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BacFITBase: a database to assess the relevance of bacterial genes during host infection
2019
Nucleic Acids Research
Preserved Fulltext
Here, we introduce the BacFITBase database for the systematic characterization of bacterial proteins relevant for host infection aimed to enable the identification of new antibiotic targets. ...
BacFITBase is manually curated and contains more than 90 000 entries with information on the contribution of individual genes to bacterial fitness under in vivo infection conditions in a range of host ...
ACKNOWLEDGEMENTS The authors would like to thank Dr Norman E. Davey for his kind support in providing ProViz for protein visualization.
FUNDING ...
doi:10.1093/nar/gkz931
pmid:31665505
pmcid:PMC7145566
fatcat:yaen6ydi4jdv5bvdxd3awra4si
Bacteria Use Structural Imperfect Mimicry To Hijack The Host Interactome
[article]
2020
biorxiv/medrxiv
pre-print
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A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2021; you can also visit the original URL.
The file type is application/pdf.
Hence, the infectious capacity of the pathogen is closely related to its ability to interact with host proteins. ...
Bacteria use protein-protein interactions to infect their hosts and hijack fundamental pathways, which ensures their survival and proliferation. ...
To further validate these results, we filtered the Y. pestis-H. sapiens network with fitness data, which measures the relevance of a given bacterial gene in infection. ...
doi:10.1101/2020.02.24.962944
fatcat:tsuua6tnvvbclbr57hqyyxw4xy
Bacteria use structural imperfect mimicry to hijack the host interactome
2020
PLoS Computational Biology
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2020; you can also visit the original URL.
The file type is application/pdf.
Hence, the infectious capacity of the pathogen is closely related to its ability to interact with host proteins. ...
Bacteria use protein-protein interactions to infect their hosts and hijack fundamental pathways, which ensures their survival and proliferation. ...
To further validate these results, we filtered the Y. pestis-H. sapiens network with fitness data, which measures the relevance of a given bacterial gene in infection. ...
doi:10.1371/journal.pcbi.1008395
pmid:33275611
fatcat:monxhdfucfaf5ejq5coyxkisqy