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An apparatus and behavioral training protocol to conduct positron emission tomography (PET) neuroimaging in conscious rhesus monkeys

L.L. Howell, J.M. Hoffman, J.R. Votaw, A.M. Landrum, J.F. Jordan
2001 Journal of Neuroscience Methods  
Specific attention was devoted to the development of an effective and comfortable head restraint device to be used in the imaging of conscious monkeys.  ...  The results document the feasibility to conduct PET neuroimaging studies of cerebral blood flow in conscious nonhuman primates.  ...  The brain images (color) shown above clearly demonstrate the ability to conduct brain activation studies during cocaine administration in awake nonhuman primates.  ... 
doi:10.1016/s0165-0270(01)00345-4 pmid:11325436 fatcat:ije6ktoblbeivolsfj2dqdotv4

Molecular Imaging of Conscious, Unrestrained Mice with AwakeSPECT

J. S. Baba, C. J. Endres, C. A. Foss, S. Nimmagadda, H. Jung, J. S. Goddard, S. Lee, J. McKisson, M. F. Smith, A. V. Stolin, A. G. Weisenberger, M. G. Pomper
2013 Journal of Nuclear Medicine  
The binding potential of 123 I-ioflupane in the awake state was on the order of 50% of that obtained with the animal under anesthesia, consistent with previous studies in nonhuman primates.  ...  of the dopamine transporter radioligand 123 I-ioflupane in mouse brain in the awake and anesthetized (isoflurane) states.  ...  in a nonhuman primate study (30) .  ... 
doi:10.2967/jnumed.112.109090 pmid:23536223 pmcid:PMC3965297 fatcat:uearificxjfmpj2rvofymlydse

Awake Nonhuman Primate Brain PET Imaging with Minimal Head Restraint: Evaluation of GABAA-Benzodiazepine Binding with 11C-Flumazenil in Awake and Anesthetized Animals

C. M. Sandiego, X. Jin, T. Mulnix, K. Fowles, D. Labaree, J. Ropchan, Y. Huang, K. Cosgrove, S. A. Castner, G. V. Williams, L. Wells, E. A. Rabiner (+1 others)
2013 Journal of Nuclear Medicine  
Neuroreceptor imaging in the nonhuman primate (NHP) is valuable for translational research approaches in humans.  ...  Cortisol levels were significantly higher under the awake condition (P , 0.05). Conclusion: We successfully performed awake NHP imaging with minimal head restraint.  ...  ACKNOWLEDGMENTS We acknowledge the staff at the Yale PET Center, especially Shervin Liddie and Siobhan Ford, and other members of the NHP team, including Brooke Roberts, Amanda Abbott, and David Campbell  ... 
doi:10.2967/jnumed.113.122077 pmid:24115528 pmcid:PMC3857935 fatcat:5ddus7phsfhmzfpwywysmsicuq

Using PET H2O15 brain imaging to study the functional–anatomical correlates of non-human primate communication

Ricardo Gil-da-Costa, Allen Braun, Alex Martin
2006 Methods  
In this article we describe methods for using oxygen-15 water (H 2 O 15 ) positron emmission tomography (PET) to explore the functional neuroanatomy of cognition in awake, non-human primates.  ...  Methods for acquiring and analyzing PET data in order to identify significant regions of brain activity in single animals are also presented.  ...  Implantation of head fixation devices in nonhuman primates is routinely done in various non-human primates laboratories, generally without complication or significant discomfort to the animals.  ... 
doi:10.1016/j.ymeth.2005.08.003 pmid:16466931 pmcid:PMC1550778 fatcat:ihkolf47lvghdgursh74d3m27i

Investigation of Cross-Species Translatability of Pharmacological MRI in Awake Nonhuman Primate - A Buprenorphine Challenge Study

Stephanie Seah, Abu Bakar Ali Asad, Richard Baumgartner, Dai Feng, Donald S. Williams, Elaine Manigbas, John D. Beaver, Torsten Reese, Brian Henry, Jeffrey L. Evelhoch, Chih-Liang Chin, Alessandro Gozzi
2014 PLoS ONE  
Significant efforts have been made to establish awake imaging in rodents and nonhuman primates (NHP).  ...  Conclusions: Our data highlight the utility and importance of awake NHP imaging as a translational imaging biomarker for drug research.  ...  Study protocol of awake imaging in non-human primates.  ... 
doi:10.1371/journal.pone.0110432 pmid:25337714 pmcid:PMC4206294 fatcat:etclnxah2bcvfcdqxdvtud6dle

Cortical activation during cocaine use and extinction in rhesus monkeys

Leonard L. Howell, John R. Votaw, Mark M. Goodman, Kimberly P. Lindsey
2009 Psychopharmacology  
Objective The present study was the first to use functional brain imaging to document acute cocaine-induced changes in brain activity during active drug use in nonhuman primates.  ...  The same subjects were trained to self-administer cocaine under a fixed ratio schedule during image acquisition.  ...  The present study was the first to use functional brain imaging to document acute cocaineinduced changes in brain activity during active drug use in nonhuman primates.  ... 
doi:10.1007/s00213-009-1720-3 pmid:19924404 pmcid:PMC2819208 fatcat:myao2zki3jcdfgfbg3u5vmfihy

Imaging Stroke Evolution after Middle Cerebral Artery Occlusion in Non-human Primates

H.E D'Arceuil, Alex J de Crespigny
2011 The Open Neuroimaging Journal  
This article reviews imaging approaches applied to the study of stroke in nonhuman primates.  ...  We briefly survey the various surgical and minimally invasive experimental stroke models in nonhuman primates, followed by a summary of studies using computed tomography, positron emission tomography and  ...  A key advantage of nonhuman primate fMRI studies is the ability to train animals to tolerate MRI scanning without the confounds of anesthetic restraint [46] .  ... 
doi:10.2174/1874440001105010216 pmid:22253663 pmcid:PMC3256846 fatcat:ehzw3ja3orf37e6bd6spn5ctfy

Comparative primate neuroimaging: insights into human brain evolution

James K. Rilling
2014 Trends in Cognitive Sciences  
Voxel: the smallest volumetric element of a brain image, analogous to a pixel, but with the added dimension of depth. 1364-6613/$ -see front matter ß  ...  Functional MRI fMRI is able to measure changes in blood flow without use of the radioactive tracers required for PET imaging. fMRI images can also be acquired in less time than it takes to acquire PET  ...  Similar efforts have just begun for nonhuman primates.  ... 
doi:10.1016/j.tics.2013.09.013 pmid:24501779 fatcat:gpgvmnrnnfbxpjfqey7jtgwmba

Nonhuman Primate Models of Addiction and PET Imaging: Dopamine System Dysregulation [chapter]

Robert W. Gould, Linda J. Porrino, Michael A. Nader
2011 Current topics in behavioral neurosciences  
The combination of nonhuman primate behavior, pharmacology and state-of-the-art brain imaging using PET will provide the foundation for future studies aimed at developing behavioral and pharmacological  ...  This chapter highlights the use of nonhuman primate models of cocaine addiction and the use of positron emission tomography (PET) imaging to study the role of individual differences in vulnerability and  ...  ) imaging in nonhuman primate (NHP) models.  ... 
doi:10.1007/7854_2011_168 pmid:22020537 pmcid:PMC3831150 fatcat:aw75ayoxkvacdmgmvrtqjvo7cu

Impact of isoflurane anesthesia on D2 receptor occupancy by [18F]fallypride measured by microPET with a modified Logan plot

Mohammed N. Tantawy, Todd E. Peterson, Carrie K. Jones, Kari Johnson, Jerri M. Rook, P. Jeffrey Conn, Ronald M. Baldwin, M. Sib Ansari, Robert M. Kessler
2011 Synapse  
They were habituated in that restrainer for 3 days prior to the experiment day to minimize restraint-related stress.  ...  scans following radiotracer injection and the implication that different types of studies can be conducted simultaneously with this method, including studies of behavioral and environmental impact on brain  ...  The other method, applicable to imaging in rats, uses a miniature PET scanner ("RatCAP") that fits on the rat's head to enable conscious rat brain imaging without the effects of anesthesia (Schulz et  ... 
doi:10.1002/syn.20955 pmid:21584868 pmcid:PMC4078917 fatcat:txoawuvvcbf6xfplsxetwz3qda

Interview with George A. Ojemann

1999 Journal of Cognitive Neuroscience  
or not at all represented in nonhuman primates.  ...  Thus most studies examine verbal processes, and only a few of our studies have utilized visuospatial ma- terials that would also be suitable for nonhuman primate investigations.  ... 
doi:10.1162/089892999563436 pmid:10402260 fatcat:w7kjplaldzg5phk5fd5quwntza

Activation of neural pathways associated with sexual arousal in non-human primates

Craig F. Ferris, Charles T. Snowdon, Jean A. King, John M. Sullivan, Toni E. Ziegler, David P. Olson, Nancy J. Schultz-Darken, Pamela L. Tannenbaum, Reinhold Ludwig, Ziji Wu, Almuth Einspanier, J. Thomas Vaughan (+1 others)
2004 Journal of Magnetic Resonance Imaging  
Purpose: To evaluate brain activity associated with sexual arousal, fully conscious male marmoset monkeys were imaged during presentation of odors that naturally elicit high levels of sexual activity and  ...  Material and Methods: Male monkeys were lightly anesthetized, secured in a head and body restrainer with a built-in birdcage resonator and positioned in a 9.4-Tesla spectrometer.  ...  Seong-Gi Kim and his staff for their guidance and technical assistance with the imaging protocols.  ... 
doi:10.1002/jmri.10456 pmid:14745749 pmcid:PMC1525212 fatcat:svbi26e3tvhthamen4my3irenm

Ketamine-induced brain activation in awake female nonhuman primates: a translational functional imaging model

Eric Maltbie, Kaundinya Gopinath, Naoko Urushino, Doty Kempf, Leonard Howell
2015 Psychopharmacology  
The strong concordance of the functional imaging data in humans with these results from nonhuman primates highlights the translational value of the model and provides an excellent avenue for future research  ...  and without risperidone pretreatment (0.06mg/kg).  ...  Special thanks to the Yerkes Imaging Center, technicians Marisa Olsen and Juliet Brown, and to Christopher Muly, MD, PhD.  ... 
doi:10.1007/s00213-015-4175-8 pmid:26660447 pmcid:PMC4761287 fatcat:vudl2ambqrb7xbddh6bimjbmii

Setup and data analysis for functional magnetic resonance imaging of awake cat visual cortex

Manxiu Ma, Chencan Qian, Yanxia Li, Zhentao Zuo, Zuxiang Liu
2013 Neuroscience Bulletin  
In recent decades, fMRI has also been used in the awake monkey experiments to localize functional brain areas and to compare the functional differences between human and monkey brains.  ...  In this study, we extended the application of fMRI to awake cats without training, receiving a fl ickering checkerboard visual stimulus projected to a screen in front of them in a block-design paradigm  ...  (from Massachusetts General Hospital) with an additional restrainer was used to hold the cats because they are smaller than average nonhuman primates.  ... 
doi:10.1007/s12264-013-1349-4 pmid:23765516 pmcid:PMC5561958 fatcat:vzywy4jsxvb5pdy3fbk2x2rl3u

Noninvasive functional MRI in alert monkeys

Krishna Srihasam, Kevin Sullivan, Tristram Savage, Margaret S. Livingstone
2010 NeuroImage  
Discussion Monkey fMRI has already proven to be a profoundly useful tool for comparing and enriching human brain imaging studies with the extensive nonhuman primate brain data.  ...  Scanning awake monkeys is uniquely challenging.  ... 
doi:10.1016/j.neuroimage.2010.01.082 pmid:20116433 pmcid:PMC2847050 fatcat:npp4chopi5hl7iu2j6y6kwnz6y
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