) blocks pathogenic oxidative pathways in the progression of diabetic nephropathy. The pyridoxamine pilot study was designed to test entry criteria and outcomes. Subjects had SCr 1.3-3.5 mg/dl, protein-to-creatinine ≥ 1,200 mg/g and used a surrogate outcome of ΔSCr over 52 weeks. Subjects had to be on a maximally tolerated dose of ACE/ ARB for 3 months; stable other antihypertensive doses for 2 months; stable diuretic dose for 2 weeks, and BP ≤ 160/90 mm Hg; or enter a Pharmaco-Stabilization Phase (PSP). This pilot failed to detect an effect on ΔSCr in intent-to-treat analysis. Methods: We queried the locked clinical trial database for subgroups in which there was a treatment effect. Results: Subjects not requiring PSP and those with entry SCr <2.0 mg/ dl had a treatment effect. Subjects entering PSP required more changes in antihypertensive medications and experienced larger ΔSCr over 52 weeks. PSP subjects with BP >140/90 mm Hg had no treatment effect, but those ≤ 140/90 mm Hg did. Conclusion: Time required for acute effects of ACE/ARB to stabilize is unknown, but these data suggest
doi:10.1159/000369310 pmid:25532068 fatcat:nxrfyabgbfgijnremftxq5ujgy

Consulting with Citizens in the Design of Wellbeing Measures and Policies: Lessons from a Systems Science Application

Michael J. Hogan, Helen Johnston, Benjamin Broome, Claire McMoreland, Jane Walsh, Bryan Smale, Jim Duggan, Jerry Andriessen, Kevin M. Leyden, Christine Domegan, Patricia McHugh, Victoria Hogan (+4 others)
2014 Social Indicators Research  
& Christakis, 1988; Broome & Cromer, 1991) , and training facilitators (Broome & Fulbright, 1995) .  ...  Department of Defence's acquisition process (Alberts, 1992) , promoting world peace (Christakis, 1987) , improving the Tribal governance process in Native American communities (Broome, 1995; Broome  ... 
doi:10.1007/s11205-014-0764-x fatcat:ra7kh2g6uvcxhaz4xrnqtwepxu

Multiphoton quantum interference in a multiport integrated photonic device

Benjamin J. Metcalf, Nicholas Thomas-Peter, Justin B. Spring, Dmytro Kundys, Matthew A. Broome, Peter C. Humphreys, Xian-Min Jin, Marco Barbieri, W. Steven Kolthammer, James C. Gates, Brian J. Smith, Nathan K. Langford (+2 others)
2013 Nature Communications  
Increasing the complexity of quantum photonic devices is essential for many optical information processing applications to reach a regime beyond what can be classically simulated, and integrated photonics has emerged as a leading platform for achieving this. Here, we demonstrate three-photon quantum operation of an integrated device containing three coupled interferometers, eight spatial modes and many classical and nonclassical interferences. This represents a critical advance over previous
more » ... plexities and the first on-chip nonclassical interference with more than two photonic inputs. We introduce a new scheme to verify quantum behaviour, using classically characterised device elements and hierarchies of photon correlation functions. We accurately predict the device's quantum behaviour and show operation inconsistent with both classical and bi-separable quantum models. Such methods for verifying multiphoton quantum behaviour are vital for achieving increased circuit complexity. Our experiment paves the way for the next generation of integrated photonic quantum simulation and computing devices.
doi:10.1038/ncomms2349 pmid:23322044 fatcat:vpp42wnw5bhatl765zwhqmzkx4

Practical Aspects of Cavitation [and Discussion]

J. M. Hobbs, R. Hickling, J. H. Brunton, A. T. Ellis, G. E. Gadd, T. B. Benjamin, A. Silverleaf, A. V. Smith, F. G. Hammitt, K. K. Shal'nev, A. Tuffrey, F. J. Heymann (+10 others)
1966 Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences  
Broom Do cavitation pits exhibit cracks ? F. G. Hammitt We have not yet made any experiments to relate cavitation damage to absorbed air content, although we plan such tests in the future.  ... 
doi:10.1098/rsta.1966.0050 fatcat:beiyjagejrcepdgp7riy3k2itu

A standardized method to determine the concentration of extracellular vesicles using tunable resistive pulse sensing

Robert Vogel, Frank A. W. Coumans, Raluca G. Maltesen, Anita N. Böing, Katherine E. Bonnington, Marike L. Broekman, Murray F. Broom, Edit I. Buzás, Gunna Christiansen, Najat Hajji, Søren R. Kristensen, Meta J. Kuehn (+11 others)
2016 Journal of Extracellular Vesicles  
Understanding the pathogenic role of extracellular vesicles (EVs) in disease and their potential diagnostic and therapeutic utility is extremely reliant on in-depth quantification, measurement and identification of EV sub-populations. Quantification of EVs has presented several challenges, predominantly due to the small size of vesicles such as exosomes and the availability of various technologies to measure nanosized particles, each technology having its own limitations. Materials and Methods:
more » ... A standardized methodology to measure the concentration of extracellular vesicles (EVs) has been developed and tested. The method is based on measuring the EV concentration as a function of a defined size range. Blood plasma EVs are isolated and purified using size exclusion columns (qEV) and consecutively measured with tunable resistive pulse sensing (TRPS). Six independent research groups measured liposome and EV samples with the aim to evaluate the developed methodology. Each group measured identical samples using up to 5 nanopores with 3 repeat measurements per pore. Descriptive statistics and unsupervised multivariate data analysis with principal component analysis (PCA) were used to evaluate reproducibility across the groups and to explore and visualise possible patterns and outliers in EV and liposome data sets. Results: PCA revealed good reproducibility within and between laboratories, with few minor outlying samples. Measured mean liposome (not filtered with qEV) and EV (filtered with qEV) concentrations had coefficients of variance of 23.9% and 52.5%, respectively. The increased variance of the EV concentration measurements could be attributed to the use of qEVs and the polydisperse nature of EVs. Conclusion: The results of this study demonstrate the feasibility of this standardized methodology to facilitate comparable and reproducible EV concentration measurements.
doi:10.3402/jev.v5.31242 pmid:27680301 pmcid:PMC5040823 fatcat:ejpzn47zdbbw7nfrvhl7jeoeea

Bone Marrow Adipose Tissue Is an Endocrine Organ that Contributes to Increased Circulating Adiponectin during Caloric Restriction

William P. Cawthorn, Erica L. Scheller, Brian S. Learman, Sebastian D. Parlee, Becky R. Simon, Hiroyuki Mori, Xiaomin Ning, Adam J. Bree, Benjamin Schell, David T. Broome, Sandra S. Soliman, Jenifer L. DelProposto (+13 others)
2014 Cell Metabolism  
The adipocyte-derived hormone adiponectin promotes metabolic and cardiovascular health. Circulating adiponectin increases in lean states such as caloric restriction (CR), but the reasons for this paradox remain unclear. Unlike white adipose tissue (WAT), bone marrow adipose tissue (MAT) increases during CR, and both MAT and serum adiponectin increase in many other clinical conditions. Thus, we investigated whether MAT contributes to circulating adiponectin. We find that adiponectin secretion is
more » ... greater from MAT than WAT. Notably, specific inhibition of MAT formation in mice results in decreased circulating adiponectin during CR despite unaltered adiponectin expression in WAT. Inhibiting MAT formation also alters skeletal muscle adaptation to CR, suggesting that MAT exerts systemic effects. Finally, we reveal that both MAT and serum adiponectin increase during cancer therapy in humans. These observations identify MAT as an endocrine organ that contributes significantly to increased serum adiponectin during CR and perhaps in other adverse states.
doi:10.1016/j.cmet.2014.06.003 pmid:24998914 pmcid:PMC4126847 fatcat:4owcqftqwjfmxp2qqsmppta7du

Variants of the elongator protein 3 ( ELP3 ) gene are associated with motor neuron degeneration

Claire L. Simpson, Robin Lemmens, Katarzyna Miskiewicz, Wendy J. Broom, Valerie K. Hansen, Paul W.J. van Vught, John E. Landers, Peter Sapp, Ludo Van Den Bosch, Joanne Knight, Benjamin M. Neale, Martin R. Turner (+18 others)
2008 Human Molecular Genetics  
doi:10.1093/hmg/ddn375 pmid:18996918 pmcid:PMC2638803 fatcat:n75al5tjwnharmpsjbcxlao6ra

Fantasy around learning and employment prospects-a case from Australia [Pg. 94]

Allie Clemans, Anne Newton, Michael Hogan, Benjamin Broome Ireland
Ireland currently has no national wellbeing index and there is a strong consensus that this is a barrier to wellbeing in Ireland (Hogan & Broome, 2012) .  ...  Online resources A Citizens for health advocacy: Exploring options for learning in the context of healthcare reform in Hong Kong Benjamin Tak-Yuen Chan Lingnan University Hong Kong Hong Kong is known  ... 

Page 156 of National Union Catalog Vol. 20, Issue [page]

1942 National Union Catalog  
(Half-title: Mc- Graw- Hit series 1n education; Harold Benjamin, consulting editor) Includes bibliographies. 1. Grading and marking (Students) 2. Education—Stat. 3.  ...  (Hal/-title: McGraw- Hill series in education ; Harold Benjamin, consulting editor) Saseeraatient foot-notes. “Readings for further study” at end of each chapter 1.  ... 

Page 670 of The Journal of the Royal Anthropological Institute Vol. 9, Issue 4 [page]

2003 The Journal of the Royal Anthropological Institute  
The women, carrying brooms and dustpans, looked as if they had been unexpectedly caught cleaning the hall.  ...  Correctly performed, the stapdans involved women carrying brooms, dish- cloths, and basins while men carried axes or spades. It demonstrated that both men and women should work in their homes.  ... 

Page 197 of Archives of Useful Knowledge Vol. 3, Issue 2 [page]

1812 Archives of Useful Knowledge  
Marshall Lewis, of Chenango, Broome county, New York, in saw mills, May 24. Charles Woolverton and Benjamin Ridgway, jun’r. of Morris Villa, Pennsylvania, a machine for dressing mill stones, May 24.  ...  NAMES OF PATENTEES. 197 John Rewey, of Berkshire, Broome county, New York, ma- chine for cutting off the ends of bolts, &c., May 8.  ... 
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