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Autism: a transdiagnostic, dimensional, construct of reasoning?

Bodil Aggernaes
2017 European Journal of Neuroscience  
A future challenge of autism research may be to develop theoretical models that can account for the impact of complex processes acting at the social level in addition to complex neurobiological and psychological  ...  Such models could profit from a distinction among processes related to (i) basic susceptibility, (ii) adaptive processes and (iii) decompensating factors involved in the development of manifest illness  ...  Acknowledgements The author is very grateful to psychologist and senior researcher Martin Vestergaard Gøtzsche, PhD, and to psychologist and senior researcher Ole Jakob Storebø, PhD, for their critical  ... 
doi:10.1111/ejn.13599 pmid:28452080 pmcid:PMC6084350 fatcat:hvm2obwk7ndijd4gsznpjcpydm

A longitudinal serum NMR-based metabolomics dataset of ischemia-reperfusion injury in adult cardiac surgery

Raluca Georgiana Maltesen, Reinhard Wimmer, Bodil Steen Rasmussen
2020 Scientific Data  
The datasets could also be used for the development of processing algorithms for NMR-based metabolomics studies and methods for the analysis of longitudinal multivariate data.  ...  Cardiovascular disease is the leading cause of death worldwide and cardiac surgery is a key treatment.  ...  Firstly, it may assist researchers studying ischemia-reperfusion models and the underlying molecular mechanisms of subsequent injury.  ... 
doi:10.1038/s41597-020-0545-0 pmid:32581368 fatcat:hpuobvhs5vdi7odxrlsd3v33f4

Investigation of the direct effects of salmon calcitonin on human osteoarthritic chondrocytes

Bodil-Cecilie Sondergaard, Suzi H Madsen, Toni Segovia-Silvestre, Sarah J Paulsen, Thorbjorn Christiansen, Christian Pedersen, Anne-Christine Bay-Jensen, Morten A Karsdal
2010 BMC Musculoskeletal Disorders  
Results: QPCR analysis and subsequent sequencing confirmed expression of the calcitonin receptor in human chondrocytes.  ...  Calcitonin significantly and concentration-dependently [100 pM-100 nM] induced proteoglycan synthesis measured by radioactive 35 SO 4 incorporation, with a 96% maximal induction at 10 nM (P < 0.001) corresponding  ...  Acknowledgements We acknowledge the patients, nurses, and surgeons at Farsoe and Gentofte Hospital, DK for helpfully providing us with tissue for our investigations.  ... 
doi:10.1186/1471-2474-11-62 pmid:20367884 pmcid:PMC2858096 fatcat:ikzeliiqufc4zh6hm7vqmin3ma

Thermotropic behavior and lateral distribution of very long chain sphingolipids

Y. Jenny E. Björkqvist, Jonathan Brewer, Luis A. Bagatolli, J. Peter Slotte, Bodil Westerlund
2009 Biochimica et Biophysica Acta - Biomembranes  
It was also evident that not only the very long acyl chain but also the specific molecular structure of the sphingolipids was of importance for their membrane properties. j o u r n a l h o m e p a g e  ...  The ability to pack tightly with ordered and extended acyl chains is a necessity for membrane lipids to partition into ordered domains in membranes and thus the 24:1-sphingolipids appeared less likely  ...  Björkqvist was supported by the National Graduate School in Informational and Structural Biology at Åbo Akademi University.  ... 
doi:10.1016/j.bbamem.2009.02.019 pmid:19272355 fatcat:yh673tc6kvacjpvtdokxwrz45i

Estrone C15 derivatives—A new class of 17β-hydroxysteroid dehydrogenase type 1 inhibitors

Josef Messinger, Bettina Husen, Pasi Koskimies, Leena Hirvelä, Lila Kallio, Pauli Saarenketo, Hubert Thole
2009 Molecular and Cellular Endocrinology  
Based on a molecular modelling approach we designed and synthesized novel C15-substituted estrone derivatives.  ...  Estrone C15 derivatives -a new class of 17β-hydroxysteroid dehydrogenase type 1 inhibitors. Molecular and Cellular Endocrinology, Elsevier, 2009, 301 (1-2), pp.  ...  Günter Gerling, Tanja Cordts, Manfred Kostrzewa and Stefan Wachsmann who performed the first 3 kg synthesis of the core intermediate 6, as well as the large scale synthesis of compounds 13 and 18.  ... 
doi:10.1016/j.mce.2008.10.022 pmid:19014997 fatcat:7bebscqi45b4nn5fbdvrtcf5b4

Antibiotic prescription patterns among Swedish dentists working with dental implant surgery: adherence to recommendations

Dalia Khalil, Margareta Hultin, Linda Andersson Fred, Nina Parkbring Olsson, Bodil Lund
2014 Clinical Oral Implants Research  
You motivated me to achieve a balance between work and life. You are a great role model.  ...  and vibrant research environment.  ... 
doi:10.1111/clr.12402 pmid:24730684 fatcat:oucpxi45vbch3knnt63kwomely

2019 EACTS/EACTA/EBCP guidelines on cardiopulmonary bypass in adult cardiac surgery

Gudrun Kunst, Milan Milojevic, Christa Boer, Filip M.J.J. De Somer, Tomas Gudbjartsson, Jenny van den Goor, Timothy J. Jones, Vladimir Lomivorotov, Frank Merkle, Marco Ranucci, Luc Puis, Alexander Wahba (+6 others)
2019 British Journal of Anaesthesia  
It is also the health professional's responsibility to verify the applicable rules and regulations relating to drugs and medical devices at the time of prescription.  ...  and accurate decisions in consideration of each patient's health condition and, where appropriate and/or necessary, in consultation with that patient and the patient's care provider.  ...  Acknowledgements The authors would like to thank Korneel Vandewiele (Department of Perfusion, Heart Centre, University Hospital of Ghent, Belgium) for his assistance with data collection.  ... 
doi:10.1016/j.bja.2019.09.012 fatcat:v44rf2wjazdxbnfcpz4us6jui4

3D model for Cancerous Inhibitor of Protein Phosphatase 2A armadillo domain unveils highly conserved protein–protein interaction characteristics

Käthe M. Dahlström, Tiina A. Salminen
2015 Journal of Theoretical Biology  
The lack of structural information for CIP2A significantly prevents the design of anti-cancer therapeutics targeting this protein.  ...  Cancerous Inhibitor of Protein Phosphatase 2A (CIP2A) is a human oncoprotein, which exerts its cancerpromoting function through interaction with other proteins, for example Protein Phosphatase 2A (PP2A  ...  Outi Salo-Ahen for technical assistance (both at the Structural Bioinformatics Laboratory, Faculty of Science and Engineering, Åbo Akademi University). We also want to thank Prof.  ... 
doi:10.1016/j.jtbi.2015.09.010 pmid:26393783 fatcat:vkuxgpi6wjezzednshj2emml5y

Chondrosarcoma in Norway 1990–2013; an epidemiological and prognostic observational study of a complete national cohort

Joachim Thorkildsen, Ingeborg Taksdal, Bodil Bjerkehagen, Hans Kristian Haugland, Tom Børge Johannesen, Trond Viset, Ole-Jacob Norum, Øyvind Bruland, Olga Zaikova
2019 Acta Oncologica  
Based on these results a dichotomous risk classification was proposed and presented by Kaplan-Meier estimates for rates of local recurrence, metastasis, and disease-specific survival.  ...  We aim to quantify known and new prognostic variables and propose a risk stratification model. Method: We selected 149 cases from the Cancer Registry of Norway.  ...  It is my name is on the cover, but this is clearly a team effort and many people have taken part on many different levels.  ... 
doi:10.1080/0284186x.2018.1554260 fatcat:ioozahq4fzeejnxmbsmeobpygm

Function and Importance of p63 in Normal Oral Mucosa and Squamous Cell Carcinoma of the Head and Neck [chapter]

Niklas Thurfjell, Philip J. Coates, Linda Boldrup, Britta Lindgren, Bodil B�cklund, Tony Uusitalo, David Mahani, Erik Dabelsteen, �ke Dahlqvist, Bj�rn Sj�str�m, G�ran Roos, Borek Vojtesek (+2 others)
2004 Advances in Oto-Rhino-Laryngology  
RT-PCR for telomerase and immunohistochemical analysis for detection of p53 and Ki-67 proteins was further performed.  ...  The exploration of the function of p63 in SCCHN cells by the use of small interfering RNA (siRNA) showed a statistically significant decreased survival for tumour cells when all p63 isoforms, the N-terminal  ...  (Oren 2003) The p53 protein has four structural domains important for its function.  ... 
doi:10.1159/000082464 pmid:15608417 fatcat:qf2rnkqlmfaanhmsy2nfudgzka

Getting Docking into Shape Using Negative Image-Based Rescoring

Sami T. Kurkinen, Sakari Lätti, Olli T. Pentikäinen, Pekka A. Postila
2019 Journal of Chemical Information and Modeling  
The failure of default scoring functions to ensure virtual screening enrichment is a persistent problem for the molecular docking algorithms used in structure-based drug discovery.  ...  The negative image-based rescoring (R-NiB) has been shown to improve the flexible docking performance markedly with a variety of drug targets.  ...  37 and GLIDE 41, 42 docking, the PDB entry editing, including the PDB-to-MOL2 conversion and removal of the unnecessary protein-bound ligands was performed in the BODIL Molecular Modeling Environment  ... 
doi:10.1021/acs.jcim.9b00383 pmid:31290660 pmcid:PMC6750746 fatcat:uxwui3nd75expoxsofvejphlvq

A Practical Perspective: The Effect of Ligand Conformers on the Negative Image-Based Screening

Mira Ahinko, Sami T. Kurkinen, Sanna P. Niinivehmas, Olli T. Pentikäinen, Pekka A. Postila
2019 International Journal of Molecular Sciences  
Secondly, the entire NIB workflow from the protein structure preparation, model build-up, and ligand conformer generation to the similarity comparison is performed for COX-2.  ...  The resulting NIB model is a drug-like entity or pseudo-ligand that is compared directly against ligand 3D conformers, as is done with a template compound in the ligand-based screening.  ...  Acknowledgments: Jason Ahokas is thanked for reviewing the protocol steps. Conflicts of Interest: The authors declare no conflict of interest.  ... 
doi:10.3390/ijms20112779 fatcat:dogazo5ytndr3ilhywius75ahi

PNAS Plus Significance Statements

2018 Proceedings of the National Academy of Sciences of the United States of America  
Determining the structure of water on metal oxide surfaces is a key step toward a molecular-level understanding of dissolution, corrosion, geochemistry, and catalysis, but hydrogen bonding and large, complex  ...  Simultaneous cancer and tumor microenvironment subtyping using confocal infrared microscopy for all-digital molecular histopathology  ...  Determining the structure of water on metal oxide surfaces is a key step toward a molecular-level understanding of dissolution, corrosion, geochemistry, and catalysis, but hydrogen bonding and large, complex  ... 
doi:10.1073/pnas.ss11525 fatcat:4pbeb5inmrajfofc77lfasysbu

Chicken Avidin-related Protein 4/5 Shows Superior Thermal Stability when Compared with Avidin while Retaining High Affinity to Biotin

Vesa P. Hytönen, Thomas K. M. Nyholm, Olli T. Pentikäinen, Jonne Vaarno, Eevaleena J. Porkka, Henri R. Nordlund, Mark S. Johnson, J. Peter Slotte, Olli H. Laitinen, Markku S. Kulomaa
2003 Journal of Biological Chemistry  
Molecular modeling and site-directed mutagenesis were used to study the molecular details behind the observed high thermostability.  ...  The thermal stability characteristics of AVR4/5 were examined using a differential scanning calorimeter, microparticle analysis, and a microplate assay.  ...  Acknowledgments-We thank Irene Helkala, Pirjo Kä pylä , Jarno Hörhä , and Paavo Niutanen for first class technical assistance. We also thank Dr. David Hyre for critical comments for the manuscript.  ... 
doi:10.1074/jbc.m310989200 pmid:14660583 fatcat:q4u7c3wzdrhjtamc4z6cbc5c3m

Pharmacological activity of C10-substituted analogs of the high-affinity kainate receptor agonist dysiherbaine

L. Leanne Lash-Van Wyhe, Pekka A. Postila, Koichi Tsubone, Makoto Sasaki, Olli T. Pentikäinen, Ryuichi Sakai, Geoffrey T. Swanson
2010 Neuropharmacology  
apparent affinities for the compound.  ...  We used molecular dynamic simulations to determine the specific interactions between NDH and residues within the ligand-binding domains of these two kainate receptor subunits that contribute to the divergent  ...  Acknowledgments This study was supported by the National Graduate School in Informational and Structural Biology (PP), the Sigrid Jusélius Foundation (OTP), Grant-in Aid for Scientific Research awards  ... 
doi:10.1016/j.neuropharm.2009.11.013 pmid:19962997 pmcid:PMC2813386 fatcat:suoo4r3qjvci3h4ws7k7fdrf34
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