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An apparatus and behavioral training protocol to conduct positron emission tomography (PET) neuroimaging in conscious rhesus monkeys
2001
Journal of Neuroscience Methods
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Specific attention was devoted to the development of an effective and comfortable head restraint device to be used in the imaging of conscious monkeys. ...
The results document the feasibility to conduct PET neuroimaging studies of cerebral blood flow in conscious nonhuman primates. ...
The brain images (color) shown above clearly demonstrate the ability to conduct brain activation studies during cocaine administration in awake nonhuman primates. ...
doi:10.1016/s0165-0270(01)00345-4
pmid:11325436
fatcat:ije6ktoblbeivolsfj2dqdotv4
Molecular Imaging of Conscious, Unrestrained Mice with AwakeSPECT
2013
Journal of Nuclear Medicine
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The binding potential of 123 I-ioflupane in the awake state was on the order of 50% of that obtained with the animal under anesthesia, consistent with previous studies in nonhuman primates. ...
of the dopamine transporter radioligand 123 I-ioflupane in mouse brain in the awake and anesthetized (isoflurane) states. ...
in a nonhuman primate study (30) . ...
doi:10.2967/jnumed.112.109090
pmid:23536223
pmcid:PMC3965297
fatcat:uearificxjfmpj2rvofymlydse
Awake Nonhuman Primate Brain PET Imaging with Minimal Head Restraint: Evaluation of GABAA-Benzodiazepine Binding with 11C-Flumazenil in Awake and Anesthetized Animals
2013
Journal of Nuclear Medicine
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Neuroreceptor imaging in the nonhuman primate (NHP) is valuable for translational research approaches in humans. ...
Cortisol levels were significantly higher under the awake condition (P , 0.05). Conclusion: We successfully performed awake NHP imaging with minimal head restraint. ...
ACKNOWLEDGMENTS We acknowledge the staff at the Yale PET Center, especially Shervin Liddie and Siobhan Ford, and other members of the NHP team, including Brooke Roberts, Amanda Abbott, and David Campbell ...
doi:10.2967/jnumed.113.122077
pmid:24115528
pmcid:PMC3857935
fatcat:5ddus7phsfhmzfpwywysmsicuq
Using PET H2O15 brain imaging to study the functional–anatomical correlates of non-human primate communication
2006
Methods
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In this article we describe methods for using oxygen-15 water (H 2 O 15 ) positron emmission tomography (PET) to explore the functional neuroanatomy of cognition in awake, non-human primates. ...
Methods for acquiring and analyzing PET data in order to identify significant regions of brain activity in single animals are also presented. ...
Implantation of head fixation devices in nonhuman primates is routinely done in various non-human primates laboratories, generally without complication or significant discomfort to the animals. ...
doi:10.1016/j.ymeth.2005.08.003
pmid:16466931
pmcid:PMC1550778
fatcat:ihkolf47lvghdgursh74d3m27i
Investigation of Cross-Species Translatability of Pharmacological MRI in Awake Nonhuman Primate - A Buprenorphine Challenge Study
2014
PLoS ONE
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Significant efforts have been made to establish awake imaging in rodents and nonhuman primates (NHP). ...
Conclusions: Our data highlight the utility and importance of awake NHP imaging as a translational imaging biomarker for drug research. ...
Study protocol of awake imaging in non-human primates. ...
doi:10.1371/journal.pone.0110432
pmid:25337714
pmcid:PMC4206294
fatcat:etclnxah2bcvfcdqxdvtud6dle
Cortical activation during cocaine use and extinction in rhesus monkeys
2009
Psychopharmacology
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Objective The present study was the first to use functional brain imaging to document acute cocaine-induced changes in brain activity during active drug use in nonhuman primates. ...
The same subjects were trained to self-administer cocaine under a fixed ratio schedule during image acquisition. ...
The present study was the first to use functional brain imaging to document acute cocaineinduced changes in brain activity during active drug use in nonhuman primates. ...
doi:10.1007/s00213-009-1720-3
pmid:19924404
pmcid:PMC2819208
fatcat:myao2zki3jcdfgfbg3u5vmfihy
Imaging Stroke Evolution after Middle Cerebral Artery Occlusion in Non-human Primates
2011
The Open Neuroimaging Journal
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This article reviews imaging approaches applied to the study of stroke in nonhuman primates. ...
We briefly survey the various surgical and minimally invasive experimental stroke models in nonhuman primates, followed by a summary of studies using computed tomography, positron emission tomography and ...
A key advantage of nonhuman primate fMRI studies is the ability to train animals to tolerate MRI scanning without the confounds of anesthetic restraint [46] . ...
doi:10.2174/1874440001105010216
pmid:22253663
pmcid:PMC3256846
fatcat:ehzw3ja3orf37e6bd6spn5ctfy
Comparative primate neuroimaging: insights into human brain evolution
2014
Trends in Cognitive Sciences
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Voxel: the smallest volumetric element of a brain image, analogous to a pixel, but with the added dimension of depth. 1364-6613/$ -see front matter ß ...
Functional MRI fMRI is able to measure changes in blood flow without use of the radioactive tracers required for PET imaging. fMRI images can also be acquired in less time than it takes to acquire PET ...
Similar efforts have just begun for nonhuman primates. ...
doi:10.1016/j.tics.2013.09.013
pmid:24501779
fatcat:gpgvmnrnnfbxpjfqey7jtgwmba
Nonhuman Primate Models of Addiction and PET Imaging: Dopamine System Dysregulation
[chapter]
2011
Current topics in behavioral neurosciences
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The combination of nonhuman primate behavior, pharmacology and state-of-the-art brain imaging using PET will provide the foundation for future studies aimed at developing behavioral and pharmacological ...
This chapter highlights the use of nonhuman primate models of cocaine addiction and the use of positron emission tomography (PET) imaging to study the role of individual differences in vulnerability and ...
) imaging in nonhuman primate (NHP) models. ...
doi:10.1007/7854_2011_168
pmid:22020537
pmcid:PMC3831150
fatcat:aw75ayoxkvacdmgmvrtqjvo7cu
Impact of isoflurane anesthesia on D2 receptor occupancy by [18F]fallypride measured by microPET with a modified Logan plot
2011
Synapse
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They were habituated in that restrainer for 3 days prior to the experiment day to minimize restraint-related stress. ...
scans following radiotracer injection and the implication that different types of studies can be conducted simultaneously with this method, including studies of behavioral and environmental impact on brain ...
The other method, applicable to imaging in rats, uses a miniature PET scanner ("RatCAP") that fits on the rat's head to enable conscious rat brain imaging without the effects of anesthesia (Schulz et ...
doi:10.1002/syn.20955
pmid:21584868
pmcid:PMC4078917
fatcat:txoawuvvcbf6xfplsxetwz3qda
Interview with George A. Ojemann
1999
Journal of Cognitive Neuroscience
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or not at all represented in nonhuman primates. ...
Thus most studies examine verbal processes, and only a few of our studies have utilized visuospatial ma- terials that would also be suitable for nonhuman primate investigations. ...
doi:10.1162/089892999563436
pmid:10402260
fatcat:w7kjplaldzg5phk5fd5quwntza
Activation of neural pathways associated with sexual arousal in non-human primates
2004
Journal of Magnetic Resonance Imaging
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Purpose: To evaluate brain activity associated with sexual arousal, fully conscious male marmoset monkeys were imaged during presentation of odors that naturally elicit high levels of sexual activity and ...
Material and Methods: Male monkeys were lightly anesthetized, secured in a head and body restrainer with a built-in birdcage resonator and positioned in a 9.4-Tesla spectrometer. ...
Seong-Gi Kim and his staff for their guidance and technical assistance with the imaging protocols. ...
doi:10.1002/jmri.10456
pmid:14745749
pmcid:PMC1525212
fatcat:svbi26e3tvhthamen4my3irenm
Ketamine-induced brain activation in awake female nonhuman primates: a translational functional imaging model
2015
Psychopharmacology
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The strong concordance of the functional imaging data in humans with these results from nonhuman primates highlights the translational value of the model and provides an excellent avenue for future research ...
and without risperidone pretreatment (0.06mg/kg). ...
Special thanks to the Yerkes Imaging Center, technicians Marisa Olsen and Juliet Brown, and to Christopher Muly, MD, PhD. ...
doi:10.1007/s00213-015-4175-8
pmid:26660447
pmcid:PMC4761287
fatcat:vudl2ambqrb7xbddh6bimjbmii
Setup and data analysis for functional magnetic resonance imaging of awake cat visual cortex
2013
Neuroscience Bulletin
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In recent decades, fMRI has also been used in the awake monkey experiments to localize functional brain areas and to compare the functional differences between human and monkey brains. ...
In this study, we extended the application of fMRI to awake cats without training, receiving a fl ickering checkerboard visual stimulus projected to a screen in front of them in a block-design paradigm ...
(from Massachusetts General Hospital) with an additional restrainer was used to hold the cats because they are smaller than average nonhuman primates. ...
doi:10.1007/s12264-013-1349-4
pmid:23765516
pmcid:PMC5561958
fatcat:vzywy4jsxvb5pdy3fbk2x2rl3u
Noninvasive functional MRI in alert monkeys
2010
NeuroImage
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Discussion Monkey fMRI has already proven to be a profoundly useful tool for comparing and enriching human brain imaging studies with the extensive nonhuman primate brain data. ...
Scanning awake monkeys is uniquely challenging. ...
doi:10.1016/j.neuroimage.2010.01.082
pmid:20116433
pmcid:PMC2847050
fatcat:npp4chopi5hl7iu2j6y6kwnz6y
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