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Imaging the neural correlates of tinnitus: a comparison between animal models and human studies

Jason W. Middleton, Thanos Tzounopoulos
2012 Frontiers in Systems Neuroscience  
Imaging in animal models of tinnitus exhibit similarities to results from human studies and have revealed hyperexcitability of auditory brain centers as a neural correlate of tinnitus.  ...  These studies have demonstrated that non-auditory brain areas, such as the limbic system, are involved in the neural basis of tinnitus, Finally human imaging studies have led to novel hypotheses for the  ...  In humans and monkeys, the latency of detection of visual stimulus changes is reduced when gamma power in visual cortex is increased (Womelsdorf et al., 2006; Hoogenboom et al., 2010) .  ... 
doi:10.3389/fnsys.2012.00035 pmid:22586378 pmcid:PMC3343475 fatcat:jhxlbqwitrdz3e52ywrcu7wmpy

Functional connectivity across the human subcortical auditory system using a Gaussian copula graphical model approach with partial correlations [article]

Kevin Richard Sitek, Noirrit Chandra, Abhra Sarkar, Bharath Chandresekaran
2022 bioRxiv   pre-print
associative auditory cortex.  ...  Given the paucity of non-invasive methods for human subcortical investigations, we aim to unveil novel information about the hierarchy and direct connections throughout the human subcortical auditory system  ...  In this study, we took advantage of the large amounts of high-resolution data collected in the 7-Tesla Human Connectome Project (HCP; four runs of 900 BOLD volumes with TR = 1 s at 1.6 mm isotropic spatial  ... 
doi:10.1101/2022.09.15.508099 fatcat:5irdtg25mrcp7c6obd2qs52kj4

Dissociated lateralization of transient and sustained blood oxygen level-dependent signal components in human primary auditory cortex

Christoph Lehmann, Marcus Herdener, Peter Schneider, Andrea Federspiel, Dominik R. Bach, Fabrizio Esposito, Francesco di Salle, Klaus Scheffler, Robert Kretz, Thomas Dierks, Erich Seifritz
2007 NeuroImage  
In human auditory cortex, the temporal blood oxygen level-dependent (BOLD) response to auditory inputs, as measured by functional magnetic resonance imaging (f MRI), consists of at least two independent  ...  Among other auditory operations, the analysis of different sound levels received at both ears is fundamental for the localization of a sound source.  ...  The capability of the auditory system to detect changes in the three-dimensional space of the environment is essential to detect potential danger.  ... 
doi:10.1016/j.neuroimage.2006.11.011 pmid:17175176 fatcat:esh6msw7r5cjlcqagowqzidw3q

Resting state functional network disruptions in a kainic acid model of temporal lobe epilepsy

Ravnoor Singh Gill, Seyed M. Mirsattari, L. Stan Leung
2017 NeuroImage: Clinical  
cortex, auditory and temporal association cortex, and posterior parietal cortex.  ...  Functional connectivity was determined by temporal correlation of the resting-state Blood Oxygen Level Dependent (BOLD) signals between two brain regions during 1.5% and 2% isoflurane, and analyzed as  ...  A difference between animal and human BOLD response in epilepsy was suggested to arise from the use of general anaesthesia in animals, as compared to no anaesthesia in humans during fMRI (Youngblood et  ... 
doi:10.1016/j.nicl.2016.11.002 pmid:27942449 pmcid:PMC5133653 fatcat:coyo4hp3bzg6dpdeompr3wark4

Accumulation of salient events in sensory cortex activity predicts subjective time [article]

Maxine T Sherman, Zafeirios Fountas, Anil K Seth, Warrick Roseboom
2020 bioRxiv   pre-print
We constructed a computational model that predicts video durations from salient events in participants' visual cortex activation.  ...  This model reproduced biases in participants' subjective reports, whereas control models trained on auditory or somatosensory activity did not.  ...  We selected 218 regions such that lower layers reflect the detection and classification of low-level features 219 (e.g. edge detection in primary visual cortex; V1), and higher layers, object-related 220  ... 
doi:10.1101/2020.01.09.900423 fatcat:df2c7wbnsjbohade37w6iemmv4

Auditory Resting-State Network Connectivity in Tinnitus: A Functional MRI Study

Audrey Maudoux, Philippe Lefebvre, Jean-Evrard Cabay, Athena Demertzi, Audrey Vanhaudenhuyse, Steven Laureys, Andrea Soddu, Bogdan Draganski
2012 PLoS ONE  
The right primary auditory cortex, left prefrontal, left fusiform gyrus, and bilateral occipital regions showed a decreased connectivity in tinnitus.  ...  Our data corroborate the hypothesized implication of non-auditory regions in tinnitus physiopathology and suggest that various regions of the brain seem involved in the persistent awareness of the phenomenon  ...  Acknowledgments The authors thank the technicians of the Department of Radiology for their active participation in the MRI studies in tinnitus patients.  ... 
doi:10.1371/journal.pone.0036222 pmid:22574141 pmcid:PMC3344851 fatcat:rucxgpcr75bwzpz5ojzy2u3zni

Trial-by-trial predictions of subjective time from human brain activity

Maxine T. Sherman, Zafeirios Fountas, Anil K. Seth, Warrick Roseboom, Ming Bo Cai
2022 PLoS Computational Biology  
By contrast, salient events in neither of two control regions–auditory and somatosensory cortex–were predictive of duration biases.  ...  We were able to reconstruct trial-by-trial biases in participants' duration reports, which reflect subjective experience of duration, purely from salient events in their visual cortex BOLD activity.  ...  Thanks also to Virginie van Wassenhove and Martin Wiener for comments on an earlier version of the manuscript.  ... 
doi:10.1371/journal.pcbi.1010223 fatcat:7jw7gfduczatdn5uo4hcfrsl5i

The mechanisms of tinnitus: Perspectives from human functional neuroimaging

Peyman Adjamian, Magdalena Sereda, Deborah A. Hall
2009 Hearing Research  
The primary motivation for studying the neural subtrates of tinnitus in humans has been to demonstrate objectively its representation in the central auditory system and to develop a better understanding  ...  The primary motivation for studying the neural subtrates of tinnitus in humans has been to demonstrate objectively its representation in the central auditory system and to develop a better understanding  ...  measured non-invasively in humans; namely inferior colliculus, auditory thalamus and cortex.  ... 
doi:10.1016/j.heares.2009.04.001 pmid:19364527 fatcat:2abzml32czb7fdl5tq5siqwa6e

Event‐related fMRI of tasks involving brief motion

Rasmus M. Birn, Peter A. Bandettini, Robert W. Cox, Reza Shaker
1999 Human Brain Mapping  
The assessment of brain function by blood oxygenation level dependent (BOLD) functional magnetic resonance imaging (fMRI) for tasks involving motion near the field of view is compromised by artifacts arising  ...  blocks of repeated task with rest (a "block-trial" paradigm).  ...  Large signal changes occur in the first few images, predominantly at edges in the image, and a much slower response is present in the motor cortex.  ... 
doi:10.1002/(sici)1097-0193(1999)7:2<106::aid-hbm4>3.3.co;2-f pmid:9950068 fatcat:4ridbf3v5bglxasmdofsjupbse

Event-related fMRI of tasks involving brief motion

Rasmus M. Birn, Peter A. Bandettini, Robert W. Cox, Reza Shaker
1999 Human Brain Mapping  
The assessment of brain function by blood oxygenation level dependent (BOLD) functional magnetic resonance imaging (fMRI) for tasks involving motion near the field of view is compromised by artifacts arising  ...  blocks of repeated task with rest (a "block-trial" paradigm).  ...  Large signal changes occur in the first few images, predominantly at edges in the image, and a much slower response is present in the motor cortex.  ... 
doi:10.1002/(sici)1097-0193(1999)7:2<106::aid-hbm4>3.0.co;2-o pmid:9950068 fatcat:cpjzn3cgtvcutb6dzskkksqlle

Connectivity graph analysis of the auditory resting state network in tinnitus

A. Maudoux, Ph. Lefebvre, J.-E. Cabay, A. Demertzi, A. Vanhaudenhuyse, S. Laureys, A. Soddu
2012 Brain Research  
In the tinnitus group, only one of the two previously described networks was observed, encompassing the auditory cortices and the insula.  ...  In the control group, the connectivity graph was divided into two distinct anti-correlated networks. The first one encompassed the auditory cortices and the insula.  ...  Acknowledgments The authors thank the technicians of the Department of Radiology for their active participation in the MRI studies in tinnitus patients.  ... 
doi:10.1016/j.brainres.2012.05.006 pmid:22579727 fatcat:r4vplq5ovfajrlcbnjeyarwi4q

Using fMRI to Examine Central Auditory Plasticity [chapter]

Deborah Hall, Cornelis Lanting, Douglas Hartley
2014 Advanced Brain Neuroimaging Topics in Health and Disease - Methods and Applications  
Based on the observed mirror-symmetric frequency gradients, both sets of authors proposed boundaries of regions in human auditory cortex homologous to A1 and R regions in non-human primate cortex.  ...  Tonotopic organization in the human auditory cortex revealed using fMRI Many studies have elucidated the functional specialization and hierarchical organization of multiple areas of the auditory cortex  ... 
doi:10.5772/58262 fatcat:tbqsim27drgslj4wfhl7xrztza

Amplitopicity of the Human Auditory Cortex: An fMRI Study

Deniz Bilecen, Erich Seifritz, Klaus Scheffler, Jürgen Henning, Anja-Carina Schulte
2002 NeuroImage  
Linear cross-correlation analysis (correlation coefficient > 0.3 corresponding to P < 0.08) of the functional data set revealed bilateral BOLD response within the auditory cortex of the nine subjects with  ...  Whereas specialized frequency-encoding patterns in the human auditory cortex are generally accepted, termed tonotopicity, a similar principle of intensity encoding-amplitopicity-is debated controversially  ...  ACKNOWLEDGMENTS The authors thank Alexander Mackenzie for help in preparing the manuscript.  ... 
doi:10.1006/nimg.2002.1133 pmid:12377146 fatcat:r6jldniklnabldp76jnnljdk6a

Neural activity underlying tinnitus generation: Results from PET and fMRI

C.P. Lanting, E. de Kleine, P. van Dijk
2009 Hearing Research  
ese results indicate that in addition to the auditory system, non-auditory systems may represent a neural correlate of tinnitus.  ...  Specifically, three mechanisms have been proposed to underlie tinnitus: () changes in the level of spontaneous neural activity in the central auditory system, () changes in the temporal pattern of neural  ...  e study is part of the research program of our department: Communication through Hearing and Speech.  ... 
doi:10.1016/j.heares.2009.06.009 pmid:19545617 fatcat:xtbdw3lbmfd2jd4zaptfps7i2e

A Rate Code for Sound Azimuth in Monkey Auditory Cortex: Implications for Human Neuroimaging Studies

U. Werner-Reiss, J. M. Groh
2008 Journal of Neuroscience  
Is sound location represented in the auditory cortex of humans and monkeys?  ...  Human neuroimaging experiments have had only mixed success at demonstrating sound location sensitivity in primary auditory cortex.  ...  Introduction For humans, the role of primary auditory cortex in processing information about sound location is uncertain.  ... 
doi:10.1523/jneurosci.5044-07.2008 pmid:18385333 pmcid:PMC3654685 fatcat:nn23pw64tnexhlgtckwkpponne
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