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Evidence of Change in Brain Activity among Childhood Cancer Survivors Participating in a Cognitive Remediation Program

P. Zou, Y. Li, H. M. Conklin, R. K. Mulhern, R. W. Butler, R. J. Ogg
2012 Archives of Clinical Neuropsychology  
Increased understanding of the underlying mechanisms of cognitive remediation is needed to facilitate development of intervention strategies for childhood cancer survivors experiencing cognitive late effects  ...  The pilot study suggests that fMRI is useful in evaluating neural responses to cognitive remediation.  ...  A study with simple visual stimulation during fMRI demonstrated that blood oxygenation level-dependent (BOLD) fMRI, the most commonly used fMRI method, is feasible in childhood survivors of ALL and brain  ... 
doi:10.1093/arclin/acs095 pmid:23079152 pmcid:PMC3500501 fatcat:7molsyftgnhcbgnceplrmbphna

The Psychoneuroimmunology of Stress Regulation in Pediatric Cancer Patients

Gillian E. White, Jessica E. Caterini, Victoria McCann, Kate Rendall, Paul C. Nathan, Shawn G. Rhind, Heather Jones, Greg D. Wells
2021 Cancers  
to be, in part, a result of cytotoxic cancer treatments.  ...  We conclude that consideration of stress regulation in childhood cancer may be crucial in understanding and treating the disease.  ...  In survivors, correct responses generated a decreased BOLD response in the posterior cingulate, incorrect responses generated a greater BOLD response in the angular gyrus, and no response generate  ... 
doi:10.3390/cancers13184684 pmid:34572911 pmcid:PMC8468382 fatcat:sgqaxgfikbayzfihnf4qdc7otm

Structural and Functional Brain Imaging in Long-Term Survivors of Childhood Acute Lymphoblastic Leukemia Treated with Chemotherapy: A Systematic Review

Kellen Gandy, Matthew A Scoggins, Lisa M Jacola, Molly Litten, Wilburn E Reddick, Kevin R Krull
2021 JNCI Cancer Spectrum  
Conclusion While the neurotoxic effects of cancer treatment are reduced in the absence of cranial radiation, survivors treated on chemotherapy-only protocols still display long-term alterations in brain  ...  assess brain structure and function in pediatric ALL survivors (diagnosed < 21 years of age).  ...  Acknowledgments: We thank the researcher investigators who published their studies in the public domain.  ... 
doi:10.1093/jncics/pkab069 pmid:34514328 pmcid:PMC8421809 fatcat:6xbbmjj7xbhofoqxureun6pyxe

Computerized Cognitive Training for Amelioration of Cognitive Late Effects Among Childhood Cancer Survivors: A Randomized Controlled Trial

Heather M. Conklin, Robert J. Ogg, Jason M. Ashford, Matthew A. Scoggins, Ping Zou, Kellie N. Clark, Karen Martin-Elbahesh, Kristina K. Hardy, Thomas E. Merchant, Sima Jeha, Lu Huang, Hui Zhang
2015 Journal of Clinical Oncology  
Acknowledgment We thank the patients and their families who volunteered their time to participate in this study and Melissa Jones, MS, and Charlene Phillips, MSN, for their work in functional magnetic  ...  Conklin HM, Khan RB, Reddick WE, et al: Acute neurocognitive response to methylphenidate among survivors of childhood cancer: A randomized, double-blind, cross-over trial.  ...  Conklin HM, Helton S, Ashford J, et al: Predicting methylphenidate response in long-term survivors of childhood cancer: A randomized, doubleblinded, placebo-controlled, cross-over trial.  ... 
doi:10.1200/jco.2015.61.6672 pmid:26460306 pmcid:PMC4652013 fatcat:2kfsskeymnfr5lfhrraqyox7va

Posttraumatic Growth Outcomes and Their Correlates Among Young Adult Survivors of Childhood Cancer

Jaehee Yi, Brad Zebrack, Min Ah Kim, Melissa Cousino
2015 Journal of Pediatric Psychology  
Objective This study aims to identify and examine posttraumatic growth (PTG) experiences, and their correlates, among young adult survivors of childhood cancer.  ...  Methods 602 long-term childhood cancer survivors between the ages of 18 and 39 participated.  ...  Moreover, there has been little exploration of PTG correlates in childhood cancer survivor populationsparticularly in long-term adult survivors of childhood disease.  ... 
doi:10.1093/jpepsy/jsv075 pmid:26286227 pmcid:PMC4707188 fatcat:nqdwpdxhbrbrronkolpfylwxyy

Male Sexual Function after Allogeneic Hematopoietic Stem Cell Transplantation in Childhood: A Multicenter Study

Anu Haavisto, Sidsel Mathiesen, Anu Suominen, Päivi Lähteenmäki, Kaspar Sørensen, Marianne Ifversen, Anders Juul, Malene Mejdahl Nielsen, Klaus Müller, Kirsi Jahnukainen
2020 Cancers  
Hence, male survivors of childhood HSCT should be interviewed in detail about their sexual health beyond erectile functions.  ...  In this multicenter study, sexual functions and possible risk factors were assessed comprehensively in two national cohorts (Finland and Denmark) of male adult survivors of childhood HSCT.  ...  Open access funding provided by University of Helsinki. Conflicts of Interest: The authors declare no conflict of interest.  ... 
doi:10.3390/cancers12071786 pmid:32635426 fatcat:zbl3pw6kzngwbnh5rptulet2uq

Vaginal development and sexual functioning in young women after stem cell transplantation, chemotherapy, and/or radiotherapy for childhood hematological diseases

Fausta Beneventi, Elena Locatelli, Margherita Simonetta, Chiara Cavagnoli, Raffaella Pampuri, Camilla Bellingeri, Irene De Maggio, Beatrice Ruspini, Santina Recupero, Giovanna Giorgiani, Arsenio Spinillo
2018 Bone Marrow Transplantation  
To study vaginal development and sexual functioning in young women after childhood hemopoietic stem cell transplantation (HSCT) and radio/chemotherapy.  ...  cases than in controls.  ...  [25] used FSFI to evaluate sexual function in young adult childhood cancer survivors, finding a higher prevalence of sexual dysfunction in this population.  ... 
doi:10.1038/s41409-018-0149-x pmid:29545593 fatcat:fr2suwsjknd3pi5jojncs4vhle

Functional Neuroimaging to Characterize Visual System Development in Children with Retinoblastoma

Scott M. Barb, Carlos Rodriguez-Galindo, Matthew W. Wilson, Nicholas S. Phillips, Ping Zou, Matthew A. Scoggins, Yimei Li, Ibrahim Qaddoumi, Kathleen J. Helton, George Bikhazi, Barrett G. Haik, Robert J. Ogg
2011 Investigative Ophthalmology and Visual Science  
R etinoblastoma, a childhood cancer of the eye, typically affects children during the first 3 years of life, a time of rapid development in the central nervous system. 1, 2 Overall survival at 5 years  ...  are the sign of the BOLD signal change during stimulation and the location of the activation in the visual cortex.  ... 
doi:10.1167/iovs.10-5600 pmid:21245407 pmcid:PMC3088553 fatcat:pwa6kvybxrdjjkaav3av72beae

Treatment Related Cognitive Impairment in Pediatric Oncology Patients: A Brazilian Experience

Danielle Garcia Ediana Gomes
2014 Journal of Nuclear Medicine & Radiation Therapy  
The objective of this study was to compare the cognitive impact of treatment modality on intellective capacity of children survivors of PFT and ALL.  ...  Acute Lymphoblastic leukemia (ALL) and Posterior Fossa Tumors (PFT) are the most common types of cancer in Brazilian children.  ...  Acknowledgements We thank Joao Carlos Alencar for the valuable assistance in data analyses.  ... 
doi:10.4172/2155-9619.1000174 fatcat:edni4q5ijzhqzhj443pv4s2qh4

Survival and long-term health and cognitive outcomes after low-grade glioma

Gregory T. Armstrong, Heather M. Conklin, Sujuan Huang, Deokumar Srivastava, Robert Sanford, David W. Ellison, Thomas E. Merchant, Melissa M. Hudson, Mary Ellen Hoehn, Leslie L. Robison, Amar Gajjar, E. Brannon Morris
2010 Neuro-Oncology  
Five-year survivors (n 5 240) received riskbased clinical assessment. Cumulative incidence of late effects 15 years from diagnosis were estimated.  ...  Risk factors for adverse health were identified using Fine and Gray's approach to Cox's proportional hazards model, accounting for death as a competing risk.  ...  screening and counseling according to the Children's Oncology Group Long-Term Follow-Up Guidelines for Survivors of Childhood, Adolescent and Young Adult Cancers until the age of 18 or 10 years from diagnosis  ... 
doi:10.1093/neuonc/noq178 pmid:21177781 pmcid:PMC3064628 fatcat:gxvlrm4p5bcyrkiuznlruzwoii

Starry sky: multiple neurocysticercosis

B Adhisivam
2004 Archives of Disease in Childhood - Education and Practice  
Yet she is also conscious that radiation and chemotherapy induced lung damage can cause respiratory symptoms in survivors of BMT and a range of other childhood cancers.  ...  There is also an increased risk of thyroid carcinoma caused by irradiation of the gland. 4 Annual thyroid function tests and neck palpation should therefore be part of ongoing surveillance in all survivors  ...  ACKNOWLEDGEMENTS Thanks to Dr Rob Primhak for help with the flow-volume loops.  ... 
doi:10.1136/adc.2004.066795 fatcat:meogrpke4vef5nhy6wpnygiyqy

The cost of cure

A Natarajan
2004 Archives of Disease in Childhood - Education and Practice  
There is also an increased risk of thyroid carcinoma caused by irradiation of the gland. 4 Annual thyroid function tests and neck palpation should therefore be part of ongoing surveillance in all survivors  ...  One year after BMT she continued to be in remission from her leukaemia.  ...  ACKNOWLEDGEMENTS Thanks to Dr Rob Primhak for help with the flow-volume loops.  ... 
doi:10.1136/adc.2004.053470 fatcat:plt5vnhxsfexhguvq7yjucqgai


2004 Archives of Disease in Childhood - Education and Practice  
There is also an increased risk of thyroid carcinoma caused by irradiation of the gland. 4 Annual thyroid function tests and neck palpation should therefore be part of ongoing surveillance in all survivors  ...  One year after BMT she continued to be in remission from her leukaemia.  ...  ACKNOWLEDGEMENTS Thanks to Dr Rob Primhak for help with the flow-volume loops.  ... 
doi:10.1136/adc.2004.050237corr1 fatcat:ro4uoqz5mfbdxmdsrholx3ozua

What lies behind chemotherapy-induced ovarian toxicity?

Irit Ben-Aharon, Ruth Shalgi
2012 Reproduction  
Seminal advances in anticancer therapy as well as supportive care strategies have led to improved survival rates, posing an emphasis on preserving an optimum quality of life after cancer treatment.  ...  This recognition has paved the way to an increasing research of long-term side effects, both clinical and preclinical and to an ongoing design of a supportive care system to evaluate and treat long-term  ...  The Childhood Cancer Survivor Study (CCSS) found that female survivors and partners of male survivors were substantially less likely to have live births compared with their siblings.  ... 
doi:10.1530/rep-12-0121 pmid:22653316 fatcat:utegkxobvjgq3n4nj6uo4oer34

Modality Specific Activations in Working Memory in Children with Cerebellar Medullobastoma: A Functional MRI Study

Duc Ha Hoang Anne Pagnier
2013 Journal of psychological abnormalities in children  
Medulloblastomas are the most common malignant childhood brain tumors arising in the posterior fossa. As a result of advances in treatment the number of survivors has increased significantly.  ...  Stimuli were presented to the participants with alternating the sensory modality (visual, auditory) and the nature of communication (verbal, nonverbal) in a blocked 1-back design during functional Magnetic  ...  Acknowledgement This work was supported by grants from French Society for Childhood Cancer (SFCE) and the Hospital Clinical Research Program (PHRC) of France.  ... 
doi:10.4172/2329-9525.1000111 fatcat:dw4itz5i3rffhhvvlj57pvc3jm
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