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Development of a multiomics database for personalized prognostic forecasting in head and neck cancer: The Big Data to Decide EU Project

Stefano Cavalieri, Loris De Cecco, Ruud H. Brakenhoff, Mara Serena Serafini, Silvana Canevari, Silvia Rossi, Davide Lanfranco, Frank J. P. Hoebers, Frederik W. R. Wesseling, Simon Keek, Kathrin Scheckenbach, Davide Mattavelli (+16 others)
2020 Head and Neck  
The Big Data to Decide (BD2Decide) project aimed to build a database for prognostic prediction modeling.  ...  This annotated database represents the HNSCC largest available repository and will enable to develop/validate a decision support system integrating multiscale data to explore through classical and machine  ...  Editorial assistance and English language editing (funded by the BD2Decide Consortium) were provided by Charlesworth Author Service.  ... 
doi:10.1002/hed.26515 pmid:33107152 fatcat:goqbn6oofvgjpe2ubkyywl5byq

A Prospectively Validated Prognostic Model for Patients with Locally Advanced Squamous Cell Carcinoma of the Head and Neck Based on Radiomics of Computed Tomography Images

Simon A. Keek, Frederik W. R. Wesseling, Henry C. Woodruff, Janita E. van van Timmeren, Irene H. Nauta, Thomas K. Hoffmann, Stefano Cavalieri, Giuseppina Calareso, Sergey Primakov, Ralph T. H. Leijenaar, Lisa Licitra, Marco Ravanelli (+8 others)
2021 Cancers  
Locoregionally advanced head and neck squamous cell carcinoma (HNSCC) patients have high relapse and mortality rates.  ...  Imaging-based decision support may improve outcomes by optimising personalised treatment, and support patient risk stratification.  ...  We hypothesise that the multicentric 'Big Data and Models for Personalised Head and Neck Cancer Decision Support' project (BD2Decide) [32, 33] dataset provides the necessary breadth to create statistically  ... 
doi:10.3390/cancers13133271 pmid:34210048 pmcid:PMC8269129 fatcat:ctq7qk6csna5tabiy2fzqsr2vi

Exploring Applications of Radiomics in Magnetic Resonance Imaging of Head and Neck Cancer: A Systematic Review

Amit Jethanandani, Timothy A. Lin, Stefania Volpe, Hesham Elhalawani, Abdallah S. R. Mohamed, Pei Yang, Clifton D. Fuller
2018 Frontiers in Oncology  
collective interpretation of data.  ... May 2018 | Volume 8 | Article 131 conclusion: Although MRI radiomic applications demonstrate predictive potential in analyzing diverse HNC outcomes, methodological variances preclude accurate and  ...  gov, 5 = chictR) Big data and models for personalized head and neck cancer decision support (BD2DECIDE) Poli T, Schcekenback K, Schipper J, Colter L, Licitra L, Gatta G, Favales F, Trama A  ... 
doi:10.3389/fonc.2018.00131 pmid:29868465 pmcid:PMC5960677 fatcat:yikfkkl3dfbd5lcginlskkhgm4

Evidence-based Public Health Policy Models Development and Evaluation using Big Data Analytics and Web Technologies

Konstantinos Moutselos, Ilias Maglogiannis
2020 Medicinski arhiv  
This work presents a cloud-based Decision Support System for public health decision-making.  ...  The Policy Development Toolkit presents a unique interface and point of reference for policymakers, allowing them to create policy models and obtain analytical results for evidence-based decisions and  ...  Such projects are BigO (Big data against childhood obesity) (21), BD2DECIDE (Decision support for cancers of the head and neck region) (22) , iASiS (Big data for precision medicine) (23) and MIDAS (Meaningful  ... 
doi:10.5455/medarh.2020.74.47-53 pmid:32317835 pmcid:PMC7164729 fatcat:dyxil5jcv5cu7ciyefeph6qjnu

Transcriptomics and Epigenomics in head and neck cancer: available repositories and molecular signatures

Mara S. Serafini, Laura Lopez-Perez, Giuseppe Fico, Lisa Licitra, Loris De Cecco, Carlo Resteghini
2020 Cancers of the Head & Neck  
For many years, head and neck squamous cell carcinoma (HNSCC) has been considered as a single entity. However, in the last decades HNSCC complexity and heterogeneity have been recognized.  ...  To contextualize the selected data, our literature survey includes a short summary of the main characteristics of omics data repositories and web-tools for data analyses.  ...  An example is represented by the European Commission funded project named "Big Data and Models for Personalized Head and Neck Cancer Decision Support (BD2Decide)" ( Identifier NCT02832102  ... 
doi:10.1186/s41199-020-0047-y pmid:31988797 pmcid:PMC6971871 fatcat:wydnloqnyff4pd2k62566viibe