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Imaging Genetics of Depression [chapter]

Matthew D. Sacchet, Lara C. Foland-Ross, Ian H. Gotlib
<span title="">2016</span> <i title="Oxford University Press"> Neuroimaging Genetics </i> &nbsp;
to emotional faces in depressed and anxious adolescents.  ...  and bilateral anterior hippocampus during processing of emotional faces, this genotype-activity relation was not observed in the control group.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1093/med/9780199920211.003.0013">doi:10.1093/med/9780199920211.003.0013</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/zdu4xjpphzavphdcuqwfy45pye">fatcat:zdu4xjpphzavphdcuqwfy45pye</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20160309052022/http://stanford.edu:80/~msacchet/pdfs/16_Sacchet_IG.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/52/e7/52e75926c45496273e5869c293a383c978e65720.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1093/med/9780199920211.003.0013"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> oup.com </button> </a>

Neuroplasticity and memory formation in major depressive disorder: an imaging genetics perspective on serotonin and BDNF

Manuel Kuhn, Ana Popovic, Lukas Pezawas
<span title="">2014</span> <i title="IOS Press"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/fs4akzkye5hwtmnx2rwx733uj4" style="color: black;">Restorative Neurology and Neuroscience</a> </i> &nbsp;
A vast number of imaging studies have demonstrated the impact of serotonin (5-HT) and brain-derived neurotrophic factor (BDNF) on emotion and memory-related networks in the context of Major Depressive  ...  However, recent findings suggest a much more complex neurobiology emphasizing epistatic and epigenetic mechanisms responsible for structural and functional changes observed in emotion and memory-related  ...  Acknowledgments The authors thank Ulrich Rabl, MD, and Lucie Bartova, MD for proof reading of the manuscript as well as for their helpful comments.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3233/rnn-139005">doi:10.3233/rnn-139005</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/23603442">pmid:23603442</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/t6z2umlstjcqrm5wububynzpt4">fatcat:t6z2umlstjcqrm5wububynzpt4</a> </span>
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Childhood maltreatment history and attention bias variability in healthy adult women: role of inflammation and the BDNF Val66Met genotype

Hiroaki Hori, Mariko Itoh, Mingming Lin, Fuyuko Yoshida, Madoka Niwa, Yuko Hakamata, Mie Matsui, Hiroshi Kunugi, Yoshiharu Kim
<span title="2021-02-11">2021</span> <i title="Springer Science and Business Media LLC"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/eramt72k3vanfg544z3nw4zrsu" style="color: black;">Translational Psychiatry</a> </i> &nbsp;
Possible mechanisms whereby childhood maltreatment affects attention bias/ABV were also explored, focusing on blood proinflammatory markers and the BDNF Val66Met polymorphism.  ...  ., attention bias variability (ABV), has been developed to better capture trauma-related attentional dysfunction. However, ABV in relation to childhood trauma has not been studied.  ...  Acknowledgements We would like to thank all participants who took part in this study.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1038/s41398-021-01247-4">doi:10.1038/s41398-021-01247-4</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/33574220">pmid:33574220</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC7878504/">pmcid:PMC7878504</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/vazndjds3jaehiuwbavhfufjsi">fatcat:vazndjds3jaehiuwbavhfufjsi</a> </span>
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Gene–Environment Interactions and Intermediate Phenotypes: Early Trauma and Depression

Orla P. Hornung, Christine M. Heim
<span title="">2014</span> <i title="Frontiers Media SA"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/lrxowc5ubndyzpoqeyubgpzigm" style="color: black;">Frontiers in Endocrinology</a> </i> &nbsp;
Hornung and Christine M. Heim have contributed equally to this work. This review focuses on current research developments in the study of gene by early life stress (ELS) interactions and depression.  ...  ELS refers to aversive experiences during childhood and adolescence such as sexual, physical or emotional abuse, emotional or physical neglect as well as parental loss.  ...  The relationship between this polymorphism and specific, emotion-related brain circuitries has also been studied in anxious and depressed adolescents compared to healthy controls (105) .  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3389/fendo.2014.00014">doi:10.3389/fendo.2014.00014</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/24596569">pmid:24596569</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC3925849/">pmcid:PMC3925849</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/eie32yh7kza53n3fiqn7oqgysm">fatcat:eie32yh7kza53n3fiqn7oqgysm</a> </span>
<a target="_blank" rel="noopener" href="https://archive.org/download/pubmed-PMC3925849/PMC3925849-fendo.2014.00014.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> File Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/e8/e2/e8e23f644348b59c3a94fe341f0d567164a7e072.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3389/fendo.2014.00014"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> frontiersin.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3925849" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Genetic approaches to understanding post-traumatic stress disorder

Lynn M. Almli, Negar Fani, Alicia K. Smith, Kerry J. Ressler
<span title="2013-10-08">2013</span> <i title="Oxford University Press (OUP)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/t7zhumcn45gvdefswsettbaxjm" style="color: black;">International Journal of Neuropsychopharmacology</a> </i> &nbsp;
Fu CH (2011) No effect of 5HTTLPR or BDNF Val66Met polymorphism on hippocampal morphology in major depression. Genes Brain Behav 10:756-764.  ...  cognition in children and adolescents with depression, generalized anxiety, and post-traumatic stress disorder.  ...  Acknowledgments This work was primarily supported by the National Institutes of Mental Health (MH071537 and MH096764 to K.J.R., MH095456 to N.F., and MH085806 to A.K.S.).  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1017/s1461145713001090">doi:10.1017/s1461145713001090</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/24103155">pmid:24103155</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC4293029/">pmcid:PMC4293029</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/nui7mbowg5avteoboudv6fvjgy">fatcat:nui7mbowg5avteoboudv6fvjgy</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190222195236/http://pdfs.semanticscholar.org/3c03/24e2fec816efe2057de6fa6c94fb8dd9efe5.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/3c/03/3c0324e2fec816efe2057de6fa6c94fb8dd9efe5.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1017/s1461145713001090"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4293029" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Supplementary_materials_for – Supplemental material for Locations for noninvasive brain stimulation in treating depressive disorders: A combination of meta-analysis and resting-state functional connectivity analysis

Binlong Zhang, Jiao Liu, Tuya Bao, Georgia Wilson, Joel Park, Bingcong Zhao, Jian Kong
<span title="2020-05-19">2020</span> <i title="SAGE Journals"> Figshare </i> &nbsp;
Supplemental material, Supplementary_materials_for for Locations for noninvasive brain stimulation in treating depressive disorders: A combination of meta-analysis and resting-state functional connectivity  ...  analysis by Binlong Zhang, Jiao Liu, Tuya Bao, Georgia Wilson, Joel Park, Bingcong Zhao and Jian Kong in Australian & New Zealand Journal of Psychiatry  ...  amygdala and anterior hippocampus responses to emotional faces in anxious and depressed adolescents. 2010 Lemogne C 19945172 Journal of affective disorders 2010 Gilbert AM 19959343 Psychiatry  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.25384/sage.12327524.v1">doi:10.25384/sage.12327524.v1</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/ntuqeyzyozfebjwsn625chesce">fatcat:ntuqeyzyozfebjwsn625chesce</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200520032657/https://s3-eu-west-1.amazonaws.com/pstorage-sage-1076303800/22729034/Supplementary_materials_for.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.25384/sage.12327524.v1"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a>

Risk for anxiety and implications for treatment: developmental, environmental, and genetic factors governing fear regulation

Catherine A. Hartley, B.J. Casey
<span title="2013-10-22">2013</span> <i title="Wiley"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/hs2remnzfbfmnf33cof2z4ajhi" style="color: black;">Annals of the New York Academy of Sciences</a> </i> &nbsp;
One of the most commonly used therapies to treat these disorders is exposure-based cognitive behavioral therapy that identifies the source of the fear and anxiety and then desensitizes the individual to  ...  , especially during adolescence.  ...  In an imaging study using similar paradigms, we have observed elevated amygdala activity in response to repeated presentation of fearful faces in clinically anxious and depressed youth relative to healthy  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1111/nyas.12287">doi:10.1111/nyas.12287</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/24147742">pmid:24147742</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC3843997/">pmcid:PMC3843997</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/mvswf4sbxnbvpcrvcpdtpzo3iq">fatcat:mvswf4sbxnbvpcrvcpdtpzo3iq</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200210065002/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC3843997&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/4a/3b/4a3b8e162271c4b4c20a29dcca6bb7c3f685ffe6.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1111/nyas.12287"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3843997" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Genetics of generalized anxiety disorder and related traits

Michael G Gottschalk, Katharina Domschke
<span title="">2017</span> <i title="Servier International"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/emz24fzomfafzkl3c6pvmsxmra" style="color: black;">Dialogues in Clinical Neuroscience</a> </i> &nbsp;
We explore etiologic factors in gene-environment interaction approaches investigating childhood trauma, environmental adversity, and stressful life events in relation to selected candidate genes (5-HTT  ...  Recent advances of linkage studies, genome-wide association studies, and candidate gene studies (eg, 5-HTT, 5-HT1A, MAOA, BDNF) are outlined.  ...  gene level, a study in 50 patients with GAD revealed that individuals with low-expression-activity polymorphisms of the 5-HTTLPR-rs25531 showed less activity in both the amygdala and anterior insula than  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/28867940">pmid:28867940</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC5573560/">pmcid:PMC5573560</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/bldm57z4xveczigu77emfiwqvm">fatcat:bldm57z4xveczigu77emfiwqvm</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200512202005/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC5573560&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5573560" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Biological markers of generalized anxiety disorder

Eduard Maron, David Nutt
<span title="">2017</span> <i title="Servier International"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/emz24fzomfafzkl3c6pvmsxmra" style="color: black;">Dialogues in Clinical Neuroscience</a> </i> &nbsp;
In this paper, we review the large amount of available data, and we focus in particular on evidence from neuroimaging, genetic, and neurochemical measurements in GAD in order to better understand potential  ...  biomarkers involved in its etiology and treatment.  ...  brain-derived neurotrophic factor (BDNF) Val66Met polymorphism is associated with GAD risk, along with an increase in serum BDNF levels. 65 However, Val66Met variation was associated with neither GAD  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/28867939">pmid:28867939</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC5573559/">pmcid:PMC5573559</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/os5unvp4kfg6vfqbiaipb2l6py">fatcat:os5unvp4kfg6vfqbiaipb2l6py</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200510013926/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC5573559&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5573559" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Integrating NIMH Research Domain Criteria (RDoC) into depression research

Mary L Woody, Brandon E Gibb
<span title="">2015</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/pjfnixhcvneptoiprwvzhcdofq" style="color: black;">Current Opinion in Psychology</a> </i> &nbsp;
Acknowledgement This project was supported by National Institute of Mental Health grant MH098060 awarded to B.E. Gibb.  ...  Hilt LM, Sander LC, Nolen-Hoeksema S, Simen AA: The BDNF Val66Met polymorphism predicts rumination and depression differently in adolescent girls and their mothers. Neurosci Lett 2007, 429:13-16. 53.  ...  Beevers CG, Wells TT, McGeary JE: The BDNF Val66Met polymorphism is associated with rumination in healthy adults. Emotion 2009, 9:579-584. 52.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.copsyc.2015.01.004">doi:10.1016/j.copsyc.2015.01.004</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/25642446">pmid:25642446</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC4306327/">pmcid:PMC4306327</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/ox6lzfri5jgbfghysbmae5hfaa">fatcat:ox6lzfri5jgbfghysbmae5hfaa</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20170812002639/http://mood.binghamton.edu/Publications/2015_Current%20Opinion_Woody%20&amp;%20Gibb_RDoC%20depression.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/c5/20/c5203986115269aab31f6e02b8d908186094dc23.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.copsyc.2015.01.004"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> elsevier.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4306327" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Polymorphisms in Serotonergic Pathways Influence the Outcome of Antidepressant Therapy in Psychiatric Inpatients

Julia Staeker, Stefan Leucht, Barbara Laika, Werner Steimer
<span title="">2014</span> <i title="Mary Ann Liebert Inc"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/w3fzpbbt4zc4jlvn7unifvulse" style="color: black;">Genetic Testing and Molecular Biomarkers</a> </i> &nbsp;
Our findings suggest the BDNF Met allele may confer increased risk for depression as individual age." 107 BDNF gene polymorphism (Val66Met) predicts amygdala and anterior hippocampus responses to emotional  ...  faces in anxious and depressed adolescents http://www.ncbi.nlm.nih.gov/pubmed/19931400 108 BDNF and CREB1 genetic variants interact to affect antidepressant treatment outcomes in geriatric depressionhttp  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1089/gtmb.2013.0217">doi:10.1089/gtmb.2013.0217</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/24192302">pmid:24192302</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/5k7hq3dzvfddln6s7nxsc4x6d4">fatcat:5k7hq3dzvfddln6s7nxsc4x6d4</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190307160054/http://pdfs.semanticscholar.org/e2d6/5c10e77a67ca6777df66a5441e684c5740fe.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/e2/d6/e2d65c10e77a67ca6777df66a5441e684c5740fe.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1089/gtmb.2013.0217"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a>

Imaging phenotypes of major depressive disorder: genetic correlates

J.B. Savitz, W.C. Drevets
<span title="">2009</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/l52eh66fdzhhbmbsefbbyzwkaq" style="color: black;">Neuroscience</a> </i> &nbsp;
In MDD, increased activity of the amygdala in response to negative stimuli appears to be a mood-congruent phenomenon, and is likely moderated by the serotonin transporter gene (SLC6A4) promoter polymorphism  ...  Hippocampal volume loss is characteristic of elderly or chronically-ill samples and may be impacted by the val66met brain-derived neurotrophic factor (BDNF) gene variant and the 5-HTTLPR SLC6A4 polymorphism  ...  ., 2009) reported that healthy adolescent carriers of the s allele exhibited stronger amygdala responses to fearful faces but anxious or depressed patients homozygous for the l allele had greater right  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.neuroscience.2009.03.082">doi:10.1016/j.neuroscience.2009.03.082</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/19358877">pmid:19358877</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC2760612/">pmcid:PMC2760612</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/tq7cpwflwbgqdll7t5cfsk2xae">fatcat:tq7cpwflwbgqdll7t5cfsk2xae</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20191107134810/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC2760612&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/d2/4a/d24ad397d78c1f02ac1975fc43a88d931992c7b2.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.neuroscience.2009.03.082"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> elsevier.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2760612" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Molecular and neurocircuitry mechanisms of social avoidance

Anne-Kathrin Gellner, Jella Voelter, Ulrike Schmidt, Eva Carolina Beins, Valentin Stein, Alexandra Philipsen, René Hurlemann
<span title="2020-09-30">2020</span> <i title="Springer Science and Business Media LLC"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/a5zaemqj4za4nekjggicuat22q" style="color: black;">Cellular and Molecular Life Sciences (CMLS)</a> </i> &nbsp;
modulators lead to pathological social avoidance.  ...  In case of confrontation with overly strong or persistent stressors and/or dispositions of the affected individual, maladaptive processes in the neuronal circuitries and its associated transmitters and  ...  and hippocampal responses to social cues in anxious and depressed patients [131, 132] .  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/s00018-020-03649-x">doi:10.1007/s00018-020-03649-x</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/32997200">pmid:32997200</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/thtvj6yei5cr3ein6g3lzkobte">fatcat:thtvj6yei5cr3ein6g3lzkobte</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20201108142443/https://link.springer.com/content/pdf/10.1007/s00018-020-03649-x.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/ab/e7/abe719b7084cb3d79f7b5f37136c24ad293df8ad.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/s00018-020-03649-x"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> springer.com </button> </a>

Translational neuroscience measures of fear conditioning across development: applications to high-risk children and adolescents

Tanja Jovanovic, Karin Nylocks, Kaitlyn L Gamwell
<span title="">2013</span> <i title="Springer Nature"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/yqxbpw34erfodkfth74s5xnlou" style="color: black;">Biology of Mood &amp; Anxiety Disorders</a> </i> &nbsp;
Future studies should focus on developmental changes in these paradigms, paying close attention to neurobiological and hormonal changes associated with childhood and adolescence.  ...  Translational neuroscience offers tools to investigate such mechanisms in human and animal models.  ...  Acknowledgements This work was supported by funding from the National Alliance for Schizophrenia and Anxiety Disorders (NARSAD) and National Institutes of Health (NIH) grants MH 98212 and MH100122 to T.J  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1186/2045-5380-3-17">doi:10.1186/2045-5380-3-17</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/24004567">pmid:24004567</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC3846696/">pmcid:PMC3846696</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/zyeqbvhhm5d7jo4o2qsp25qpmm">fatcat:zyeqbvhhm5d7jo4o2qsp25qpmm</a> </span>
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Psychophysiological Markers of Anxiety Disorders and Anxiety Symptoms [chapter]

Seung-Hwan Lee, Gewn-Hi Park
<span title="2011-08-01">2011</span> <i title="InTech"> Anxiety Disorders </i> &nbsp;
Reduced BDNF expression in the hippocampus was observed in response to stress, which may contribute to hippocampus-dependent memory deficits and the decreases in hippocampal volume associated with patients  ...  Recent studies investigated the relationship between a SNP in the BDNF gene, Val66Met, and psychopathology, which yielded conflicting results (Jiang et al., 2005) .  ...  How to reference In order to correctly reference this scholarly work, feel free to copy and paste the following: Seung-Hwan Lee and Gewn-Hi Park (2011) .  ... 
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