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Behavioral and neural stability of attention bias to threat in healthy adolescents

Lauren K. White, Jennifer C. Britton, Stefanie Sequeira, Emily G. Ronkin, Gang Chen, Yair Bar-Haim, Tomer Shechner, Monique Ernst, Nathan A. Fox, Ellen Leibenluft, Daniel S. Pine
2016 NeuroImage  
Considerable translational research on anxiety examines attention bias to threat and the efficacy of attention training in reducing symptoms.  ...  Perturbed fronto-amygdala function consistently arises in attention bias research on adolescent anxiety.  ...  Increased attention bias to threat in anxious relative to healthy children and adults is one of the most consistently observed associations in research on anxiety (for review see Bar-Haim et al., 2007  ... 
doi:10.1016/j.neuroimage.2016.04.058 pmid:27129757 pmcid:PMC5139370 fatcat:gitphmplzbbjdo4kap77l3v2qq

Attention biases, anxiety, and development: toward or away from threats or rewards?

Tomer Shechner, Jennifer C. Britton, Koraly Pérez-Edgar, Yair Bar-Haim, Monique Ernst, Nathan A. Fox, Ellen Leibenluft, Daniel S. Pine
2011 Depression and Anxiety  
Building on this work, we then turn to the treatment of pediatric anxiety, where manipulation of attention to threat and/or reward may serve a therapeutic role as a component of Attention Bias Key words  ...  The study of attention biases appears particularly pertinent to developmental research, as attention affects learning and has down-stream effects on behavior.  ...  The first assesses attention orienting in infants and then charts the stability of anxious behavior into adolescence.  ... 
doi:10.1002/da.20914 pmid:22170764 pmcid:PMC3489173 fatcat:5slktonxpbhsfay2lrgznuptcy

Training-associated changes and stability of attention bias in youth: Implications for Attention Bias Modification Treatment for pediatric anxiety

Jennifer C. Britton, Yair Bar-Haim, Michelle A. Clementi, Lindsey S. Sankin, Gang Chen, Tomer Shechner, Maxine A. Norcross, Carolyn N. Spiro, Kara M. Lindstrom, Daniel S. Pine
2013 Developmental Cognitive Neuroscience  
Intra-class correlation demonstrated stability of neural activation in response to attention bias in the ventrolateral prefrontal cortex and amygdala.  ...  Therefore, ABMT research should take into account the impact of attention bias stability on attention training response, especially in pediatric populations.  ...  Acknowledgments This research was supported in part by theIntramural Research Program of the National Institute of Mental Health (NIMH), National Institutes of Health and the National Alliance of Research  ... 
doi:10.1016/j.dcn.2012.11.001 pmid:23200784 pmcid:PMC3606014 fatcat:k5mvdhkduvfcnffsqjw7j4a5d4

A Systems Neuroscience Approach to the Pathophysiology of Pediatric Mood and Anxiety Disorders [chapter]

Wan-Ling Tseng, Ellen Leibenluft, Melissa A. Brotman
2013 Current topics in behavioral neurosciences  
Emerging evidence suggests that these disorders are mediated by abnormalities in the functions and structures of the developing brain.  ...  Throughout the chapter, we highlight the relationship between neural and behavioral findings, and potential novel treatments. The chapter concludes with directions for future research.  ...  ABMT reduces attention bias to threat (Eldar et al. 2012 ) and increases attention bias toward positive stimuli (Waters et al. 2013 ) while reducing anxiety symptoms and clinical severity ratings in  ... 
doi:10.1007/7854_2013_252 pmid:24281907 pmcid:PMC4482127 fatcat:r5awc6onejgadgktalhy6hf4yq

Amygdala and Ventrolateral Prefrontal Cortex Activation to Masked Angry Faces in Children and Adolescents With Generalized Anxiety Disorder

Christopher S. Monk, Eva H. Telzer, Karin Mogg, Brendan P. Bradley, Xiaoqin Mai, Hugo M. C. Louro, Gang Chen, Erin B. McClure-Tone, Monique Ernst, Daniel S. Pine
2008 Archives of General Psychiatry  
The amygdala and the ventrolateral prefrontal cortex constitute a neural circuit that is responsible for detection of threats.  ...  Objective: To investigate amygdala and ventrolateral prefrontal cortex activation during processing of briefly presented threats in pediatric GAD. Design: Case-control study.  ...  This suggests that different neural processes underlie the common behavioral result of attentional bias to masked angry faces.  ... 
doi:10.1001/archpsyc.65.5.568 pmid:18458208 pmcid:PMC2443697 fatcat:ixlgxpa6c5duzjvrjfcefrl4ke

Attention Biases to Threat Link Behavioral Inhibition to Social Withdrawal over Time in Very Young Children

Koraly Pérez-Edgar, Bethany C. Reeb-Sutherland, Jennifer Martin McDermott, Lauren K. White, Heather A. Henderson, Kathryn A. Degnan, Amie A. Hane, Daniel S. Pine, Nathan A. Fox
2011 Journal of Abnormal Child Psychology  
Previous research, focused largely on adolescents, suggests that attention biases to threat may sustain high levels of behavioral inhibition (BI) over time, helping link early temperament to social outcomes  ...  The current study examined the interrelations among BI, attention biases to threat, and social withdrawal already manifest in early childhood.  ...  large attention biases to threat.  ... 
doi:10.1007/s10802-011-9495-5 pmid:21318555 pmcid:PMC3756613 fatcat:omy4xtd74zctnlt4lbmzo4phyu

Childhood Antecedents and Risk for Adult Mental Disorders

Daniel S. Pine, Nathan A. Fox
2015 Annual Review of Psychology  
, and its relations to a third group of disorders, the emotional disorders.  ...  In the next section, the review describes how research on genetic contributions to psychopathology has elucidated the nature of risk for two groups of disorders, the neurodevelopmental and psychotic disorders  ...  Brain-imaging studies indicate that neural expressions of attention bias may be more stable and more responsive to ABMT than are behavioral expressions of attention bias (Britton et al. 2013a ).  ... 
doi:10.1146/annurev-psych-010814-015038 pmid:25559116 fatcat:op7xmb5vrbcixjkfqqwqslsseu

Neural and behavioral responses to threatening emotion faces in children as a function of the short allele of the serotonin transporter gene

Moriah E. Thomason, Melissa L. Henry, J. Paul Hamilton, Jutta Joormann, Daniel S. Pine, Monique Ernst, David Goldman, Karin Mogg, Brendan P. Bradley, Jennifer C. Britton, Kara M. Lindstrom, Christopher S. Monk (+3 others)
2010 Biological Psychology  
These results indicate that in children and adolescents, s-allele carriers can be distinguished from l-allele homozygotes on the basis of hypervigilant behavioral and neural processing of negative material  ...  Moreover, sallele carriers showed greater neural activations to fearful and angry faces than did l-allele homozygotes in various regions of association cortex previously linked to attention control in  ...  Sherdell for their assistance in participant recruitment, screening, and conducting structured behavioral interviews.  ... 
doi:10.1016/j.biopsycho.2010.04.009 pmid:20493234 pmcid:PMC2914171 fatcat:j5odqkvuqbc6vdwyt557yomneu

Patterns of Neural Connectivity During an Attention Bias Task Moderate Associations Between Early Childhood Temperament and Internalizing Symptoms in Young Adulthood

Jillian E. Hardee, Brenda E. Benson, Yair Bar-Haim, Karin Mogg, Brendan P. Bradley, Gang Chen, Jennifer C. Britton, Monique Ernst, Nathan A. Fox, Daniel S. Pine, Koraly Pérez-Edgar
2013 Biological Psychiatry  
Background-Biased attention to threat is found in both individuals with anxiety symptoms and children with the childhood temperament of behavioral inhibition (BI).  ...  Although perturbed frontoamygdala function is implicated in biased attention among anxious individuals, no work has examined the neural correlates of attention biases in BI.  ...  We would like to thank the participants and families for their continued involvement in our study.  ... 
doi:10.1016/j.biopsych.2013.01.036 pmid:23489415 pmcid:PMC3725217 fatcat:cfau2vitoraj3khrqpdjbrip3e

The developmental psychopathology of irritability

Ellen Leibenluft, Joel Stoddard
2013 Development and Psychopathology  
Focusing on both normative and pathologic development, we review the construct of irritability from its origins in aggression and disruptive behavior research to its contemporary relevance for affective  ...  Finally, we argue for therapeutic trials targeting severe irritability that address emotional aspects of irritability in addition to the associated disruptive behavior.  ...  The literature seeking to define the neural correlates of frustration in healthy subjects is limited, and the corresponding literature in clinical populations is extremely sparse.  ... 
doi:10.1017/s0954579413000722 pmid:24342851 pmcid:PMC4476313 fatcat:ihskrznbsfbjnmeylil4txujoq

Heterogeneity of the Anxiety-Related Attention Bias: A Review and Working Model for Future Research

Tracy A. Dennis-Tiwary, Amy Krain Roy, Samantha Denefrio, Sarah Myruski
2019 Clinical Psychological Science  
The anxiety-related attention bias (AB) has been studied for several decades as a clinically-relevant output of the dynamic and complex threat detection-response system.  ...  We review existing research and propose a working model of AB heterogeneity positing that AB may be best conceptualized as multiple subtypes of dysregulated processing of and attention to threat anchored  ...  A lack of stability in AB was also reported in a study of 12 healthy adolescents who completed the dot probe during two fMRI scans approximately 3 months apart (Brown et al., 2013) .  ... 
doi:10.1177/2167702619838474 pmid:33758680 pmcid:PMC7983558 fatcat:rpk6dqlzhnb7lerh2oqg4osnv4

A developmental neuroscience perspective on affect-biased attention

Santiago Morales, Xiaoxue Fu, Koraly E. Pérez-Edgar
2016 Developmental Cognitive Neuroscience  
We also review the general mechanisms and neural correlates of affect-biased attention, as well as the current evidence for the co-development of attention and affect.  ...  There is growing interest regarding the impact of affect-biased attention on psychopathology. However, most of the research to date lacks a developmental approach.  ...  Acknowledgement Support for manuscript preparation was provided by grants from the National Institutes of Health (MH094633, MH103627) to Koraly Pérez-Edgar.  ... 
doi:10.1016/j.dcn.2016.08.001 pmid:27606972 pmcid:PMC5067218 fatcat:vasyk7plwne5lbb7dum5mnbiam

Vigilant attention to threat, sleep patterns, and anxiety in peripubertal youth

Emily J. Ricketts, Rebecca B. Price, Greg J. Siegle, Jennifer S. Silk, Erika E. Forbes, Cecile D. Ladouceur, Allison G. Harvey, Neal D. Ryan, Ronald E. Dahl, Dana L. McMakin
2018 Journal of Child Psychology and Psychiatry and Allied Disciplines  
We present one of the first studies to use objective measures to examine associations between vigilant attention to threat and difficulties initiating and maintaining sleep in an early adolescent anxious  ...  Key points • Vigilant attention to threat is common in anxious youth and undergoes developmental changes in adolescence.  ...  DM has relocated to the Psychology Department at Florida International University and the Neurology Department at Nicklaus Children's Hospital in Miami, Florida.  ... 
doi:10.1111/jcpp.12923 pmid:29718535 fatcat:rau6xv4s45efbdvzngxxxb4gem

Behavioral Inhibition and Developmental Risk: A Dual-Processing Perspective

Heather A Henderson, Daniel S Pine, Nathan A Fox
2014 Neuropsychopharmacology  
The present review is focused on the relation of BI to two types of information processing: automatic (novelty detection, attention biases to threat, and incentive processing) and controlled (attention  ...  Later in development, children with a history of BI tend to display normative levels of performance on controlled attention tasks, but they demonstrate exaggerated neural responses in order to do so, which  ...  Special thanks to Sonya Troller-Renfree for comments on an earlier draft of this paper.  ... 
doi:10.1038/npp.2014.189 pmid:25065499 pmcid:PMC4262899 fatcat:kbccwpr7x5a4tcx3xaawbzwnvq

A Preliminary Investigation of Neural Correlates of Treatment in Adolescents with Generalized Anxiety Disorder

Julie Maslowsky, Karin Mogg, Brendan P. Bradley, Erin McClure-Tone, Monique Ernst, Daniel S. Pine, Christopher S. Monk
2010 Journal of child and adolescent psychopharmacology  
During fMRI acquisition, a probe detection task with emotional (angry, happy) and neutral faces allowed for assessment of neural response to threat.  ...  Objective: Generalized anxiety disorder (GAD) is a prevalent and debilitating psychiatric condition of adolescence.  ...  Further work is warranted to better understand the effects of treatments on attention bias to threat.  ... 
doi:10.1089/cap.2009.0049 pmid:20415605 pmcid:PMC2865364 fatcat:7ye5jdm5xbgcniprthwwcdllkm
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