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Feminismo, reconocimiento y tolerancia

Axel Rivera Osorio
2019 Debate Feminista  
Este artículo busca mostrar la diferencia entre los paradigmas que han guiado al feminismo, pasando de la búsqueda por la igualdad hacia una búsqueda de la libertad. El feminismo ayudó a crear mayores grados de reconocimiento y tolerancia al generar nuevas articulaciones simbólicas a lo largo del siglo XX y en lo que va del XXI. No se trata de un camino unívoco. Los feminismos se han movido en diferentes paradigmas para ser capaces de incrementar los ámbitos de reconocimiento social; aquí se
more » ... enta vislumbrar algunos pasos para que esto fuera posible, en un contexto donde lo político se juega entre la dislocación y la configuración de nuevas identidades políticas, así como en la reconfiguración de la esfera pública.
doi:10.22201/cieg.2594066xe.2019.58.06 fatcat:xsnqgl22jnh2tgotbx23zzgwba

Categorización de la atención fonoaudiológica: una propuesta para adultos en contexto hospitalario

Axel Pavez, Bernardita Letelier-Vera, Carolina Rivera-Rivera
2020 Revista Chilena de Fonoaudiología  
Existe la necesidad de desarrollar herramientas que demuestren el impacto de la intervención fonoaudiológica en el ámbito hospitalario, lo que exige implementar modelos asistenciales y de gestión, que favorezcan la demanda clínica y la eficiencia de los procesos y de los equipos. Diversas profesiones del área sanitaria han empleado modelos de categorización de la atención que, junto con satisfacer las demandas de los pacientes, traducen las actividades de su disciplina en términos de gestión.
more » ... tualmente, en el ámbito fonoaudiológico no se cuenta con herramientas de este tipo que permitan determinar la cantidad de atenciones necesarias para una persona en contexto hospitalario. Debido a lo anterior, en el artículo se presenta la creación, desarrollo y aplicación de una matriz cuali-cuantitativa. El objetivo de la matriz es valorar y estandarizar la carga de trabajo fonoaudiológico requerido para cada paciente adulto hospitalizado, considerando su contexto clínico global. Esta matriz de categorización considera cinco variables clínicas evaluadas durante la rehabilitación del paciente y cuatro calificadores en relación con el orden de severidad. Se establecen y proponen diferentes categorías de atención que entregan una carga terapéutica recomendada (desde 1 a 2 atenciones semanales en casos leves hasta 2 atenciones diarias en casos complejos). Finalmente, se discute su uso y los beneficios de su implementación como una herramienta que permite optimizar procesos de gestión, determinar brechas y justificar la inclusión de nuevos fonoaudiólogos en el contexto hospitalario.
doi:10.5354/0719-4692.2020.60192 fatcat:vnlrmxxscrhkhlnhpq7qx6uxbi

Trabalho em equipe interdisciplinar de saúde como um espaço de reconhecimento: contribuições da teoria de Axel Honneth

Lilian Miranda, Francisco Javier Uribe Rivera, Elizabeth Artmann
2012 Physis  
O presente estudo teórico tem como objetivo relacionar uma discussão sobre o trabalho em equipe interdisciplinar nos serviços públicos de saúde com os principais conceitos do filósofo contemporâneo Axel  ...  Trabalho em equipe interdisciplinar de saúde como um espaço de reconhecimento: contribuições da teoria de Axel Honneth | 1 Lilian Miranda, 2 Francisco Javier Uribe Rivera, 2 Elizabeth Artmann | 1 Doutora  ...  Rivera (2003) aponta a existência de uma cultura contraditória em transição no contexto hospitalar.  ... 
doi:10.1590/s0103-73312012000400016 fatcat:tnbvn42l6vgyjpq5jcsalyigwq

Accounting for Uncertainty When Estimating Counts Through an Average Rounded to the Nearest Integer [article]

Roberto Rivera, Axel Cortes-Cubero, Roberto Reyes-Carranza, Wolfgang Rolke
2021 arXiv   pre-print
A reasonable point estimator of excess deaths would be (Rivera and Rolke 2018, 2019) (Ȳ −X)n 2 = (Y − n 2 n 1 X) whereX = X n 1 andȲ = Y n 2 . Let ξ * ≡ Y − n 2 n 1 X.  ...  Excess death models have shown discrepancies with the official death toll from the Covid-19 pandemic , Hurricane Katrina (Kutner et al. 2009; Stephens et al. 2007) , Hurricane Maria (Rivera and Rolke  ... 
arXiv:2107.01618v1 fatcat:2t462wtskfhqbnhsuqkt6m7f4a

Lyman Alpha Reference Sample: X. Predicting Lyman alpha output from starforming galaxies using multivariate regression [article]

Axel Runnholm, Matthew Hayes, Jens Melinder, Emil Rivera-Thorsen, Göran Östlin, John Cannon, Daniel Kunth
2020 arXiv   pre-print
. , 2014 Östlin et al. 2014; Rivera-Thorsen et al. 2015) .  ...  More details can be found in Rivera-Thorsen et al. (2015) 2.2.2.  ... 
arXiv:2002.12378v1 fatcat:jgmqpzajvjgrpkvzxhzgmsuapq

RT States: systematic annotation of the human genome using cell type-specific replication timing programs [article]

Axel Poulet, Ben Li, Tristan Dubos, David M Gilbert, Juan Carlos Rivera-Mulia, Zhaohui Qin
2018 bioRxiv   pre-print
The replication timing (RT) program has been linked to many key biological processes including cell fate commitment, 3D chromatin organization and transcription regulation. Significant technology progress now allows to characterize the RT program in the entire human genome in a high-throughput and high-resolution fashion. These experiments suggest that RT changes dynamically during development in coordination with gene activity. Since RT is such a fundamental biological process, we believe that
more » ... an effective quantitative profile of the local RT program from a diverse set of cell types in various developmental stages and lineages can provide crucial biological insights for a genomic locus. In the present study, we explored recurrent and spatially coherent combinatorial profiles from 42 RT programs collected from multiple lineages at diverse differentiation states. We found that a Hidden Markov Model with 15 hidden states provide a good model to describe these genome-wide RT profiling data. Each of the hidden state represents a unique combination of RT profiles across different cell types which we refer to as "RT states". To understand the biological properties of these RT states, we inspected their relationship with chromatin states, gene expression, functional annotation and 3D chromosomal organization. We found that the newly defined RT states possess interesting genome-wide functional properties that add complementary information to the existing annotation of the human genome.
doi:10.1101/394601 fatcat:d6otjjznhffq3mkhj262cyoshe

Main Functions and Taxonomic Distribution of Virulence Genes in Brucella melitensis 16 M

Aniel Jessica Leticia Brambila-Tapia, Dagoberto Armenta-Medina, Nancy Rivera-Gomez, Ernesto Perez-Rueda, Axel Cloeckaert
2014 PLoS ONE  
Many virulence genes have been detected in attenuated mutants of Brucella melitensis 16 M; nevertheless, a complete report of these genes, including the main Cluster of Orthologous Groups (COG) represented as well as the taxonomical distribution among all complete bacterial and archaeal genomes, has not been analyzed. In this work a total of 160 virulence genes that have been reported in attenuated mutants in B. melitensis were included and analyzed. Additionally, we obtained 250 B. melitensis
more » ... andomly selected genes as a reference group for the taxonomical comparisons. The COGs and the taxonomical distribution profile for 789 nonredundant bacterial and archaeal genomes were obtained and compared with the whole-genome COG distribution and with the 250 randomly selected genes, respectively. The main COGs associated with virulence genes corresponded to the following: intracellular trafficking, secretion and vesicular transport (U); cell motility (N); nucleotide transport and metabolism (F); transcription (K); and cell wall/membrane/envelope biogenesis (M). In addition, we found that virulence genes presented a higher proportion of orthologs in the Euryarchaeota and Proteobacteria phyla, with a significant decrease in Chlamydiae, Bacteroidetes, Tenericutes, Firmicutes and Thermotogae. In conclusion, we found that genes related to specific functions are more relevant to B. melitensis virulence, with the COG U the most significant. Additionally, the taxonomical distribution of virulence genes highlights the importance of these genes in the related Proteobacteria, being less relevant in distant groups of organisms with the exception of Euryarchaeota.
doi:10.1371/journal.pone.0100349 pmid:24964015 pmcid:PMC4070974 fatcat:ecsdorsjdjaqplhxlj33auxlju

Methylation of histone H3 lysine 9 occurs during translation

Carlos Rivera, Francisco Saavedra, Francisca Alvarez, César Díaz-Celis, Valentina Ugalde, Jianhua Li, Ignasi Forné, Zachary A. Gurard-Levin, Geneviève Almouzni, Axel Imhof, Alejandra Loyola
2015 Nucleic Acids Research  
Histone post-translational modifications are key contributors to chromatin structure and function, and participate in the maintenance of genome stability. Understanding the establishment and maintenance of these marks, along with their misregulation in pathologies is thus a major focus in the field. While we have learned a great deal about the enzymes regulating histone modifications on nucleosomal histones, much less is known about the mechanisms establishing modifications on soluble newly
more » ... hesized histones. This includes methylation of lysine 9 on histone H3 (H3K9), a mark that primes the formation of heterochromatin, a critical chromatin landmark for genome stability. Here, we report that H3K9 mono-and dimethylation is imposed during translation by the methyltransferase SetDB1. We discuss the importance of these results in the context of heterochromatin establishment and maintenance and new therapeutic opportunities in pathologies where heterochromatin is perturbed.
doi:10.1093/nar/gkv929 pmid:26405197 pmcid:PMC4627087 fatcat:ju2yzs7yd5d4pp5z3jsfrvv73y

Spatial adaptive sampling in multiscale simulation

Bertrand Rouet-Leduc, Kipton Barros, Emmanuel Cieren, Venmugil Elango, Christoph Junghans, Turab Lookman, Jamaludin Mohd-Yusof, Robert S. Pavel, Axel Y. Rivera, Dominic Roehm, Allen L. McPherson, Timothy C. Germann
2014 Computer Physics Communications  
In a common approach to multiscale simulation, an incomplete set of macroscale equations must be supplemented with constitutive data provided by fine-scale simulation. Collecting statistics from these fine-scale simulations is typically the overwhelming computational cost. We reduce this cost by interpolating the results of fine-scale simulation over the spatial domain of the macro-solver. Unlike previous adaptive sampling strategies, we do not interpolate on the potentially very high
more » ... l space of inputs to the fine-scale simulation. Our approach is local in space and time, avoids the need for a central database, and is designed to parallelize well on large computer clusters. To demonstrate our method, we simulate one-dimensional elastodynamic shock propagation using the Heterogeneous Multiscale Method (HMM); we find that spatial adaptive sampling requires only ≈50 × N 0.14 fine-scale simulations to reconstruct the stress field at all N grid points. Related multiscale approaches, such as Equation Free methods, may also benefit from spatial adaptive sampling.
doi:10.1016/j.cpc.2014.03.011 fatcat:uioyerrurjgnrd7hkvn2czcofm

"That's all Fake": Health professionals stigma and physical healthcare of people living with Serious Mental Illness

Eliut Rivera-Segarra, Nelson Varas-Díaz, Axel Santos-Figueroa, Whitney S. Rice
2019 PLoS ONE  
People living with a Serious Mental Illness (SMI) die earlier than the general population due to preventable medical conditions. Latinos living with SMI are a particularly vulnerable population with higher prevalence of chronic medical conditions. Stigma has been identified as a factor that fosters health inequities for Latinos/as with SMI, particularly Puerto Ricans. Although personal and social consequences of stigmatization have been well documented, research regarding the role of cultural
more » ... ctors on healthcare interactions is scarce. Furthermore, little research has focused on addressing stigma from the perspective of healthcare professionals. We investigated this process through a qualitative design using semi-structured individual interviews with 11 healthcare professionals (8 physicians and 3 nurses) in Puerto Rico. We conducted a thematic analysis to analyze the data. Following a thematic analysis, we found three main themes and nine sub-themes related to the stigmatization process. Some participants reported perceptions of dangerousness and uneasiness, social distance and inadequate care. Participants also emphasized a lack of medical training regarding SMI within the Puerto Rican context. These findings support the need to develop culturally appropriate public health interventions targeting healthcare professionals in order to address stigma and eliminate health disparities among Latinos/as with SMI.
doi:10.1371/journal.pone.0226401 pmid:31851706 pmcid:PMC6919598 fatcat:iggzmwwkozetjeeeysbhgosnqi

Use of sucrose to diminish pore formation in freeze-dried heart valves

Andrés Vásquez-Rivera, Harriëtte Oldenhof, Daniele Dipresa, Tobias Goecke, Artemis Kouvaka, Fabian Will, Axel Haverich, Sotirios Korossis, Andres Hilfiker, Willem F. Wolkers
2018 Scientific Reports  
Freeze-dried storage of decellularized heart valves provides easy storage and transport for clinical use. Freeze-drying without protectants, however, results in a disrupted histoarchitecture after rehydration. In this study, heart valves were incubated in solutions of various sucrose concentrations and subsequently freeze-dried. Porosity of rehydrated valves was determined from histological images. In the absence of sucrose, freeze-dried valves were shown to have pores after rehydration in the
more » ... usp, artery and muscle sections. Use of sucrose reduced pore formation in a dose-dependent manner, and pretreatment of the valves in a 40% (w/v) sucrose solution prior to freeze-drying was found to be sufficient to completely diminish pore formation. The presence of pores in freeze-dried valves was found to coincide with altered biomechanical characteristics, whereas biomechanical parameters of valves freeze-dried with enough sucrose were not significantly different from those of valves not exposed to freeze-drying. Multiphoton imaging, Fourier transform infrared spectroscopy, and differential scanning calorimetry studies revealed that matrix proteins (i.e. collagen and elastin) were not affected by freeze-drying. Heart valve diseases are one of the main causes of death worldwide and represent an increasing problem in medical practice 1 . Currently, heart valve dysfunction is typically treated via replacement with mechanical or biological prostheses. Risks associated with mechanical valves include hemorrhage and thromboembolism 2 . Bioprosthetic valves are made by treating bovine or porcine tissue with glutaraldehyde. These glutaraldehyde-treated tissue matrices are inherently different from native matrices because proteins are irreversibly cross-linked 3 . Bioprosthetic valves have been implicated in fibrosis, calcification, degeneration and immunogenic complications 4 . Decellularized heart valves hold promise as alternative for mechanical or bioprosthetic valves. The histoarchitecture of decellularized heart valves closely resembles that of native tissue, and implanted valves have been shown to be repopulated with autologous cells resulting in tissue regeneration and growth 5 . The use of decellularized heart valves to replace a malfunctioning heart valve reduces the risk of immunogenic rejection, whereas anti-coagulation therapy is generally not required 6 . In the surgical practice, sufficient availability of decellularized heart valves of different sizes is required. To satisfy this demand, appropriate preservation methods are needed to preserve valves until they are required. If it were possible to dry heart valves without damaging the tissue, this would increase their shelf-life and ensure off-the-shelf availability, while decreasing the incidence of bacterial contamination. Freeze-drying allows for easy transport and room temperature storage. Biological materials are generally prone to degradation, particularly when they are immersed in water and at higher temperatures. Previous studies have shown that heart valves can be stored at 4 °C in 50-80% sucrose solutions or in pure glycerol for up to 52 and 12 weeks, respectively 6,7 . However, stored samples showed separation and clumping of collagen as well as changes in microscopic structure and elastic properties. Moreover, valves that are stored in liquid have an increased risk of bacterial contamination during prolonged storage. These
doi:10.1038/s41598-018-31388-4 pmid:30154529 fatcat:jh5iftb7nnbsxddc5suhwmln44

Bax Inhibitor-1-mediated Ca2+ leak is decreased by cytosolic acidosis

Santeri Kiviluoto, Tomas Luyten, Lars Schneider, Dmitrij Lisak, Diego Rojas-Rivera, Kirsten Welkenhuyzen, Ludwig Missaen, Humbert De Smedt, Jan B. Parys, Claudio Hetz, Axel Methner, Geert Bultynck
2013 Cell Calcium  
Bax Inhibitor-1 (BI-1) is an evolutionarily conserved six-transmembrane domain endoplasmic reticulum (ER)-localized protein that protects against ER stress-induced apoptotic cell death. This function is closely connected to its ability to lower steady-state ER Ca 2+ levels. Recently, we elucidated BI-1's Ca 2+ -channel pore in the C-terminal part of the protein and identified the critical amino acids of its pore. Based on these insights, a Ca 2+ -channel pore-dead mutant BI-1 (BI-1 D213R ) was
more » ... eveloped. We determined whether BI-1 behaves as a bona fide H + /Ca 2+ antiporter or as an ER Ca 2+ -leak channel by investigating the effect of pH on unidirectional Ca 2+ -efflux rates. At pH 6.8, wild-type BI-1 expression in BI-1 −/− cells increased the ER Ca 2+ -leak rate, correlating with its localization in the ER compartment. In contrast, BI-1 D231R expression in BI-1 −/− , despite its ER localization, did not increase the ER Ca 2+ -leak rate. However, at pH < 6.8, the BI-1-mediated ER Ca 2+ leak was blocked. Finally, a peptide representing the Ca 2+ -channel pore of BI-1 promoting Ca 2+ flux from the ER was used. Lowering the pH from 6.8 to 6.0 completely abolished the ability of the BI-1 peptide to mediate Ca 2+ flux from the ER. We propose that this pH dependence is due to two aspartic acid residues critical for the function of the Ca 2+ -channel pore and located in the ER membrane-dipping domain, which facilitates the protonation of these residues. (G. Bultynck). extraluminal protons are exchanged for intraluminal Ca 2+ ions [19] . As a result, a reduction in pH was found to increase BI-1-mediated lowering of the ER Ca 2+ content. This process was further influenced by cardiolipin, phosphatidylserine, the BH4 domain of Bcl-2 and chemotherapeutic drugs [20, 21] . Recently, we described that the C-terminal domain of BI-1 contains a Ca 2+ -permeable channel pore that permeates Ca 2+ through ER membranes and interacts with IP 3 R channels to sensitize them to low levels of IP 3 [10]. Both mechanisms contribute to BI-1's ability to lower the steady-state ER Ca 2+ levels and to preserve mitochondrial bio-energetics and survival processes like autophagy [8] . However, other reports showed that BI-1 negatively regulates autophagy [22] similarly to anti-apoptotic Bcl-2 family members [23, 24] . Importantly, the domain harboring the BI-1 Ca 2+ -channel pore (a.a. 198-217) is located upstream of a proposed pH-sensing domain and dips into the ER membrane [9] . This structure is supported by a recent study of Smith and coworkers, who came to the same conclusion that the topology of BI-1 fits a six-transmembrane domain protein with a C-terminal loop domain [12] . We identified the negatively charged residues that are critical for BI-1's potency to lower the ER Ca 2+ -store content [9] . Mutating one Asp residue in full-length BI-1 (BI-1 D213R ) is 0143-4160/$ -see front matter
doi:10.1016/j.ceca.2013.06.002 pmid:23867001 fatcat:pq4q2du5qbdqrmnfujemfuq3qm

Plasmonic emission enhancement from Er3+-doped tellurite glass via negative-nanobowtie

V. A. G. Rivera, Y. Ledemi, Y. Messaddeq, E. Marega Jr., Ali Adibi, Shawn-Yu Lin, Axel Scherer
2014 Photonic and Phononic Properties of Engineered Nanostructures IV  
Metallic negative-nanobowtie is a new suitable structure for development of nanoantennas that can be integrated on wide number of optical devices. Nevertheless, metallic negative-nanobowtie with absence of gap deserve attention special, because in addition to present similar properties from regular nanobowtie, can also interacts with different systems, like gain materials. One of remarkable class of such material is rare earth ions, not only for the enhancement on measured intensity, but also
more » ... s easiness to implement it on glasses, which constitute the main type of substrate adopted on plasmonic structures. In this work we performed the analysis of effects due implementation of erbium (Er 3+ ) rare earth ions into tellurite glass over a pattern of negative-nanobowtie on absence of gap between its tips, fabricated by focused ion beam (FIB) technique from gold (Au) films with 240 nm thickness. Here, the negative-nanobowties are vertically excited by an argon laser (Ar) at 488 nm and were performed to verify the dependence of nanobowtie's geometry over the electric field along its symmetry axis. An asymptotic energy gap between the localized surface plasmon polariton modes and the ion spectral position was observed, which couple strongly with the 2 H 11/2  4 I 15/2 radiative emission of the Er 3+ . Besides, the 4 S 3/2 → 4 I 13/2 electronic transition is an indirect transition that was improve due to negative-nanobowtie in comparison with the 4 I 9/2 → 4 I 15/2 . Downloaded From: http://proceedings.spiedigitallibrary.org/ on 02/27/2014 Terms of Use: http://spiedl.org/terms Proc. of SPIE Vol. 8994 899421-5 Downloaded From: http://proceedings.spiedigitallibrary.org/ on 02/27/2014 Terms of Use: http://spiedl.org/terms
doi:10.1117/12.2040215 fatcat:xw4lje34jfesjfurnm34h7wsqu

Estigma hacia problemas de salud mental entre profesionales de la salud en adiestramiento en Puerto Rico

Norka Polanco Frontera, Isabel Cajigas Vargas, Eliut Rivera Segarra, Nelson Varas Díaz, Axel Santos Figueroa, Ernesto Rosario Hernández
2013 Salud & Sociedad  
., 2012; Hatzenbuehler, Phelan, & Link, 2013; Rivera-Segarra & Ramos-Pibernus, 2013; U.S. Department of Health and Human Services, 1999) .  ...  social que determina si reciben o no servicios de salud así como la calidad y expectativas de vida de estas personas (Corrigan, et. al. 2010; Harrison & Gill, 2010; Hatzenbuehler, Phelan, & Link, 2013; Rivera-Segarra  ... 
doi:10.22199/s07187475.2013.0003.00003 fatcat:wa6tvr5nwvdhnarlcc3zmq7xuu

A20-Deficient Mast Cells Exacerbate Inflammatory Responses In Vivo

Klaus Heger, Kaat Fierens, J. Christoph Vahl, Attila Aszodi, Katrin Peschke, Dominik Schenten, Hamida Hammad, Rudi Beyaert, Dieter Saur, Geert van Loo, Axel Roers, Bart N. Lambrecht (+3 others)
2014 PLoS Biology  
Mast cells are implicated in the pathogenesis of inflammatory and autoimmune diseases. However, this notion based on studies in mast cell-deficient mice is controversial. We therefore established an in vivo model for hyperactive mast cells by specifically ablating the NF-kB negative feedback regulator A20. While A20 deficiency did not affect mast cell degranulation, it resulted in amplified pro-inflammatory responses downstream of IgE/FceRI, TLRs, IL-1R, and IL-33R. As a consequence house dust
more » ... ite-and IL-33-driven lung inflammation, late phase cutaneous anaphylaxis, and collagen-induced arthritis were aggravated, in contrast to experimental autoimmune encephalomyelitis and immediate anaphylaxis. Our results provide in vivo evidence that hyperactive mast cells can exacerbate inflammatory disorders and define diseases that might benefit from therapeutic intervention with mast cell function. . These authors contributed equally to this work. PLOS Biology | www.plosbiology.org A20 Limits FceRI, TLR, and IL-33R Signals PLOS Biology | www.plosbiology.org
doi:10.1371/journal.pbio.1001762 pmid:24453940 pmcid:PMC3891641 fatcat:aqmpdxllmjb5rm4z3hijhg6nfa
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