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BacFITBase: a database to assess the relevance of bacterial genes during host infection

2019 Nucleic Acids Research  
Here, we introduce the BacFITBase database for the systematic characterization of bacterial proteins relevant for host infection aimed to enable the identification of new antibiotic targets.  ...  BacFITBase is manually curated and contains more than 90 000 entries with information on the contribution of individual genes to bacterial fitness under in vivo infection conditions in a range of host  ...  ACKNOWLEDGEMENTS The authors would like to thank Dr Norman E. Davey for his kind support in providing ProViz for protein visualization. FUNDING  ... 
doi:10.1093/nar/gkz931 pmid:31665505 pmcid:PMC7145566 fatcat:yaen6ydi4jdv5bvdxd3awra4si

Bacteria Use Structural Imperfect Mimicry To Hijack The Host Interactome [article]

Marc Torrent, Natalia Sánchez de Groot
2020 biorxiv/medrxiv   pre-print
Hence, the infectious capacity of the pathogen is closely related to its ability to interact with host proteins.  ...  Bacteria use protein-protein interactions to infect their hosts and hijack fundamental pathways, which ensures their survival and proliferation.  ...  To further validate these results, we filtered the Y. pestis-H. sapiens network with fitness data, which measures the relevance of a given bacterial gene in infection.  ... 
doi:10.1101/2020.02.24.962944 fatcat:tsuua6tnvvbclbr57hqyyxw4xy

Bacteria use structural imperfect mimicry to hijack the host interactome

Natalia Sanchez de Groot, Marc Torrent Burgas, Arne Elofsson
2020 PLoS Computational Biology  
Hence, the infectious capacity of the pathogen is closely related to its ability to interact with host proteins.  ...  Bacteria use protein-protein interactions to infect their hosts and hijack fundamental pathways, which ensures their survival and proliferation.  ...  To further validate these results, we filtered the Y. pestis-H. sapiens network with fitness data, which measures the relevance of a given bacterial gene in infection.  ... 
doi:10.1371/journal.pcbi.1008395 pmid:33275611 fatcat:monxhdfucfaf5ejq5coyxkisqy